/ng/ - nootropics general

[Anonymous No.14836176]

post & discuss noots

>where can I get noots
pglchem
bromantane.co
nootropics depot
iqbase
rupharma
bgpharma
group buys organized by longecity, nootropicsrebirth, nootopics, pax's server, etc.
Alibaba (be careful)
IndiaMART
hhd pharma (epobis source, eg. https://hhd-pharm.en.made-in-china.com/product/YolxiRHPayTS/China-Wuhan-Hhd-Epobis-Peptide-Purity-99-Have-in-Stock-Factory-Shop.html))
[math]\vdots[/math]

>resources
receptor database: https://www.biotune.org/2019/07/what-receptors-do-antidepressants-and.html
cureDAO: https://wiki.crowdsourcingcures.org/
MEpedia (tons of info on CFS): me-pedia.org
WikiPathways: https://www.wikipathways.org/
nootropicsrebirth: https://chat.nootropicsrebirth.com/home

>SYNTHESIS ORDER SHEET:
https://docs.google.com/spreadsheets/d/1MHez3SFSagYdJqaoQ5PwV8uExSovOrZ20ERDhmjTaF8

[Anonymous No.14836238]

how do you even get started with this shit ?

[Anonymous No.14836242]

How can something have a negative probability anon?

[Anonymous No.14836243]

>>14836242
probability of being (positively/negatively) life-changing. It's most likely like that.

[Anonymous No.14836245]

>>14836176
black bamboo rhizome extract. what ???

[Anonymous No.14836246]

>>14836245
seems like it helps https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286084/

[Anonymous No.14836280]

post probability to permanently damage your cognition, long-term

[Anonymous No.14836288]

>>14836242
If the probability is 110% that OP is a faggot, then there is a negative probability that he isn't one.

[Anonymous No.14836297]

>>14836176
where to get decent supplement products that are any good and not fill of garbage filler or bad compounds?

[Anonymous No.14837308]

>>14836176
so according to this, doing math is the best thing you can do?

[Anonymous No.14837327]

>>14836176
Real dihexa is the best. There has never been real dihexa on the market.

[Anonymous No.14837333]

>>14836176
>doing math
I have been going through a math undergrad and solving calculus problems for hours every.singe.day. for the last year straight, and I don't feel any smarter. If anything I feel dumber and burned out.

[Anonymous No.14837346]

>>14836176
what does number of ratings mean? And to what extent does this affect intelligence? I dont know almost anything but im pretty curious about how can a relatively simple substance change completly the brain chemistry

[Anonymous No.14837353]

>>14837346
start reading some basic biochemistry and pathways
some of these little substances can induce literal unhinged schizophrenia in you while some can lift your life to new levels
biochemistry is fun

[Anonymous No.14837366]

>>14837353
I already have schizophrenia so I dont have nothing to lose woohoo

[Anonymous No.14837377]

>>14837366
>I already have schizophrenia
prove it

[Anonymous No.14837389]

>>14837377
how tf can i prove I have szhiophrenia

[Anonymous No.14837403]

>never go to lectures
>watch video lectures online at 2x speed while browsing 4chan and playing videogames
>3.8 GPA in major, math.

I can't concentrate on anything unless I'm constantly hyperstimulated from various directions. I wonder if I would be more successful if I could concentrate more. It takes me forever to finish any task.

[Anonymous No.14837427]

>>14837389
>ngmi

[Anonymous No.14837468]

Show me a compound that does one of these things

- permanently increases IQ
- enhances language learning at least while under it's influence
- enhances musical instrument learning at least while under it's influence

Why would I bother at all with any of these compounds posted in the OP, what are some of these idiots even chasing
>ugh today I felt more mental clarity and had less brain fog yadda yadda
who fucking gives a shit

[Anonymous No.14837492]

>>14837468
do you want it ?

[Anonymous No.14837499]

>>14837492
I realize that after decades of people experimenting and posting their experiences on the internet, there isn't anything regarding cognitive enhancement that is more revolutionary than just "doode take some amphetamine derivative"

[Anonymous No.14837502]

>>14837499
found it on erowid

[Anonymous No.14837528]

Nootropics are cope for midwits. Geniuses don't need this stuff. Anyone who accomplished anything remarkable in life never needed this stuff, they were just born that way.

