I HAVE FOUND THE CURE TO CANCER

[Pax No.14648737]

DEFEROXAMINE CURES CANCER

> High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines
https://pubmed.ncbi.nlm.nih.gov/29562821/
> An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells

> Fryknäs, M., Zhang, X., Bremberg, U. et al. Iron chelators target both proliferating and quiescent cancer cells. Sci Rep 6, 38343 (2016).
https://doi.org/10.1038/srep38343
> Deferoxamine Inhibition of Human Neuroblastoma Viability and Proliferation
https://aacrjournals.org/cancerres/article/48/24_Part_1/7189/493542/Deferoxamine-Inhibition-of-Human-Neuroblastoma
> Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death
https://www.frontiersin.org/articles/10.3389/fonc.2021.794735/full
> Deferoxamine Increases Breast Cancer Radiosensitivity

> Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
https://www.e-cep.org/journal/view.php?number=2009520212
> A Case of Positive Tumor Marker Response after Intra-arterial Deferoxamine Infusion Therapy in a Hepatocellular Carcinoma Patient with Decompensated Liver Function
https://www.e-jlc.org/journal/view.php?doi=10.17998/jlc.14.2.127

Intranasal deferoxamine targets the brain primarily and suppresses inflammation improving central insulin sensitivity and this has downstream effects within the periphery by improving insulin sensitivity, insulin transport to the brain as well as supporting the function of our hypothalamus.
> Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

[Pax !!cu2HYeafqTG No.14648802]

>>14648737
There's a lot of data here to suggest that iron chelation will improve chemotherapy and help reverse oncogenic transformation. Through the mitigation of hypothalamic inflammation within the brain with intranasal deferoxamine and insulin would help maintain peripheral insulin sensitivity and may improve survival in cancer, and improve diabetes, liver disease, many different facets of cognitive and metabolic disorders that are all treatable by reducing inflammation within the hypothalamus and promoting cerebral insulin supersensitivity. I would not say that this would cure cancer I'm sure that I can make the statement that it wouldn't cause cancer and will improve the therapeutic index of chemotherapy and I'd be happy enough with people developing an understanding to which they can apply that towards helping others or perhaps even changing the direction of scientific research. Happy to see you excited. This should be evaluated based on the evidence presented and people can form their own insights based on it.

[Anonymous No.14648827]

btw im trans idk if that matters

[Anonymous No.14648852]

>>14648802
How's the deferoxamine treating you as of late? BTW whats the link to your discord

[Anonymous No.14649112]

>>14648737
meds, schizo.

[Anonymous No.14649759]

Are these those famed /sci/entists?

[Anonymous No.14649826]

>>14649759
yeah the very same that get laughed at by real scientists.

[Anonymous No.14649926]

I also found the cure to cancer. Collagen protein misfolding.

[Anonymous No.14652077]

>>14648827
fail

[Anonymous No.14652123]

>>14648802
Hey Pax (hope I'm replying to the real one and not just one LARPing as him), I just wanted to say I highly appreciate your research. You are definitely onto something, and I say that after having skimmed through many of the studies you have posted.
I assume all the imposters are people from rivaling nootropic spaces, as this seems far too much work for a troll doing it for the lulz, so to remain credible, having just a tripcode may not be enough as the well has been poisoned too much already.
I have the following proposition which you may consider: Write a meta-analysis and try to submit it to researchgate. You can sign up there without having a degree in something and if your paper is formatted correctly, it'll easily be accepted. So just do some [math]\LaTeX[/math] and you'll have a beautiful paper ready to submit in no time. Having it all in one place on a reputable website will always just require linking to it to shut trolls down. It will also be indexed on Google Scholar, making more academics knowledgeable about this very potent treatment.

[Pax !!cu2HYeafqTG No.14653775]

>>14652123
> I just wanted to say I highly appreciate your research. You are definitely onto something, and I say that after having skimmed through many of the studies you have posted.

Thanks!
> the well has been poisoned too much already.

We've come far in the past week and I see all of the support, the threads on deferoxamine made by so many different imposters it feels kind of appropriate to say that we've created a reality where there's people that impersonate me and almost blindly go through all efforts to share my research I believe we're past the point of contention. There's about 12 of us and we report amazing improvements in our heath and cognition. My memory is as good as you might possibly imagine and improvements in all cognitive domains including hearing and eyesight.My reaction time is significantly better, I don't experience sadness or anxiety whatsoever. If i can summarize everything in one sentence we just feel life more!

