/CG/ - Chemistry General: Comfy Structures Edition

[Anonymous No.8389930]

Old thread reached bump limit

Post some comfy pictures, papers, schemes, and maybe a few challenge problems we can work out together.

[Anonymous No.8389942]

>>8389930
Theorem: If there is an isomorphism between the graphs of two molecules, then they are the same molecule.

Prove it, chemfags.

[Anonymous No.8389958]

>>8389930
Small fucking world. I was in that lecture.

[Anonymous No.8389988]

>>8389942
Hw are you defining "chemical graph" in this case, so that BeH2 and H2O are different? N-1 loops on a node for atomic number N? What about isotopes, stereoisomers, etc?
I saw a book calling itself chemical graph theory once but I'm not aware of any seminal achievements
Group theory, though, is open season

[Anonymous No.8389999]

>>8389988
>Group theory, though, is open season

Group Theory studies graph isomorphims.

[Anonymous No.8390117]

>>8389942
Waste of time jerkoff. That doesn't separate things such as rotamers and atropisomers. Here's an example called helicene.

[Anonymous No.8390171]

One for the orgo boys

"Things that look vaguely like drugs, I guess" for 200

[Anonymous No.8390264]

If I get my Bachelor's in Materials and Nanoscience, can I get my Master's in ECE?

[Anonymous No.8390281]

>>8389942
Yes, but you have to augment the graph with chirality information:
http://www.daylight.com/dayhtml/doc/theory/theory.smiles.html

Chemists love graph theory. We've used graph isomorphism to check if two molecules are the same for some time now. Except we don't use graph isomorphism, we use canonical SMILES which reduces the problem to a speedy string comparison.

Graphs are great, however, some molecules cannot be represented as graphs. Pic related is a pain in the ass.

>>8389988
You add node labels specifying atom type, hybridization, etc. See SMILES.

Also this:
https://en.m.wikipedia.org/wiki/Molecular_graph

>>8390264
>> nanoscience
Is a fucking overspecialized bullshit field
>> ECE
Now why would you do that? It's grad school anything goes, so yeah you could

[Anonymous No.8390293]

>>8390281
Are you guys p chemists? Is what p chemists do? Im nearing the end of my chem undergrad and dont know wtf youre talking about, except recognizong ferrocene

[Anonymous No.8390345]

>>8390281
https://en.m.wikipedia.org/wiki/Molecular_graph
Oh, I knew that much. Any seminal papers or applications, though, or is it just for things like cheminformatics?

>>8390171
Pretty sure 3 has a diels alder somewhere. Probably step 2 given the heating, with protonation of the vinyl ether by TFA and ring breaking/reforming in step 1, but that's about all I got
Haven't done this in a while

[Anonymous No.8391052]

copypasted

>>8386629
P2N3-, which proves our theories about aromaticity

[Anonymous No.8391057]

>>8390171
isnt 2 some variation on pictet-spengler

[Anonymous No.8391412]

>>8390171

Gee Billy, how come your mom lets you have two equivalents of trimethylaluminium

[Anonymous No.8391483]

Post yfw first reading Heathcock's total synthesis of methyl homosecodaphniphyllate

[Anonymous No.8391488]

>mfw Safrole synthesis
https://erowid.org/archive/rhodium/chemistry/safrole.html

[Anonymous No.8391507]

>>8391488

I bet you're the same guy from last thread, why does everyone have such a hard-on for safrole? Piperonal is a much better starting material and I bet the formylation of the piperonyl Grignard reagent goes better than the allylation.

[Anonymous No.8391529]

>>8391483
>Heathcock's total synthesis
Goddam just looked it and I'm going fokken crazy soos a mal naiier
How the fuck rings man

[Anonymous No.8391552]

If chemistry has good job prospects, why can't they get a 4chan pass?

[Anonymous No.8391571]

>>8391507
>I bet you're the same guy from last thread
You're right. Excuse me for being so easy to read.

>why does everyone have such a hard-on for safrole?
Because most recipes on the internet use it?

>Piperonal is a much better starting material
Why is that so?
I read that you need to wait a fuckton of time just to convert it into MDP2P.
https://erowid.org/archive/rhodium/chemistry/mdp2p.piperonal.html
>After 20 days a mixture was filtered. Light brown filtrate was filtered again after 5 days to afford next crop of product.

>>8391552
Is that the next step in attention whoring?

[Anonymous No.8391586]

>>8391552
>good job prospects
Hell no, why do you think we make drugs lmao

[Anonymous No.8391663]

>>8391571
>Because most recipes on the internet use it?

Only because it is (or used to be) the most readily-available precursor. If you're going to the trouble of making your precursors all the way from catechol, there are other options available to you.

Condensation of piperonal with nitroethane would be straightforward and give an easy-to-purify crystalline product, and all the reductions after that are straightforward, rather than having to muck around with amalgams or reductive aminations or methylamine, which is seriously regulated as we all know from that episode of Breaking Bad.

[Anonymous No.8391676]

>>8391412
lol'd more than i should have

[Anonymous No.8391683]

>>8391529

You forgot to post yfw anon

Prime opportunity for shitposting a cute animu girl and you threw it away

[Anonymous No.8391688]

>>8391663
This. Piperonal is a far easier precursor, perhaps trivially so if you have a parr bottle https://erowid.org/archive/rhodium/chemistry/ns.hydrogenation.html
Shulgin notes that the "standard" nitroaldol conditions are ineffective and should be modified somewhat https://erowid.org/library/books_online/pihkal/pihkal100.shtml

I find it a little odd he had a kugelrohr, but no parr bottle.

[Anonymous No.8391717]

>>8391663
>>8391688
But then you get MDA, not MDMA, or am I missing something?
I thought synthesizing MDMA from MDA wasn't very efficient?

[Anonymous No.8391724]

>>8391688

It's not that much of a deviation away from the nitrostyrene synthesis conditions, he makes mescaline the same way. You could argue it's better to use nitroethane in smaller amounts rather than as a solvent, because you'd use less.

>>8391717

It's trivial to put the methyl group on, reflux with formic acid in toluene with a Dean-Stark trap to formylate the amine, then reduce the formamide with LAH or whatever other reducing agent you want. Alternatively Boc-protect the amine, methylate with MeI, then de-Boc.

Sure it's not particularly redox efficient, but LAH and formic acid are cheap.

[Anonymous No.8391952]

>>8391724
isnt methyliodide hard as fuck to get tho

[Anonymous No.8391984]

>>8391952
No? Literally just make it with methanol, matchheads, and iodine?

>Sad!

[Anonymous No.8392217]

>>8389942
you can do it with matrices and group theory math which Im currently learning now in class, but im too lazy to do it for you. it would take a bit of time.

[Anonymous No.8392220]

>>8391952
if you are a grad student you can literally get anything you want.

[Anonymous No.8392247]

Is Material Sciences any good?

[Anonymous No.8392268]

>>8392247
Sounds like a meme degree.

[Anonymous No.8392326]

>>8392220
except a girlfriend

[Anonymous No.8392355]

>>8392220
>>8392326
And first authorship.
Fuck you, Dr. Michael

[Anonymous No.8392364]

>>8390293
Hahaha no, I'm not even a chemist, although I publish in chemistry journals and go to chemistry conferences

[Anonymous No.8392371]

>>8392364
microbio? physics?

[Anonymous No.8392394]

>>8392371
Engineering

[Anonymous No.8392532]

>>8392355
Starting 4th year chem phd. I have two first authors published. Number 3 is under review with JACS.

I don't have any other papers. I'm the only white person in my lab and none of the chinese want to work with me.

[Anonymous No.8393321]

Bumping with winners of this year's nobel prize in chemistry.

Suck it total synthesists!

[Anonymous No.8393571]

>>8393321
my professor worked with Stoddart at UCLA, said he was a really nice guy

Maybe I can meet him someday

[Anonymous No.8393578]

>at office hours for orgo II
>maybe 15 people there
>professor asks anyone going forward in chemistry to raise their hand
>I raise my hand, I'm the only chem major in the room
>Prof tells me that I'm much rarer than I'd think and wished me good luck going forward

Wtf? why don't people study chemistry? biochem is so fucking lame

[Anonymous No.8393646]

What jobs can I get with a PhD in chemistry?