[Anonymous No.14837546]

modafinil is all you need if you can quack hack. if you're not interested in getting an Rx kratom is the best. nicotine is helpful in short bursts but you pay the toll in withdrawals quickly.

[Anonymous No.14837552]

>>14837528
>Anyone who accomplished anything remarkable in life never needed this stuff, they were just born that way.

Then why are people getting stripped of their titles for PED use?

[Anonymous No.14837573]

>>14837546
This man gets it. Saves me multiple replies. If you want power and net positive in your life then all you need is regular stimulant use, be it coffee, cigs or amph derivatives

[Anonymous No.14837920]

Currently drinking red wine and vaping weed & nicotine on 300mg luvox and 4mg brexpiprazole
https://www.hindawi.com/journals/omcl/2020/1941480/

[Anonymous No.14837930]

>>14836176
I really like this graph, is there some historical trace of this to see how new shit falls off to gauge how hype relates to actual effectiveness long term.

[Anonymous No.14838642]

I take a bi-weekly dose of DMT+ harmine and tetrahydroharmine. I basically take beta-carbolines with this frequency for about 1 year and a half

the only thing I can say is that my personality changed for the better. Less autism, more assertiveness, and no more anxiety. Different people that used to know me wondered what I did to change, while people that meet me just now comment on my laid-back personality.
In my experience this kind of stack and dosing lowers the neurosis trait by a lot, and this has been also confirmed in a certain study

IMO neuroticism is at the root of pretty much most personality disorders today. I definitely feel different after having taking beta-carbolines regularly, like shedding a personality skin, I pretty much can't relate to the me I was before I started all of this

[Anonymous No.14841340]

>>14838642
>bi-weekly dose of DMT
how much,?

[Anonymous No.14841368]

>>14838642
>taking beta-carbolines regularly
Can do even better taking low dose ibogaine, but fucking junkies have driven its price through the roof

[Anonymous No.14841399]

>>14836176
schizopill me on intronasal deferoxamine

[Anonymous No.14841402]

>>14837427
Here we see pictured the schizophrenia-transhumanism-leftism wordy meme spectrum explained by example.
Jreg would pretend to be amused but pretending to be impressed for ad revenue.

[Anonymous No.14841407]

>>14837546
Modafinil was no more effective than me than placebo.
In fact, conscious self-aware placebo was better.

[Anonymous No.14841448]

>>14837308
Yes, people look for manmade drugs when the best thing you can do is do math, lift weights, eat healthy and do cardio

[Anonymous No.14841543]

>>14836176
>get armodafinil
>more effective than any substance or activity I have ever tried in my life
>borderline supernatural levels of productivity
>three months of absolutely exponential explosion in my business and finances (self-employed)
>cue this Saturday
>does nothing
>take two
>does nothing
>since then laying on the couch with takeout doing fuck all on a “tolerance break”
If it never works again I will never recover from this psychologically. It was like being a real human for the first and last time.

[Anonymous No.14841550]

>>14837528
Nah most workaholics throughout the ages were on whatever stimulant was popular at the time, even if that just means a lot of caffeine.

[Anonymous No.14841589]

>>14841543
Yeah pretty much the same experience. Fuck that shit.

[Anonymous No.14841605]

>>14841589
Fuck.
It’s never coming back, is it?

[Anonymous No.14841651]

>>14841605
Not completely. You can wait 6 months and then have like one good day off it, but nothing like it was in the beginning, and after that it's shit again.

[Anonymous No.14841669]

>>14841651
Fuck I hate being alive. Can’t have shit in Detroit.

[Anonymous No.14841893]

>>14841543
don't exagerate with stims

[Anonymous No.14841903]

>>14841893
I’m not exaggerating. I’d tried adderall and everything else before. On armodafinil I worked 80-100-hour weeks every week for three months straight. Obviously I also had no sleep cycle whatsoever and would have been too visibly stimulated and sleeping at random times to have kept a job if I wasn’t reporting to myself, showered maybe twice a week, and didn’t go outside.

[Anonymous No.14841962]

>>14841543
Could be that you got a dud batch, Indian produced generics are notorious for that.

[Anonymous No.14842355]

>>14841962
Damn it, now you’ve given me hope.