I can say its everything I've gotten from researching for 8 years its insane how its possible for me to learn as much as i now know like the back of my hand.

I hope its been entertaining. The imposters have little credibility and people see through that.

[Anonymous No.14653816]

>>14648802
could you throw metformin into the mix/

[Anonymous No.14653986]

>>14653775
discord link

[Anonymous No.14654043]

>>14653986
gibe

[Anonymous No.14654443]

>>14653775
As long as it doesn't affect you too much, it's fine I guess. Just know that most people now know you as the meth guy and think of DFO as tantamount to it. A paper summarizing everything is always better and getting one onto researchgate isn't difficult in the slightest. Even the 12000rpm schizo who claims to have refuted conservation of angular momentum got his schizophasia published there, they aren't that strict.

[cassandra malcador true swanns proposal true void eldritch star god NEO Gods admin No.14654631]

>>14648737
https://youtu.be/p94kEhmGmgI

https://youtu.be/edQ9q0z7Bp4

https://youtu.be/2dusXy85ABM

you don't need that even

use the frequencies above

everything is energy frequencies vibration

can be spirit matter movement density

even physics gravity science(lower alchemy) et. al is energy

[Anonymous No.14654642]

>>14648802
How's your fungus infection? Went blind yet?

[Anonymous No.14654643]

>>14654631
>et. al
do you even know what et al. means you massive fucking brainlet kek

[Anonymous No.14654658]

>>14654443
Did he refute anything tho or was it just bullshit?

[Anonymous No.14654671]

>>14654658
His "proof" doesn't really have anything to do with the conservation of angular momentum, is loaded with untrue assumptions, and he also never really refuted the huge amounts of proofs for it, always replying "b-but nature refutes this". He also doesn't know what the lack of conservation of momentum really implies. It's about as schizo as you can get.

[Anonymous No.14654676]

>>14654671
Sounds based. I fucking hate science, I would have a drink with this schizo genius

[Anonymous No.14654690]

>>14648802
I'm curious, if this removes iron from the brain that is slowly deposited, could you still get effects from this without doing it daily? do you just need to do this for a week or some amount of time until your brain is free of iron and then your brain will have a desired efficacy for quite some time? I suppose it would depend on how long it takes for the iron to accumulate and how long it takes for deferoxamine to get it out?

[Anonymous No.14654692]

>>14654676
Go to your local asylum and you'll find hundreds of such people. The medical term for them is "schizotypals". I'm sure the nurses would love it if you were to take care of them for free.

[Anonymous No.14654700]

>>14654692
>magical beliefs
Insert Chad image here. Holy fucking based.

[Anonymous No.14655449]

>>14654692
wtf if that's right then i'm a schizoid freak

[Pax !!cu2HYeafqTG No.14655739]

>>14654690
> could you still get effects from this without doing it daily?
Yes the effects that we've noticed especially myself is that the effects of deferoxamine are long term and shared similar effects in everyone that's tried it. For people that've done a gram or less all show strong benefits even at less than 500mg. The cost for 500mg is close to $6 if put in context for the whole box. I've dosed about 4 grams so far. I have high levels of mental stamina throughout the day, my emotional resiliency is almost robotic, I don't experience any anxiety for the most part, I'm euphoric almost at all times. I can write reviews of the literature based on a photographic memory of biology and can dedicate large portions of time to describing these ideas without stopping.

