This is beyond comprehension

[Anonymous No.9783465]

Let's say you get unlimited funding to properly research DMT. Where would you even begin to explain why something so similar to serotonin can induce such odderwordly and impossible states of mind.
This will launch you to another dimension that feels realer than reality. How is this possible?

[Anonymous No.9783474]

>>9783465
Because your brain has the means to make you feel anything you can feel obviously. Environmental stimuli work within the range of sensations the brain can give. So a drug which causes your brain to malfunction can cause a whole host of bizarre experiences. It's not magical, it's just a confused brain.

[Anonymous No.9784106]

>>9783474

The true question is why a serotonin analogue can have such an effect on the mind. It's not just the hallucinogenic property of the trip, you legitimately feel as if you've left your body to explore the universe.
Also DMT doesn't affect your mind in the sense that you don't feel doped or high, it acts exclusively on your senses.

[Anonymous No.9784110]

>>9783465
I guess I would take a broad, thorough survey of all of its physiological effects, like effect on heart rate, respiration, endocrine levels, body temperature, etc., and try to draw any connections between those and the subjective experiences of the test subjects via trip reports, and see what parts of the dmt experience might be attributable to physiology

[Anonymous No.9784129]

>>9783465
>odderwordly

[Anonymous No.9784157]

>why does it feel like youve left your body to another dimension
Because youre basically wildly hallucinating 24/7 in the first place dummy.
>but its so similar to seratonin!
Lots of chemicals are only a single molecule apart but have wildly different behaviors, your drug factory of a brain is no different.
DMT is basically like dumping a shitload of dream drug into your skull without being asleep, which is why it feels so otherworldly

[Anonymous No.9784170]

>>9784129
Have you tired it? It doesn't even begin to describe the experience.

[Anonymous No.9784187]

>>9784170
>have you tired it
>you tired it
>tired it

sorry I forgot how the eire do it.

[Anonymous No.9784189]

>>9784106
What do you mean why? Because it's "designed" to do that? The answer would just be that it has a particular mechanism that uniquely affects a specific part of the brain in a specific way. Would that satisfy you or are you just looking for your preconceived metaphysical mumbo jumbo to be confirmed? Because it never will be.

[Anonymous No.9784202]

>>9784189
>It's "designed" to do that
Lel.
There's no shame in admitting you don't have a clue

[Anonymous No.9784222]

next level junkie coping

[Anonymous No.9784303]

>>9784222

What makes you think there is a need to cope with non toxic, non addictive natural psychedelics?

[Anonymous No.9784842]

>>9784303
Non addictive drugs are, in essence, addictive to addictive -soul searching- personalities.

[Anonymous No.9784861]

>>9783474
>nothing happens when you die
>trust me

[Anonymous No.9784875]

>>9784106
>The true question is why a serotonin analogue

Have you ever considered that in some cases it is a single amino acid change which can make the difference between a functioning protein and a non-funtioning one? That a single amino acid change can be the cause of a virus being pathogenic in a certain host vs not being?

Minor changes can have significant impacts on the capability of that something to effect. There's nothing amazing about DMT being 'so' similar to serotonin yet 'so' different when you realise this.

[Anonymous No.9784994]

You can't have these threads in a board as pretentious as /sci/. No one dares consider anything outside what they already think they know, most haven't even tried it or want to so they immediately disregard it as something below them.

But to those that have been through the mandala understand there is something truly captivating about the substance and its an absolute shame that there is so little actual research being made.

[Anonymous No.9785003]

>>9784994
>No one dares consider anything outside what they already think they know
/sci/ in a nutshell
atheists in a nutshell
agnostics in a nutshell
Religious ppl in a nutshell
all sheep.

[Anonymous No.9785025]

>>9784994

This.

Often /sci/ acts no better than a regular chimp out. Absolute garbage tier attitude and unscientific thinking from twats who have no business being here.