[Anonymous No.14842476]

>>14841903
yeah armodafinil gets the job done but fucks with sleep pattern

[Anonymous No.14844149]

>>14841962
>>14842355
no luck. I tried one from a different batch and still nothing.
Oh well. At least I got it for a little while.
Back to being garbage.

[Mr. Psychology No.14844202]

Just wanted to mention that all amphetamines are neurotoxic - this includes adderal, modafinil and other drugs for adhd.

[Anonymous No.14844235]

>>14844202
Afinils aren’t amphetamines

[Anonymous No.14844306]

>>14844202
Bullshit, but w/e.

This is obviously not a pharmacological question but a psychological one. Literally millions of you on a crusade against the one psych drug that actually unambiguously works to treat the shit it's prescribed for. Why? You don't have to take it, your kids won't have to take it. Why do you hate it so much when a person who can't follow through on plans, keep track of details, regulate their emotions gains function and maybe becomes a productive member of society instead of a low tier wage slave or a criminal?

[Anonymous No.14844403]

>>14844306
The same reason they’re nasty about/to anyone with any kind of problem, failing, or perceived defect.
Bad Person Disease.

[Anonymous No.14845058]

taking some TAK-653. Apparently actually increases IQ

[Anonymous No.14845089]

>hey goys, buy my snake oil
commercial advertising spam thread

[Anonymous No.14845585]

>>14845058
Well, have you proven the Riemann hypothesis?

[Victor No.14846077]

Caffeine is the best. The best is in coffee. Everything else is whack. Even so, if your problem is even medication related you should figure out how to self-motivate effectively.

[Anonymous No.14846082]

>>14845089
do you see him advertising a vendor you fucking retard?

[Anonymous No.14846088]

Semax, PRL-8-53, and Dihexa all worked for me. I spent a few months learning Hebrew (inb4 muh kike) and was making pretty good progress, everything about the grammar felt intuitive. I stopped as my priorities shifted but even a year later I would have random thoughts in Hebrew and almost respond to people in Hebrew before I would catch myself.

[Anonymous No.14846103]

Any recommendations for someone who needs to quit booze? I need to feel good and repair some of the brain damage from excessive alcohol.

[Anonymous No.14846175]

>>14836176
where do binaural beats enter

[Anonymous No.14846179]

>>14846175
in the dumpster fire

[Anonymous No.14846182]

>>14846179
ok thanks

[Anonymous No.14846200]

>Caffeine improves cognition
>Lack of sleep impairs cognition
>Caffeine impairs sleep

I don't get it

[Anonymous No.14846220]

>>14846200
Caffeine is a payday loan for your brain

[Anonymous No.14846270]

Is it possible to get phenylpiracetam anymore?
t. Leaf

[Anonymous No.14846282]

>>14836176
Here we are again with this twatty chart. Nothing in this chart makes sense. Nobody understands anything about receptors, their functions, or how their ligands bind. People really think "taking thing = getting gooder."

The entire planet wipes its hairy ass on this godforsaken board.

[Anonymous No.14846542]

>>14837377
Even Jreg doesn't want to gatekeeping schizophrenia

[Anonymous No.14846548]

>>14837377
the glowies are schizo and the schizos are glowies

[Anonymous No.14846820]

Eating less or exercising a lot so that the calories go to your body instead of your brain is very helpful to me. There is less overheating, so thoughts are much more essential and clear. It has made learning cuneiform languages easier.

[Anonymous No.14847597]

I used to take nootropics a lot. Here was my stack:
1.) Phenylpiracetam
2.) Oxiracetam
3.) Aniracetam
4.) Choline
5.) PRL-8-53 (every now and then)

The first two months was great. It went downhill afterwards though. I noticed that it doesn't seem to have the same effect as before. So, I then started doing Adderall XR (30 mg) and Ritalin (30 mg). Long story short, now I'm hooked on both. Fuck me right...

[Anonymous No.14848094]

Anyone know where the fuck I can buy phenylpiracetam nowadays?

[Anonymous No.14848107]

>>14846220
This is what all of these drugs are. Our brains will always just rebalance itself to account for the drug, and now you're stuck taking it just to feel normal. It's not worth the trouble. You're abusing the short-term imbalance.

