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16584827 No.16584827 [Reply] [Original]

Is there any scientific backing to Nootropics? Every time I dig into stuff I see shilled online, there's studies proving it's just placebo.

For context, I have OSA(~30 AHI), treatment resistant MDD, and TBI. Every treatment I've tried has failed; CPAP machine didn't help(currently trying to get a BiPAP), antidepressants, TMS, TRT, multivitamins, microdosing shrooms, blood tests dont show any deficiencies, etc. I take caffeine pills and smoke cigarettes just to barely stay awake through the day, but some days I just can't focus at all. I never have motivation; I have to force myself to do everything through pure willpower. I'm not fat, and working out isn't help.

My first time doing shrooms "cured" me for a few days but I went back down after smoking weed.

>> No.16584832

>>16584827
coffee and tobacco are nootropics. yes they are real.

>> No.16584854

>>16584827
Scienceᵀᴹ: Smoking weed depletes gluthathione, supplement glutathione and NAC.

>> No.16584857

>>16584827
Can you rephrase your post without acronym and tell us what you've "tried"?

>> No.16584907

>>16584854
I'm not a stoner. I just used to smoke occasionally with friends when they offered, but I'm never touching that shit again.
>>16584857
I have moderate/severe sleep apnea, treatment resistant major depressive disorder, and I was diagnosed with traumatic brain injury during depression testing but I have no idea what caused it and when.

Treatments that didn't help:
>continuous positive airway pressure machine(I'm trying to get a bilevel positive airway pressure machine)
>transcranial magnetic stimulation
>testosterone replacement therapy

>> No.16584909

>>16584907
Do you have troubles to focus? Or you just is very way down? You should maybe look at St.John's Worth(Hypericin)

>> No.16584910

Does selank and other peptides work? How do use it without having a troon nurse ask to mix X cc of Y and z mg of K into A.

>> No.16584911

Also I'm only 23. Been dealing with depression since I can remember. I'm convinced my brain got fried by ADHD meds growing up, but every psychiatrist I brought that up to says that's not possible.

>> No.16584915

>>16584909
Some days I have trouble focusing, yeah. But the complete lack of energy is persistent.
>You should maybe look at St.John's Worth(Hypericin)
Thanks I'll take a look at it. Do you happen to have any sources showing its effectiveness?
>>16584910
I'm a little wary of all the peptides and other research chemicals flooding the market, but I'll look into it.
>How do use it without having a troon nurse ask to mix X cc of Y and z mg of K into A.
If you're talking about injectable compounds, just draw them both into a syringe.

>> No.16584941

>>16584915
I mean I have no idea how to use peptides. Some say to dissolve peptide in isotonic saline then put a few drops in nose. Others say peptides might cause allergic reaction. Idk doesn't seem too effective.
On related note, there was a guy posting tons of empty bottle of cerebrolysin which he supposedly took over 2 years. If that shit really worked, he'd have been a trillionare by now lol.

>> No.16584950

>>16584915
https://pubmed.ncbi.nlm.nih.gov/10647752/
https://pubmed.ncbi.nlm.nih.gov/28064110/, it

It's like antidepressant but it also boosts dopamine.

You should also excercise...

Maybe something with mitochondria... Look at ECGC and PQQ.

Maybe just lack of histamine...

Phenylpiracetam is also good stimulant.

>> No.16585010

>>16584827
Hijacking this thread with no survivors:
28 year old male, generally healthy.
Background of slightly low blood pressure, past history of asthma that has been long resolved since over a decade and a half, mild dust/pollen allergies.
Usually I had slightly elevated hemoglobin levels, and for years I've had hemochromatosis - management thereof consisted of blood donation, twice a year kept it under check.
Two years ago I stopped donating blood after I started getting migraines out of the blue, odd for a male, but doctors blamed genetics (my grandma and two aunts have it).
For around 8 months I've hardly had any migraines, and the 4 attacks that did occur were very mild as to not even require any medication.
This coincided with a slightly low serum iron saturation (~17%) even when transferritin and ferritin remained over the middle of the normal range.
In the middle of that period I had another test where transferrin saturation went up to ~23%, and ferritin and transferrin went up in absolute values.
Last month I went back to swimming (had stopped because of migraine-induced vertigo a year before), once I started pushing my limits a bit, I kept getting really dizzy - especially on any postural change, including in the water still.
Following another blood test I find out my iron stores are basically depleted (less then 70ng/ml ferritin), 13% transferrin saturation and 236 mg/dl transferrin.
Hemoglobin, MCV...etc is all fine, though vitamin D is extremely depleted (8ng/ml).
But I'm already feeling the effects: shortness of breath, increased sleepiness/drowsiness, confusion, brainfog...etc
I am going to a gastroetreologist to rule that out, but I doubt it anyhow.
Mind you, my diet is quite balanced, I have a lot of veggies, and meat more than enough with variety.