[Anonymous No.9785040]

I've heard to many thing about this substance that I ended up trying it but the experience ended right at the infamous "mandala", I heard the low pitch sound and felt a tremble similar to turbulence on a plane and right when I thought I was about to be launched through the visuals dissolved and I was completely sober 10 seconds later.

Has anyone gone through? Does the sound / shaking ever stop?

[Anonymous No.9785044]

>>9783465
Don’t multiple people see machine elves or something?

[Anonymous No.9785119]

>>9785025
>who have no business being here.
how unwelcoming. It's almost as if you have an ego or something ;)

[Anonymous No.9785151]

>>9784875
All of these phenomena are equally puzzling and compelling for an appropriate explanation. Why should slight changes in molecular structure cause big changes in the cascading cause and effect? Understanding this would have big impact on pharmacology and other fields.

[Anonymous No.9785154]

>>9784842

Everything that causes the release of dopamine has the exact same potential effect you illiterate nigger.

[Anonymous No.9785157]

>>9785119

Its only unwelcoming if you're said twat :^)

[Anonymous No.9785181]

>>9785157
disregards the ego part
;)

[Anonymous No.9785196]

>>9784157
you're right about the wildly hallucinating part but wrong about everything else
he draws the comparison to serotonin not because of superficial molecule structure (as you said) but because almost all hallucinogens work on a serotonin receptor (5ht2a) and act in place of serotonin. as well your brain doesn't even come close to mimicing sleep and 5ht2a receptor activation literally makes it harder to fall asleep

[Anonymous No.9785251]

>>9785025
It's most of the science community. Which is understandable to question new experiences and theories, but so many dont even question them. They try to answer or explain new things with old models that dont actually fit because finding something new destroys their superiority complex and reminds them they actually know just as little as joe schmoe at the bar down the road and that's a terrifying concept to someone who's life is entirely built on their "knowledge"

[Anonymous No.9785257]

>>9785151
But people do know this.. It's literally a book or a Google search away. Your perspective of a very well understood atomic and molecular process, as interesting as it is to you, is really just placing poetic meaning on a physical ontology.

[Anonymous No.9785266]

4chan - it's Japanese for family!

[Anonymous No.9785267]

>>9785257
I thought we didnt understand how electrons interact with each other, or our universe. I could be wrong, my understanding of the functionality of the electron is very limited

[Anonymous No.9785272]

>>9785267
1

[Anonymous No.9785273]

>>9785257

>But people do know this
The thread is very obviously about what we do NOT know. There is no need to shit up the thread with your insatiable thirst for attention.

[Anonymous No.9785274]

>>9785267
convalescent field harmonics

[Anonymous No.9785280]

>>9785274
Yeah you'll have to elaborate. Nothings coming up on that term

[Anonymous No.9785283]

>>9785280
I am, if you hadn't noticed.

[Anonymous No.9785286]

>>9785283

[Anonymous No.9785289]

>>9785286
You are off center still a little, but that's okay.

[Anonymous No.9785294]

>>9785289
How's this

[Anonymous No.9785297]

>>9785294
Closer to 4chan territory 'relatable'. Incest.

[/psy/mon|三|/sci/mon No.9785318]

Buddha blooms now

現在佛花

أزهار بوذا الآن

[Anonymous No.9785323]

E8 can simulate the skeleton of the mandala you see right before being launched to hyperspace

https://www.youtube.com/watch?v=E-LC_l3gNuc

[Anonymous No.9785706]

>>9783465
drugs just make you delusional. Don't put so much meaning in chemicals that make you hallucinate. It comes off as arrogant and ignorant.

[Anonymous No.9785723]

>>9785151
>Why should slight changes in molecular structure cause big changes in the cascading cause and effect?
See, this is what I find frustrating. People itt tried answering your question but it wasn't what you wanted to hear so you immediately dismissed them as ignorant and closed-minded. And yet with your question you show that you lack basic knowledge of organic chemistry. What makes you feel entitled to call out actual scientists on being wrong? Seriously, go read a chem book and all your questions will be answered.

