Psilocybin and psychedelics.

[Anonymous No.11003583]

General thread related to psychedelics. Particularly interested in references to studies done on their effects on different layers of the brain.
Microdosing experiences and recommendations encouraged.
Microdosing is my current area of interest. I self medicate and have found psilocybin particularly helpful in my circumstances. However dosage is problematic for reasons which should be obvious.
I would prefer to use psilocybin over LSD because ergo contains a plethora of toxins. LSD extractions are also complex.
What I am specifically seeking is any references to papers or other reading material describing processes which can be used to extract psilocybin (a fairly simple process) to make microdosing more reliable. Also I am especially interested in any techniques which can render psilocybin stable. I assume the best way of doing so is by converting it into a salt.
This is a thought experiment only. Nobody is intending to break any laws in this thread. Information and discussion is not against the law, especially in the united states where it is my understanding that freedom of speech is a very important right.

[Anonymous No.11003597]

>>11003583
microdosing is the same level of bullshit as homeopathy

[Anonymous No.11003601]

>>11003597
>citation required

[Anonymous No.11003676]

>>11003597

Even though research in that area has shown the opposite, but I guess you don't want to hear that.

https://www.biorxiv.org/content/10.1101/384412v2

[Anonymous No.11003698]

>>11003583
Psychedelics are a scam of the century. They work not by making you more open minded, by making your mind malleable. They don't turn you automatically into a hippie, but allow your sitter to instill anything he wants in your mind an you WILL believe it. I could make you a communist, a Nazi or whatever if I had a time to prepare and sit a psychedelic session with you. This is the real reason why MKultra banned those drugs. Going around on psychedelics with people you cannot 100% trust makes you extremely vulnerable.

[Anonymous No.11003706]

Psychedelics are a scam of the century. They work not by making you more open minded, by making your mind malleable. They don't turn you automatically into a hippie, but allow your sitter to instill anything he wants in your mind and you WILL believe it. I could make you a communist, a Nazi or whatever if I had the time to prepare and sit a psychedelic session with you. This is the real reason why MKultra banned those drugs. Going around on psychedelics with people you cannot 100% trust makes you extremely vulnerable.

[Anonymous No.11003737]

>>11003676
>https://www.biorxiv.org/content/10.1101/384412v2
well the abstract doesn't look promising
>While this study provides quantitative support for the cognitive enhancing properties of microdosing psychedelics, future research has to confirm these preliminary findings in more rigorous placebo-controlled study designs.

oh my god they are citing Erowid in a scientific paper
>Erowid (2017) Psilocybin mushrooms effects. The Vaults of Erowid.
https://erowid.org/plants/mushrooms/mushrooms_effects.shtml

>38 subjects total, serious self-selection bias b/c subjects were attendees of a conference on micro-dosing

I am not giving a close read to 31 pages of an obvious clown show.

[Anonymous No.11003743]

>>11003676
Interesting. In summary they do something but more studies are needed. Pic related.

>>11003706
You are entirely correct. Psychedelics make the weakminded extraordinarily susceptible to influence. They are the primary key to brainwashing. Choose your friends carefully.
However... Microdosing is likely to overcome this issue. Still, if you are weak minded and susceptible to influence perhaps it is best to avoid these substances in the presence of others and to use them to reprogram your own mind. As I have done. Although I do not consider myself weak minded.
Thank you for emphasising the potential dangers of psychedelic usage. It is also very possible to reprogram you own mind with utter rubbish. Seems most people end up on this path. Again microdosig MAY circument these potential problems.

[Anonymous No.11003745]

>>11003676
>https://www.biorxiv.org/content/10.1101/384412v2
>anecdotal accounts
>non-blinded
>doesn't understand what a placebo effect is
fuck off brainlet

[Anonymous No.11005327]

There is this as well. Pic related. I am not very good at finding the study though. Is anybody more capable able to find the actual paper?

[Anonymous No.11005566]

Boomers and shills against psychedelics

Gee, where have I seen that before?