Doctor isn't too concerned, and I understand that only my bound iron/stores are depleted, but its fucking annoying - I finally feel what its like to have an NPC brain.
Halp anons.

>> No.16585527

>>16585010
My tiredness stopped when I started taking CoQ10 with Omega3+DHA,EPA

But you seen like you have different problems.

>> No.16585529
File: 36 KB, 819x900, neon-teethjak.png [View same] [iqdb] [saucenao] [google]
16585529

Methylene Blue + Ashwagandha (cycle the latter)

>> No.16586202

>>16585529
Just be mindful that MB is a potent MAOI. I'm on it myself 3x/week but it's imperative to avoid high tyramine foods ~8h either side of dosing, and one has to be aware of potential interactions with other substances, especially seritonergics

>> No.16586391

>>16584911
Maybe you didn't tell them the whole story.

>> No.16586884

>>16584950
Thanks, I ordered a few bottles of Perika to try.
>ECGC and PQQ
>Phenylpiracetam
Added to the list, thanks. Do you happen to know a good source for
phenylpiracetam? It sounds very interesting.
>lack of histamine
Why do you think that?
>>16586202
What effects does it have on you?
>>16586391
I did. Every psychiatrist is convinced that ADHD drugs do not have long-term effects on brain development. They probably bury their heads in their asses because they prescribe ADHD meds to kids and don't want the guilt.

>> No.16586939
File: 121 KB, 1170x1155, never-goon-v0-ug2n0fwfu1ad1.jpg [View same] [iqdb] [saucenao] [google]
16586939

>>16586884
Amphetamine causes delusions, whose essence is a problem of causation. "Winning" the argument that way makes their condescension explicit. In other words: if you can't be right you must be crazy which makes you right.

To elaborate on causation: if Invasion of the Body Snatchers (1978) becomes real, it's possible to still agree on the observable facts, but the protagonist has still gone crazy because their feelings and explanation are "wrong".

>> No.16587111

>>16584827
Maybe? If the science behind "gut flora" is accurate what you consume might have a bigger impact on the body.
https://youtu.be/VzPD009qTN4?si=XOIRQ6ClFdNydrd6

>> No.16587238

>>16584827
>Is there any scientific backing to Nootropics?
Yes but its been over-run by people who care more about money than they do about truth and health.
A safe assumption is that 90% of them are either useless, or actively harmful.

There is also an interesting "duration paradox" in health, where compounds that harm the liver in the short-term, will appear to benefit health in the short-term, while destroying it in the long-term. Many, many compounds, herbs, spices, and drugs, fit into this pattern.

>> No.16588627

>>16587238
The 90% figure is over-stated. I've gone super-deep in the nootropic chemicals but also stayed away from many dangerous-looking ones. It's probably more 20% good shit, 60% ineffective shit, 20% dangerous shit. A few of them are legit anti-dementia drugs that have good evidence of preventing neurodegeneration, such as RFK Jr.'s methylene blue. (protip: non USP-grade shit is super toxic, though)

>> No.16588692

>>16584915
Look into the peptides SS 31 and Mots C. They restore mitochondria function and create more mitochondria. You can read reviews of them on reddit, lots of people say it gives them energy. Most people underdose it though, SS 31 is supposed to be taken at 20-50mg a day, and I think mots c is 10-20mg a day

https://www.peptidesciences.com/ss-31-25mg?queryID=de81b9200677ad63e1a0c988f31d6df2&objectID=188&indexName=psm2_default_products

https://www.peptidesciences.com/mots-c-10mg

You can get it cheaper from China from companies like Jenny Chem

>> No.16588708

>>16585010
Have you gotten your kidney values checked? Or done a protein piss test?