[Anonymous No.8393663]

>>8393321
>Jean-Pierre Savage

He should roast the other people nominated at his acceptance speech.

[Anonymous No.8393721]

>>8393646
>getting a job
Ha, go do engineering you fucking pleb

[Anonymous No.8393728]

>>8393646

You can become a chemist.

[Anonymous No.8393851]

>>8393646
tutor

[Anonymous No.8394189]

What is the best filtration process to get solids out of solvents to collect with very few or no solid material loss?

[Anonymous No.8394358]

>>8393321
Total synthesis hasn't won an award since 1990 and probably won't unless the committee wants to give a prominent chemist a "lifetime achievement" Nobel. Corey won it for "retrosynthetic analysis" -- he is by no means the first person to take a molecule apart backwards, so this was clearly just a premise for lifetime achievement (albeit deserved). Moreover a lot of these machines probably take longer to synthesize than some natural products...

If you *really* want to stick it to organic chemistry, stick it to methodology programs. Asymmetric catalysis got one (!) prize, and other than the only real organic methodologies that win are those with serious industrial clout (cross coupling and metathesis).

[Anonymous No.8394362]

>>8393646
Depends on your discipline man

[Anonymous No.8394432]

>>8390171
>>8391483
>>8391488
>>8391571
>>8391663


what is your guys' education level? im a first year grad student prospecting to join an organometallics group, mostly focused on the organic aspect. how long did it take you guys to become as adept and intuitive with these kind of reactions? im also interested in doing shulgins work when i have the skills

[Anonymous No.8394618]

>>8391586
Just like how you make burgers for the big corp.

[Anonymous No.8394663]

>>8394189
Do you have to filter it? I would gently evaporate off the solvent and then scrape it from the container.

[Anonymous No.8394668]

>>8393646
high school teacher

[Anonymous No.8394670]

>>8393728
I thought that was undergrad

[Anonymous No.8394679]

>>8394189
Ice it and vacuum filter it out. To speed up the process use a pipette to get some of the clean solvent out first

[Anonymous No.8394685]

>>8393578
Genome is pretty cool man. My dream is to know how to clone a person

[Anonymous No.8394739]

>>8394679
Sinter funnels are sweet. Paper has to fit your buchner funnel exactly, and you may get fibers in your compound if you scrape the solid off too hard (alternatively, lose product in the paper.)
Worry more about clean and complete crystallization, though.
You may want to rotovap the filtrate too

[Anonymous No.8394838]

>>8392247
yes
source: me

[Anonymous No.8394912]

>>8394670
you become a fucking slave if you have a B.Sc. 75% of my lab came back to grad school after working for a couple years because they said "fuck this"

>>8393721
this. I'm co-advised between a chemistry prof and a materials engineering prof. kind of an unusual arrangement that just so happened to work, but I get engineering experience and a PhD in inorganic. fucking awesome.

[Anonymous No.8395284]

>>8394362
is there a chemistry discipline that's not in decline?

[Anonymous No.8395455]

>>8391412
kek´d

[Anonymous No.8395536]

>>8395284
oil companies are making hundreds of billions in revenue per year, pharma is collectively making over a trillion dollars in revenue, polymers and plastics i'm sure are doing just fine...

[Anonymous No.8395548]

>>8395455
I was asking for realsies :'(

[Anonymous No.8395734]

>>8394432
>how long did it take you guys to become as adept and intuitive with these kind of reactions?

For me it just came from reading Pihkal a lot and thinking about the reactions a lot. All the chemistry in there is so classical and robust that it's much more likely to work than most modern preps, it still amazes me how much Shulgin accomplished without chromatography or NMR. I mean he did these multi-step syntheses basically in his shed, characterising the intermediates by melting point and TLC, and purifying them by distillation or recrystallisation, it's a real testament to his skill.

[Anonymous No.8395771]

>>8389930
Posted this comfy structure in another thread.

[Anonymous No.8395851]

>>8395771

Mid tier: cubane
High tier: dodecahedrane

Have you ever seen the synthetic route towards that shit

The cubane route is neat though actually, and at least comprehensible to mere mortals.

[Anonymous No.8395860]

>>8395851
Nah I haven't, but I have read about dodecahedrane. It's nuts but I find cubane more interesting because of the larger bond angle deviation from a typical sp3. IIRC, the bond angles of dodecahedrane are close to 109.5.

Gonna wiki it now though to check out the synth.

[Anonymous No.8395873]

>>8395860
>Gonna wiki it now

You mean "going to look it up on wikipedia"?

christ

[Anonymous No.8395926]

>>8395851
>Mid tier: cubane
>High tier: dodecahedrane

I wanna do shit like that, should I study organic chemistry?

[Anonymous No.8395952]

>>8395873
I'm sorry that my expedient language has upset you.

[Anonymous No.8395963]

>>8395952

"Wiki" isn't a verb, it's a noun, and Wikipedia is just one example of a Wiki.

You people make me so angry I could shit

[Anonymous No.8395972]

>>8395963
that's how languages evolve, especially germanic ones, stop being such insufferable autist

[Anonymous No.8395988]

>>8395963
It might be time to take a break from 4chan for a bit, my man.

[Anonymous No.8395995]

>>8390281
Silly chemists just learn to draw

[Anonymous No.8396007]

Water is a better solvent for some organic reactions than most chemists think.

Chemists should use more water.

[Anonymous No.8396018]

>>8396007

Water company shills pls leave

And good luck with your Grignard reactions

[Anonymous No.8396023]

>>8390171
This is why I like physical chemistry. I hated orgo. It was too qualitative and I resented the learning process which at the time I considered to be rote memorization. I'm in a physical organic chemistry course now as a senior undergrad, but it's a graduate course at my Uni, and man I have respect for you organic guys. Physical organic is perfect for me because I get to apply physical/mathematical concepts to organic systems. The professor and some of these grad students have such an intuition for organic reaction mechanisms it blows me away.

[Anonymous No.8396032]

>>8395995
>> using cellulose and graphite in the digital age
Can you directly convert your drawing to a molecular dynamics simulation?

[Anonymous No.8396047]

>>8395926
Yes.

[Anonymous No.8396060]

>>8396032
Yes.

[Anonymous No.8396082]

>>8396060
Ok, so what's the rotational energy barrier for those rings?

[Anonymous No.8396092]

>>8396082

About 3.50

[Anonymous No.8396097]

>>8396060
Fuckin kek.

[Anonymous No.8396142]

>>8396092
3.50 what?

[Anonymous No.8396189]

>>8396060
It's all, like, vibrations, man.

[Anonymous No.8396330]

>>8390345
>>8391057
>>8391412
>>8390171
Anyone want to write one out?
Fair warning, I don't have a key

[Anonymous No.8396462]

>>8396007
I think it works well for some reactions, but it can be substrate dependent in a number of cases. There's a lot of cool micellular chemistry that's "aqueous" I guess.

[Anonymous No.8396674]

Which of these should I major in?
Waterloo by the way.

[Anonymous No.8396676]

mathematical physics
its not stamp collecting like the rest of the options

[Anonymous No.8396680]

Why is the boiling point of Dimethylformamide lower than Dimethylsulfoxide?

[Anonymous No.8396702]

>>8396674
Chemistry or Mathematical Physics

[Anonymous No.8396704]

>>8396676
>>8396702
What about Material Sciences? Also, what kind of jobs can I get by majoring in those.

[Anonymous No.8396709]

>>8396704
Not sure
Materials is a meme field, a very interesting meme field at that, but my understanding is that it's very limited in terms of employment. Other people here might be able to elaborate.

Mathematical Physics, if you do well you could go into physics, or you could probably get into finance if you wanted.

[Anonymous No.8396721]

>>8396674

the math phys program looks sexy

I say that as a physics major with math minor
would have double majored had I decided earlier on but now I'm just left to taking an ass ton of math classes

[Anonymous No.8397658]

>>8396680
Stronger non-covalent interactions in DMSO relative to DMF. Presumably the largest contributor is the more polarized S=O bond (better described as S+-O-) relative to the polarized amide system (wherein the nitrogen bears some positive charge and the oxygen some negative charge).

