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/sci/ - Science & Math

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7115433 No.7115433[DELETED]  [Reply] [Original]

How do I make this?

It's Modafinil

>> No.7115500

>>7115433
I don't understand. It looks simple enough for an organic chem III student to do.

And if it's a drug, there's obviously tons of papers in the literature for synthesizing. Heck I see some already just through libgen

>> No.7115507

You order it from India

>> No.7115513

>>7115500
it's a kind of adderall but safer, only it's expensive as hell or you'd need a prescription.

I want to make it with a friend in HS (I'm 18 so no underage b8) who's interested in chemistry and will be studying it next year.

We don't understand it

Is it doable in a normal (school) lab? Also could you link these libgen files (most practical ones)

>> No.7115525

There's almost no point to make this drug on a cost-benefit principle.

>> No.7115526

>>7115513
>Is it doable in a normal (school) lab?
>(most practical ones)
I wouldn't know what's practical or not. If it's a hazardous chemical, you don't really have a choice since it's chemistry otherwise you fuck up your yields or whatever.

Are you seriously trying to synthesize prescription drugs for your own use? What method are you using to purify it or whatever? Do you have access to NMR to actually confirm you have what you want?

Don't be stupid.

>> No.7115543

>>7115513

In a college organic lab? Absolutely, the only step that might be a bit messy is oxidizing the sulfur. This would be one of the easiest active compounds that could be made really. Not sure what salts of modafinil are common though

>> No.7115545

>>7115526
We live in the Netherlands (kinda near DSMs and Sabiqs factories. We will go to a school trip about spectral analysis. Other dude is mailing the teacher right now to see if we can use NMR and IR machines. Him and I kinda have connections there
also we have all the things.
we only need >2diphenylmethylthioacetate, how to get this easily?

This gun b gud

nvm 5grams 700 bucks Fuck.
any other fun ideas, we already did aspirin.....

>> No.7115608

bump

>> No.7115864

another one

>> No.7115896

>>7115864
What are you asking for?
I just googled modafinil synthesis and tons of resources are available. Look at a few schemes, see if you can get your hands on the starting materials, and get to work.

>> No.7115910

>>7115896
>nvm 5grams 700 bucks Fuck.
starting materials are expensive

So, instead I'm asking for ideas/stuff to synthesise
We'll have access to NMR and IR analysis
We already made aspirin, all I really need are fun (advanced for high school seniors) ideas that we can do

We don't have much to do, and have lots of free time anyways

>> No.7115919

>>7115910
>We already made aspirin
Aspirin is one of the easiest compounds to synthesize though. It's what we did the first day in our first ochem lab course.

>> No.7115931

>>7115910

If you want to start from easily available materials, I'd start with benzhydrylbromide, react it with thiourea to give the thiol and react the thiol with chloroacetamide. Then just oxidize the sulfur and your done.

>> No.7115969

>>7115931
We could do that, purity will go down though

>> No.7115970

>>7115919
Is it cheaper to synthesize your own aspirin or buy it OTC?

>> No.7115977

>>7115969

If your in highschool, you will not be able to get this pure anyway without someone holding your hand. Not trying to be a dick, but I doubt one could do the work-ups without experience.

>> No.7115982

>>7115970
I'm sure it's cheaper to buy it OTC.

>> No.7116039

>>7115977
I understand, teacher will probably help us

he has a masters in org. chem but he hasn't worked in industry for a long time

perhaps we could get people from DSM to help us, but that chance is slim...

>> No.7117144

bump

>> No.7117337

>>7115433
We'll probably be able to print any molecule with a 3D printer eventually. Though the average Joe would be restricted from printing what he wants obviously.

>> No.7117346 [DELETED] 

>>7117337
I really doubt that. Especially the 3D printer part.
Even if you would somehow be able to print single molecules. You usually want more than <span class="math">10^20[/spoiler] of them.

>> No.7117348

>>7117346
>>7117337
I really doubt that. Especially the 3D printer part.
Even if you would somehow be able to print single molecules. You usually want more than <span class="math">10^{20}[/spoiler] of them.

>> No.7117352

>>7117337
3D printers are just localizing polymerization reactions.

Being able to print "any" molecule is possible, but not in the way you think. That's what high throughput screening was pretty much about, but it really only stopped at variations of the same structure for convenience (easy reactions).

>> No.7117525

any ideas?

>> No.7117736

you can just freely synthesise drugs in your school's lab

what

>> No.7117770

>>7117736

yes and.....?

obviously we can't go and make meth, but medicine should be completely fine

>> No.7117936

>>7115513
Modafinil isn't anything like Adderall. Why don't you just buy some Adrafinil first and try it before you just fucking synthesize a drug that you will most definitely fuck up.

