Aging General

[Anonymous No.12165848]

This is/ag/ also what's the most important pillar of aging that if solved would save us the most time?

[Anonymous No.12165854]

Recomend me somebooks other than ending aging..

[Humans are savage. No.12166095]

So the human body can only replicate itself over and over so many times before you run out or until the cells are damaged enough they can no longer keep going is what causes aging. Theoretically, by having nano robots that constantly go around repairing cells we would never age. But that's just thought. Going from thought to the drawing board to seeing it in reap life is hard.

[Anonymous No.12166111]

>>12166095
aging is intentional, it's a biological death switch to allow room for the next generation. many of the massive societal problems we're experience today are a result of people not dying.

[Anonymous No.12166197]

>>12166111
This. Just imagine a ruling caste that lives for hundreds of years.

[Anonymous No.12166559]

>>12166197
Why a caste, once the tech is there everybody is immortal.

[Anonymous No.12166961]

>>12166197
why don't the current caste care?

[Anonymous No.12166975]

/sci/ doesnt have a sqt so, tell me how do i get smarter? what food do i need to eat to become intelligent

[Anonymous No.12167066]

>>12166975
Since this is /ag/ i suggest NAD supplements. That shit is important for sirtuins and immunity and decreases with age. Not so long ago there was an online aging conference with lots of talks on NAD. I liked Verdin's presentation the most but I cant find it on the channel.
https://www.youtube.com/channel/UClOnplI2mzpJlwdX3vlOMJA

[Anonymous No.12167079]

>>12166975
einstein's cum

[Anonymous No.12167082]

Lab grown organs will fix it. Just replace dysfunctional, old organs with new ones. The only issue then is how to keep the brain healthy

[Anonymous No.12167086]

>>12166111
This. Alzheimer’s literally only exists because we live longer than our brains were designed to handle. Cancer is such a big killer simply because we spend so long being alive that we’re pretty much bound to get, and lose to it, at some point.

[Anonymous No.12167110]

>>12165848
Look up the shortening of telomeres and its relation to aging. Telomeres are found at the end of our chromosomes and are believed to be linked to the process of aging. The reason why they believe this is because telomeres shorten as people become older.

[Anonymous No.12167112]

>>12166559
That's cute

[Anonymous No.12167116]

>>12167086
I wonder if whales and tortoises that live for hundreds of years get Alzheimer's.
I mean, I can believe that tortoises have bad memory, but doesn't whales have to remember how to navigate to very specific places? Why can't our brain last as long as theirs?
As for cancer, elephants have much more cells than humans, but the elephants have 20 copies of a gene that suppress cancer, meanwhile we have only 1. Perhaps someday it might be possible to Integrate that gene or develop something similar in our DNA. Pretty sure it wouldn't cover all types of cancer thought.

[Anonymous No.12167421]

>>12165848
>the most important pillar of aging that if solved would save us the most time?

Thick, dark, healthy hair.
People spend many billions of dollars a year on trying to hide hair loss and hair coloring.

[Anonymous No.12167431]

>>12167421
just dye hair

[Anonymous No.12167736]

>>12165848
You can't reverse aging.
You have ~40 trillion cells, each of these has worn out DNA that needs to be repaired, and this worn out DNA is always being replicated and accumulating more errors faster than you can fix 40 trillion copies. For every one piece you fix, a trillion more worn out pieces are being replicated and mutated further, completely negating your efforts.

This is the entire reason death evolved in the first place. There are animals that can basically live forever, but they are limited in complexity, because there is a tipping point beyond which trying to maintain trillions of cells indefinitely is less efficient than the biological equivalent of planned obsolescence.

[Anonymous No.12167759]

>>12167736
Just use proteins that repair DNA automatically. They already exist in the human body since babies need completely fresh and repaired DNA

[Anonymous No.12167851]

>>12167421
Schizos often go gray very early (20's even earlier), while autists often never do. That might be something to look into.