[Anonymous No.8397742]

>>8396330

I would give it a go but I don't have a camera/scanner for a written answer or chemdraw for a computer answer.

Maybe if you posted mid-tier problems rather than elder-god-tier problems, the answers could be written in ms paint.

[Anonymous No.8397967]

>>8389930
Just starting to study chemistry as my first ever BA this year, any tips for brainlets and beginners like me?

[Anonymous No.8397986]

>>8395851
"Dodecahedrane is a chemical compound first synthesised by Leo Paquette of Ohio State University in 1982, primarily for the "aesthetically pleasing symmetry of the dodecahedral framework". It is the simplest hydrocarbon with full icosahedral symmetry.
You know it's comfy when it was synthesized just for being comfy.

[Anonymous No.8398015]

>>8393646
Methamphetamine kingpin.

[Anonymous No.8398240]

>>8391552
The real gift is not in the earnings, it's in the savings. Chemists have access to bulk materials that allow them to produce gargantuan quantities of expensive equivalents at discount price.

[Anonymous No.8398534]

>>8398240
This.
Garage fine chemicals plant master race reporting in

[Anonymous No.8398575]

>>8396060
mega kek lad

looks about right

[Anonymous No.8398696]

how to learn steichometry

[Anonymous No.8398781]

>>8398696
multiply by 1
repeat as needed

[Anonymous No.8398796]

>>8394432
Sounds like the stuff I'm working on. The finish is a new type of controller device.

electroluminescent "skin" combined with graphene

http://www.nature.com/articles/srep02373

[Anonymous No.8398806]

>>8398781
hwlp more pls

[Anonymous No.8398809]

>>8398696
Better to learn steak chemistry instead
https://www.youtube.com/watch?v=pd9rtfgEpds

[Anonymous No.8398838]

>>8398809
this seems cool
but ireally need help

[Anonymous No.8399018]

i'm trying to figure out the ratio of moles between water and sodium carbonate
# of moles for Na2CO3 0.00811
# of moles for water 0.477
when i divided them i got 58.8
but then that could make the chemical formula Na2CO3 * 59H2O
what am i doing wrong?

[Anonymous No.8399025]

>>8394912
>slave
Explain?
Do you mean as sort of Fuck the Man kind of thing?
Working conditions terrible (i.e heaps of unpaid hours)?
Or you just follow someone else's instructions to make things, rather than come up with your own theories? (i.e being a "chef" that just chops up vegetables and follows recipes, whereas a head chef will have all the creativity inventing recipes etc)
I'm currently finishing B. Sc and would rather avoid just doing another 2 years study to just become a high school teacher, it seems most of my cohort of Chem students are doing the same thing.

[Anonymous No.8399035]

>>8395963
I just googled it
>https://en.wiktionary.org/wiki/wiki#Verb
It is a verb now.

>>8399018
I'm glad you figured it out anon

[Anonymous No.8399233]

>>8399035

No, that's wrong, you're wrong. Wiktionary is biased.

That's like saying "there's no harm in water fluoridation, it says so in this booklet published by the water fluoridation institute".

[Anonymous No.8399383]

How does one become a chemist?
What is most important to be a good chemist?
How would you raise a kid to become a genius chemist?

[Anonymous No.8399535]

What's left to look for when researching Chemistry?

[Anonymous No.8399742]

>>8399535

Making even bigger marine sponge alkaloids

[Anonymous No.8399848]

I've been tinkering with computers since I was young and I dont know anything about chemistry and was interesting in selflearning more about it like I do computer programming, just tinkering with it selflearning and hacking interesting things together.
But looking into it I read online that doing this would be illegal, and owning the stuff to do this is illegal, and if I tried anyway I would get a visit from three letter agencies and get put on a bad list or even go to prison.
Why is this?? This is retarded why dont they apply the same logic to computers and make it illegal to posses copies of compilers, diassemblers, debuggers, network socket programming APIs, etc?

[Anonymous No.8399861]

>>8399848
because you could seriously hurt, injure or kill yourself, others around you, and the environment for a long time requiring a costly cleanup
and also, drugs. no one wants you to be able to make drugs. or explosives. or posion. or anything, really, because fuck giving people responsibility with stuff they buy.

[Anonymous No.8399865]

>>8399861
same type of argument is that someone could could use the toolset that comes with a standard Linux distribution to create powerful cyberweapons that could do something like take down the power grid or take down a bank, etc. Developers and hackers use the same toolsets. So why not apply the same logic and ban these tools?

[Anonymous No.8399867]

>>8399535
Nanomachines son. We have all these really cool molecular motors and molecular mechanisms, but we don't really have good ways to put them together.

Individual rotaxanes are amazing, by electrochemically reducing or oxidizing them we can cause them to expand and contract with more relative force and strain than natural muscles. If we could find a way to make long chains of them, we could have amazing artificial muscles.

This is only the beginning.

[Anonymous No.8399869]

>>8399865
>>8399848
What a great idea anon! I had no idea these tools even existed! We'll pass laws to ban them right away
----a politician

[Anonymous No.8399874]

>>8399742
this, absolutely

big advancements and big money to be made

[Anonymous No.8399889]

>>8399869

[Anonymous No.8399895]

>>8399848
>tinkering with it selflearning and hacking interesting things together.

You can't "hack" molecules together, you will just end up with brown, uncharacteriseable tar.

[Anonymous No.8399901]

Can a methyl group have a doublet of doublets signal in an H NMR spectrum?

[Anonymous No.8399903]

>>8399895
I dont know anything about chemistry. But just as a basic example the characters in popular tv series Scorpion and The Big Bang Theory use chemistry in practical ways in the projects they are working on. But this is fantasy, no law abiding citizen is allowed to use chemistry in any practical ways because you're forbidden from getting the stuff to do it, and if you do acquire and own the stuff to do it you go to jail.

[Anonymous No.8399930]

>>8399901

R2C-CHF-CH3

Assuming it's not a fluorine-decoupled spectrum

[Anonymous No.8400022]

>>8399930
Can you help with the structure of this molecule?

[Anonymous No.8400024]

>>8400022
>>8399930

[Anonymous No.8400079]

>>8400024
>>8400022
is that all the info?

[Anonymous No.8400097]

>>8400022
>>8400024

2-butenal?

[Anonymous No.8400158]

>>8400079
Yeah that's all I have, I thought it was crotonaldehyde but for that the doublet of doublets at around 2ppm would have to just be a doublet

[Anonymous No.8400188]

>>8400158

No I think crotonaldehyde is right, you get a very small splitting due to 4J coupling, which is fine in an allylic system.

[Anonymous No.8400253]

>>8396676
What's the difference between mathematical physics and physics?

[Anonymous No.8400476]

>>8400253
physics is a real thing, the other is a gimmick, like physics engineering

[Anonymous No.8400504]

>>8396060
underrated

[Anonymous No.8400544]

>>8400022
>>8400024
>>8400158

I'm going to be your best friend, anon.

http://sdbs.db.aist.go.jp/sdbs/cgi-bin/cre_index.cgi

[Anonymous No.8400753]

G-Guys. I'm majoring in biology.
The biology, anatomy/immunity, and calculus classes were easy as fuck.
Why is general chem so hard though? How do I git gud with remembering states for complete ionic shit and balancing acidic/basic/redox reactions? It's been 2 months into this class, and I'm only understanding stoichiometry now. I'm fucked.
How can I become a chemistry autist? Any babby sites you can recommend?
Now I'm not surprised how some call general chem a weeding out course.

[Anonymous No.8400765]

>>8399848
>tinkering around with chemicals
Well you know that a lot of it has already been figured out? Foremostly, you can't put two clear fluids together and even remotely understand the mechanism without learning the rote material first. Chemistry isn't 100% playing-around-till-it-works these days because all the previous chemists in our history have already figured out for us that you can convert a ketone group into an OH group via certain mechanisms.