[Anonymous No.9785725]

>>9783465
neural feedback loops

yeah i tried it

[Anonymous No.9785729]

>>9785318
>現在佛花
... that doesn't look good. doesn't feel ancient neither.

[/psy/mon|三|/sci/mon No.9785794]

>>9785729
莉莉的精液

[Anonymous No.9785974]

>>9785267
We don't have a 100% understanding, no. But we do know on a fundamental level how the observable universe works (including how dmt is synthesized etc), and this basic fundamental understanding of physics will never change. Not in 500 years, not ever.

[Anonymous No.9785978]

>>9785723
This

>>9785273
Take notice.

[Anonymous No.9785980]

https://youtu.be/xv0mKsO2goA

Op try this. It won't directly speak of what information you are seeking for (in itself, a problem), but as another poster has pointed out - it will explain very poignantly that the answer you seek can't possibly be true.

Unless of course you want to write a new core theory and somehow prove general relativity is wrong (to this date, it has made predictions with 100% accuracy in regards to our 'experienced' universe.

Enjoy - I feel you would like it if you were high.

[Anonymous No.9785992]

>>9785974
>and this basic fundamental understanding of physics will never change. Not in 500 years, not ever.
Why do people say this when everything we know has been constantly changing throughout human history?

[Anonymous No.9785995]

>>9785992
Because the core theory is different. Yes we will discover more about quantum mechanics and gravity, but in regards to the actual physical world we experience and can measure, we have 100% working theories that predict exactly what we set out to do.

This time it is different. If you would like to know more on why this is, I could provide you with a book or a lecture explaining why.

[Anonymous No.9786002]

>>9785995
that essay on the "levels of wrongness" or whatever the fuck it was called is a good one. We're not gonna wake up tomorrow and see that scientists discovered the earth is actually a cube. We have, in the past, discovered it's not a sphere though and is actually an oblate spheroid. Similar to one of the examples used in that essay. The specificity of things we are wrong about will increase and the amount of scraps of "bad theory" we have to throw away will decrease.

[Anonymous No.9786004]

>>9785992
Start by watching >>9785980

Sean Carroll is awsome, surprised more here don't sprout his stuff. Really makes me think people on this board try to talk about physics and don't even understand the well established basics that have been around for quite some time.

Heck, even a brief history of time explains all of this. I literally saw some thread the other day bashing Feynman, then directly under was a thread about quantum mechanics and some pseudoscience undergraduate opinion on anti matter.

I encourage everyone with even the slightest interest in the universe to understand the philosophy and science of physics.

Once you have a good grasp on it, you won't have to worry about meme questions like souls, time travel, time itself etc. It's not a mystery, but a process explains by entropy, atomic theory and path internal formulation of quantum mechanics.

[Anonymous No.9786010]

>>9785995
Link me up brudda. I'm not denying the science or anything, I just have a hard time putting all my chips in on anything anymore

[Anonymous No.9786011]

>>9786002
Yeah this. Baysian reasoning should inform us. I haven't heard about this essay, but I will look it up.

The big picture is an excellent book that is pretty much this.

[Anonymous No.9786018]

>>9786010
https://youtu.be/xv0mKsO2goA

Not as relevant, but excellent none the less and covers similar ideas

https://youtu.be/rEr-t17m2Fo


If you enjoy this stuff, his book the big picture is an incredibly insightful read that expands these concepts and relates them to conciousness, biology, morality. A good book for anyone who wants to arm themselves with the tools on how to assign credences to what is real and what isn't. Sorry for the shilling

[Anonymous No.9786021]

>>9786018
Nah this is exactly the type of material I've been looking for lately

[Anonymous No.9786024]

>>9786021
Hope you enjoy!

