Accurate Genomic Prediction for Height

[Anonymous No.9179141]

Abstract

We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning). Replication tests show that these predictors capture, respectively, ~40, 20, and 9 percent of total variance for the three traits. For example, predicted heights correlate ~0.65 with actual height; actual heights of most individuals in validation samples are within a few cm of the prediction. The variance captured for height is comparable to the estimated SNP heritability from GCTA (GREML) analysis, and seems to be close to its asymptotic value (i.e., as sample size goes to infinity), suggesting that we have captured most of the heritability for the SNPs used. Thus, our results resolve the common SNP portion of the "missing heritability" problem - i.e., the gap between prediction R-squared and SNP heritability. The ~20k activated SNPs in our height predictor reveal the genetic architecture of human height, at least for common SNPs. Our primary dataset is the UK Biobank cohort, comprised of almost 500k individual genotypes with multiple phenotypes. We also use other datasets and SNPs found in earlier GWAS for out-of-sample validation of our results.

[Anonymous No.9179144]

manlets will never be born again

[Anonymous No.9179423]

http://www.biorxiv.org/content/early/2017/09/18/190124

bump with link I forgot

[Anonymous No.9179431]

>>9179141
That's pretty neat.

[Anonymous No.9179459]

>>9179141
I understand to get this correlation they had to look at 20,000 SNPs. Are they able to find out which SNP contributes the most to height?

[Anonymous No.9179474]

>>9179459
believe this is what you would want to look at. It's generally a lot of minor effects.

[Anonymous No.9179523]

[Anonymous No.9179550]

>>9179523
>4f75636821
Fucking kek.

[Anonymous No.9181020]

>>9179141

Once they engineer to first babies for height, they will be surprised to find that they all grow up into ugly brainlets plagued by all kinds of developmental problems.