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/sci/ - Science & Math

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2204554 No.2204554 [Reply] [Original]

What advances do we need to make for clinical immortality to be possible?

>> No.2204561

1. Cure cancer
2. Figure out how to get DNA to be passed on from one generation of cells to the next without any loss.

>> No.2204567

>>2204561

I mean more specifically, obviously we need to limit damage during chromosome division, the question is what do we need to do THAT.

>> No.2204571

we're basically brute forcing DNA sequences to see what happens now that its mapped, its only a matter of time before immortality is reached via that method

>> No.2204570

>>2204561
>cancer
immortal cells that serve no purpose other than reproduction

>> No.2204591

>>2204571

Can you elaborate on this please?

>> No.2204597

>>2204554

We've got to figure out how to stop telomeres from shrinking from one generation to the next, which we've actually made decent progress in recently (albeit in mice).

>> No.2204635

>>2204597

Any links on this? Not because I am saying you are making this up, I just want to read in detail.

>> No.2204646

>>2204635

http://www.guardian.co.uk/science/2010/nov/28/scientists-reverse-ageing-mice-humans

or http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09603.html if you have access

>> No.2204649

>>2204646

Thanks, I genuinely appreciate it.

>> No.2204669

try looking up mechanical immortality, much more intersting! ------- i wanna be uploaded :)

>> No.2204693

>>2204554
I'll try to answer as comprehensively as I can

1. We need to figure out a way to periodically moderate the accumulation of age related glycation endproducts, or AGEs, in our connective tissues. AGEs are responsible for most age related pathologies involving connective tissue, such as skin senescence, macular degeneration and atherosclerosis. It also causes increased rigidity and shrinkage of all cartilage in your body as you get older. This, for the most part, is what causes people to "look" older.

2. An advanced, form of gene therapy that continually repairs DNA damage in somatic cells. Either that or better repair enzymes added to our genome. I think that ultimately this will mean one gene therapy treatment that adds the necessary genetic code to repair DNA damage faster than it accumulates and lengthen telomerres. This would effectively be a preventative cure for cancer.

That's what I can think of off the top of my head. I'm sure that once treatments like this are implemented new pathologies will arise along the way.

>> No.2204704

>age related glycation endproducts, or AGEs

Gentlemen, this is what happens when a generation young enough to read science fiction begins to do actual science.

>> No.2204721

>>2204704
Not sure what you are implying. I didn't read about advanced glycation endproducts in a science fiction book.

I'm not an expert on the topic but even first year undergraduates learn about glycoproteins making up the extracellular matrix between cells and constituting most of what collagen is.

It makes sense that the build-up of glycoprotein connections between cells over-time results in a more rigid, brittle structure.

>> No.2204727

>>2204721

The retarded acronym, dumbass. It's a long way from DNA to AGE.

>> No.2204763

>>2204727
Again, I'm not sure what you're trying to say. Glycation itself has little to do with DNA. Although DNA may be the answer through enzymes that could break the glycation bonds in the matrix between cells.

AGE stands for Advanced Glycation End products.

>> No.2204777

>>2204763
He thinks AGE is a silly acronym, like BUTTS.

>> No.2204785

>>2204777
Well, we can just say glycation then. We need to moderate glycation in our bodies.

>> No.2204833

The 7 types of aging damage:
-Cell loss, tissue atrophy
-Nuclear [epi]mutations
(only cancer matters)
-Mutant mitochondria
-Death-resistant cells
-Tissue stiffening
-Extracellular aggregates
-Intracellular aggregates

We have ideas to fix all of these.
http://www.sens.org/sens-research/research-themes

>> No.2204841
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2204841

http://en.wikipedia.org/wiki/Aubrey_de_Grey
http://www.truththeory.org/do-you-want-to-live-forever/

>> No.2204909

actually we need to have our cells have the capabilities of cancer cells

if cancer has a continuous blood supply providing oxygen, fuel & removal of waste they can live forever

>> No.2204920

>>2204909
>most boards on 4chan will live forever

>> No.2204933

>>2204920

lol...i work in the health profession and read up on cancer. not many people know that cancer can live forever

>> No.2204977

>>2204841
Grey is delusional. And he's not even a scientist.

>> No.2205027

>>2204977
grey is overly optimistic and his PhD is honorary but he has the education and is contributing to science none the less

I'm not one of these people on his wagon but I think to say the he isn't a scientist isn't fair

De Grey is probably the first of many people that will be marginalized for trying to defeat aging due to people's natural tendency to resist revolutionary changes in how we live our lives.. until it happens

You can't deny that the unstated but implicit goal of modern medicine is to extend healthy lifespan. It's going to happen eventually and I don't blame people like De Grey for trying to make it happen a little faster than it would otherwise.