>> No.16588712
File: 138 KB, 1344x319, Nootropics.png [View same] [iqdb] [saucenao] [google]
16588712

you could start taking peptides and or nootropics (not meme ones that are glorified vitamins) like Semax, Cerebrolysin, Dihexa, Isrib, Epobis, Neboglamine, Tak 653, and Tropisetron to improve your memory, focus, creativity, motivation, mind clarity, and enhance your ability to understand problems. They also repair brain damage, including age related degradation, and increase reaction time + hand eye coordination.
You can take them intranasally as well to get more of it directly to your brain, which is especially beneficial for Cerebrolysin since the alternative is injecting it and the recommended dosing that way is 5ml a day which is a lot to inject.
cosmicnootropic.com and rupharma.com have cerebrolysin + semax
Science.bio has Dihexa and isrib
pglchem.com and isrib.shop have isrib
jennyschem.com has Epobis but it's not listed, you have to email them and say a friend told you they have Epobis, I confirmed this with someone who bought it from there and posted pics of it + his experiences with it on r*ddit
everychem.com has Tak 653, Tropisetron, and Neboglamine
Other good sources include peptidesciences.com, umbrellalabs.is, and amino asylum
Heres where to get steroids steroidsourcetalk.cc/index.php
You need to get your account approved by the owners of science.bio to purchase things on there, just say you are researching the effects of UV light on degradation of chemicals and look up a bunch of lab and safety equipment on google and say you have that in the approval form.
If you're interested in reading more about these substances I'd recommend the nootopics, nootropics, and peptides subreddits

>> No.16588715

>>16588712
Another substance you should look into is called Emeramide. From what I've read it's some revolutionary drug that is very good at removing heavy metals from your body and is apparently quite safe, I've read no other metal chelator comes close to it in terms of effectiveness. It was developed by an anti vaxxer to remove mercury from your body that came from vaccines, which I've also read never leaves your body and instead just goes to a different part of it and causes problems there. Removing mercury and other heavy metals that may be in your brain would bring mental benefits to you.
This site was listed by the person I heard about emeramide from on here as a place that sells legit emeramide
www.sacredpurity.com

>> No.16588747

>>16588715
NAC is also a fairly heavy-duty chelator: https://link.springer.com/chapter/10.1007/978-981-10-5311-5_10

With the amount Bryan Johnson takes, he's probably deficient in most of the metals he's not supplementing (protip: especially copper and chromium).

>> No.16588978

>>16586884
I don't know where you live, but if you use duckduckgo, you can still find RC's or nootropics vendors... Use "<product> price <localcurrency>" pattern in search engine that is not AI slop but still depending on keywords.

>> No.16588981

>>16586884
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.1014539/full

Abnormal doesn't mean bad.

Also there was study that showed, more synapses literally and smaller some from METH use, but I can't find it now.

>>16586939
That's meme, AMPH cause focus, that's made of ignoring what's going on around you, and that's pretty much dangerous somehow, but low doses really are safe.

>> No.16588997

>>16586884
>lack of histamine
I didn't remembered histamine was neurotransmitter, when I had copy of neuropharmacology book, it was there on some pills, but I didn't realized it's a neurotransmitter.

But ask AI about histamine role in sleep and you'll know.

>> No.16589002

>>16584827
https://www.nature.com/articles/s41380-018-0334-8

Maybe this will interest you too. Get well soon.

>> No.16589334

>>16588981
>That's meme
It's not a question of probability because >>16584911 believes they were harmed. Instead of validating the individual, which might do something to fix their illness, you misinterpret my argument as being against amph in general.

>> No.16590194

>>16588692
Thanks anon, will definitely look into it as long as the prices are more reasonable than the links you sent
>>16588712
I recognize some of those compounds but that's a lot of stuff to look into. Thanks.
>>16588715
Sounds interesting. I don't recall any issues with heavy metals in my blood work, but I'm not sure if I even had that checked. Will definitely read up on it some more, thanks
>>16588978
Thanks. Are you familiar with any forums I should look into that discuss sources seriously with minimal shilling?
>>16588981
That seems to be about methamphetamines which could have completely different effects than amphetamines no? I did read some studies that show amphetamine use during brain development can lead to depression later on, but I don't think I've seen any study explaining why.
>>16588997
Thanks
>>16589002
Definitely sounds interesting, I already happened upon it and have it on my list already. Thanks fren
>>16589334
I'm not looking for validation, but I do wish my psychiatrists at least took the possibility seriously and helped me look at a solution from that angle instead of just trying generic blanket depression treatments that didn't even slightly help. My last psychiatrist was more eager to try BPD medication even though I have no mania lol

