/sci/ - Science & Math

[Anonymous No.10198109]

Tobacco smoke cures visual blurring and auras caused by migraines. Why does this happen? Wouldn't increased blood pressure worsen the problem?

[Anonymous No.10198117]

>>10198109
nicotine is psychoactive, and thus goes right to neuroreceptors. the effects of blood pressure only indirectly affect neurological processes, but chemicals that interact directly with neurotransmitters can have much more profound effects than things that only act through indirect mechanisms

[Anonymous No.10198149]

>>10198109
The cause of migraine with aura isn't clearly understood, so there's not much you can say.

[Anonymous No.10198163]

>>10198117
So nicotine's effect on the brain's neurotransmitters is what fixes the problem, and its physical effects, such as increased blood pressure, have minimal or possibly insignificant ramifications?

[Anonymous No.10198173]

>>10198109
Blood pressure: Tobacco smoking causes a paradoxical fall in blood pressure to fall in many individuals owing to nitric oxide modulation actions independent of nicotine. Moreover, heavy smokers have a mild level of MAO inhibition from the constituents of tobacco smoke which causes norepinephrine to be partially displaced with octopamine, likewise precipitating hypotension to some extent. Indeed, physicians of the past were perplexed when smokers presented LOWER blood pressure than even their non-smoking patients.

As for the migraine relief: Tobacco contains significant amounts of the antioxidant and antimigraine agent Coenzyme Q10, which alleviates or entirely abolishes migraines and headaches in many individuals both as an prophylactic and abortive agent.

[Anonymous No.10198196]

>>10198163
No. He is incorrect. Hypertension aggregates migraines in almost all individuals and the mechanism proposed for the headache relief is vague and ultimately empty.

[Anonymous No.10198225]

>>10198196
well i'm that guy and i'd say that nobody knows for sure what will be the subjective effects of psychoactive drugs on particular individuals.

granted, maybe in general, drugs that cause hypertension might in general have effects that are true on-average on psychological things. however, psychoactive drugs indisputably have psychological effects that go beyond what is understood in terms of on-average effects of respiratory(slash any other non-psychoactive drugs).

take for example alcohol. it's a psychoactive drug that has effects on behavior and subjective experience that go beyond what could be understood in terms of its effects on the non-CNS systems

[Anonymous No.10198241]

>>10198196
>aggregates
Aggravates*
>>10198225
Neuropsychopharmacology is increasingly dissecting the mechanisms of psychoactive drugs play. Your post would have made perfect sense 30 years ago, but now we have a good idea of what they do and how they interact with the body, including acute and downstream effects on autonomic processes.

[Anonymous No.10198255]

>>10198241
>Neuropsychopharmacology is increasingly dissecting the mechanisms of psychoactive drugs play. Your post would have made perfect sense 30 years ago, but now we have a good idea of what they do and how they interact with the body, including acute and downstream effects on autonomic processes.
then, in order, explain how LSD causes psychedelic experiences, and then explain how nicotine causes increased mental acuity and reaction time

[Anonymous No.10198260]

>>10198255
err.... not increased reaction time.... shorter reaction time

[Anonymous No.10198369]

>>10198109
I assume it has something to do with cAMP and nitric oxide. I have visual snow, which I believe to be a mix relative of parietal / temporal lobe epilepsy and migraine, and cacao greatly intensifies it possibly by that mechanics. I think it has a strong vascular component.

[Anonymous No.10198373]

>>10198260
>reaction time
"It increased reaction time."
So they did it faster?
"They did it slower. Reaction time was increased."
I hate this thing.

[Anonymous No.10198382]

>>10198260
"It increased reaction time."
So they did it slower?
"They did it faster. Reaction time was increased."
I hate this thing.

[Anonymous No.10198396]

>>10198109
vasoconstriction

[Anonymous No.10198415]

>>10198173
>heavy smokers have a mild level of MAO inhibition from the constituents of tobacco smoke
No shit?

[Anonymous No.10199187]

>>10198255
5ht2a agonism
Cholinergic stimulation

[Anonymous No.10200599]

>buy pack of filter less cigarettes
>only smoke when studying
>brain correlates studying with the good-feeling of nicotine
>studying becomes enjoyable

I'm considering trying this out for the memes. I've been wanting to study up on some new coding languages and brush the rust off the ones I know in hopes of getting a better paying job.

[Anonymous No.10200631]

>>10200599
>one cigarette outside of studying sessions doesn't hurt
>one week later
>you're in a room full of empty cigarette packs
>the camera zooms in on your corpse continuously smoking a new cigarette for each second
>violently coughing blood
>this studying method really works!