[Anonymous No.14848545]

>>14836176
>Abuse stimulant Monday to Thursday
>Abuse depressors Friday to Sunday
>Psychodelics when I feel fancy
It isn't that hard to crack the code, people. Just make sure that you rotate the substances and always use the minimum working dose. Eat healthy and do sports too.

[Anonymous No.14848596]

>>14847597
Honestly this is really where all roads lead. You take a bunch of crap that doesn't work and finally settle for the amphetamines you were going to take all along.

[Anonymous No.14848603]

>>14845058
>TAK-653
looks yummy

[Anonymous No.14848611]

>>14848603
I think he died bro.

[Anonymous No.14848620]

>>14848596
Yup, not gonna like DoC right now is Adderall, Ritalin, or Coke. For those trying to go down this road, just take it slowly. Don't ever make my mistake.

[Anonymous No.14848812]

>>14846103

Just stop wanting to drink. View it as poison.

But B vitamins for sure. Stay hydrated, don't overthink it or get anxious. Just chill like you have the flu. Hard cravings gone in 3 days.

[Anonymous No.14849878]

anyone here ever take ephedrine?

[Anonymous No.14849908]

>>14836238
>how do you even get started with this shit ?
Ask instead why would you want to?? Drink tea instead, patrician taste and all that plus it is GRAS and beneficial.

>>14849878
I did in the past when coughing a lot but it made me so drowsy I stopped. I don't udnerstand why people want their brain to go into hibernation.

[Anonymous No.14849925]

>>14849908
>but it made me so drowsy I stopped
It's a CNS stimulant literally how?

[Anonymous No.14850099]

im a shy incel will taking phenibut transform me into a social diva??? what are other nootropics/drugs to make me more normie/social/sex haver behaviour?

[Anonymous No.14850338]

>>14849925
I have no idea, I was just unable to think clearly and that was just dosage according to prescription. I can use noscapine and still be able to work.

[Anonymous No.14850430]

>>14837333
this is the peak of the human experience. your life is spoiled and these differentials are wasted on you.

[Anonymous No.14850683]

>>14849925
>>14849908
>made me drowsy
Ritalin does that to me especially if I snort it. Sometimes I feel as I were given antipsychotics since it supressess suicidal ideation, antisocial tendencies and violent thoughts too

[Anonymous No.14850813]

>>14836176
The nootropics Reddit shit is a meme. It’s all bullshit. If you want to enhance cognitive performance take some sort of amphetamine. Every other nootropic is a fucking joke.

[Anonymous No.14851591]

>>14836176
Reminder, anything that makes you grow braincells, is going to turn you completely retarded, because it's the delicate pruning of neurons that makes you smarter, not the growing. It could be 10 years before you finally finish pruning all the new braincells you've grown, or you might never be able to prune them at all, leaving you retarded forever.

[Anonymous No.14851621]

>>14850813
I thoughth green tea would be fine.

[Anonymous No.14851712]

>>14850683
There’s a bomb mail
Pipe in your box

[Anonymous No.14851714]

Sucks that no stimulant without tolerance exists.

[Anonymous No.14853433]

>Be tourist from /biz/
>Do Noot Noots and DMT to trade and to live, laugh, love a few years ago
>Did Moda as well as stacked memory and attention boosting noots
>Pretty much the only thread on /sci/ aside from MathGen with more than 20 posts
>Full of shills
You get these JIDF faggits here too, hey? Clearly over target. Shame a lot of patents never leave the vault.

[Anonymous No.14853934]

I hate tolerance breaks so much.
I may as well be dead.

[Victor No.14854647]

Only caffeine tablets and coffee are realistic. /b/ real

[Anonymous No.14854753]

>high iq
>unmedicated severe adhd
how much would medication actually help me anons? anyone have experience with adhd itt?

[Anonymous No.14854817]

>>14836242
That diagram is garbage and started out as a parody on 4ch. Attribution was deleted but it remains garbage.

[Anonymous No.14856365]

>>14850099
ashwagandha, nsi-189, amphetamines, F-Phenibut, Selank, etc.

