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/sci/ - Science & Math

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File: 32 KB, 300x180, Telomere.png [View same] [iqdb] [saucenao] [google]
7598238 No.7598238 [Reply] [Original]

Is there more to aging besides telomeres?

>> No.7598252
File: 270 KB, 647x721, Alzheimer CpG.png [View same] [iqdb] [saucenao] [google]
7598252

>>7598238
Yes

>> No.7598283

>>7598252
Is it just me or is the right side of that pic blurry

>> No.7598284

>>7598238
Yeah, cells have a set limit of how many times they can replicate. Cells communication with one another plays an effect on aging. I'm not 100% sure on this one, but I believe Oxygen and free radicals also effect aging.

>> No.7598289

>>7598284
Oxidative stress is the term you're looking for.

>>7598283
maybe a little, probably an artefact since I had to crop the image twice to get rid of space on the right side

>> No.7598292
File: 273 KB, 699x752, Screenshot 2015-10-18 at 15.55.31.png [View same] [iqdb] [saucenao] [google]
7598292

>>7598283
>>7598289

>> No.7598294

>>7598292
>>7598283
No idea why it's blurry
http://www.nature.com/neuro/journal/v17/n9/full/nn.3786.html

>> No.7598302

>>7598238
Yes. Telomere shortening only occurs during cell replication - in mature, post-differentiated tissues that don't do much in the way of cell division, such as the human brain, the telomeres would stay put.

So unless you believe that aging doesn't affect the brain, there's more to aging than telomere shortening.

>> No.7598307

Would just creating an artificial extremely efficient method of DNA repair + a way to kamikaze certain cells be enough along with telomere extension?

>> No.7598331

>>7598307
No. Some cells can't be replaced effectively and some cells are damaged in a way that doesn't include telomeres (or DNA damage), like aggregates of intracellular amyloid will continuously lead to an Alzheimers pathology unless you remove the aggregates. And if you remove those cells you cause brain damage

>> No.7598338

>>7598331
>Some cells can't be replaced effectively
Not with that attitude. With how biotechnology and genetic engineering are advancing it won't be too much of a problem soon enough.

>> No.7598341

>>7598238
obviously

>> No.7598343

>>7598338
No it's a major problem. By the time we can replace cells effectively, we would probably be advanced enough to have ended the need to replace them ever; such as genetic engineering, prophylactic treatment of conditions, epigenetic targetting medications, prion catalysis by nanotech etc.

I doubt it will happen

>> No.7598344

>>7598331
i love amyloid fibrils, one of my favorite structure in biology

>> No.7598349

>>7598344
That's nice anon :)

>> No.7598350

>>7598344
Im sure they love you too.

>> No.7598352

>>7598349
>>7598350
you can't tell me that those steric zippers don't make you feel some sort of way

>> No.7598353

>>7598338
>With how biotechnology and genetic engineering are advancing
and how is that, exactly? do you actually read current publications on the subject, or are you just another scientism spewing high schooler