[Anonymous No.11006145]

>>11005566

Holy shit checked

[Anonymous No.11007712]

>I don't understand how it works and refuse to do any research so it's wrong

[Anonymous No.11007735]

>>11005327
>high potential for abuse
>zero potential for addiction and helps significantly with other addictions
>medically speaking does what SSRIs are supposed to do but way better
Thanks Nixon

[Anonymous No.11007785]

>>11003583
>Microdosing
I have only one first-person narrative on it. I took a very small cap (mexicana, freeze-dried) about an hour before a Germanic History final exam. I'm pretty sure it opened me up, but the U doesn't return the finals so I never really found out what the prof thought. I did get an "A" in the class though.

[Anonymous No.11007789]

>>11005566
checked

[Anonymous No.11007812]

>>11007712
nope

[Anonymous No.11008202]

Any ideas how to reliably decarboxylate Ibotenic Acid into Muscimol? One paper I read suggests drying, but that still leaves 3:2 ratio in favor of the neurotoxin.

[Anonymous No.11008214]

>>11003706
If they make your mind malleable and you put it to productive use like learning stuff or doing art/design it's fairly productive and healthy

[Anonymous No.11008221]

>>11008214
Yes that's why the establishment is pushing them.

[Anonymous No.11008254]

>>11008202
I have read that the skin contains most of the toxins. Skinning and drying is probably the best you can do unless you feed them to reindeer and collect the urine.
Some tribes would feed them to their wives and then drink their urine.
I have avoided amanitas.

[Anonymous No.11008269]

op microdosing on mushrooms is retarded for this reason:

alcohol relaxes you by releasing serotonin, you get a huge amount of serotonin from being very drunk and this is part of what causes you to be drunk.

psilocybin is literally just serotonin.

so instead of microdosing on mushroms just drink a beer its the same fucking thing

[Anonymous No.11008279]

>>11008269
This is the most retarded fucking thing I have read on 4chan in years. You must have never done mushrooms to literally say 'hurr durr psilocybin don't real just get drunk it's teh same!!1!'

[Anonymous No.11008280]

>>11003676
Funny, this is the first time I've seen a paper linked to on 4chan of people that I know personally. I used to work in that department.

I'm not arguing for or against microdosing here, but I felt like I needed to point out that these people do shit work. Just saying.

[Anonymous No.11008394]

>>11008202

You dry them, grind them into a power with a blender, and cook them in water at EXACTLY 190 degrees Fahrenheit for 1 hour, filter out the soild mush with cheese cloth. Any hotter than that and the muscimol breaks down into non psychoactive substances, any cooler and the Ibotenic Acid doesn't break down into Muscimol.

You'll need to buy one of those thermometers that you can attach to the side of a boiler to keep track of the water's temp.

Muscimol is water soluble so you just drink the mushroom tea water left over.


This is pretty much the ONLY way to consume Amanita Muscaria without the stomach ache and also get the psychoactive benefits

[Anonymous No.11008397]

>>11008394

Also note that the tea without any other flavoring added will taste like complete ass, but you're not drinking it for the flavor

[Anonymous No.11008399]

>>11008269
>I'll just go on the internet and make shit up, nod to myself and call it a day

[Anonymous No.11008407]

>>11008394
>>11008397

Also forgot to mention. A single good dose will be about 12 dried grams to 1 litre of water

[Anonymous No.11009342]

>>11008407
I found 3 small caps today. Will dry them in dehydrator and probably just eat them. It's too little so I don't expect much at all, but have read positive anecdotes in regards to microdosing.

[Anonymous No.11009611]

>>11009342

You better be careful with wild mushrooms anon. I'd purchase them from a reputable vendor online, they have actual mycologists pick them.

[Anonymous No.11009625]

>>11009611
No worries Anon, I am very familiar with wild mushrooms and Amanita Muscaria is impossible to mistake.

Anyway, I made a tea out of it. Will report back if I feel any noteworthy effects.

[Anonymous No.11009636]

Micro dosing is such a waste, i can't believe some people are actually defending it.
Homeopathy tier clown fiesta.
Do you even realize how high you rank on the hipster pseud scale?
Christ.