[Anonymous No.14856400]

>>14837468
Not even trying to mock you, but microdose mushrooms is close to what you’re looking for; the fact you put “permanently increases iq” makes me think you’re probably pretty young or just don’t really know what iq is or how it works, because if you got better at the latter two but there was no “iq increase”? Would that somehow be a loss? And for the record I feel like it would be hard to gain fluency in a language and learn an instrument and not feel sharper whenever you’re called upon to perform a task/take a test. But without a doubt microdosing mushrooms should quite literally loosen your tongue making new syllables easier to practice and as for music it often just makes practice more pleasurable and intuitive

[Anonymous No.14856433]

Flipping a pure steel knife in the air while I walk through the woods is a habitual leisure activity. It's precise trajectory and rotation must be perceived upon reapproach so you can step either forward or backward if necessary, and move your hand either up or down accordingly to catch without blade contact. Since TAK, I had an urge to flip the knife significantly higher than is my typical limit. Despite there being more time for gravity to exert it's acceleration on the knife, the first thought that occured specifically regarding a focus on it's rotations as it neared me was "time feels slowed". What happened next was that I accurately caught it. With high repeatability, another thought "I wonder if the reason people say their perception of time changes as they get older is due to them losing reaction speed and hence informational processing".

[Anonymous No.14856566]

>>14856400
I want to believe anon, someday I will try this
them

> because if you got better at the latter two but there was no “iq increase”? Would that somehow be a loss?
no of course not, and the 3 things I touched upon don't have to be linked and I was not implying that they are linked. What I was saying is that I would be happy with any of those three

my point is that none of those compounds that people take seem to bring back the neuroplasticity you had as a kid that allowed you to soak a new language effortlessly (I learned english by myself before I was even 10 by just watching cartoon network in english, without a teacher or anyone IRL talking it around me)
regarding musical learning, again I don't hear about compounds that allow one to learn a musical instrument like you do as a kid, you can never catch up with your motor skills. There is this one study that tested valproate on adults and it seems to allow you to recognize musical pitches by reactivating a part of the neural pathways that are active when you are a kid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848041/

When I see people post their stacks I don't get it, what are they even trying to do with it? They have a racetam, some caffeine, some vitamins, and all they can say "ugh I sperged a little less when talking with the cashier" "ugh I spent 3 ours studying what an accomplishment!".

the nootropics reddit is one big waste of time, just look at an example of a post
>1g in the morning, 500mg at night. My anxiety and rumination are almost completely gone. Depression much better. Sleep has been super restful. LOVING this stuff so far.
>I usually spend the day with constant thoughts in my head either distressing or just random phrases/ songs I enjoy. All gone. I can meditate without having millions of little
Nigger who even cares about this stuff, where are the big guns?

[Anonymous No.14856571]

>>14851591
>Reminder, anything that makes you grow braincells
none of the compounds that are paraded as the ones that enhance neuroplasticity can lead to any growing of braincells in most of the cerebral areas. The one exception where they may act is that one part of the hypocampus responsible for emotional regulation and is linked a bit with memory, but I have not seen a paper that examined the use of subtances that enhance neuroplasticity in vitro and their actual effect on humans on mental or emotional traits
but none of those compounds that grow neurons in vitro have a chance of affecting something from your prefrontal cortex for example

[Anonymous No.14856946]

>>14837920
PAM of d2 autoreceptors is antidopaminergic. That makes brex a no for high iq low energy sorts. It would probably help midwits with a lot of energy but no brain.

[Anonymous No.14856991]

>>14856566
>my point is that none of those compounds that people take seem to bring back the neuroplasticity you had as a kid that allowed you to soak a new language effortlessly
You don't know what neuroplasticity is. Your nucleus basalis can be stimulated to induce critical phases, which, btw, end well before age 10.
Another thing you don't understand is that there is no point in neurogenesis if it's aberrant synaptogenesis. Opioids, like kratom, for instance, cause aberrant synaptogenesis; literally "muh new connections" made to induce addiction, hence why quitting is so difficult.
AMPA PAMs, through enhanced selectivity, don't cause aberrant synaptogenesis. For example, the way TAK enhances synaptogenesis is something the brain was already anticipating: It strengthens the function of the prefrontal cortex and information processing neurons' very selectivity, and so it improves learning and in some regards can intensify consciousness.

