/sci/ - Science & Math

[Anonymous No.10986011]

Nootropics with permanent positive effects?

[Anonymous No.10986016]

>>10986011
>Nootropics
>>>/x/

[Anonymous No.10986021]

>>10986016
>meth, caffeine, nicotine are x tier and do literally nothing
Consider my almonds activated

[Anonymous No.10986022]

>>10986011
>reading a book
>learning an instrument
>learning a new language

sometimes I rail a line of algebra in the morning just to perk myself up a bit

[Anonymous No.10986028]

>>10986016
It's not /x/, but it isn't what most people think either.
Only legitimate nootropics today are all stimulants. So basically get coked up or snort some adderall, that's the best you can hope for.
Non-stimulant nootropics are incredibly weak meme crap.

[Anonymous No.10986031]

>>10986022
Wholesome activities anon

[Anonymous No.10986042]

>>10986011
Lsd, if you take it by yourself. Taking it by yourself is key, because it allows you to enhance your own learning techniques, instead of trying to mimic someone elses.

[Anonymous No.10986248]

MERCURY

[Anonymous No.10987001]

>>10986011
I also enjoy fantasy.

[Anonymous No.10987016]

>>10986011
Regular cardiovascular exercise and proper diet as well as a stable sleeping pattern

[Anonymous No.10988481]

>>10986011
Cerebrolysin.

[Anonymous No.10988520]

>>10986011
nootropics are just homeopathic medicine for people who think elon musk is cool

[Anonymous No.10988548]

>>10988520
No, they're stimulants.

[Anonymous No.10988587]

>>10988520
Most nootropics have scientific studies that show they enhance certain aspects of brain cognition (though the results of some studies may be exaggerated for marketing purposes)

[Anonymous No.10988717]

>>10986011
no fap

[Anonymous No.10989849]

tianeptine

[Anonymous No.10989860]

Check out examine.com which has reviews on a lot of them. It seems most of the non-stimulants only work if you are unhealthy, and have only minimal effect when your healthy. Imo getting really autistic about diet and exercise is better than supplements

[Anonymous No.10989955]

>>10986011
Nootropics are a huge waste of time. Targeted Neuroplasticity Training (TNT) is where it's really at! This is what drone pilots and other top level positions require now. Permanent IQ enhancement technology.
https://www.darpa.mil/program/targeted-neuroplasticity-training

[Anonymous No.10989961]

Psilocybin microdosing unironically helped me learn Euclid and basic chemistry in a few weeks, but it also gave me permanent hppd.

[Anonymous No.10989972]

>>10989961
All the rage in Silicon Valley
https://www.forbes.com/sites/robertglatter/2015/11/27/lsd-microdosing-the-new-job-enhancer-in-silicon-valley-and-beyond/#3feb048e188a
https://www.sfgate.com/news/article/Some-SIlicon-Valley-tech-workers-are-taking-LSD-6660115.php

[Anonymous No.10989994]

>>10986011

This dog's owner deserves to be shot. wtf

[Anonymous No.10990031]

>>10989961
Even without drugs learning those two things is easily doable in a few weeks if consistently given a few hours a day

[Anonymous No.10990370]

>>10988717
only works for low T producing males. I literally become homocidal after 3 days and a danger to society after 5 and it don't stop at that.

[Anonymous No.10990391]

Modafinil

[Anonymous No.10990888]

>>10990370
That's the point.
nofap is black pill agit-prop.

[Anonymous No.10991289]

>>10990370

You're posting on 4chan on a science and math board you're not a danger to anyone.

[Anonymous No.10991803]

>>10986011
does eugenics count as a nootropic?

[Anonymous No.10991861]

>>10991803
actually it's the opposite, if stupid people breed more the the average iq is lower and yours is higher, if you kill off dumb people you become dumber

[Anonymous No.10991871]

big brain...
so lead is a nootropic for me if I add to everyone else's water supply?

[Anonymous No.10991874]

>>10991861
big brain...
so lead is a nootropic for me if I add to everyone else's water supply?

[Anonymous No.10991920]

>>10989972
I posted this earlier in the thread but I'll do it again - this is literally homeopathy for nerds who like elon musk.

[Anonymous No.10991929]

>>10986011
Supposedly Modafinil causes (obviously permanent) neurogenesis in the prefrontal cortex.

[Anonymous No.10991932]

>>10988520
nootropics work but the weird ones will kill your liver before you enjoy the brain-benefits. Things like modafinil and amphetamines are obviously efficacious drugs but they have side effects, and nobody likes a crazed methhead (i can notice you assholes in class with your crazy stare and word salad).

[Anonymous No.10991957]

>>10991929
very interesting.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371677/

>In the modafinil-treated group, we found, in the post-drug period, greater centrality in the bilateral primary visual cortex [BA17], the brain region highly specialized for processing visual information.
...
>These frontal areas are known to modulate attention levels and some core processes associated with executive functions, and, specifically, inhibitory control and working memory (WM). These functions depend on each other and co-activate frontal areas along with the posterior visual cortex to re-orient attention toward visual stimuli and also enhance cognitive efficiency.
...
>Thus, within this framework, it is conceivable that the modafinil-driven increased FC we have found to occur between the V1 and some prefrontal areas reflects the active involvement of visual-, attention-, and WM-dependent networks that were set in motion by the rs-fMRI protocol and, possibly, boosted by the drug.
...
>Preclinical evidence suggests potential beneficial effects. In theory, modafinil-driven FC changes may lead to enhanced experience-dependent synaptic plasticity and neurogenesis as well as behavioral and cognitive benefits (Minzenberg and Carter, 2008). The notion is supported by preclinical evidence showing that modafinil, through increased dopaminergic and noradrenergic transmission, promotes adult neurogenesis, especially within the hippocampus (Brandt et al., 2014). Furthermore, in preclinical models, modafinil has been shown to improve spatial learning and fear conditioning, inhibitory control, WM functioning, and sustained attention

[Anonymous No.10991960]

>>10991932
amphetamines are fairly temporary too and can have long term negative consequences for your executive functions. Look up dopamine down regulation.