[Anonymous No.8400772]

>>8400753
>https://www.khanacademy.org/science/chemistry
Good for babbies

[Anonymous No.8401945]

>sub-100-view organic mechanism videos on YT

https://www.youtube.com/watch?v=6qgkfc8Zq38

Why don't kids like the chemistry these days

[Anonymous No.8402352]

Hello bros, can u please give examples of E1, E2 and E1CB reaction mechanisms with biomolecules?.

[Anonymous No.8402363]

>>8402352
why with biomolecules?

[Anonymous No.8402372]

>>8402363
Its for biochem class, extra points for the test and i cant find any anywhere.

[Anonymous No.8402515]

>>8402352
Anyone?

[Anonymous No.8402895]

Any recommendations for a book that treats group theory fairly rigorously (i.e. in theorem-proof style) with a focus on chemical applications?

Seems like every text out there is determined to give us poor inept chemfriends a cookbook treatment of the subject

[Anonymous No.8404144]

>>8399901
If you have coupling other than vicinal coupling or diastereotopic protons (somehow), then yes.

[Anonymous No.8404181]

How can I acquire one of my professors copies of their old exams? Im struggling in biochem and at least want to know what old exams were like

[Anonymous No.8404489]

>>8404181
ask someone who already took the class?

[Anonymous No.8405810]

>>8402515
lad just look through the slides for some molecules

theres plenty of examples

[Anonymous No.8406448]

>be undergrad doing chemistry
>realise the only thing that holds my interest is the way subatomic particles behave
So, am I fucked? Should I switch to Physics? Can I go on to study this sort of thing postgrad with a chem bachelor?

[Anonymous No.8406486]

>>8406448
depends on your supervisor. chances are low without the right supervisor.

[Anonymous No.8406487]

>>8406448
Uh yeah sounds like you're a particle physicist in the making.
I'd switch to physics or at least concentrate on physical chemistry.

[Anonymous No.8406488]

>>8389930

i'm studying chemistry on khan academy, learning all the mathematics first and stuff. but what is a good source that will show me experiments i can do with household chemicals to really test my new knowledge? thanks.

[Anonymous No.8406690]

>>8406488
How much chemistry do you actually know?

[Anonymous No.8406735]

>>8397986
>imagining the nmr spectrum for this
hnnnnnng

[Anonymous No.8406740]

>>8406735
>one singlet

Not at all sexy.

[Anonymous No.8406746]

>>8406740
You're not aroused at the thought of all those hydrogens and carbons being equivalent?
Fucking faggers on my /sci/

[Anonymous No.8406791]

help. a. fucking. brainlet.

pls

[Anonymous No.8406796]

So i've got to answer a which is the relation between michael reaction and cancer, anyone to give me a hand?

[Anonymous No.8406797]

>>8395963
Take a chill pill man. Language is constantly evolving. You understood what he meant, and he saved some time - some people are busy. Everybody wins.

[Anonymous No.8406804]

>>8406791
this is a tough one

[Anonymous No.8406807]

>>8406791
t1/t2 = p1/p2

[Anonymous No.8406812]

>>8406807
How can you assume they're ratios are equal to each other?

[Anonymous No.8406817]

>>8406812
Ideal gas laws

[Anonymous No.8406821]

>>8406807
Incorrect

I will give you autists a hint:

Answer is [math]7.0 \times 10^{2} C[/math]

[Anonymous No.8406852]

>>8406746
I prefer molecules with elaborate splitting patterns wherein each of the protons is uniquely split and beautiful.

[Electrolytes No.8407017]

Why won't HF completely dissolve in solution, yet HCl or HBr can?

Same with HNO3 and HNO2 - what is it that makes the former dissolve better?

[Anonymous No.8407030]

>>8395771
jesus this must be incredibly strained how does this even form?

[Anonymous No.8407036]

>>8391683
go away chemloli

[Anonymous No.8407040]

>>8407017
>Why won't HF completely dissolve in solution, yet HCl or HBr can?
F will not readily dissociate in solvents

[Anonymous No.8407050]

OFFICIAL TIER OF CLASSES AND SHIT FOR CHEMISTRY

-Gen Chem 1: basic high school chemistry
-Gen Chem 2: On par with AP chemistry and you'll never use anything you learn here ever again beyond knowing what a Buffer does.

Orgo1: basics of orgo, definitely good to know, basic mechanisms, groups, and how they interact, electrophils, nucleophils, all sorts of -mers, isomers, stereoisomers, etc
Orgo2: advanced mechanisms, applied orgo chemistry, biochem, biologically active molecules, food chemistry, protective and removing groups, etc

Pchem1: nothing to do with chemistry, literally word problems/math class.

Pchem2: literally nothing to do with chemistry, all fucking math

Pchem 3: fucking kill yourself, this isn't even math as much as it is theory

Inorganic 1: basic inorganic chemistry, ligand, crystal field theory, mirroring and shit.

Inorganic 2: more inorganic chemistry, deals with molecular structure and how metals interact in such structures

Biochem: applied organic chemistry, pretty straight forward

Biochem 2: kill yourself this shits all about biology now.

[Anonymous No.8407056]

>>8407050
I had this Lab class called "Advanced Synthesis" and this one lab involved this smelly ass shit called Toluene Sulfonic Acid. This was used in some fucking reaction that smelled like absolute rotten shit. It was all done in a fume hood but it didn't help at all. This shit had to reflux for like 2 hours and it stank the entire time. Some other girl in the class threw up because the smell was so bad. I would rather smell resorcinol than any sulfur compound. Thiols and anything with sulfur 9/10 times smells like shit. Avoid evaporating anything with smelly thiols, thats almost the worst since it just makes all your equipment smell like shit

[Electrolytes No.8407059]

>>8407040
Is this something that should be intuitive (i.e how strongly electronegative it is), memorise, or should it be okay if I just know how to use a Solubility guideline?

If intuitive: Currently I see Cl, Br, and F all in the same Group and thus expect it to separate into anions liek the others can,

[Anonymous No.8407067]

>>8407059
>Is this something that should be intuitive (i.e how strongly electronegative it is), memorise, or should it be okay if I just know how to use a Solubility guideline?
Most salts of Cl, Br, and other halides normally dissolve in other polar solvents like water and acetone. F is special which is why so few chemistry classes talk about it is because it has so many special rules to it.

NaF, CaF and the like will readily dissolve in water, but I don't think other things involving -F will. Fluorine is very strange as its extremely electronegative, far more than Cl.

Unlike Cl, F doesn't so much as form ionic bonds as it does cling to things like a stank to a hunk of shit. Its easy to make Cl work in things like markovnikov reactions, but F simply won't

[Anonymous No.8407079]

>be me in Organic Chemistry Lab I
>theres this skrillex looking girl with half her head shaved off
>we're doing an experiment using 10% bromine in dichloromethane, which is a toxic volatile liquid that should be kept in the good
>skrillex decides that she needs to add it to her solution but didn't read the manual on how nasty it was so she takes it out of the hood over to her desk and pours herself off like 10ml or some shit.
>she notices the smell and says "this smells smelly"
>she then gives it to her lab partner who was equally clueless and says "that that does smell funny"
>teacher comes in from the restroom and asks why the bromine stuff is out of the hood
>loses her shit when the brown vapors start billowing out of one of the student's beakers
>quickly puts the shit back into the hood and opens a window.

[Anonymous No.8407083]

>>8407079
>me again in Orgo I
>our community college was super poor
>we had to share thermometers
>used to have a lot, most broke because students are dumb
>had a few mercury thermometers left over from the time when they were legal to use
>skrillex has the mercury one
>she drops it
>smashes on her counter top
>mercury beads everywhere
>She fucking starts poking and playing with it!
>teacher isn't watching, helping another kid
>suddenly the teacher starts walking towards her
>"oh shit" as she brushes it off the counter onto the floor
>the mercury beads scatter and she kids them under the table
>told the teacher there was mercury about
>got the spill kit, told skrillex she had to pay for a new thermometer

[Anonymous No.8407089]

>>8407059
HF isn't a strong acid also it doesn't readily lose its H+ so its considered a weak acid. However I remember a part about how different concentrations of HF have different solubility and enthalpy so the rates of dissociation vary a lot

[Anonymous No.8407093]

>>8407089
Also HF isn't ionic, its more covalent which is why it doesn't completely dissociate in water. However it is sold in concentrations of 50% and 70% readily.