[Anonymous No.11009743]

>>11009636

Normally I agree with this, but it really depends on the substance. Daily micro dosing LSD has been proven to increase creativity and general awareness in a few different studies

[Anonymous No.11009807]

>>11008269
ive done mushrooms alot of times, you can get them for 150$ an ounce in my town. some day youll realize how dumb you look attributing such special bullshit to mushrooms my sides

[Anonymous No.11009868]

>>11000011

[Anonymous No.11009913]

>>11008202
>Muscimol
>Ibotenic Acid
>>11008254
>>11008394
Those will only make you sick. Amavadin is what you're looking for.

[Anonymous No.11009968]

>>11009913
I prefer psilocybin. It is easily accessible, has been used by humans for tens if not hundreds of thousands of years and I have experience with it.

I will look into this substance though. Always interested to learn about new things.

[Anonymous No.11009996]

>>11009968
Be careful though, there is a possibility it can trigger mania.

[Anonymous No.11010046]

>>11009968
Amanita Muscaria has been used traditionally for millennia as well, they are just more misunderstood than psilocybin mushrooms.

Ibotenic acid is a psychoactive and mildly toxic, it will give you stomach cramps. Muscimol on the other hand, which is a broken down form of ibotenic acid, is several more times pyschoactively potent and will not give you stomach cramps.

[Anonymous No.11010148]

>>11010046
It doesn't have any mild altering effects though, it can at best make you what could be described as dead drunk.

[Anonymous No.11010171]

>>11010046
It doesn't have any mild altering effects though, it can at best make you what could be described as dead drunk. Anything else is the amavadin.

[Anonymous No.11010570]

>>11003583
Is this the psychedelics general?
Tried 1P-LSD for the first time last week and that shit is amazing. 70ug
Felt as if I was peering through my own unconscious.

Anyone knows how long till tolerance returns to base level?
Reading up microdosing guides, it seems to be 48 hours

[Anonymous No.11011203]

>>11009625
So aside from disgusting taste, after roughly 30 minutes of ingesting the three small caps, I started feeling sick to my stomach and had to hold back vomiting for the rest of the evening. Even now in the morning I feel like after a heavy drinking session. As for the "trip", I certainly did notice something but it was neither strong nor pleasant at all. The strongest effect, aside from nausea, was a mild dissociation.

I'm glad I first tried a small dose. Never again.

[Anonymous No.11011223]

>>11009625
It's not. Other amanitas are quite deadly too if you mistake them for muscaria.

[Anonymous No.11011302]

>>11011223
The only even remotely similar is Pantherina, which is basically just Muscaria on steroids. Still the coloration is distinct.

[Anonymous No.11011319]

>>11003597
This 100%, it's absolute nonsense, psycho-symmantic bs.
>.t retired druggy
>>11003601
>me

[Anonymous No.11011361]

What do you need in order to get into psychedelics research?
Psychiatry MD? Neurology MD? PharmD? Some PhD?

[Anonymous No.11011371]

>>11003706
i went full Charles Manson (except for the murdering) with some friends in my early 20s, can confirm.

[Anonymous No.11011524]

>>11008399
Kek

[Anonymous No.11011543]

>>11011361
Johns Hopkins is starting a psychedelics research program. Neuroscience I think

[Anonymous No.11011797]

>>11011302
There indeed are Amanita Muscaria lookalikes

[Anonymous No.11012212]

>>11010171
>musicmol isn't psychoactive

Nigga wat?

[Anonymous No.11012262]

>microdose
>microagression
>microplastic
Micro prefix fixation it is. I maintain a microinterest in these matters.
>>11005327
Can go the other way, too.
>>11003583
Effective or not for any therapeutic use, I would like to see them (and other stuff too) legalized. And training on how to use them be given at around the same time as sexed.

[Anonymous No.11012270]

>>11003706
Thats crazy.
I've done acid several times while dating the woman I am now married to. Maybe we brainwashed each other into this.

[Anonymous No.11012296]

>>11012212
Muscimol makes you drunk, sick and sweaty, the effects you want to avoid. Amavadin creates the effects you seek.

[Anonymous No.11012323]

>>11011371
what does that mean?

[Anonymous No.11012358]

>>11010570
3-5 days
but don't overdo it

[Anonymous No.11012693]

I wish i could but after having a run in with the law fuck that.