>> No.7118443

>>7117936
it's for fun, I won't be using it. It's just cool to make something that is used in the real world.

any ideas? preferably kinda hard synthesis with easily availible ingredients

>> No.7118545

Is it for a "profielwerkstuk"? I have made an ant alarm pheromone for mine 6 years ago, by doing a Grignard reaction and an oxidation. Grignard reactions are awesome chemically and can be pretty tricky to get it to work sometimes. I did the experiment at the RuG because my school didn't have proper equipment, but yours might. https://www.google.nl/url?sa=t&source=web&rct=j&ei=p-z8VO-OL4OhPdC1gVg&url=http://irs.ub.rug.nl/dbi/437c9d43a2287&ved=0CDUQFjAH&usg=AFQjCNG28Q29beoz2bAF8LeYnegbZuvevg&sig2=ab-h_VOE_wgVudJAAjNgwA

>> No.7120303

>>7118545
No it isn't, we already did our profielwerkstukken. It's more for fun. Thanks for your link, now our project of Modafinil isn't doable (spoke to teacher today) at school because of regulations and we don't have the starting materials

>> No.7120338

>>7115513
Modafinil is nothing like adderall. It's not even been proven to be dopaminergic. I think it actually works on hypothalamic histamines. Also you're fucking retarded if you think this is the sort of drug you could just synthesize in a high school. You'd be hard pressed to synthesize asprin with the basic high school lab equipment. Also you'd have to have a pretty firm grasp on advanced organic chemistry and I highly doubt you do. Also good luck finding the precursors.
In short, no, YOU absolutely can't synthesize this drug.

>> No.7120369

>>7120338
the guy I'm doing this with has a firm grasp, also teachers (worked in industry) would help. Also we have access to DSM (ever heard of it?)

So, yes, I, can do it, with lots of help ofcourse.

but school is not allowed to have a lot of the starting materials, so we will have to contact DSM probably (slim chance)

>implying I want to actually take it
If I would, I'd just order it from India. No, this is a fun project.

So, do you have ideas? Already made aspirin 99.8 percent yield
>easy as fuck lel

>> No.7120382

>>7115910
Who the fuck gives some high school kids access to a fucking NMR? A cheap second hand unit costs more than a house by itself.

>> No.7120389

>>7120369
>Already made aspirin 99.8 percent yield

>comparing making aspirine to synthesizing drugs

top kek

>> No.7120402

>>7120369
>the guy I'm doing this with has a firm grasp
what is in AP lel
You're not going to make it, give it up. No teacher is going to risk helping some retarded chem 2 student manufacture a controlled substance. Also you're never going to get the precursors, unless you know a medical chemist who works in pharmacological synthesis. If you want to synthesize or isolate psychotropic drugs you're going to have to stick meth, DMT,LSA, and mescaline.

>> No.7120411

>>7120369
I'm not >>7120338 but you're a cunt.
Don't you have an intro chem test to study for?

>> No.7120425
File: 34 KB, 300x225, 1031.gif [View same] [iqdb] [saucenao] [google]
7120425

>>7120369
>Already made aspirin 99.8 percent yield
>easy as fuck lel
mfw I said that as a joke, and this faggot's actually proud of his middle school grade chem skils.

>> No.7120485

>>7120382
Children loving companies ofcourse

>>7120411
>>7120425
lol

>>7120402
okay, you're right. Do you have better ideas for us?

>> No.7120516

>>7120485
>Do you have better ideas for us?
Try making meth or extracting DMT. The supplies you'll need are much more available and it's something that's feasible for a high school student to do, but it isn't completely over simplified.

>> No.7120578

>>7115513
>Is it doable in a normal (school) lab?

what is a 'normal school lab'?
i doubt your high school lab has nmr or x-ray chromatography facilities, or even a mass spectrometer. i also doubt that it provides all the precursor chemicals you need.

tell us what equipment the lab offers you.

>> No.7120586

>>7116039
>teacher will probably help us

your teacher will help you synthesize a controlled substance?
don't get caught because that will cost him his job and probably get him jailed.

>> No.7120623

>>7120578
We'll have access to DSM's lab (has everything you said and more)

>>7120516
Something that won't land us in jail and the teachers would help us with....

>> No.7120626

>>7120623
>Something that won't land us in jail
You started a thread about how to synthesize a controlled substance. Are you fucking retarded?

>> No.7121740

Making small amounts of Modafinil in the Netherlands won't get you in any trouble and it's very doable.
Benzhydrol, thiourea and chloroacetamide are what you need and they're not expensive.

Patent: US2004/2547 A1, 2004 ;
To a suspension of benzhydrol (35.00 g, 0.188 mol, 1 equivalent) and thiourea (17.40 g, 0.226 mol, 1.20 equivalents) in tetrahydrofuran/water (35.5 ml/52.5 ml), was added an aqueous 48percent HBr solution (25.3 ml, 0.226 mol, 1.2 equivalents) over a 10 min period.
During the addition, the reaction mixture is heated to 70° C.
After 3 h stirring at 70° C., the uronium intermediate was hydrolyzed by addition of an aqueous 9.3N potassium hydroxide solution (58 ml, 0.542 mol, 2.88 equivalents) over a 55 min period.
After 1.5 h stirring at 70° C., chloroacetamide (26.6 g, 0.282 mol, 1.5 equivalents) in a tetrahydrofuran/water (80 ml/79 ml) solution was added over 15 min.
After 1 h stirring at 70° C., the reaction mixture was cooled down to 55° C. and the stirring was stopped.
The lower aqueous phase was removed, and the reaction mixture was again stirred.
Acetic acid (34.7 ml, 0.601 mol, 3.2 equivalents) was added.
Hydrogen peroxide 30percent (38.4 ml, 0.376 mol, 2 equivalents) was slowly added over 30 min.
After 1 h stirring, the reaction mixture was cooled to 20° C. and water (263 ml) was added.
The resultant suspension was stirred at 0° C. overnight.
The suspension was then filtered and the solid was washed with water, and dried to yield modafinil (47.9 g, 80.4percent).