[Anonymous No.8407105]

>>8407089
This. It's weaker than acetic acid in terms of pKa.
The problem is it's toxic as the everloving fuck and exposures often go unnoticed until serious symptoms develop

[Anonymous No.8407112]

>>8407105
HF is still reactive as fuck.

When fluorine first touches water, it'll make HF, and HF can eat through glass really well.

[Anonymous No.8407115]

>>8407056
>can't handle TsOH without making a stench
Get gud my future burger flipping friend

[Anonymous No.8407119]

>>8407115
thiols smell like shit dude

[Anonymous No.8407131]

>>8389930
What's the most dangerous chemical you've ever worked with /sci/

[Anonymous No.8407133]

>>8407131
Fentanyl

[Anonymous No.8407148]

>>8407131
Phenol

[Anonymous No.8407251]

>>8407079
>>8407083
Nobody cares

[Anonymous No.8407300]

Which is the reaction between a secondary amine and a ketone?

[Anonymous No.8407322]

>>8407300
>secondary anime

[Anonymous No.8407348]

>>8407300
a ketwo

[Anonymous No.8407357]

>>8407300
Ketamine, obviously

[Anonymous No.8407360]

>>8407322
>>8407348
>>8407357

Jajajajaja, the sad thing is that it isn't a joke :'|

[Anonymous No.8407387]

>>8407131
Benzoyl peroxide powder is pretty interesting.

[Anonymous No.8407392]

>>8407357

[Anonymous No.8407405]

>>8396023
Feelsbro. I love Phy. Chem. and also feel like I'm seeing wizards when I watch those guys.

[Anonymous No.8407445]

>four residue long peptide derivative
>mimics ketamine's rapid acting and long-lasting relief from treatment-resistant depression https://www.ncbi.nlm.nih.gov/pubmed/26997507
>seems to enhance cognitive performance and reverse NMDAR-associated cognitive impairment http://www.allergan.com/news/news/thomson-reuters/rapastinel-glyx-13-shown-to-improve-ketamine-or-pc
>four fucking residues

[Anonymous No.8407451]

Do any of you study chemical engineering?

What's it like? Do you like the material at all or are you just in it for the money?

[Anonymous No.8407454]

>>8407451
>are you just in it for the money?
https://www.youtube.com/watch?v=kNxxncydX2o

[Anonymous No.8407466]

>>8407451
I study biochemical engineering, which has almost nothing to do with Chem. engineering. But I can say it is dope.

[Anonymous No.8407471]

>>8407466
I studied biology and Ochem was the biggest love/hate relationship I ever had.

If I could do it again I would do bioE or chemE.

Is there any good books for an intro on the topic or will I just start to hate it if I get too curious.

[Anonymous No.8407513]

>>8407471
Most "manuals" we use are actually directed towards chemical engineering, but the interesting part is repurposing these models and making them work in biological systems.

That is how I explain it most of the time.

As for a full head-on intro, I normally point to unitary processes on fermentation batches, because it is very clear how these disciplines "mesh" together.

And any resource used by chemical engineers could be a nice general intro.

SOrry for being kinda vague, but I have a shit ton of work and not enough coffee...

[Anonymous No.8407576]

>>8407300

[Anonymous No.8407580]

>>8407576
>cyclohexane

[Anonymous No.8407607]

>>8407466
>which has almost nothing to do with Chem. engineering
Wat. Don't you basically make pipes for proteins or something instead of pipes for other chemicals?

[Anonymous No.8407700]

>>8407607
>pipes for proteins
>>>/solidphase/

[Anonymous No.8407739]

>>8407119
Trust me, I know
If you play your cards right you won't smell a single whiff

[Anonymous No.8407783]

>>8407739
Nah M8 that shit stinks no matter now you use it

[Anonymous No.8408014]

Hi /CG/.

I'm trying to determine the pH of a 60mM solution of a diprotic acid.

First I have [math] K_w = \frac{[H][OH]}{[H_2O]} = 10^{-7}, K_1 = \frac{[A][H]}{[AH]} = 10^{-3}, ~and~ K_2 = \frac{[AH][H]}{[AH_2]} = 10^{-7.4}[/math].
Since there must be an equilibrium, all my charges must balance, and I have [math] [H] = [A] + [AH] + [OH][/math]

Then I rearrange my equations to substitute into the charge equation with known values.
[math] [OH] = K_w \cdot \frac{[H_2O]}{[H]}[/math]
[math] [AH] = K_2 \cdot \frac{[AH_2]}{[H]}[/math]
[math] [A] = K_1 \cdot \frac{[AH]}{[H]} = \frac{K_1}{[H]} \cdot \frac{K_2 \cdot [AH_2]}{[H]} = K_{12} \cdot \frac{[AH_2}{[H]^2}[/math]

Then I can substitute these into my charge equation to get a polynomial in [H].
[eqn] [H]^3 - (K_2[AH_2] + K_w[H_2O])[H] - K_{12}[AH_2] = 0[/eqn]
Since I know K_w, K_1, and K_2, and [AH_2] = 0.06, I can solve for [H]. When I solve for [H] in this polynomial I get a pH of 2.63 which cannot be true since it would make the pH lower than any of the pKas. So something about either my substitutions or my equilibrium equations are wrong.

Any guidance?

[Anonymous No.8408080]

>>8407131
Probably butyllithium, but a couple of pretty unhealthy ones (TMS Diazomethane, e.g.)

[Anonymous No.8408122]

>>8408014
I found my problem. It is not [AH_2] which is 0.06, it is the sum of the species which is 0.06. So I need a mass equation to combine terms in the charge equation.

[Anonymous No.8408185]

I want to learn general chemistry and organic, too.
On my own, since my profs are dumb and just rehearse their totally noninformative PowerPoint presentation.
What is a good choice?

[Anonymous No.8408204]

>>8408185
Khan Academy
You knew this, and you only asked because you wanted to feel like you were taking proactive steps to teach yourself without actually teaching yourself, you motherfucker

[Anonymous No.8408235]

>>8408185
MIT open courseware and similar stuff is available too

[Anonymous No.8408287]

>>8408235
>>8408204
Touché
And, Thank you

[Anonymous No.8408339]

>>8407131

Sec-butyllithium is pretty frisky, although more people have probably worked with tert- , which I haven't.

Recently used some DAST which again quenches quite violently with water.

I think the worst chemical I've used is probably chlorosulfuric acid, I was carrying a litre bottle across the lab and I don't like to imagine the consequences of dropping something like that.

I have also worked with triphosgene but it's OK as long as everything is kept in the hood and quenched with ammonia.

[Anonymous No.8408350]

>>8408185

Read Clayden, Greeves, Warren and Wothers, the GOAT chemistry textbook

[Anonymous No.8408843]

>>8408350
Sophomore orgo books are pretty fungible in my experience

[Anonymous No.8409052]

>>8408843
https://www.amazon.com/Organic-Chemistry-Mechanistic-Penny-Chaloner/dp/1482206900

This book goes about teaching organic chemistry a different way.

Mechanism knowledge is a critical aspect of understanding organic chemistry so if you hate mechanisms and counting electrons well give up now.

This book teaches organics doing mechanisms instead of just theory and mindless memorization of reactions or groups although they are important as well in their own way

[Anonymous No.8409147]

Here-s the most pathetic question in the thread.

I-ll start studying Chemistry in 2 weeks, and I-m a chronic weed smoker (it-s the only thing that is keeping my clinical depression at bay, without it I-m suicidal all the time (it has been this way since my early childhood).

I think that I can stop smoking it, buckle up, be miserable until I start getting it and then hop on the weed train again (I guess in 4 years from now), but I-d love to hear other opinions from people who have already studied it.