HDACIs are interesting, but you're a massive faggot for conveniently ignoring the one billion serious side effects that come with them (and no, PRL-8-53 is a D amino acid oxidase inhibitor, not an HDACI). Just use Bromantane, ALCAR, and Omega 3s for indirect HDACI. Actually, direct HDACI are fucking terrible in terms of side effects, don't do them, retard.
Also, don't understand why you're seething over that shill subreddit (obviously, the good shit is not being discussed on some popular subreddit). It should be pretty obvious why they ban conversation on anything interesting: The moderators literally run a large "noot" (these days due to the FDA: a herbal supplement) company. They have to get people interested in their nonsense plant-based garbage. But hey, keep on being an angry fucking brainlet who doesn't know shit while actual neuroscientists are working to get interesting compounds synthesized. The D21 peptide has started synthesis, TAK is being sent out (atm very promising reports), then there's tabernanthalog, etc.

[Pax !!cu2HYeafqTG No.14857278]

>>14856991
That's an incredibly apt appraisal of the current environment in the noot space.Plant based noots or at least their current application is a joke and somewhere I feel that is what most people should play with. I've noticed the phenomenon become far too common of people mixing far too many noots in their stack or place strong reliance on a base of compounds like Dihexa and Isrib in their stack.
I wish more understood the risks associated with Isrib and dihexa but so many are just chasing a high.
I've noticed some become incredibly neurotic to the point they're paralyzed with anxiety and intolerant of social situations, similar to Autism.
Worse yet is the quality of discussion has fallen substantially or the ambition to pursue new avenues falls on the narrow subset in the community which have access to labs and think that the newest plant based compound or small molecule to come across their attention is incredibly novel.
I have faith that the community will continue to grow and I hope that it leads to more people becoming more literate about medicine and particularly neuroscience so that change can come to this broken regulatory system.
I've seen some fairly novel peptides and research come out in the past years I'm disgusted in the disparity between application of therapeutics in the lab and the research that is then translated into clinical trials or even go on to become "FDA approved". If some of the best work that I've seen has come from lab research from 10-30 years ago and hasn't reached human trials yet then we are witnessing pure nepotism.

I've paid for the synth of a fragment of soluble amyloid precursor protein alpha(The non amyloidogenic product of app processing which supports memory, neurogenesis, microtubule formation, and protein synthesis).
From an appraisal of the supporting literature it's most effective around the nanomolar range. From what I observed it could possibly be the strongest compound I encountered yet.
I'll update soon.

[Anonymous No.14857374]

>>14857278
Wasn't there even some teenager in sir's discord that got autism trying to induce synaesthesia in himself (for whatever reason)? People pay far too little attention to staying healthy/take that for granted. But it's to be expected. Most (healthy) people that get interested in noots in the first place are immature, impulsive, and constantly searching for novel things to the point of this seriously inhibiting their working memory. And since young people usually check all those marks, I'm generally not as optimistic as you in that regard. There'll always be an influx of such people, no matter how hard you try to gatekeep.
As such, I should also mention that I seriously hope Bam pays attention to the D21 peptide being safe. I dislike his view of prioritizing cognitive enhancement over health and his recent positive comments on opioids made me lose some trust in him. Thus, I really appreciate the amount of effort you put into clearly explaining the side effects of deferoxamine. I honestly find it ridiculous to deny intranasal deferoxamine's potential to treat chronic diseases.
Already looking forward to your write-ups on sAPPα.

[Pax !!cu2HYeafqTG No.14857375]

>>14850099
No. Phenibut may improve your social anxiety for a bit but it comes with the development of tolerance and dependence. Don't play with strong gabaergics they're basically benzo garbage. If you want to become less socially inept you may have to actually bite the bullet and think of talking to people in person in the real world and not think to yourself that you're really above anyone because you're insecure.
Coming to the noot space it's not incredibly uncommon that everyone is out to pursue drugs just as a social outlet and getting high hides our insecurities. Taking care of yourself and being a strong part of other peoples personal life offline will be good for you.
Otherwise snorting insulin/Rapamycin/Deferoxamine have had great utility for me over the past year and there's few compounds I'd place above those for improving sociability.
>>14851714
>>14853934
I've had great benefits from using intranasal insulin and for me the experience I've had with that over the past year had been magical. While not overwhelmingly powerful compared to classical noots it would reduce tolerance to nicotine and reduce the damage that amphetamines would induce on braincells.
Deferoxamine also has great utility as a stim itself and potentiates other stims while reducing their negative sides.
> Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania
https://www.sciencedirect.com/science/article/abs/pii/S0278584608000730
> Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure
https://pubmed.ncbi.nlm.nih.gov/28884876/
> Intranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation
https://pubmed.ncbi.nlm.nih.gov/28917981/