>> No.16590233
File: 72 KB, 1x1, Lyophilized vials prices---2024_1739807596637.pdf [View same] [iqdb] [saucenao] [google]
16590233

>>16590194
Here's the price list for jennyschem.com. This is only for the lyophilized, ready to inject pre vials. It doesn't list SS-31 on here but I was just told by a rep that the pricing for SS 31 is $165 for ten vials that are 10mg each. I was also told there was going to be a new pricing lost on Friday which should include more of the stuff they sell

>> No.16590234

>>16590233
>there was going to be a new pricing list on Friday

>> No.16590280

This is a good link to read through. Author is a schizo dickhead but there's good information on EMF damage caused by things like phones, and supplements that prevent EMF damage with studies to back it up
pills.gg/

>> No.16590362

>>16590233
Thanks for the spoonfeeding fren. Definitely appreciated.
>SS 31 is $165 for ten vials that are 10mg each
So according to your dosing recommendation, I will be injecting 2-5 vials a day, which comes out to $33-82.5 per day? The low end is tolerable if it really does fix me, but the high end is nearly unaffordable for me unfortunately. Also while not illegal, I'm sure some eyebrows will be raised if I'm importing 60+ vials of research chemicals from China every month. Also I'm assuming it's 10mg/mL? That's quite a bit of fluid to be injecting daily.
>>16590280
I know this thread is about a pseudoscience-adjacent topic, but let's keep the schizobabble to a minimum please. Although I definitely do appreciate the good intentions.

>> No.16590364

>>16590194
>thanks
You're welcome, get well soon.

>> No.16590513

>>16590362
> I will be injecting 2-5 vials a day
Yes
>eyebrows will be raised if I'm importing 60+ vials of research chemicals from China every month
Buy them all at once. You could do a 60 day cycle which is the length people take these 2 peptides to reverse early to mid stage kidney disease. There's also no guarantee customs will go through your packages.
>Also I'm assuming it's 10mg/mL?
It's dry powder so you mix in however much bacteriostatic water you want. You could do .2ml, that should dissolve 10mg worth of powder

Heres the video on reversing kidney disease with the 2 peptides if you're interested
https://youtu.be/rZRzUWb8UrM?t=455

>> No.16590690

Alright so for now, here's what I'll be trying on the supplements side:
>St. John's Wort(Nature's Way Perika; https://archive.is/SYQpC): 3x 300mg
>Lithium Orotate(Pure Encapsulations Lithium Orotate; https://archive.is/ijrKC): 10mg AM + 5mg PM
>B-complex(Seeking Health B Complex MF; https://archive.is/9NUol))
>L-Methylfolate(Carlyle L Methylfolate; https://archive.is/1TPaM sorry about the shitty archive): 15mg
>L-Tyrosine(Now Supplements - L-Tyrosine; https://archive.is/jVNqV): 10x 750mg
>EGCG(NOW Foods Supplements, EGCg Green Tea Extract; https://archive.is/km0iU): 2x 200mg
>PQQ(Nutricost PQQ; https://archive.is/ACnB1): 20mg
>Manganese(Source Naturals Manganese; https://archive.is/3Gp7O): 10mg
I think what I'll do is start off with SJW, then add an additional supplement every day. I will post updates here daily, in case anyone else can benefit from me pissing money away.

If these prove ineffective(which I assume they will), I will move on to the peptides.
>>16590513
Oh, I misunderstood. I was under the assumption that the powders were already reconstituted. That sounds much more reasonable.
Do people generally not take it for life? Just short cycles?

>> No.16590693

>>16590690
remember anon, every "nootropic" that doesn't require a prescription is a placebo meme

>> No.16590739

>>16590690
EGCG can mess up your liver so watch out for that
>Do people generally not take it for life >Just short cycles?
Short cycles
>>16590693
Most nootropics don't require prescriptions because they're research chemicals and haven't been regulated because the people that write the laws don't know about them

>> No.16590746

>>16590739
>anon is injecting himself with experimental chemicals from China to become smarter
I kneel.