[Anonymous No.14656145]

>>14655739
Where does the euphoria come from, mechanistically? I'm not too familiar with the HIF-1α and VEGF pathways

[Anonymous No.14656173]

>>14655739
what's your discord link

[Anonymous No.14656190]

>>14655739
>>14656173
this

[Anonymous No.14656558]

>>14656190
fucking faggot is quick to speak about the intracellular ramifications of deferoxamine in full detail but goes radio silent when someone wants to join his discord and be apart of his shit

[Grin2b No.14657268]

>>14656558
The discord is full of mouthbreathers. Pax also disabled invites, so sorry, I can't create one for you. A few days ago, he went absolutely paranoid and disabled all the current invites, prevented people from making them, etc.
His discord tag is Pax1l#7887 though, his other one dogwasher12#3553. Maybe he'll invite you, who knows.
But as I said, most people there are retarded. One guy hasn't noticed any benefits from DFO and keeps on coping as to why that may be, even considering now to put that shit into his eyes lol. If you think that place is where neuroscientists and scholars reside, as Pax claims, you're gonna be disappointed

[Pax !!cu2HYeafqTG No.14657699]

>>14657268
pic related
>>14656145
Iron accumulation within our braincells promotes cerebral insulin resistance which leads to defects in autophagy and failure of our mitochondria in cognitive decline. Removing the iron that's within the lysosome of our brain cells improves their mitochondrial function and this supports our metabolic functions through improvements in insulin sensitivity reducing hypothalamic inflammation as a consequence of reduced insulin transport to the brain in metabolic disorder. Improving insulin transport and sensitivity within the brain increases neurogenesis, atp generation, protein synthesis and synaptic trafficking of neurotransmitter receptors to the cell surface. Insulin activates Nachar7 receptors on cholinergic gaba interneurons(somatostatin) and this increases synchronicity between the frontal lobe and hippocampus in gabaergic inhibition. Somatostatin interneurons reduce the activity of parvalbumin interneurons disinhibiting pyramidal neurons that are dopamine sensitive to promote reward.
> Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593079/
> Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
Nature Communications volume 6, Article number: 8543 (2015)
> Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766825/
> Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis
Cell Death & Disease volume 8, page e2676 (2017)
> Iron chelation down-regulates dopamine transporter expression by decreasing mRNA stability and increasing endocytosis in N2a cells
https://pubmed.ncbi.nlm.nih.gov/21147099/
> Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina
> https://www.biorxiv.org/content/10.1101/2021.03.30.437706v1.full

[Anonymous No.14657777]

>>14653775
>My memory is as good as you might possibly imagine and improvements in all cognitive domains including hearing and eyesight.My reaction time is significantly better
proof?

[Anonymous No.14657821]

>>14657699
Why do you do meth when it causes brain damage when you want to get smarter

[Anonymous No.14657824]

>>14657777
based quads of truth. Pax will never post any evidence

[Pax !!cu2HYeafqTG No.14657838]

>>14657777
I have a photographic memory of the medical literature as its known to me. I lead a large group of individuals willing to learn neuroscience from me. I've had phd students, neurologists in training, neuropharmacologists, and former neuroscientists say that I understand more than them. I have been told countless times that I've changed lives with my research.


https://desuarchive.org/fit/thread/67429324/
This thread is all taken from writeups that I've made describing the pathology and mechanisms of neurological and metabolic disorders as well as enterprising therapeutics such as deferoxamine to slow the progression of those disorders and improve health and well being.
> Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease
https://www.sciencedirect.com/science/article/abs/pii/S0022510X17304628
> Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome
https://pubmed.ncbi.nlm.nih.gov/28726200/
It's demonstrated that ames dwarf mice which live 70% longer than wildtype mice also possess significantly better cognitive functions which don't decline with aging. These mice have insulin receptor supersensitivity due to the loss in function of their growth hormone receptor. This promotes increased transport of insulin and IGF1 to the brain. They have significantly improved cognitive and metabolic health through a reduction of inflammation and significantly stronger glutamatergic homeostasis.
> Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging
https://pubmed.ncbi.nlm.nih.gov/25711529/

[Anonymous No.14657900]

[Anonymous No.14657946]

>>14657838
>I've had phd students, neurologists in training, neuropharmacologists, and former neuroscientists say that I understand more than them
Just from reading tons of pubmed articles? Or did you also go through some books? I'm a math PhD but I've been interested in anti-aging for years and want to commit my free time to it

[Pax !!cu2HYeafqTG No.14658022]

>>14657946
I've been glued to studying the science of longevity for 8 years and about a year and a half ago I really hit my zenith because I met so many incredible researchers who formed a large community of nootropics scholars and I took it upon myself to double down on the efforts that I spent years studying just for the opportunity. Nowhere did i imagine when I first began that I'd get to where I am now. Being surrounded with incredibly knowledgeable people makes it easy to pick up on the concepts of neuroscience because you're constantly running into debates, networking, organizing projects and sharing research. The wasoru archives are fantastic if you just want to start diving into the archived threads on deferoxamine. I've gotten a tripcode on the 19th of june so everyone else past that point is provably an impersonator. I came to 4chan after people began taking my writeups and posting them on 4chan so I took the opportunity to jump in with the crowd and cleared the air on intranasal deferoxamine while gaining a large group of supporters, many of which have used deferoxamine and had dramatic improvements in their health and cognition.
Post >14547801 is where I can say things really got crazy!