[Anonymous No.9786032]

I think that the real question isn't:
>The true question is why a serotonin analogue can have such an effect on the mind.
But why a substance that we natural produce can makes us feel that way and which effects it cause in our body and perception when we produce it endogenously.

[Anonymous No.9786307]

All you faggots are completely wrong about DMT not being similar to serotonin. No one said that it’s molecular structure is similar to serotonin or argued that this could ever be important .DMT is an agonist that binds to the fucking 5ht receptors. Guess what the endogenous agonist is for the 5ht receptors are? (Hint: it’s the name of the fucking receptor)

[Anonymous No.9786740]

>>9786032
Dont forget it's naturally produced in thousands of plant species as well

[Anonymous No.9786816]

>>9784994
man stfu. you must be a real impressionable kid to believe in other dimensions and that kind of bullshit. i've done both ayahuasca and vaped freebase, yes it can change your psychology a lot and it should be studied (as a potential cure for depression etc) but impressionable new age idiots like you make it out to be magical. yes we get it you need escapism, but this isn't the board for that

>>>/x/

[Anonymous No.9786825]

>>9786816

>but yeah you're right

sweet jesus you are the biggest faggot in the thread

[Anonymous No.9786837]

>>9786825
this board isn't about spooks. there is a board for this, and it's /x/

[Anonymous No.9786838]

>>9786837

the thread isn't about spooks, either

[Anonymous No.9786840]

>>9786740
Yeah I know, but that still without answering the question.

[Anonymous No.9786841]

>>9786838
there are faggots who think dmt takes you to alternate dimensions itt, and there are faggots who don't understand biology. one should gtfo back to /x/, the other should study more

[Anonymous No.9786846]

>>9786841

most of the faggots here are insecure niggers like you, there is so little actual information out there about the effects of DMT that immediately disregarding it as nothing at all only or even worse, some /x/ tier shit only exposes you as the massive retard that you are

this thread is about discussing how would someone even begin a proper study on its effects and attention whoring kids like you just jump to completely unrelated conclusions just to feel at ease with the fact that we just don't know yet

[Anonymous No.9786874]

>>9786846
>i'm insecure for not being an /x/fag

kys kid

[Anonymous No.9786886]

>>9786874

>that common core reading comprehension

[Anonymous No.9786996]

>>9786816
Whoa this guy has all the answers

[Anonymous No.9787046]

>>9786996
>whoa dude dmt is like sacred, do you know how high i got last time i scored?

[Anonymous No.9787051]

>>9787046
Never done it m8. My family has a history of schizophrenia so I stay away for now

[Anonymous No.9787114]

>>9787046

>if I don't understand it I must mock it as magik

literal retard

[Anonymous No.9787116]

>>9785040
For me, the sound intensified until I "popped" through...really hard to describe.

The experience you had reminds me of the times I didn't smoke enough. At that stage you should still be taking hits if your goal is to break through.

[Anonymous No.9787126]

>>9783465
You can't study subjective experience empirically.
>>>/x/
And that's coming from t. shroomhead

[Anonymous No.9787136]

>>9784157
>Lots of chemicals are only a single molecule apart but have wildly different behaviors, your drug factory of a brain is no different.
This. See hemoglobin and chlorophyll

[Anonymous No.9787138]

>>9787114
i do understand it. you're the one mystifying hallucinations and this isn't the place to do it

>>>/x/

[Anonymous No.9787145]

>>9787138
>>9787126

>I do understand it

[Anonymous No.9787155]

>>9787145
>saying "you don't understand" is a valid argument

it's not junky

[Anonymous No.9787161]

>>9787155
To be fair, you havent really said anything that implies you understand the effects of DMT on the brain either apart from, lol u hallucinate

[Anonymous No.9787177]

>>9785040
It's normal, you just took to little, used wrong technique or something.
Not everyone reach breakthrough, especially on first try. I've never went there even though I've smoked it many times.
You might find it interesting: https://youtu.be/6umdf4Ef970

>>9785044
This is just a generic term for other beings you might find there.