>> No.2205134

So is 30 years an honest estimate for this? Too long or too short?

Or is it all just a pipe dream?

>> No.2205179

>>2205134
According to Grey it's more like 5

>> No.2205186

Stop living in cities.
Eat non-proceed raw food.
Work out.

be natural

>> No.2205204

>>2204909
so... we need to replace all of our cells with cancer.
What if cancer is natures way of giving us immortality? What if, though all the deaths that cancer causes, a mutant arrives. One that is born and has all of its cells replaced with "cancer" type cells. Assume that they are not a baby forever.

>> No.2205214
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2205214

>>2204841
>Aubrey de Grey
>author of Ending Aging
>47
>looks 80

>> No.2205225

So I just watched that whole 1.5 hour film on Grey. All in all I'm hopeful that life can be extended indefinitely, but I'm not sure whether in reality we'll be able to break 150 in our lifetimes.

>> No.2205231

>>2205204

There's a theory for that already, it's called evolution. Jackass.

>> No.2205246
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2205246

>>2205214

He claims to be 47, but secretly he's at least 140. Pic related.

>> No.2205251

>>2205204
so... we need to replace all of our cells with penises?
What if penises is natures way of giving us immortality? What if, though all the deaths that penises causes, a mutant arrives. One that is born and has all of its cells replaced with "penises" type cells. Assume that they are not a baby forever.

>fixed for less stupidity

>> No.2205254

>>2205246

Russia's Greatest Sex Machine!

>> No.2205260

>>2204909

So do cancer cells produce telomerase then? Or how do they prevent genomic degredation? Or are you talking about single cells surviving forever rather than a culture? If so, source?

>> No.2205263
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2205263

>mfw when Grey is actually Rasputin

>> No.2205282

No jobs in this shit. :(

FUCK SOCIETY

>> No.2205285

Holy fuck. Bringing this topic back to reality now...

Biological immortality certainly isn't impossible according to what we know right now...but scientists in the fields of gerontology and cancer research overwhelmingly agree that they are nowhere near a breakthrough. In other words, unless something crazy as shit happens that nobody is expecting, we won't be discovering immortality anytime soon.

And shut the fuck up about cancer being immortal. Your shit is stupid.

>> No.2205288

>>2205260
http://en.wikipedia.org/wiki/HeLa

>> No.2205290

>>2205285

according to what you know, learn to physics first before talking about immortality,... the idea is just as childish as it sounds when you look at it with real knowledge

>> No.2205292

>>2205290

Alright you asshole, i thought the implication was obvious but I guess it has to be spelled out for you and other morons that misinterpret my post.

Biological immortality is possible as long as we confine "immortality" to a certain timeframe. If we do not discover a way off the earth by the time the sun dies, we'll fucking die. If heat death is the end of the universe and we can't find some way around it, we're dead.

In short, my point was that biological immortality if feasible WITHIN THE OBVIOUS FUCKING BOUNDARIES YOU COCKMUNCH

>> No.2205293

>>2205288

So it does produce telomerase. Sweet. Is that something that's true for all cancer cultures though, or just that specific line?

>> No.2205298

>>2205292
>>2205285

dumbass

not a single point made in >>2205292 is in any way related to the points you brought up in >>2205285

>gerontology and cancer research
does not imply
>sun dies, heat death, the end of the universe

>> No.2205303

>>2205298

No, I'm sorry, it doesn't. I'll remember to spell everything out for the retards next time.

>> No.2205310

>>2205303

>implying you aren't one of those retards, if not queen retard
>implying making a completely unrelated post is "spelling out" an older post
>implying implications were implied

>> No.2205356

>>2205298

I did not even talk about heat death or sun dying off, but about all of our body not being perfect to be in a stable state for forever, cancer is not the only thing you die off, biological immortality is just a stupid idea of people that stopped to science on high school level.

Why do you think many people get an apoplectic stroke? Because our blood vessels are so perfect ? These bitches wear out pretty fast and we have a lot more problems in our body than that...

>> No.2205412

>>2205356

>implying implicitly implied implications

>> No.2205452

I lol'd.
>>2205292 is irrelevant to
>>2205290

>>2205290 believes his answer is so obvious that there's no need to explain further.

>> No.2206650

>>2204833
yeah totally
this shit needs funding!!!
money
money
money
and jobs

>> No.2206660
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2206660

clinical immortality you say?

are you ready to make some sacrifices?

>> No.2206706

>>2205288
Always wondered what would have happened to her if she didn't get surgery.