[Anonymous No.10991962]

>>10991960
absolutely. they are definitely not something people should take.

[Anonymous No.10992636]

>>10990391
just made me shit

[Anonymous No.10992695]

If you’re not using Ritalin and you’re in a cognitively demanding field, you’re being cucked by the DEA.

It doesn’t make you smarter but it’s a damn powerful motivator.

[Anonymous No.10992896]

>>10991960
Interestingly, people with actual ADHD/ADD don't down regulate even after extended uses as long as they don't abuse amphetamines typically.

[Anonymous No.10992903]

>>10987016
These are not nootropics you fucking moron.

[Anonymous No.10992963]

>>10986022
is the language thing a meme? does it really help? it’s just SO impractical for us native speakers, i would think just grinding math instead is better.

[Anonymous No.10992971]

what about lions man, mang?

[Anonymous No.10992973]

>>10992963
every human is a native speaker

[Anonymous No.10993314]

>>10992971
they live in savannah not the tropics

[Anonymous No.10993432]

>>10992636
Probably you didn't have anything to do the day, used it only once and took way too much.

[Anonymous No.10993449]

>>10991920
Actually, the more you dilute, the more the activity of a dissolved molecule or the fugacity of a gas is increased. It gets equal to 1 at infinity dilution.

[Anonymous No.10993912]

>>10991957
Seems legit.
What's your dosing anon?

[Anonymous No.10993935]

>>10992903
Proper diet is a nootropic

[Anonymous No.10993960]

Sulbuthiamine promotes the growth of D1 dopamine receptors

[Anonymous No.10994264]

>>10986022
>>10987016
good posts

[Anonymous No.10994456]

>>10991932
Isnt modafinil much safer than amphetamines though?

[Anonymous No.10994504]

>>10993912
I take adderall like a proper retard now.
But when I used to buy modafinil I would dose around 150-200mg a day.
So 100mg in the morning and depending on how long the day was going to be either 50mg or 100mg before lunch.

>>10994456
It's much safer because it produces very little sympathetic nervous system stimulation. Modafinil basically just keeps you awake and alert. Amphetamines do that too but can make you feel amped up, spontaneous, and unnaturally energetic at an extra cost to your long term health.

[Anonymous No.10995823]

>>10993960
Under which dose?

[Anonymous No.10995830]

>>10994504
Try adding some piracetam anon.
It potentiates both Adderall and Modafinil.
https://psychonautwiki.org/wiki/Piracetam

[Anonymous No.10996006]

>>10986011
Echoing this >>10988481
Also, look into P21.

>>10993935
Nootropics are a drug class, this is an established pharmacological classification. Merely because nootropics and a 'proper diet' ('proper' being subject to dispute) share certain attributes (potential enhancement, maintenance, exogeny), they may be analogous, but not equivalent. To reason otherwise is to commit false equivalence. In fact, it's also a category error. It seems as if the term 'nootropic' is becoming a Ship of Theseus in that the definition has d/evolved from Corneliu E. Giurgea's (the inventor of the first racetam and the very word 'nootropic') strict criteria of 5 traits to a lazy catch-all umbrella term for cognitive enhancement. So while all of those things that anon responded to may be excellent for the brain and/or body, that anon is right, they aren't nootropics. Including these: >>10986022

[Anonymous No.10996626]

>>10996006
What's your experience with P21 and Cerebrolysin anon?

[Anonymous No.10996768]

>>10986011
>Anyone know anything about Adrafinil

What are the other metabolites formed by its breakdown (and what enzyme does it use) ?

[Anonymous No.10996797]

>>10986011
This dog reminds me of that dog with ham on it's face that manged to get 100k likes because some guy played a prank claiming it was a burn victim forma house fire saving it's family.

[Anonymous No.10996810]

>>10986011
yes do enough meth and the world have a net positive with the death of one more brainlet

[Anonymous No.10996813]

>>10996768
from wiki
>Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in very similar pharmacological effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45–60 minutes when taken orally on an empty stomach.

A prodrug is basically a drug that is "nested" inside of a compound which when metabolized one or some of the resulting metabolites are pharmacologically active.
The active metabolites of Adrafinil are the exact same as the metabolites of Modafinil - Modafinil sulfone and Modafinil acid.
Usually, the purpose of a prodrug is to increase bioavailability (more is exposed to enzymes in the liver) or to reduce the potential for abuse. There's a lot of research into creating prodrug versions of Ritalin and Adderall to make it easier to market by taking away the potential for it to be crushed up and snorted for a stronger higher. ]
There's really no point in choosing Adrafinil over Modafinil because the bioavailability is basically the same, Armodafinil is measured at ~80% and Modafinil is suspected to be ~80%.

As for specific enzymes:
> CYP2C19 in human liver microsomes. It also caused a small, but concentration-dependent, induction of CYP1A2, CYP2B6 and CYP3A4 activities and suppression of CYP2C9 activity in primary cultures of human hepatocytes. Clinical studies have been conducted to examine the potential for interactions with methylphenidate, dexamfetamine, warfarin, ethinylestradiol, and triazolam. The only substantive interactions observed were with ethinylestradiol and triazolam, apparently through induction of CYP3A4, primarily in the gastrointestinal system. Overall, the results of the interaction studies suggest that modafinil has the potential to affect the pharmacokinetics of drugs that are metabolized by certain CYP enzymes.
https://link.springer.com/article/10.2165%2F00003088-200342020-00002