[Anonymous No.9787186]

>>9787145
I'm not >>9787138
I'm not saying I understand it. I'm saying it's not viable for study.

[Anonymous No.9787209]

>>9787155

>pretending you understanding something is

you should try your luck at /r9k/ with that much desperation for attention

[Anonymous No.9787219]

>>9787209
i'm literally a neurobiologist who has done dmt more than 100 times. you're ridiculous

[Anonymous No.9787223]

>>9787219

you're fucking pathetic

[Anonymous No.9787242]

>>9787219
>neurobiologist
Yeah find that tumor, monkey boy

[Anonymous No.9787277]

>>9787242
electrophysiologist you dumb junkie

[Anonymous No.9787350]

>>9787277
Oh so you look at the other part of the scan got it. Sounds rough

[Anonymous No.9788080]

probably mostly has to do with dampening the thalamus' filtering of sensory information

[Anonymous No.9788455]

>this whole thread

Puny humans and their fragile egos.

[Anonymous No.9788633]

>>9788455

[Anonymous No.9788692]

It used to bother me that theres little research being done (government doesnt want us to know the truth durr hurr) BUT i recently stumbled upon a short video on youtube of a man of alleged IQ 200 (just type in high IQ or man with IQ 200) who is researching how the mind-physical space is related, trying to prove god and after life and what not so dont worry, *somebody* and that somebody just happens to be the smartest guy ever alive is currently deriving formullas on related topic as we speak.

[Anonymous No.9788711]

>>9788692
this post made me laugh irl.

[Anonymous No.9788749]

>>9786002
>>9786011
I assume this is the one: https://chem.tufts.edu/answersinscience/relativityofwrong.htm

[Anonymous No.9790184]

>>9785044
>multiple
It's like same space, with same distortion causes same product... You so retarded.

[Anonymous No.9790186]

>>9783465
It makes your brain plastic. That's it. You can actually move synapses you couldn't otherwise.

[Anonymous No.9790203]

>>9783465
How is the nootropic thread deleted and this one not?

[Anonymous No.9790515]

Alligator android alien rape fest

[Anonymous No.9792463]

>>9783465
DMT, contrary to serotonin, does not only act on serotonin (5-HT) receptor, but also seems to have affinity with sigmoid-1 receptors (which could explain why DMT could potentially help patients with schizophrenia).
This was discovered in 2009: https://www.ncbi.nlm.nih.gov/pubmed/19213917

[Anonymous No.9792499]

>>9792463
Another article (more like a review, actually) debunks the link between pineal gland and DMT as well as the myth that DMT is released near death. The article is called ""N,N-dimethyltryptamine and the pineal gland: Separating fact from myth" (2018). Here are the conclusion (copy-paste from the paper):

>1. DMT is not produced in concentrations significant to activate CNS 5-HT2A receptors, and is rapidly broken down by MAO if it is produced.
>2. There is no evidence to suggest that DMT can accumulate within the brain or within neurons at physiologically relevant concentrations; such inferences are either not supported by direct experimental evidence or are based on flawed experiments.
>3. Endorphins, especially DYN, are released during stress, and DYN has very high affinity for the KOR, which can mediate hallucinations and out of body experiences. Other endorphins can mediate euphoria and analgesia through activation of mu or delta opioid receptors.
4. Asphyxiation or cardiac arrest paradoxically lead to brain activation and result in marked increases of brain neurotransmitters such as dopamine, norepinephrine, and 5-HT, the latter of which can stimulate 5-HT2A receptors.
>5. Asphyxia induces excessive release of the excitatory amino acid, glutamate. Drugs such as ketamine, which also raise cortical glutamate, can produce out of body experiences.
>6. Although the romantic notion that DMT is released from the pineal gland to produce altered states of consciousness at various times of stress is appealing to some, more well-studied systems provide more sound explanations for out of body experiences.

full article: scihub. tw/10.1177/0269881117736919