>> No.16590747

>>16590739
>the people that write the laws don't know about them

it's actually the people WHO write the laws, but you have the general idea. you can just look at Trump or Sleepy Joe or Mitch McConnell or RFK Jr. and see the dopamine skill issues at the tip of the Alzheimer's iceberg.

>> No.16590751

>>16590693
Yeah, I'm assuming that will be the case. Doesn't hurt to try supplements, though. Ive been suffering for as long as I can remember, risking another month or two for the potential of finding a safer & more readily available solution is worthwhile imo.
>>16590739
I thought EGCG was only toxic above 800mg/day?
>Short cycles
So a single short cycle could potentially fix me? I like the sound of that much better than taking shit every day for the rest of my life.
>>16590746
And stronger.

>> No.16590792

>>16590751
>I thought EGCG was only toxic above 800mg/day?
I've read an anecdote on reddit from a guy who was drinking green tea daily (he didn't specify how much) for 6-8 months and when be got his blood tested his liver values had doubled from his previous test
>So a single short cycle could potentially fix me?
Potentially. It worked for those kidney disease patients in the vid I linked earlier so it might work for you. Mitochondria dysfunction is linked to lots of problems

>> No.16591690

>>16590746

What chemicals?
I'm going to inject the same chemical so I can have a conversation with this crazy person.

>> No.16592927

My theory is that anything that boosts brain performance is bad for the heart.

Betaine, choline, TMAO, and homocysteine appear to progress disease, starting with the gut micro biome / blood axis. So if you take any supplements that boost TMAO or you have bad gut bacteria, you’re probably causing some kind of damage. A lot of nootropics send bloodflow to the brain and increase choline. The choline especially is associated with disease progression. We know that excess animal products cause disease. They increase choline, TMAO and homocysteine. Regular diet gives enough choline to function.


Caffeine is also another one. Over 80mg causes arteries to not adapt to blood flow. They get a slight bump in blood pressure. That’s not good over time.

>> No.16592935
File: 845 KB, 2448x3264, IMG_20170603_194900605.jpg [View same] [iqdb] [saucenao] [google]
16592935

>>16592927
>My theory
Pssh...yeah, "theory"...pfft...

>> No.16592949

>>16592935
I FUCKING KNEW you're degenerate, but snorting celluose is whole new level of degeneracy.

>> No.16592957

>>16592949
Caffeine pills are roughly half binder which is soap scum, not cellulose.

>> No.16592999

>>16592927
And why should I trust your theory especially when you say shit like
>excess animal products cause disease
?
Do you have any practical solutions that align with your theory? Because honestly I'd rather die of a heart attack at 50 while enjoying life than live as I am now.
>they get a slight bump in blood pressure
Meh, my blood pressure is already high and the testosterone isn't helping. Multiple doctors couldn't locate the cause so I'm on ACE inhibitors and daily vasodilators.

>> No.16593048

>>16592935
When I said "get help" and "take your meds" I meant professional help.
Please get help, you illiterate moron.

>> No.16593084

>>16592949
Cult is mentally unhinged retard to the point it boggles belief. He is next to ChrisChan on the level of mental retardation and stupid beliefs. I wish he would get help

>> No.16593229

>>16584911
>Take amphetamine derivative
>Have a sort of brain fog
That's a very common side effect of stimulants and amphetamines. I used for about a year and a half and it took almost a year to cut through the brain fog, though it wasn't exactly a brain fog, it was almost as if thinking was hard, so I just wouldn't do it.

Some people who used to tweak never recover from it and always seem a little scatter brained. ADHD meds are this generations Lead Paint. It's almost the same behavior in former addicts and people with lead poisoning

>> No.16593614

Don't worry about too many nootropics gamers; just lift weights and trust in Jesus Christ. ICXC

All you need is Rhodiola ngl.

>> No.16596577

Took SJW for 3 days so far, and nothing to report. Should take 2 weeks for an effect. Waiting for the rest of the supplements to come in.

>> No.16597202
File: 77 KB, 600x378, 1714415308548482.jpg [View same] [iqdb] [saucenao] [google]
16597202

>>16584911
>Been dealing with depression since I can remember.