[Anonymous No.12167877]

>>12165848
>>12166111
>aging is intentional
It might be not in the way you think. It seems that basically all dietary advice is the opposite of what we should actually be doing.
Most "aging related" disorders can be traced down to too much calcium, too much iron, too little copper and manganese and chromium seems to somehow dystegulated, though it's hard to tell what it does.
Zinc is a nasty element that pushes itself into other metal sites and often ruins proteins that way. I suppose it might be a toxin and ALL its proteins should be using other metal and we are just full of zinc because of how widely it is used.

[Anonymous No.12167889]

>Copperschizo enters the thread

[Anonymous No.12167933]

>>12167082
Nice

[Anonymous No.12167959]

>>12167082
Wrong. Transplanted organs soon reach the recipient's age, the effect would be minimal if any.

[Anonymous No.12168751]

>>12167421
are you retarded?

[Anonymous No.12168813]

>>12167110
While that is a large component of aging, it also isn't the only component. The easiest component of aging to tackle is senescent cells, which are cells which have been damaged or have reached their hayflick limit and no longer perform their job and simply suck up resources. There are drugs being tested right now that target these cells iirc.

[Anonymous No.12169740]

>>12165848
There are reports of people in the 100's growing a new set of teeth, this proves man is supposed to live much longer than we currently do. (Read Genesis ch 5).

[Anonymous No.12169744]

>>12169740
https://english.vietnamnet.vn/fms/odd-news/73656/hanoi--90-year-old-old-man-has-new-teeth.html

[Anonymous No.12169772]

>>12167851
lol source or you're talking our your ass

[Anonymous No.12170225]

>>12168813
>>12168813
The easier one is arguably the calcification, as it might be refuced by reducing calcium intake and drinking distilled water.
https://www.fightaging.org/archives/2013/10/considering-mineralization-in-aging/

[Anonymous No.12170314]

>>12167877
was waiting for the copper schizo to appear
like clockwork

[Anonymous No.12170359]

>>12166975 algae oil and eggs
Probably not NAD

[Anonymous No.12170369]

>>12167959 source?

>>12167082 Which has most prospects: lab-grown organs, animal-grown ones, 3D printed ones or sth else like stem cells based organ repair?

[Anonymous No.12170392]

[Anonymous No.12170406]

>>12170225
Are you fucking serious? What about all this campaigning for milk-drinking? FUCK

[Anonymous No.12170411]

>>12170406
Afaik calcium is good for you especially your bones. Any studies saying otherwise?

[Anonymous No.12170436]

>>12170406
You're replying to copperschizo
He got it in his head that aging is caused by bad diets with too much or too little metals
Now he just looks for data that supports his belief

[Anonymous No.12170448]

>>12170406

lol dairy is incredibly bad for your health

also vitamin D makes you absorb calcium
vitamin K2 transports it where it needs to go

and calcium is probably the most tightly regulated mineral in your body, look up what a parathyroid gland/s does.

[Anonymous No.12170541]

>>12170406
It's a scam. Basically every study concludes those with lower intakes are better of, but "we should not make hasty conclusion because of confounding factors" (like the others move more, etc, as if it couldn't be the result of drinking milk) or some similar nonsense.

[Anonymous No.12170542]

>>12170406
>>12170411
It's a scam. Basically every study concludes those with lower intakes are better of, but "we should not make hasty conclusion because of confounding factors" (like the others move more, etc, as if it couldn't be the result of drinking milk) or some similar nonsense.
>>12170436
Because that is what the data show, while there us no data supporting the current dogma. Concerning copper, some random nutritionist declared that the correct intake is 1mg, with no data or reason to believe such and everybody jusg sticks to it.

[Anonymous No.12170545]

>>12170541
Can you link directly to these studies in reputable academic journals?