Rapamycin also has great potential for mitigating amphetamine related side effects and neurotoxicity.
https://www.hindawi.com/journals/omcl/2018/6124745/

[Anonymous No.14857446]

>>14857278
>Plant based noots or at least their current application is a joke
It's all market driven. One of the best nootropics out there is ibogaine, it's also a kick-ass psychedelic. One need not take it in large doses at all to reap the benefit. But all you ever hear about is it being used to treat addiction because that's where the big money for it is.

[Pax !!cu2HYeafqTG No.14857465]

>>14857374
> Wasn't there even some teenager in sir's discord that got autism trying to induce synaesthesia in himself (for whatever reason)?
Yeah there's a large number of people that I've known with noot stacks 10+ compounds long and I think those are some of the harder people to relay info to because they feel what they're doing is great for them and they won't really listen to reason. I've known someone in my server for a time that probably gave one of the first dose reports on intranasal deferoxamine and they were taking that on top of a huge arrangement of other noots and magic mushrooms. Strangely enough they wanted to bring up the idea of me making conjugates every time I see them and my response usually was I'm not interested. It's a bit disheartening to see some people come to me on a repeat basis and ask me my opinion on one of their recent finds. I'm in the same boat relating to you my belief that most who identify as being a scholar in noots are not deeply invested in learning the base essentials. If you really want to optimize cognition and longevity then starting from the point of correction of metabolic disorder and cognitive function are essential before even considering what comes after.
> I seriously hope Bam pays attention to the D21 peptide being safe.
If I have faith that it can be completed I think he has far too much going on to really invest much time into understanding those risks like he used to. He really is dead set in his own biases that correction of metabolic abnormalities is not paramount to cognitive performance it has limited his pursuit past understanding the project where he's placing all of his pride into finishing.
We've had discussions where we have related to each other similar ideas of emotional struggles but having come from different upbringings it has led to different outcomes in how we handle our sense of entitlement.
Do you mind sharing with me what they had said about opiates that got your attention?

[Pax !!cu2HYeafqTG No.14857511]

>>14857446
I can see why the nootfather would be personally vested in maintaining their business and grabbing a niche which can allow them to stay on top of the market. I don't even think that it's a bad route to take seeing that they're a multimillionaire likely with a family and circle of closely knit employees with some enthusiasm to continue to bring in enough funds to keep the business afloat.
I don't really see why plant based compounds can't find their niche or be better explored. i've been looking at intranasal DHA-curcumin microemulsions for a while. I think that incorporating Borneol, geniposide, berberine, and retinoid acid/vitamin D can be incorporated to make a intranasal solution that would be competitive.
Ibogaine, mushrooms, and other serotoninergic hallucinogens are fairly well regarded from people I've known to be the most well read in the community. Being into drugs you're likely to meet some people that have had years of experience with a large range of compounds and noots have come into focus as a means of maintaining their health and cognition for many more years. Then I know people who're generally younger than me who're exceptionally conscientious and love life that are out to enrich their lives and I think those groups are the lifeblood of what makes me happy to be a part of the community.
I haven't taken any classical psychedelics but from what many have said to me I really go hard on the compounds and concepts Im most enthusiastic about.
I've been enjoying MGF and IGF2 for the past few days. I can say those 2 compounds certainly have played a large part in pulling me out of a slump I've had recently. I've stuck to using about 100mcg each of IGF2 and MGF intranasally per day. I should look into making a small writeup about my thoughts of each soon to put my thoughts together.
My favorite noots always have been the ones that give a powerful sense of clarity and brighten your sense of eyesight and give new crispness to your other senses.

[Anonymous No.14858243]

>>14846175
>>14846179
>>14846182
Don't listen to him, morphic fields are where it's at.
https://mega.nz/folder/JtxVjLrC#gZLlDjzYXZ9JoLUbNiszOg
https://mega.nz/folder/gwhExJYZ#SPti9mWa7XDzaqYn9qXwMQ
Unironically probably safer than experimenting with research chemicals.