I spent most of my life in a deep depression. From puberty until my early thirties I was nothing but miserable. On a whim I bought some mushrooms from my weed dealer. Went to my local hiking spot and took an 8th. It was horrible, but afterwards I had a clarity I never experienced in all my time. I quit smoking the next day, cigarettes seemed so ridiculous. I also started excercising and fasting 1 day a week. I bought more mushrooms and did it again a few weeks later. It was a little less horrible and I felt a strange euphoria and pride in myself for quitting smoking and exercising. I realized during this trip I was horrible to everyone around me. Spent the next month apologizing to everyone around me for being a selfish, petty, vindictive asshole. I did some research and decided to up the dose considerably. Every trip was less painful and more rewarding. People began to notice the changes in me. My father told me he was proud of me for the first time as an adult.

>> No.16597204
File: 432 KB, 720x868, 1727068007838196.jpg [View same] [iqdb] [saucenao] [google]
16597204

>>16597202
Four times a year I go for a 2 day hike in to the wilderness where I can see the stars perfectly. I feel this part is very important. I prefer a nice clearing on a hill in a thick forest. I spend the hours leading up to sundown collecting firewood and chugging water. Once the sun goes down I start my fire and take 90 grams of fresh, not fucking dried, mushrooms I cultivate myself. This experience will likely be the most painful and soul-wrenching experience of your life except for the final hour or so. Do NOT fight it. Make NO attempt to control it. Accept what you see. Once you come down, before you go to sleep, write down what you have learned. This may seem a vague instruction, but you will know exactly what I mean in the moment. On the hike back to your car or whatever consider what you were shown. Over the following days and weeks implement these changes in to your life. If you do not, the next experience will be much, much worse than the first. Do not do this more than once a season. Do not talk about this with people. Its not fun, its not for recreation, its not to be bragged about. I am aware psychedelics get a bad image from filthy hippies and degenerates, do not add to it. Do not be picrel

Good luck, anon.

>https://darksitefinder.com/map/?i=/%234/39.00/-98.00
You want one of the places marked black to dark blue.

>> No.16597322

>>16597202
>>16597204
See >>16584827
>My first time doing shrooms "cured" me for a few days but I went back down after smoking weed.
I've tried tripping multiple times since, including multiple 5g trips, but I can't replicate that first time unfortunately. I am not taking 90g of shrooms in one session, but thanks for the advice and I'm glad it worked for you.

>> No.16597398

>>16597322
90g of fresh mushrooms is equal to 9g dried out moron. He points that out.

>> No.16598470

Day 6 of SJW and day 2 of Lithium
I feel like it's easier to lock in and get stuff done. I'm not looking for distractions. I feel a slight pressure in my forehead and my face is tense(furrowing brows, clenching teeth, etc). Easier to ignore cravings. I feel more flat, almost like I'm dissociating, very similar to how I felt on ADHD meds but much milder. Obviously it's too early to draw conclusions, could just be a coincidence or related to sleep. Will hold off on adding other supplements for a few days.
>>16597398
Oh, I didn't notice that. I'll keep that as a last resort, growing mushrooms is a pain.

>> No.16599058

>>16588712
I've heard tak 653 is quite hit or miss in practice, and quite unremarkable when it 'hits', i.e. mild anti-depressant.

>> No.16599181
File: 536 KB, 1522x1084, IMG_2202.jpg [View same] [iqdb] [saucenao] [google]
16599181

Avoid pharmaceutical drugs

And its hyperforin you want in st johns wort
Dont dose above 5mg hypericin

>> No.16599235

Today I was arguing on twitter about methlyene blue and the guy blocked me, but I think he may have been right. I don't mind the names and general asshole behavior, but I'm bothered that I won't be able to ask for clarification.
So what's the consensus here. Doable for small dosing therapeutic purposes, or toxic in all forms.

Most of the standard articles you can find reporting on its safety is for short term usages for things like cyanide poisoning where even if it is long term dangerous it's definitely better than dying so they prescribe it w/ no worries.

>> No.16599244

>>16588712
did the guy in pic related provide proof for his claims regarding his iq

>> No.16599246

>>16590690
Hey anon (and other anons), just two things I want you to add to your stack:
- vitamin C / ascorbic acid (500mg)
- LOTS (like, 8-10 cups) of water.
I recently read a report on the effect hydration has on the brain. They compared dehydrated, ad-libitum, and hydrated (10 cups). The "forced" hydration was much more positive then the ad-libitum / drink whenever you get thirsty. Since it's only water there's literally no downside / added expense so you may as well you know.