[Anonymous No.11012928]

>>11011371
>>11012323
Full blown psychosis. I’ve been there, brotha. Psychedelics are not what they’re cracked up to be. When I was in that phase, I just kept tripping even though I was definitely gambling with my mental health. The people who really push psychedelics are def suspicious.

[Anonymous No.11013031]

>>11009743
> microdosing daily
God I really hope you're NEET or some memedegree student, I'd never trust any scientific conclusion from you


>>11012928
Based

[Anonymous No.11013327]

>coworker tells me he's microdosing
>tells me when he started
>way worse at his job since doing that
>got fired a few weeks ago

Lol

Microdose is probably bs or at least not useful self administered. Maybe if studied theres a way to do it but self medicating like that just makes you slightly high all the time without even noticing.

A single larger dose once every few months is very healthy though.

[Anonymous No.11013384]

>>11012693
If it makes you feel any better Amanita Muscaria is 100% legal in the US

[Anonymous No.11013391]

>>11013031
I didn't mean to suggest that I microdosed LSD or anything, I was just passing along what studies have shown. Personally if I take a psychedelic I'm going all in.

[Anonymous No.11013402]

>>11003706
Yeah for sure, they're still fun tho

[Anonymous No.11013441]

>>11013327
https://www.rebeccalieberman.com/project-ara-biome
Did they microdose?

[Anonymous No.11013490]

Lsd cured me of my ptsd and has allowed me to live a normal life and become a productive member of society. AMA

[Anonymous No.11013564]

>>11013490
Rollin'

[Anonymous No.11016086]

>>11013490
Rollin, hope I don't get Russell again

[Anonymous No.11016133]

>>11009611
always wanted to try them, any vendors you recommend?

[Anonymous No.11016238]

>>11008269
Not sure if trolling or just retarded

[Anonymous No.11016614]

>>11016133
Link:
http://shamansgarden.com/p-27-washington-state-amanita-caps-grade-a.aspx


Follow the Tea recipe above, seriously. >>11008394
>>11008407
You'll have way less stomach discomfort that way

[Anonymous No.11017311]

>>11012262
False. In the same study people who had "negative" experiences had practically no side effects after a certain time period, while those who had a positive experience got all the positive effects (anxiety reduction etc)

[Anonymous No.11017358]

>>11012270
Well, are you both happy?

[Anonymous No.11017405]

>>11016614
awesome thank you!

[Anonymous No.11019579]

For those of you who are playing around with this anyway

[Anonymous No.11019621]

>>11008269

[Anonymous No.11020006]

Question: If I bubble up N2O through a distilled water LSA extract that also contains a small portion of ethanol/acetaldehyde, what would happen? Would I make ammonium nitrate or nitric acid or someshit? Is it possible that the aldehyde and amide would bond, with H2O and N2 (g) as byproducts?

What if the same dist. H2O/ethanol/acetaldehyde/LSA extract also contained caffeinated soda, phenylalanine, beta-hydroxybutyrate salts (including Mg BHB), and anise extract (contains an edible ether, anethole)? Could it be explosive? Would anything react?

Pic related is a rough idea of what I am talking about. I highly doubt it would work, the mechanism is more than likely wrong but maybe a different mechanism could happen? I have neglected to look into the pKas, heat, or catalysts that could be required for any of this. It seems harmless enough to experiment with, but I need to know if N2O could create any hazardous byproducts in this case.

[Anonymous No.11020261]

>>11003706
Bullshit. Sure, maybe it won't make people more open minded, who knows, I won't argue that. But they are not brainwashing drugs like you see in the movies. I've never seen anyone just blindly believe what people have to say while they're on lsd. In fact, I've seen the opposite. I say would people are more willing to consider new ideas in that state of mind, but also, people generally become more critical of information that's presented to them (to an extent that's unhelpful for day to day living). It's difficult to think anything matters once you experience surreality (the only thing actually that matters is staying alive). You start to think everyone is full of shit (because they are). You also realize you yourself are full of shit, and that's just how things are. That's not conducive to being able to be brainwashed

[Anonymous No.11021014]

>>11013490
Roll