[Anonymous No.12170554]

>>12170542
In many of the threads you post your warped beliefs in, an anon will respond to you and explain how your claims are incorrect, or how you are misrepresenting the data. For example, no one who is qualified would deny metals play important roles in healthy functions (such as iron in red blood cells). But they would entirely reject the claim made in a previous thread that too much calcium causes strokes or other diseases with neuron death.
I’ve seen your posts before, and you posted the same aorta calcification page. But you’ve misrepresented it with your own erroneous interpretation. Calcium intake (within the ranges observed in patients) has little impact on rates of aorta calcification. Whereas reduced calcium intake causes osteoporosis. Your argument is that we should consume less calcium, yet I can easily find hundreds of studies detailing diseases caused by calcium deficiency (such as osteoporosis)

[Anonymous No.12170565]

>>12166111
no, they are a result of people ageing

[Anonymous No.12170571]

>>12170554
>Whereas reduced calcium intake causes osteoporosis.
No it doesn't. This claims misrepresents other studies, which show thag indeed liwer intakes result in less minerals in bones, but more collagen, which is the opposite and starts with collagen falling apart. The decline in mineral density only folliws that. In fact rodents fed "very low" calcium diets keep their teenage bones for life.
There basically no way to ever disprove old, mistaken knowledge with the current state of science once it's widely accepted as true. Since then, it's basically impossible to prove otherwise, because for example the 1mg copper intake is assumed to be a fact. While it is a well documented fact that copper deficiency makes the brain synapses get stuck (LTP), because we "know" the low intake is correct, the sticking of synapses must be a beneficial mechanism, and its lack must be a defect! And it's like that with everything.

[Anonymous No.12170575]

>>12170554
>Whereas reduced calcium intake causes osteoporosis.
No it doesn't. This claim misrepresents other studies, which show that indeed lower intakes result in less minerals in bones, but more collagen, which is the opposite and starts with collagen falling apart. The decline in mineral density only folliws that. In fact rodents fed "very low" calcium diets keep their teenage bones for life.
There basically no way to ever disprove old, mistaken knowledge with the current state of science once it's widely accepted as true. Since then, it's basically impossible to prove otherwise, because for example the 1mg copper intake is assumed to be a fact. While it is a well documented fact that copper deficiency makes the brain synapses get stuck (LTP), because we "know" the low intake is correct, the sticking of synapses must be a beneficial mechanism, and its lack must be a defect! And it's like that with everything.

[Anonymous No.12170577]

>>12170554
>Whereas reduced calcium intake causes osteoporosis.
No it doesn't. This claim misinterprets other studies, which show that indeed lower intakes result in less minerals in bones, but more collagen, which is the opposite of osteoporosis which starts with collagen falling apart. The decline in mineral density only follows that. In fact rodents fed "very low" calcium diets keep their teenage bones for life.
There basically no way to ever disprove old, mistaken knowledge with the current state of science once it's widely accepted as true. Since then, it's basically impossible to prove otherwise, because for example the 1mg copper intake is assumed to be a fact. While it is a well documented fact that copper deficiency makes the brain synapses get stuck (LTP), because we "know" the low intake is correct, the sticking of synapses must be a beneficial mechanism, and its lack must be a defect! And it's like that with everything.

[Anonymous No.12170588]

>>12170577
>There basically no way to ever disprove old, mistaken knowledge with the current state of science once it's widely accepted as true
There is a way. You get a PhD and do the experiments, rather than interpreting the data in a way that fits your schizo hypotheses.
The other way is to write a well-referenced paper that reviews all the relevant publications, and submit it to a journal; this doesn’t require a PhD, it just requires you to do something useful instead of shitposting on 4chan

[Anonymous No.12170595]

I really hope they find something to extend life.
I fucked up my teens and 20s because of crippling anxiety and wasted most of it in my room.
I with i can get them back

[Anonymous No.12170603]

>>12170588
>You get a PhD and do the experiments,
As I said, that doesn't work. You are required to interpret the experiment so that it doesn't contradict what is already known. So no matter what you do, you only add more garbage by inventing reason why your experiment doesn't contradict what is "established science", or you may forget about getting it publushed.