>> No.16599252

>>16593229
>Some people who used to tweak never recover from it and always seem a little scatter brained. ADHD meds are this generations Lead Paint.
Me. It feels so bad bros. I was able to finish a degree but I felt much more dumberer compared to my at-the-time colleagues. It's still there even now. I have experienced some clarity in between just so I know what I'm missing it feels like.

>> No.16600203

Still feeling a slight boost from the Lithium I think. That or the better weather. Took the B complex and L-methylfolate earlier. I got a pretty intense burning sensation in my chest earlier while doing cardio and had to sit down for about 10 minutes, and then about 30 minutes later I started having stomach pain(which is still ongoing 20 minutes later). Am I overdosing or is that the burger I swallowed last night making it's way through my pipes? Who knows
>>16599246
I find that hard to believe but whatever, cant hurt to try.

>> No.16600212

>>16599252
That's strange, all studies seem to suggest an upregulation of dopamine receptors from long-term psychostimulant treatment. You should be fine if U take them in moderation. From experience, I only became addicted after sleeping for only 2 days a week for a year.

>> No.16600217

>>16584827
You should just take dexamphetamine, everything else shilled here are borderline placebo supplement megadoses.

>> No.16600283

>>16599246
Sometimes you have to think before you drink, because not peeing is having mental tax, if you need it much.

>> No.16600285

>>16600217
Do you really think that phenotropil and NSI-189 are stuff, that are supplements? Like sure you can buy them "as supplements" but in fact, that's not nutrition, but medication.

>> No.16600293

>>16600285
>Do you really think that phenotropil and NSI-189 are stuff, that are supplements?
No, but where can you get phenotropil outside of Russia?

>> No.16600305

>>16600293
Amazon US sells that.
In Europe there's some companies selling that. Some of them also sell grey market drugs.

>> No.16600354

>>16600305
>Amazon US sells that
No it doesn't. Post a link.

>> No.16600367

>>16600354
https://www.amazon.com/Phenylpiracetam-Powder-Purity-99-9-Grams/dp/B0DM2MRTHL/ref=sr_1_2?dib=eyJ2IjoiMSJ9.u5GNj6kGox-nwdnMaUGzt4LCqdqYNYtCgQQ8kvMZf_1yb2bPn7Fyu6MBOoVTF36NnT9erN5eLIfFhzd29wpPpkG2RpbPdJtraD33KoQ_EMwhcbOF7cAT5k60lo5eWSB4wZV4YJ2bJcUvwSoFYLogYQVNtLFKdlr29vNeLsMQ_7r0Lnx-6YbB5vdwy92cmDRTn9S1Q52P8NArmGBy1IYJDPwpIZEfMHoSZKpFuDHuvl0.KO4w8FrkB9MYyy2A0b4zeK25MSChbJYoVMx6H69gvGg&dib_tag=se&keywords=Phenylpiracetam&qid=1740600800&sr=8-2

>> No.16600605

>>16600367
I guess you're right. Tho that looks sketchy and has no reviews.

>> No.16600996

>>16600605
I think you make that money in less than hour.

>> No.16601188

>>16584827
if you're retarded chemicals won't help

>> No.16601302

>>16599244
>>16588712
guess ill go fuck myself. thanks

>> No.16601751

>>16592927
>We know that excess animal products* cause disease.
*only when cooked in seed oils

>> No.16602816

>>16601751
Not all seed oils are bad.

>> No.16603122

Pharmacology is zero sum.
Go and exercise. Do lots of cardio and weighlifting. That's the only thing that will give you a net benefit in the long run.

>> No.16603297

>>16603122
Post body

>> No.16604499

Bump

>> No.16604500

Exercise/activity checklist/schedule for Brain training?