[Anonymous No.14658034]

>>14658022
:O

[Anonymous No.14658103]

>>14658022
alright. I already studied your dfo effortposts quite a bit, really appreciate them. Guess I'll just make threads every now and then about questions I have regarding the mechanisms as long as you're active here. /sci/ definitely needs more effortpost, especially with regards to biology and other natural sciences. We've only really had such before in math and physics (in fact, an anon here proved a rather big conjecture in math before https://www.wikiwand.com/en/Superpermutation#/Lower_bounds,_or_the_Haruhi_problem ).

[Anonymous No.14658303]

>>14658022
Also Pax, what exactly is the diet of the mice in the studies you posted? Specifically the iron intake? Most of the time, that data isn't given.

[Anonymous No.14658394]

>>14658022
Please answer here sir. I gave you a (you)
>>14657821

[Anonymous No.14658911]

>>14648737
>>14648802
is that actually a picture of you, Pax?

[Anonymous No.14658913]

>>14658911

[Anonymous No.14658915]

>>14658913
Is pax the same person as copperschizo?

[Anonymous No.14658918]

>>14658915
not sure but he's been talking about iron doing bad stuff to the body for a year at least

[Anonymous No.14658941]

>>14658918
probably the same person
Nice to see the face matches the kind of person i thought would post that shit

[Anonymous No.14658945]

>>14658941
have you heard his voice before? This is it, btw https://vocaroo.com/1hmJkw10q0dd
He spammed his voice messages in the /med/ general for some reason

[Anonymous No.14658960]

>>14658941
I worked at a psychiatry for a few months and it's insane how often the physiognomy matches the schizophrenia. But I guess it isn't that surprising since of course schizos don't take care of themselves and not doing so for years will make you look like a methhead

[Pax !!cu2HYeafqTG No.14659876]

>>14658394
There are many imitators and impersonators and i've made my tripcode after someone had made posts trying to assert that I use methamphetamine. If you believe the fables told about me and are so incredibly easy to manipulate based on the whims of trolls then you're blinded by the greater lies meant to conceal the truth about Deferoxamine and neuroscience from you. It's very highly possible that the smear campaign against me is meant to drive a greater wedge in the nootropics community as a whole and turn men into beasts. I've known and been associated with a large network of scholars, neuroscientists, narcicists and psychopaths and I will not shy away from telling the truth so that humanity at large can be free to explore their collective destiny freed from the system of greed perpetuated by the most self interested and evil intentions that man could ever fathom. Greed and the seeking of capital is apathetic to the will to improve human quality of life. The system of greed that they perpetuate is powerless to stop the collective ascension of humanity and even if something were to happen to me then still the truth is out there. I will stop at nothing in order to bring a brighter future for humanity to light. The world is rotting.
https://www.youtube.com/watch?v=i_DwUYXifrw
>>14658303
It's been demonstrated in mice that are placed on low iron diets have improvements in metabolic health and slowed cognitive decline but I believe its inconsequential to the inflammatory effects of LPS, Saturated fats, oxidized cholesterol, Covid, other viruses, alcohol, hard drugs, microplastics all promoting defects in cerebral insulin sensitivity promoting transcriptional drift from glutamatergic disinhibition leading to the promotion of endozapine release from neurons increasing gabaergic tone and promoting cognitive decline from hepatic encephalopathy. Insulin resistance leads to the defects in the channeling of iron into protein synthesis and leads to epo resistance.

[Anonymous No.14660026]

>>14659876
>inflammatory effects of LPS, Saturated fats, oxidized cholesterol
I already debunked this in the last thread >>14658605
>>14658616
please explain how I'm wrong