[Anonymous No.14858255]

>>14836176
Why not slap on an EEG cap and do some neurofeedback until your brain looks more on the EEG like the brains of bigsmart people?

https://tagsync.com/

[Anonymous No.14858474]

>>14837377
Not that anon but my pituitary gland is apparently calcified accorded to a CT scan. That affects some things maybe.

But I don't have the money to get a second opinion.

Don't think I'll be schizophrenic tho, but I'll maybe have some mood swings when I get older.

Or it's just nothing.

[Anonymous No.14858627]

So guys, these are the noots I've looked into. These are the "natural" ones that seem to work and have studies behind them:

- omega 3's (1000mg + DHA)
- creatine
- iodine (potassium iodide)
- b complex (thorne)
- caffeine
- l-theanine

Additional:

- zinc 15mg
- magnesium glycinate 400mg

Can any of you big brain geniuses give any input? Does this check out?

[Anonymous No.14858634]

>>14858627

forgot to add:

- cpd choline

[Anonymous No.14858636]

>>14858243
Only "safer" by virtue of being pseudo-scientific nonsense. Just don't be retarded, eat healthy, and take noots.

[Anonymous No.14858641]

>>14858627
I'll look into the rest later, just make sure your omega 3s are high-quality, not rancid once they arrive.

[Anonymous No.14858646]

>>14858641

Thanks anon <3

[Anonymous No.14858680]

>>14857375
>No. Phenibut may improve your social anxiety for a bit but it comes with the development of tolerance and dependence. Don't play with strong gabaergics they're basically benzo garbage. If you want to become less socially inept you may have to actually bite the bullet and think of talking to people in person in the real world and not think to yourself that you're really above anyone because you're insecure.
its over
>Otherwise snorting insulin
that sounds kinda fucked up

[Anonymous No.14858698]

>>14858680
have sex

[Anonymous No.14858701]

>>14850099
Genuine question: Do you think your incelibacy is a personality disorder? As in: Do you choose to act that way or are you incapable of acting any other way despite disliking it?

[Anonymous No.14858707]

>>14850099
Testosterone.
You want to get laid, testosterone makes men what we are. So take the direct path to your goal like a high T person always does.

[Anonymous No.14858715]

>>14858698
but I can't

[Anonymous No.14858717]

>>14858701
>>14858701
>Do you choose to act that way or are you incapable of acting any other way despite disliking it?
the latter
im just a shy, awkward dude with no friends

[Anonymous No.14858731]

>>14858717
Was there not even one day of your life when you weren't a shy awkward dude?

[Anonymous No.14858813]

>>14858731
When I was with my friends back in highschool I guess

[Anonymous No.14859205]

>>14858813
You probably have SPD. Read this https://digitalcommons.pepperdine.edu/cgi/viewcontent.cgi?article=1412&context=etd

[Anonymous No.14859264]

>>14859205

[Anonymous No.14859364]

>>14859264
not necessarily.
>Fairbairn was amongst the first to note that schizoid states are present to some degree in all people, and span a continuum from normal to severe and debilitating (Fairbairn, 1940). Recent authors assert the normalcy of temperamental introversion (Cain, 2012), the biases of object relations theory toward the primacy of relationship (Modell, 1993; Storr, 1988), the creative and regenerative functions of reclusive behaviors (Storr, 1988), and the gains and pleasures of seclusion (Rufus, 2003) as counterarguments to pathologizing schizoid-like behavior.

[Anonymous No.14859396]

>>14859264
>>14859364
think of the part that designates it as a "disorder" as controversial and antiquated. You're also not a schizo, nor have you said enough to really diagnose you with anything. It's just a terrible term. But if you desire treatment and think it's serious, you should know that most psychologists are fucking terrible when it comes to that, so it would probably just better to read some research on treating it. 99.9% of therapists don't know of the latest research regarding that "disorder".

[Anonymous No.14860401]

>>14859264
Faggot, like I told you, testosterone will fix all your problems.

[Anonymous No.14860835]

Intranasal deferoximane I can't find in the image. Am I blind? Or is it not listed

[Anonymous No.14862245]

>>14860835
See >>14854817

[Anonymous No.14862755]

What are benefits and risks of tanking pure nicotin (patches or chewing gum)?
I know its better than smoking i guess but can i still fuck myself over taking pure nicotin?