What is the mental load that one has to carry to successfully study Chemistry? Is it possible to go through the Bs and Ms courses baked, considering that I can mantain lucidity through the high? (I-ve basically already studied Calculus 1 and 2 while baked with great results).

Please don-t hate on me too much.

[Anonymous No.8409168]

>>8409147
Lots of chem majors are stoners. However I would suggest going in to look at psychiatric medication. Look into prozac because, at least for me, it mimics the mood effects of weed and if i take it on weed it fucks my brain up bad.

[Anonymous No.8409749]

>>8409147
>I-ll
>it-s
>I-d
>don-t

I do not hate you I just want to punch you in the nuts, what's wrong with your apostrophe key

[Anonymous No.8409910]

>>8408014
>>8408122
So actually I still don't understand what's happening.

When I generate this expression correctly (as judged by a lot of the materials I find online), I find an equilibrium by solving for [H] and get some value. Not only do I know that this value is wrong, but it is empirically wrong.

The first problem I had was that my compound is a zwitterion so the charge equation needed some modification. But even with that correction, [math][H] + [AH_2] = [A] + [OH][/math], the resulting polynomial balances at the incorrect point. For pKas of 3 and 7.4 I get an equilibrium at pH 3.87 but the empirically-determined value is pH 5.2.

I went about it another way, by analyzing the distribution of species for the compound and simply setting the two charged species equal. In this equation the concentration cancels and I am simply left with [math][H] = \sqrt{K_1\cdot K_2}[/math], giving a pH of exactly 5.2, is what is empirically determined within measurement error.

What I don't understand is why the full equation, including the self-ionization of water, gives such incorrect results. Am I using the full equation incorrectly somehow? Does it represent something different that I'm using it incorrectly?

[Anonymous No.8409984]

>>8409147
>I-ll, it-s, I-d, don-t

[Anonymous No.8409992]

I don't get this?

Why doesn't an increase in mass of a molecule, increase the distribution of velocity? Because is it not increasing the kinetic energy, and thus quanta that can be distributed, allowing for a larger velocity range?

please help explain

[Anonymous No.8410012]

>>8409992
It says right in your picture that ALL particles have the same Ke, right?

So if the mass increases then velocity has to decrease to keep the kinetic energy the same, and vice versa.

So less massive particles will move faster, and the more massive particles will move slower. So as the molecular weight decreases the fraction of the particles with a higher velocity will increase.

[Anonymous No.8410017]

>>8409992
For the same velocity, increasing the mass *does* increase the kinetic energy (KE = (1/2)mv^2).

[Anonymous No.8410064]

>>8409749
>>8409984

I was my dad's laptop, he did fuck up his keyboard somehow.

[Anonymous No.8410075]

>>8410064

Big cums on the ol' Hewlett Packard aye?

[Anonymous No.8410603]

>>8406448
physical chemistry

[Anonymous No.8410621]

What is your favourite heterocycle?

I found out about Ullazines for the first time today, they're pretty dank

[Anonymous No.8410632]

>>8409147
I was stoned every day from 16 - 18, and when I started college I stayed sober for a while, but then started again. I found out quickly that I can't do maths while I'm stoned - I need to hold information in my working memory to do it, and when I'm stoned I keep forgetting what I'm doing and end up having to start over, which is frustrating when you're already slightly sedated and want your work done with so you can commence a more pleasurable activity. Procrastination is also an issue.

In semester 2 I quit weed, but also started a blurry mixture of using and abusing stimulants and opiates. It actually worked out great, but I missed a lot of classes due to being immobile due to comedowns, but always made it up again by being able to study in 12 - 14 hour marathons and matriculated into one of the highest prestige courses in second year.

I stayed up all night on speed studying for Calc II, but I took too much and got the shakes and felt too anxious to go into the exam hall the morning after, so I smoked some heroin to eliminate the tremors and walked in feeling like a shining beacon of golden perfection even though I probably looked like shit, set into the exam with obsessive precision and managed to ace it despite teetering on the brink of passing out at points.

I quit amphetamine that summer because I couldn't control my usage and was suffering memory problems from sleep deprivation.

Sober now and doing better than I was as a stoner in first semester of the first year, but not quite as good as I did when I was on my peak game when balancing the amphetamine properly. There are costs and benefits to weigh up though, and I wouldn't go back to it.

[Anonymous No.8410638]

>>8389930
Any type of cyclic 6-carbon hydrocarb ring is as comfy as FUQ, particularly when the substituents are equatorial or the electrons resonate a la benzene ring.

[Anonymous No.8410648]

>>8410632
How the fuck are you not dead yet?

[Anonymous No.8410718]

>>8410648
Humans are remarkably resilient to damage caused by drugs--at least when it comes to survival. You might get significant brain damage in varying forms (memory loss, focus impairment, stuttering, inability to concentrate, sleeplessness, anxiety, sluggishness etc) but most of the time people will live even after abusing huge amounts of drugs.

There are reports in the literature of just absolutely heroic doses of drugs being survived somehow. Its remarkable what the body can do to survive. However i would not recommend this as a suggestion to take large doses of drugs, you should try to keep the dose small to avoid tolerance and keep side effects down.

Most of the time when people die from drugs, its from overdosing a COMBINATION of drugs with synergistic effects, like alcohol and opiates which depressing the breathing 9x more than usual, and then dying from asphyxiation because people thought they simply fell asleep.

One drug at a time? Or ones with non-interacting effects or overlapping action in opposite directions? Is far safer and more survivable.

[Anonymous No.8410756]

>>8410632
Exam nodding is best nodding
Drive nodding and heavy machinery operation nodding are a close second and third

[Anonymous No.8410901]

>>8395926
you wanna green text on four chan and name drop meme molecules?

[Anonymous No.8410913]

>>8410638
Symmetric aromatics are my shit. They are oddly gorgeous.

[Anonymous No.8411011]

>>8410718
Me again - organic brain damage doesn't really occur with stimulants outside of dopaminergic neuronal damage with high and intravenous doses of methamphetamine (may this is due to it's higher lipophilicity than unmethylated amphetamine, and the related more pronounced ability to cross cell membranes and the blood brain barrier. The neurological structural damage of methamphetamine hasn't been replicated with prescription amphetamine). Moreover, even measurable organic damage like the type seen in heavy methamphetamine users isn't a big deal - take for a congenital example, the medical equivalent hydrocephalus;

https://en.wikipedia.org/wiki/Hydrocephalus#Exceptional_case

in cases where neurological obliteration is visited on the brain, compensatory mechanisms are extremely effective in circumventing the damage and connecting alternative pathways with limited neurons to convey the information needed. This is neuroplasticity, and it means even behavioral and organic degeneration from severe drug abuse isn't necessarily a life-long sentence to severe cognitive deficit, though it can be.

Amphetamine, while also damaging to dopaminergic neurons at high doses, is reasonably safe at low chronic usage.

Opioids, neurologically, dindu nuffin. There are plenty of historical cases of extremely intelligent and prolific opiate addicts, from de Quincey to Bulgakov.

On that note, Paul Erdos is an example of a highly productive speed fiend in the sciences - he was an amphetamine user for much of his later life.

Even though I took a few heroic doses of amphetamine and phenmetrazine, I'm convinced that my memory problems were the result of two or three all-nighters a week, both when on stimulants and sober, during that time period. My memory problems didn't begin to resolve cessation of stimulant use, but they started to get better after I started sleeping reasonable hours. There is a wide body of literature linking chronic sleep deprivation to cognitive deficits.

[Anonymous No.8411041]

>>8411011
You're forgetting MDMA has neurotoxic metabolites.
Opioids are indeed essentially non-toxic, and although they carry a severe dependence liability withdrawals are never lethal, in contrast to various gabaergics. Though the kappa opioid receptor seems to have some psychiatric relevance.
Chronic use of NMDA antagonists often causes cognitive issues. This is subject to ongoing investigation >>8407445

[Anonymous No.8411061]

>>8411041
As far as I'm aware, methadone is the only opioid in common use which is also an NMDA antagonist.

Studies have found cognitive deficits in opioid users on maintenance therapy - someone once tried to convince me this was evidence that opioids were neurotoxic, but why aren't the same results present amoung those in chronic pain management? I'm confident it is a property of NMDA antagonism unique to methadone.