[Anonymous No.10200652]

>>10200631
>SMOKE BAD!
t. Low IQ person that assumes the worse with a slippery slope fallacy, as bad as possible.
I've been doing what he has for years and feel absolutely no compulsion to smoke. I'll just stop smoking for weeks to months to years for the heck of it. The only people who get addicted to smoking packs of cigarettes a day are not very intelligent and they of all people need the cognitive enhancing benefits the most.

[Anonymous No.10200687]

>>10198109
Chewed tobacco slime alleviates the pain of bee stings.

[Anonymous No.10201041]

>>10200599
just use nicotine gum or the tabocoless pouches, or even a vape

[Anonymous No.10201051]

>>10198109
Anyone have an opinion on nicotana rustica (Aztec / Hopi tobacco)? I have some. Never tried any tobacco and haven't the slightest how much to smoke, given that it's 9x stronger.

[Anonymous No.10201089]

>>10201041
Not as effective, and infinitely worse for you in combination with any other stimulant for reasons above. Pure nicotine is much more anxiogenic too.

[Anonymous No.10201092]

I did get these migraines. Then I cut a bunch of crap out of my diet. I haven't had one for two years maybe even longer I can't remember the last one now. Just diet and exercise

[Anonymous No.10201098]

Post the paper regarding filter in cigarette causes cancer

[Anonymous No.10201100]

>>10201098
https://academic.oup.com/jnci/article-abstract/109/12/djx075/3836090/Cigarette-Filter-Ventilation-and-its-Relationship

http://tobaccocontrol.bmj.com/content/11/suppl_1/i51

[Anonymous No.10201101]

As filter ventilation increases, the cigarette is burned down less rapidly on the smoking machine, and there are more puffs per cigarette (54–59).

As the tobacco rod burns down less rapidly, there is more time for the coal to smolder and form more toxic constituents (54,55,57).

With increased ventilation in the range of most commercial cigarettes, there is decreased air flow through the burning coal tip and lower coal temperatures, resulting in more incomplete combustion and toxic constituents (60–66). An important publication for the chemical yields of two commercial cigarettes that differ by the amount of filter ventilation shows that most toxic constituents are statistically significantly increased (67). The analysis of this study was done with smoke constituent yields on a per-mg-of-nicotine basis, mimicking smoke intake for a smoker adjusting their smoking behavior to compensate for lower nicotine delivery. Among the increased toxicants was (N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK), a potent lung carcinogen, in agreement with other published studies (57,64,68–72). Blocking ventilation holes decreases NNK levels (73).

Increasing filter ventilation increases cigarette smoke mutagenicity as measured by the Salmonella Reverse Mutation Assay (Ames test), which is a highly replicated and extensively used assay for the screening of mutagenic potential (74–78) (Supplementary Figure 1, available online) (79). Filter ventilation increases mutagenicity across the full range of cigarette ventilation (69,74,80). An internal tobacco company study assessed six different design parameters to model the contribution of various design changes, including ventilation to mutagenicity, using 30 different research cigarettes (81). Filter ventilation statistically significantly increased the mutagenicity of tar independent of other cigarette designs and tobacco formulations (Figure 6) (81).

[Anonymous No.10201106]

[Anonymous No.10201117]

Are you suggesting I should stop juuling and jump on smoking unfiltered cigarettes?

[Anonymous No.10201132]

>>10200652
if its good on brain bad on lungues what about just wearing a patch?
i remember i (non smoker) tried patches once and didn't get any feeling from the patches except when i took them off i got instantly remarkably depressed

[Anonymous No.10201139]

>>10201117
Depends how heavily you juul or what you are using it for really. My suggestion is to try both. Most e-cigarette users simply are using these devices for socializing rather than as a performance enhancing drug, and as such won't derive much if any benefit from theraputic tobacco. I for one, find pure nicotine anxiogenic and unpleasant.

[Anonymous No.10201143]

>>10198415
https://www.ncbi.nlm.nih.gov/pubmed/15582589

[Anonymous No.10201147]

>>10201089
>nicotine other than cigarettes not effective
>nicotine is anxiogenic
hm? so what is it in cigarettes that makes them efficacious for things mentioned in this thread if not nicotine?

[Anonymous No.10201152]

>>10201139
Performance. Helped me through very stressful times when I used to daytrade with my partner. I only switched recently for health reasons.

[Anonymous No.10201156]

>>10201152
Also only vape 1/4 or less pod a day, nothing too much. Just get the nic buzz and back to work

[Anonymous No.10201178]

>>10201147
There are many potential explanations from the the numerous antioxidant constituents such as coenzyme q10 and the polyphenols to the ultra low doses of carbon monoxide (which is increasingly being explored in medicine as a theraputic target) to the beta-carboline alkaloids among countless others which suffice to explain the additional beneficial effects of tobacco. From my research, tobacco is a panacea to which there is no equal. I consider low amounts of tobacco, 1-5 unfiltered cigarettes a day, not only harmless but healthful.