Supplements are one thing but your habits and stimuli matter way more for neurogenesis

>> No.16604828
File: 501 KB, 737x986, 1714500478031878.png [View same] [iqdb] [saucenao] [google]
16604828

listen, anon, as a guy with ADHD, I tried so much different shit to get dopamine in my brain (caffeine, nicotine, exercise, meditating, vitamins, herbal supplements, etc.), and the only thing that really made a difference was getting diagnosed and getting medicated. methylphenidate didn't work for me, but lisdexamfetamine has basically allowed me to live the life that I've always wanted.
if you really, absolutely think there is something medically wrong with your brain, get yourself checked out by a psychiatrist, and take real stimulants. these laboratory leftovers that they sell on the internet is a waste of your time and your money.

there are four types of nootropics:
> shit you need a prescription for (dexamfetamine, methylphenidate) (S tier)
> shit your mom told you about (sleep, veggies, exercise) (A+ tier)
> shit everybody consumes already (caffeine, nicotine, etc.) (C tier)
> shit that doesn't work (everything not listed above) (F tier)

>> No.16604981

>>16604828
How did methylphenidate not work for you? For me, it just made me jittery and anxious. Haven't tried lisdex yet

>> No.16605081

Was pretty busy and forgot about posting updates. But nothing really helped so far, I'm gonna start taking the rest of the stack today.
>>16603122
>>16604500
I haven't exercised for a while due to spine issues, but I just got clearance from my doctor to weightlift again, just need to avoid vertical load on my spine. Not sure what cardio I can do other than stationary cycling.
>brain training
I'm a software engineer, is that not enough "brain training"? Outside of work I also read related textbooks
>>16604828
Huh, I guess I'll go see a different psychiatrist and try other ADHD treatments.
>lisdexamfetamine has basically allowed me to live the life that I've always wanted.
How did you feel before and after?
>>16604981
You should make it clear you're not the anon he's replying to

>> No.16605093

>>16604828
Even lisdexamfetamine is not a perfect drug with no downsides. Of course, if you have ADHD, the benefits are likely numerous.
>>16604981
Methylphenidate is a scam drug that doesn't work, stick to amphetamines.
Also, caffeine sucks. Nicotine is fine if you take it pure and in low doses.
>>16605081
Walking/running is good cardio. S tier cardio is swimming.

>> No.16605097

>>16605093
>Walking/running is good cardio.
I walk about 30-60 minutes a day, but running is out of the question due to my spine issues.
>S tier cardio is swimming.
I don't have access to a pool or a swimmable lake within a reasonable distance unfortunately.

>> No.16605106
File: 734 KB, 1080x667, 1668728191439430.png [View same] [iqdb] [saucenao] [google]
16605106

>>16605097
Swim in the sand

>> No.16605712

>>16604981
It worked for about a month and then stopped kind of suddenly, doctor said that means its not for me. I was taking instant release and I really hated the pill->spike->work->crash->redose cycle. Compared to being unmedicated it felt like I had opened my third eye, but now that I'm on extended release amphetamines can see that I wasn't taking the most effective medication for me. I'm on a fairly low dose of lisdexamfetamine and it works better than when I was taking 3x20mg methylphenidate, which is basically the maximum safe dose.
"Lisdex" is in comparison a much longer effect that you only need to take once in the morning. You do need to plan around it because you can't just pop it when you're about to sit down to work, but it often lets me forget that I have adhd because I'm not popping pills all day, which for me is a benefit. Overall its a little difficult to describe the exact difference rigorously, its just ... better? More focus, more motivation, basically no euphoria (which is distracting when you're trying to lock in).

>>16605081
Internally, it improved my focus, motivation and thought patterns. When I was unmedicated, thoughts in my head felt kinda slippery, coming and going easily. Math, which I always thought I suck at, is someting I've grown to love now that I can completely think through long proofs without breaking my chain of thought.
There were external changes that I didn't notice myself. People around me noticed that I spoke more coherently and seemed more confident (controlled impulses -> less OCD). Apparently I walked/moved more like a normalfag too, unmedicated I have an awkard "bear" walk.

>>16605093
Overall I tolerate stimulants really well. Before being medicated I would often drink 200-300mg coffee a day with no side effects other than trouble falling asleep if I didn't take care to stop after 3 pm. Haven't really had any issues with Elvanse so far, I do need to watch my eating because I am low-BMI

>> No.16606595

>>16605093
>lisdexamfetamine
>dyslexamphetamine
I think they choose lysine over any other amino acid because of the name only.

>> No.16606636

>>16605712
I fucking hate lisdexamphetamine - it gave me heart palpitations and made me too anxious to focus properly. I switched to dexamphetamine after 2 years, and felt so fucking rejuvenated. I think lisdexamphetamine only works for people with ADHD.