> MDMA
Do I sound like a dirty hippie to you?

What metabolites? I'm aware that there is a vast body of evidence linking MDMA use to memory loss and also valvulopathy, but I wasn't aware it's been narrowed down to a specific metabolite.

[Anonymous No.8411106]

>>8411061
>methadone is the only opioid in common use which is also an NMDA antagonist.
>I'm confident it is a property of NMDA antagonism unique to methadone.
Yeah, those were separate thoughts
>Do I sound like a dirty hippie to you?
No. It's a common entactogenic stim

[Anonymous No.8411307]

>>8410756

>exam nodding

What? Can you seriously take a STEM exam on heroin?

To be fair I've just noticed that while I know the common effects of heroin I really don't know how it affects your thought process. Care to elaborate?

[Anonymous No.8411377]

>>8407131
n-butyl lithium
dimethyl sulfate
sec-butyl lithium
decaborane

cant think of any others off the top of my head. thanks for reminding me im probably going to die young.

[Anonymous No.8411398]

>>8411377
I believe it was Claisen who said a chemist in good health is no chemist at all.

[Anonymous No.8411704]

>>8411307
>Can you seriously take a STEM exam on heroin?
Of course. It's only slightly more dangerous than driving on heroin.

[Anonymous No.8411876]

>>8411377
>dimethyl sulfate

Fucking this

I can't believe how blasé everyone in my lab is about this, they run alkylations which involves heating the substrate in refluxing dimethyl sulfate as the solvent

I mean, Jesus Christ

[Anonymous No.8412094]

I have to give a presentation about the reactivity of nine-atom deltahedral clusters of group 14. Read a few papers about it now and the field is full of comfy structures.
This one is [math][Pd_{2}@Ge_{18}]^{4-}[/math], it is the result of the reaction of [math]Ge_{9}^{2-}[/math] with [math]Pd(PPh_{3})_{4}[/math].

[Anonymous No.8412120]

>>8407131
>Phenol
>Benzoyl peroxide
>Pyridine
>Benzene
>Dimethyl sulfate
>Several boranes
>n-Butyllithium
>Ethidium bromide
>Aquateous HF solution
>98 % H2SO4
But there's probably a lot more.

[Anonymous No.8412248]

>>8398240

You made me actually laugh. Thank you, kind chemanon.

[Anonymous No.8412266]

>>8406488

True knowledge is when you're able to use household chemicals in your experiments to make more complex, more fun molecules.

On the other hand...
http://www.kosmos.de/produktdetail-149-149/chemielabor_c_3000-401/

[Anonymous No.8412495]

>>8412248

>that filename

That's a really good classic prep, lovely crystals if you do it right.

[Acid Dissociation No.8412577]

>>8407017
So I would advise looking up hard/soft acid base theory. Essentially, ions that have similar charge density and similar orbital size bond stronger. A proton and fluorine ion are closer in size than a proton and a chlorine or bromine ion. Another way to think about it is the stability of the products for the dissociation of the acids. F- is less stable in aqueous solution than Cl- or Br-, again due to the fluorine having a relatively higher charge density than Cl- and Br-. As for HNO3 and HNO2, again the NO3- ion is more stable than the NO2- ion. This is because nitrate has more resonance forms than nitrite. Also, the nitrate ion carries a positive formal charge on the nitrogen, which could help stabilize the two negative charges spread across the three oxygens. Nitrite has one negative charge spread over two oxygens with no real positive charge on the nitrogen. Apparently the difference in stability of the two is better for nitrate in aqueous solution. Hope that helped.

[Acid Dissociation No.8412582]

>>8407300
You get an enamine I believe

[Anonymous No.8412840]

>>8407300
>amine
take your pedophile cartoons back to >>>/a/

[Anonymous No.8413446]

How do I alkyne (or pi bond in general)?

[Anonymous No.8413450]

>>8413446
elimination

also, what is the joke in"alkynes of retarded". I've seen it lots of times, yet I don't get it still

[Anonymous No.8413470]

>>8413450
>I've seen it lots of times, yet I don't get it still
Perhaps bait but...its yet another pun that's not funny because of how obvious it is (such as back-side attack). "Alkynes of retarded" [math]\to[/math] "All kinds of retarded"

[Anonymous No.8413477]

Can you fuck up isolating hash oil with acetone to the point where the hash oil is toxic?

[Anonymous No.8413490]

>>8413477
Try to work with acetone vapours some day. Those vapours are an explosive mess.

[Anonymous No.8413499]

>>8412495

Second experiment I did in ochem lab. Was so successful I fell in love with it. A yield of over 90% is pretty good for a beginner I guess.


>>8413477
With enough effort put into it, you can fuck up anything you want anon.
It mostly happens if you don't put too much effort into something, though. I'd advise you not to smoke your source material while working on that though. Might be a bit explosive.

[Anonymous No.8413506]

>>8401945
because there aren't chem labs in schools anymore because muh liability
looking back on those times in hs when I accidentally nitrogen dioxide and the fume hood was broken, I'd say it's a good thing overall

[Anonymous No.8413527]

>>8413446

Corey-Fuchs Homologation > Seyferth-Gilbert reaction > Bodendorf reaction > Colvin reaction > Eliminating HX with a strong base like a fucking scrub

[Anonymous No.8413569]

>>8409147
Lol, get some fucking psychiatric help faggot.

[Anonymous No.8413585]

>>8399025
I am just an undergrad, but from what we have been told, bachelors aren't treated like degree holders by the industry, and they do about the same things you can do if you just learned the craft of a lab worker. You do not go for those jobs after your MSc.

[Anonymous No.8413587]

>>8399233 (I am not a robot.)
Wikitionary does have quotations to show that it is used outside of wikitionary.

You just wrote something like "if you publish things about water fluoridation, your position is always wrong if you are affliated with the water fluoridated institute, no matter where you have your information from."

[Anonymous No.8413603]

>>8407059
I know I am late with this, but you might want to get comfortable with the HSAB theory, which is basically a better model of acids than what you know about Lewis basis and acids. In this case, H and F are relative small ions, making them hard Lewis acods and basis respectively. That makes them very stable as a compound, unlike HI which is a hard base and a very soft base, and thus dissociate very easily.

General rules of thumbs:
Hard = small size, high charge so that charge is localised.
Soft = big size, low charge so that charge is dislocalised
Acids and bases are stable if they are both soft, or both hard.

This serves as an easy model to explain:
-why many heavy metal sulfides (HgS, Ag2S) and silver(I) halogenides are barely soluable, with the exception of AgF (Hg and Ag are very large, S2- is large)
-why some complexes, f.e. [AlF6]3- are very stable (Al3+ has high charge and is hard like F-)
-why hydrofluoric acid dissolves glass (O2- is softer than F- which might seem a bit counterintuitive regarding the charge, but F- is still a tad smaller than O2-).

It's not a perfect theory but I hope I could illustrate what the HSAB concept is good for / what it can explain well.

[Anonymous No.8413790]

>>8407112
>it reacts with glass therefore it's strong
kys chemlet
the only reason it can do that is because glass contains silicon oxide

[Anonymous No.8413809]

anyone got any pro-tips for using a Schlenk-line?

Starting lab work on monday in complex chem.

[Anonymous No.8413849]

>>8413809

Open the vacuum side to air *before* turning the pump off when you're finished.

I cannot stress this enough.

[Anonymous No.8413901]

>>8413450

Is English your first language, anon?

[Anonymous No.8413905]

>>8413569

[Anonymous No.8413919]

>>8413901
nope

[Anonymous No.8414031]

>>8394685
The secret is caffeine bro.

[Anonymous No.8414061]

>>8406448
>the only thing that holds my interest is the way subatomic particles behave
Chemical physics, physical chemistry, there's even shit like quantum chemistry or variations on that theme. You can easily take a postgrad in a number of fields.

You'd probably be better off going into this as a chemist imo.

