/sci/ - Science & Math

I performed iron-loading into a transferrin molecule for my undergrad inorganic chemistry lab.

>>9697147
So what then, is there basically just an open hole where the metal binds to gases like H2 to capture them? Sort of hemoglobin but more generalized to capture different kinds of gases?

>>9697147
Interestingly you can make these through mechanochemical engineering (ball milling), this is a fairly recent development, at-least compared to MOF's themselves.

They are neat.
Bad for storage, but promising for passive gas separation and flow based catalytic structures.

For example, separating different chain length hydrocarbons from a mixture without having to add much energy

>>9697164
Pretty much just ultra porous typically 1000-2500 m^2/g or higher even. Pore diameter typically 1-20 nm but there are thousands of different ones around now. I believe it usually binds at the metal sites but some of my reading I've seen people functionalise the ligands joining the metals for interactions there.

The capacities can be a lot higher per gram than molecules like haemoglobin.

>>9697147
yes
>>oxygen selective materials
BOOOOOOOOOORRRRRRIIIINNNNNNGGG! Gas separation and storage are cool, but the real fun applications for MOFs are organizing molecules together in 3D space. Unless of course you are using flexible MOFs. I would say more, but I was the only one in the world to do that kind of work and I don't wish to be identified(haven't published yet). Let's just say this though, if you organize the right stuff in 3d space you can kick ass at gas storage and separation.
>>9697164
that's not a MOF, GET OUT! Gas molecules are attracted by surface area mainly, but you can use the metal nodes for things. Mainly it's surface area though.
>>9697172
ball milling, small milling, it's fucking easy to make MOFs. Fuck BASF makes MOFs BY THE TON!
>>bad for storage
you ain't seen nothing yet. We've figured out the limits for static MOFs, but flexible MOFs have a lot of potential. Haven't you heard of the Coudert group's pressure amplifying MOF? It does this crazy thing where if you push on it, it pushes back harder.

>>9697184
Binding can be at any of the moieties, doesn't have to be just at the metal centre.

>>9697192
>that's not a MOF, GET OUT

Okay maybe not hemoglobin because the iron binds to the surrounding structure, but transferrin is definitely an example of a MOF.

>>9697197
get your goddamn spaghetti tangles out of here! For something to be a MOF it must form a periodic structure held coordinated together by metal in at least one dimension. Really anything less than two is pushing. Shit I don't think that goddamn spaghetti tangle of your even has any form of symmetry, you can't even call it a metal organic polyhedra(MOP)

>>9697147
Flavor of the month desu
More hype than content

>>9697192

>Coudert group's pressure amplifying MOF
Had a squiz at their nature letter, interesting

>>9697147
Spent a half year of my bachelor thesis building functional spin crossover MOF's. Didn't work for shit as they were crazy expensive and had phase transitions at -100 C.
It is a very applied field yet I have seen very little exciting applications.

>not researching the infinitely more challenging COFs

>>9698261
COFs are cool. Not as perfectly periodic, but cool

>>9697147
>oxygen selective materials
what you're looking for is hemoglobin

>>9698889
Too big to put in a ultra porous material, probably would be denatured quite easily too.