[Anonymous No.12170611]

>>12170603
>As I said, that doesn't work. You are required to interpret the experiment so that it doesn't contradict what is already known
This is an incredibly retarded thing to say.
Germ theory and prions are two of the first counter examples that come to mind.
Prions went against the dogma of the time, and are now accepted.
You just don’t want to do any actual work, you want to keep shitposting about your schizo ideas.
Studies get published all the time going against the dogma (https://pubmed.ncbi.nlm.nih.gov/30845820/ as an example).
You just want to find an excuse for why no one believes you or why no one has the same opinion as you.
You’re as bad as Tooker and his Riemann “proof”

[Anonymous No.12170614]

>>12167736
In order to fix agin we need a DNA back up

[Anonymous No.12170648]

>>12165854
David Sinclair’s Lifespan is good book. Too bad resveratrol and NMN are difficult to get for a reasonable price in the quantities you need it. Do any of you happen to know where laboratories buy their stuff in bulk?

[Anonymous No.12170729]

>>12170611
Adding new knowledge doesn't equal contradicting dogma.
Anyway it is pointless, since the lack of copper makes people schizophrenic, as you can never repair your mistaken beliefs once your synapses get stuck.
This is how you get the people stuck on denying global warming, or even flat earthers, and no matter how much you try, you cannot help them. Or things like you seem to talk somebody out of something, but thd next week they seem to be back at their default. Women in complete denial of being abused. Etc.

[Anonymous No.12170771]

>>12170729
Nice word salad schizanon

[Anonymous No.12170795]

>>12170771
It isn't word salad.

[Anonymous No.12170810]

>>12170369
If you seed a collagen scaffold with cells or stem cells from the patient, those cells will have the same telomere damage, the same level of DNA-methylation and other epigenetic alterations, the same biological age basically. Ideally the cells that seed the scaffold would be rejuvenated ones but still have the same DNA as the recipient to minimize rejection.

So how could one rejuvenate cells? Maybe we could use the body's own machinery do so? The DNA of a newly fertilized egg is rejuvenated by various proteins, it's telomeres lengthened and methylation and some epigenetic alterations are removed so that the new individual has DNA that is biologically young (if this didn't happen, the DNA would degrade beyond function in a couple of generations). So maybe the proteins active in this rejuvenation could have a use in rejuvenating the DNA of adults?

[Anonymous No.12170828]

>>12170810
So you think if we could make human cells with tellomere length as long as in lab mice, we would live to be a thousand years old?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742037/?report=reader

[Anonymous No.12171358]

>>12170729
>Anyway it is pointless, since the lack of copper makes people schizophrenic, as you can never repair your mistaken beliefs once your synapses get stuck.
This is wrong, schizophrenia is related to excess copper
This is actually hilarious. You are a schizo who promotes copper supplementation. Jesus fuckin christ, you're fucking your own brain up kid

[Anonymous No.12171361]

>>12170828
Long telomerase doesn't make one live longer.
There has been studies with genetically modified mice with extremely long telomerase but it didn't affect their lifespan. They lived just as long as regular mice

[Anonymous No.12171605]

>>12171358
>Interestingly, experimental manipulations that decrease copper produce demyelination, increases in dopamine, and behavioral impairments reminiscent of some SZ symptoms.