[Anonymous No.8414190]

>>8407112
>When fluorine first touches water, it'll make HF
>>>/g/enchem

[Anonymous No.8414297]

What is the absolutely fastest way to finish the BS in chemistry?
Accumulate as many credits as possible in the first years?

[Anonymous No.8414423]

>>8413790
>chemlet

sensibly chortled

[Anonymous No.8414445]

>>8413790
I didn't comment on the acidity, overall HF is as weak as acetic acid.

You can't store Fluorine in glass. Fluorine is stored in Nickle containers because the fluorine will react with the nickel inside, making a barrier of Nickel Fluoride.

I didn't say HF was strong, HF will simply react when F finds a better thing to bind to

[chemloli No.8414454]

>>8414445
yes

[Anonymous No.8414698]

>>8413587

Good job replying to that week-old post

The other anon might be dead by now for all you know

[Anonymous No.8414704]

>>8414698
Or committed

[Anonymous No.8414982]

>>8414454
>implying I'd post Akari
>filename not matching up with post time
>using past alias
try harder next time

>>8397742
>Maybe if you posted mid-tier problems rather than elder-god-tier problems, the answers could be written in ms paint.
give a synthesis for pic related then

[Anonymous No.8415098]

>>8414982
A stereoselective one?

[Anonymous No.8415113]

>>8415098
Yeah it's stereoselective; what about it? Here's another structure [for ants] that you could try if you want.

[Anonymous No.8415208]

>>8415113
Surely it's not this simple? Haven't done this in a while and I usually end up overthinking it, so I'll just put this here for feedback

Lol I don't know if that heterodienophile is even a real thing. But this way the direction of attack is irrelevant. Methyl chloroformate could snap a group on after ring formation I guess

[Anonymous No.8415216]

Taking babby general chem next semster. Wish me luck.

[Anonymous No.8415230]

>>8415208
You got the diels-alder correct. As for the synthesis above, that last step is questionable although I myself admit to be rusty at those type of syntheses so I could be wrong. I'll work out a mechanism with arrows and see what happens

[Anonymous No.8415244]

>>8415208
>hot conditions to try and DA with a nitrogen double bond
I really hope you use cheap round bottom flasks in your lab.

[Anonymous No.8415267]

>>8415230
I think aryl ethers are more liable to acid than base. Someone had a selective melatonin hydrolysis procedure based on that

[Anonymous No.8415270]

>>8415208
While I will admit your DA solution was better than mine (no 50-50 mixture) I will strut myself on high for using only a trans isomer based reactant, and as >>8415244 said, no boom.

The chlorination one was way 2-EZ. I even synthesized the precursor I used just to make sure I wasn't cheating.

[Anonymous No.8415282]

>>8415270
HCl won't chlorinate the ring and would cleave the ether. I don't think your ether formation works either.

[Anonymous No.8415313]

>>8413809
Dont break the glass.

[Anonymous No.8415377]

bump

[Anonymous No.8415433]

>>8415244
>I really hope you use cheap round bottom flasks in your lab.
Yeah, we buy all pre-starcracked ones and save like 90% lmao

[Anonymous No.8415642]

>>8410648
idk

[Anonymous No.8415700]

>>8415270

I really don't like the look of that diene for the Diels-Alder, it's 8-pi antiaromatic.

[Anonymous No.8415799]

>>8412577
It did. Thank you

[Anonymous No.8415810]

>>8413603
Not late - still here


So it's HSAB like the other anon suggested. It isn't something mentioned in any of our material this semester which is curious.

Cheers for the explanation man

>>8414297
How many yrs does your BS in Chem take as per the uni's recommended guidelines?
Of course, do as many classes as you can... not much else.

[Anonymous No.8416768]

>>8414297
Get as many credits as you can each year? Take summer classes, pay attention to prereqs, plan ahead
I don't know why you'd want to finish with the bare minimum as fast as possible rather than free up your later years for specialized topics/grad courses though, usually people ask about that

[Anonymous No.8416772]

>>8416768
Forgot to add
Propose a mechanism for the rearrangement in the last step

[Anonymous No.8416803]

>>8416768
>>8416772

Think you've lost a carbonyl oxygen somewhere along the way m8

[Anonymous No.8416819]

This is a bit embarrassing but I'm at a total loss as to how to proceed. Is anyone willing to help me out?

[Anonymous No.8416837]

>>8416803
Yeah, it's evolved as water in imine formation

[Anonymous No.8417000]

>>8416803
Lel
http://www.masterorganicchemistry.com/2010/05/24/imines-and-enamines/

[Anonymous No.8417009]

Must everything be a general nowadays?

[Anonymous No.8417041]

>>8416819
Epoxidation is my first thought, as the methyl and oh groups will necessarily be syn, but you do get the enantiomer unless there's some wonky asymmetric reagent for this
I assume the other double bond can be reduced with some selectivity beforehand

[Anonymous No.8417062]

>>8417041
Thank you very much, this makes a lot more sense now. I don't know why I didn't think of epoxidation.

[Anonymous No.8417067]

>>8417041
Huh, well fuck me, turns out there's an actual named reaction
https://en.wikipedia.org/wiki/Sharpless_epoxidation

[Anonymous No.8417254]

>Biology
>fucktarded normies and premeds
>Chemistry
>quiet reserved posters, helpful and stay in their generals
>Chemical Physics
>Generally helpful and low profile
>Physics
>MUH IQ MUH APPLIED PHYSICS MUH ALPHA NERD
>Math
>HURRR DURRRR I AM LE HIGH IQ SMART PHYSICS IS ONLY APPLIED MATH WE ARE THE BEST 300K STARTING HAHAHQHEIAHWKSJAHEHAJEUWHA

Are chemists the best /sci/ posters?

[Anonymous No.8417285]

>>8417254
Maybe, but we could always be better.
I'm gonna post some seminal papers in the next general we can talk about

Did they raise the bump limit?

[Anonymous No.8417287]

Redpill me on why I should get a Bachelor's/Master's in Chem over Engineering?

[Anonymous No.8417335]

>>8417254
someone should make a variant of that meme that goes something like

> dignified chemists discussing reaction mechanisms and providing literature references and worked examples to back up their statements
> oh no here come the physicists
> circle of shit eaters

Also, the rarely sighted biologists don't fare much better considering most threads even tangentially related to biology or genetics rapidly devolve into race bait and shitposts, and it ends up in almost every case with one person who knows what they're talking about arguing with multiple polphysicists commenting outside their field.

[Anonymous No.8417349]

>>8417287
You shouldn't unless you love chemistry

[Anonymous No.8417352]

Is there any compact table that lists different types of functional groups for various IR spectra? Ex: X functional groups absorbs this range and appears as a strong + sharp signal

>>8417254
pls take that bait to the uni generals, not here

[Anonymous No.8417383]

>>8417335
>polphysicists
They are the fucking worst

[Anonymous No.8417394]

Thoughts on Ken Houk? Is anyone familiar with his research?

[Anonymous No.8417398]

>>8417335
>polphysicists
>people are still majoring in political physics in 2016

Those solvent-free benzodiazepine syntheses seem pretty interesting too, ref?

[Anonymous No.8417402]

>>8417394
He and his group are a bunch of salami-publishing faggots

[Anonymous No.8417406]

>>8417402
what's so bad about it?

[Anonymous No.8417410]

>>8417406
It's misconduct

[Anonymous No.8417412]

>>8417410
you're saying they are plagiarists?

[Anonymous No.8417415]

>>8417410
>>8417412
nvm just googled it

Would it be a mistake to join his lab then?

[Anonymous No.8417450]

New thread: >>8417380

>mfw I was just about to make it a lewd amine edition /cg/ and you beat me to it you bastard
>pic related

[Anonymous No.8417490]

what does /CG/ think of pic related?

[Anonymous No.8418119]

>>8417450
I was debating whether to use some cluster compound or a yuri scene from Hibike! Euphonium.

[Anonymous No.8418682]

>>8416837
>>8417000

You fucking idiots

Clearly the problem is how a cyclohexanone ring gets reduced to a cyclohexane ring in the last step that has no conditions listed, and, given that the image name is about methoxetamine, we can reasonably assume is, in fact, mistaken