[Anonymous No.12171629]

>>12171358
In other words it has been tried and the effec is the opposite of what was expected. I could also link several studies where copper deprivation leads to the increase in dopamine (up to fivefold) in animals deprived of copper. But you need to be more severely deficient than usual to get to the point of what makes one diagnosed with schizophrenia, nevertheless the average person is severelly affected

[Anonymous No.12171653]

>>12171361
>Long telomerase doesn't make one live longer.
You're wrong
>https://mask.link/asigobatufas
>Mice with hyper-long telomeres show less metabolic aging and longer lifespans

[Anonymous No.12171662]

>>12171361
https://www.pnas.org/content/109/5/1743
>We found telomere length at 25 d to be a very strong predictor of realized lifespan (P < 0.001); those individuals living longest had relatively long telomeres at all points at which they were measured

[Anonymous No.12172228]

>>12170225
Low calcium intake induces a stress from PTH since blood calcium needs to be balanced, weakening the cells to calcium accumulation and paradoxically causing calcification. Calcification is an energy problem, not just too much calcium. It's like saying fibrosis is due to eating too much collagen.

[Anonymous No.12172260]

>>12165848
as a gerontophile i hope we dont find an answer for that

[Anonymous No.12172368]

>>12172260
for instance, i find the woman on the left hotter than the one on the right of op's pic

[Anonymous No.12172458]

>>12172228
The body can't create nor destroy calcium; if it cannot balance the absorbtion with excretion, the extra calcium has to go somewhere.

[Anonymous No.12172487]

>>12172458
Big if. We can excrete calcium as well as bind it in the bones. Vitamin k is useful for the latter, and is produced by certain bacteria in the gut flora (meaning the low RDA could actually be a rather high RDA that some people could be unable to meet with food if they lack the bacteria).

[Anonymous No.12172513]

>>12172487
You're replying to a schizo

[Anonymous No.12173816]

>>12172487
Yes, but the RDI is actually determined to not allow excreting more than is absorbed and there is even a safety margin applied to that. So no, most people are not capable of keeping their calcium in balance.
>>12172513
Shut up.

[Anonymous No.12173869]

>>12173816
kill yourself

[Anonymous No.12173945]

>>12173869
Try taking copper, you will see it will make you more skeptical, yet open minded to new ideas, as well as many other cognitive benefits.

[Anonymous No.12173980]

>>12165848
Joint aging

[Anonymous No.12174003]

>>12170595
Aging is a program: the program tells your tissues how old they are supposed to be. This is proven by the surgically-cojoined mouse study where an old mouse and a young mouse were sewn together and had a common blood circulation. The old mouse got younger and the young mouse got older, in all the standard measures of aging. So we now know that aging is not irreversible, that it is governed by a "clock" somewhere in the body and that the signalling system consists of factors in the blood.

[Anonymous No.12174039]

>>12166111
>aging is intentional
there is no intention in evolution

[Anonymous No.12174056]

>>12166559
>once the tech is there
The wealthy are already living longer, healthier lives than you due to stem cell research and procedures that are prohibitively expensive to your caste.

[Anonymous No.12174063]

>>12174003
>that it is governed by a "clock" somewhere in the body
You cannot know that from the experiment.

[Anonymous No.12174069]

>>12174056
Italians live longer than americans.
Diet is a lot more important than money.

[Anonymous No.12174442]

>>12174063
We can draw the conclusion that there might be one or many clocks but if there is more than one they are synchronized by signals carried in the blood.

[Anonymous No.12174451]

>>12174003
They did a similar thing recently where they replaced blood with a solution of isotonic albumin + saline instead, and it also de-aged the mouse. Seems more like the blood gets filled with degenerative factors rather than signalling substances.

[Anonymous No.12174494]

>>12174069
I bet i they cut back on the pasta they'd live even longer than that too

[Anonymous No.12174548]

>>12174442
No. You can't conclude on any clock. In facg why would young bloid reset the clock? It myst be something that accumulates in the body, some toxin the body cannot get rid of. (The opposite is unlikely, as there is no reason why the body would stop manufacturing something vital)

[Anonymous No.12174574]

>>12174442
No. You can't conclude on any clock. In fact why would young blood reset the clock? It must be something that accumulates in the body, some toxin the body cannot get rid of. (The opposite is unlikely, as there is no reason why the body would stop manufacturing something vital)

[Anonymous No.12174615]

>>12174574
If taking whatever it is away reverses aging then I call that a signal rather than a toxin. A toxin is something that causes damage while a signal is something that changes a set point which is what is happening. The programmed signal theory is also a consistent explanation for the lifespan differences between similarly sized and body temperature creatures such as the mouse (2 years) and the arctic tern (34 years).

[Anonymous No.12175046]

>>12170810
>The DNA of a newly fertilized egg is rejuvenated by various proteins, it's telomeres lengthened and methylation and some epigenetic alterations are removed so that the new individual has DNA that is biologically young (if this didn't happen, the DNA would degrade beyond function in a couple of generations)

God is pretty smart putting these fail safes in our bodies to make sure we die

[Anonymous No.12175149]

>>12175046
What does your god have to do with anything?

Brainless retarded dumbass has to resort to stupidity to make sense of the world.
Fuck off godboi.

[Anonymous No.12175255]

>>12174615
>A toxin is something that causes damage
Does it not cause damage?
>also a consistent explanation for the lifespan differences between similarly sized and body temperature creatures such as the mouse (2 years) and the arctic tern (34 years).
So is producing less of the toxin.

[Anonymous No.12175824]

>>12167877
Get help you schizo. Zinc literally protects DNA from damage.

[Anonymous No.12175841]

>>12169744
This literally happened to my grandmother. She grew a third set of teeth in her 80s. We also have insane teeth genes in our family as neither my mother nor I have ever had a tooth cavity or tooth pain with just basic teeth hygiene and our bones are freakishly strong too.

I've almost 30 and I've never been to a dentist in my entire life. All my teeth are healthy, white and have no cavities. Never had a fracture even when falling from 30 foot tall roof tops. Also, none of my ancestors died before the age of 90 on either my mother or my father's side. It's all in the genes. Dad has shit genes for teeth though, most most of them by the age of 40.

[Anonymous No.12175867]

>>12170595
just exercise bruh

[Anonymous No.12175910]

I have a fetish for fat, weight gain, and obesity. I understand both sides of the argument, that YES obesity flat out causes more stress and difficulties on your body, but this does not stop you from also having healthy habits such as proper nutritional intake with vitamins/minerals, good calories, that will also factor into your body at the same time.
That said, I understand obesity accelerates the aging process of individuals based on how much extra weight they carry, but what causes this? Are there factors one could do to also counteract or minimize this aging rate?

[Anonymous No.12175924]

>>12175149
Typical midwit nihilistic cope

[Anonymous No.12176097]

>>12166111
*stupid people not dying

[Anonymous No.12176218]

>>12166559
>once the tech is there everybody is immortal.
>everybody
>everybody
>everybody
>everybody

[Anonymous No.12176446]

>>12175924
Spare us the suffering of religious nutcases who resort to mentioning their beliefs in the supernatural every time they don't have anything else to say that would further our understanding of the world in which we live.

Fuck off godboi, fuck off permanently, fuck off and tell your god that they are not the first and certainly not the last supernatural entities to be worshipped by ignoramuses who lack education and critical thinking skills.

[Anonymous No.12176741]

>>12167759
So you mean eating baby flesh makes me young?
(Is that how africans make up their ooga booga vodoo "treatments"?)

[Anonymous No.12176806]

>>12165848
Obesity
Heart disease
Cancer

[Anonymous No.12177181]

>>12170595
This is me.... Maybe I'll get out more

[Anonymous No.12177587]

>>12176446
>all this schizo rage

Another typical "scientist" heathen who is driven mad when he tries to grasp the perfection of God's design.

All you need do is let God into your heart and see the real truth anon. Life won't be insufferable for you anymore.

[Anonymous No.12177628]

>>12177587
Go away, science only

Godbois take it up the ass and ask for more.
Please god, give me your dick so I can love you more. Yes god, you are the best god in the world, no one can defeat you, you can take my ass any time, I want to sit on your dick and worship you until you come in my anus.