/sci/ - Science & Math

>>9658785
So I take that the website will be up this week?

>>9658797
Hopefully in the next couple days. The domain is purchased and one of the anons from the previous thread made a really nice site layout, so now it's just a matter of putting it all together. Going to be working on it some more tomorrow.

>>9658823
Did you email that Stanford researcher about our prominin comparisons?

>>9658785
I'll design the logo!

>>9659191
Go ahead, sir.

>>9659191
>>>/g/

>>9658785
wait so let me get this straight, how close to the meme claim of "curing blindness" are you actually getting?

Are you curing a condition that makes up what % of blind people?
will this only affect the outer eye?

what level of damage could it fix?

could it help someone who has completely lost his eye to grow a new one?

could it repair damge in the optical nerve?

>>9660040
The main goal here is to cure retinitis pigmentosa type 25, it affects about 1 person in 4000 so is fairly rare. During those threads OP also discovered that EYS protein replacement theory could potentially help treat other types of optic disk damage, though the extent of it's therapeutic capabilities as well as damage reversal remains to be seen.

For now this project is in the proof of concept phase.

>>9660093
but concretely, what percentage of blind people could be helped?

could you heal say, 50% of all blind people?
Could you help people who use glasses?

>>9658785
Econ major that lurks /sci/ sometimes here. I'm afraid that I cannot help too much on this project, but I can give some advice related to business (have acquaintances who laugh at me for studying econ who tell me what business is like. I'm not concerned about money, I just hope to help folks, that's why I study econ).
I am afraid that is extremely difficult for investors to invest in a concept. Those that may be interested will certainly question the feasibility and how widespread the marketplace for such a drug. Very rarely will you find an investor who will invest in idea that seems incredibly ludicrous, unless however they themselves are insane. Most investors want just the vital numbers of a company, I suggest that you try to raise awareness as much as possible in a discreet way and try launch a kick-starter.

Just to keep everyone in the loop:

I guess the reason they were being so evasive about telling me the details of the sequencing results is that I'm actually heterozygous for the EYS variant. Combining that with the fact that my mother also has the same genotype despite not being affected, they're really up in arms over what's wrong now.

In parallel with that, I've possibly had some minor improvement since switching to methotrexate recently. Now the question is whether this may be related to npAIR after all. I'm seeing a neurologist tomorrow and I'm supposed to hear more back from the ophthalmologists later this week.

I'm not gonna lie: I'm pretty fucking pissed about all of this. These people have basically ruined my life over the last two years by doing their best not to treat something that may have been relatively fixable. Depending on how this plays out, I may try to seek damages and use that to fund the project. Nobody else should have to go through this and I would still like to produce a treatment for RP.

I just want to be transparent with everyone that I'm not trying to fake some kind of genetic disease for attention or financial benefit. We'll see what happens next with what they say.

>>9660252
the way it usually works in science is that someone spins a startup out of some lab work that accomplishes not much of anything, that then gets bought by a big biotech company

it's actually not as hard as you might think to get investors for biotech exactly for that reason.

>>9660411
is it known whether the EYS variant has full expressivity? if it doesn't, just because your mother didn't have the disease isn't a guarantee you won't get it either

having improvement on a different drug is a fuckre, though

>>9660419
You'd still have to establish a modem or so to be acquired (company or intellectual property). I do not know too much about this project but I am extremely curious about it and will continue to follow it.

>>9658871
Still reading a bit more about it. I want to be able to pose my question in the correct terms.

>>9660040
>>9660111
EYS is a photoreceptor-specific tissue repairing growth factor, so it has the potential to treat many causes of retina-associated blindness. These could include retinitis pigmentosa, stargardt's disease, AMD, posterior uveitis, diabetic retinopathy, retinal vein occlusion, etc.

Though at a bare minimum we should be able to treat RP25 which is caused by loss of EYS function.

>>9660252
>>9660419
>>9660434
Our plan is to crowdfund a small amount and demonstrate that it works in zebrafish. Once we have concrete proof that this isn't just some crackpot idea, the hope is that we'll be able to attract investors to fund preclinical and clinical development. We may also spin off some EYS research papers along the way for added credibility.

>>9660428
Normally RP25 is autosomal recessive, so I would need to two mutated copies in order to have the disease but I only have one. They knew about this from the start but they didn't tell me. One copy has a threonine->threonine substitution, but also a glycine->asparagine substitution, so I sort of wonder if that second mutation introduced an extra glycosylation site that's pissing off my immune system. I need more data.

Neither agrin nor EYS have any predicted interactions in PIPS. Perlecan has a couple. I've never trusted prediction protein/protein interaction databases though, they almost always rely on shit data sources. If you can pull together the money, I'd recommend contracting a company to do a yeast two hybrid screen for you.

If I get a break from grading in the next couple days I could try my hand at some comparative sequence analysis.

DNS is live. You can access the site at openeys.org, and the slack invite link is now slack.openeys.org. Also there's wiki.openeys.org.

>>9660502
We've tried doing some sequence analysis, but we're definitely not experts and we could really use some help. What we know so far is that it seem to be more closely related to perlecan than agrin. The first roughly 600 residues are homologous to notch signalling proteins, which is the same with perlecan and agrin. The rest of the protein seems to be involved in laminin binding and possibly angiogenesis modulation.

The primary interaction that we're concerned with is with membrane prominin-1 receptors that are specific to EYS, but it's also theorized to have interactions with laminin, collagen, and actin.

The first part of the protein is most definitely a growth factor, but I would really be curious to learn more about what exactly the rest of the protein does. Isoforms 2 and 4 contain just the notch-like region and are only 600 residues long, but isoforms 1 and 3 are over 3100 residues in length.

Holy shit, i feel like a brainlet now.

>>9659191
i can help, what are we looking to make?

>>9660737
Our main logo idea is to have an eye with a rainbow iris and an off-white sclera. Basically something like pic related, but with a radial iris and the background set to the alpha channel.

>>9660737
We need a logo for the main site (http://www.openeys.org/)), that can be adapted for use on either light or dark backgrounds. Some people in the previous thread floated a few ideas >>9625696 >>9627774

Also if we could trace over pic related to turn it into an SVG, it would go on the landing page as the second image.

>>9660737
Also if we could trace over the right half of this image to turn it into an SVG, it would go on the front page too.

>>9658785
>No, just extremely motivated.
how did you do that?

>>9661061
Here's a visual field from a little over a year ago. It hasn't exactly gotten better since then.

Day 40:

The website is looking really good and pretty much just needs some images at this point. Also making progress whipping the whitepaper into shape. I think we're on track to meet our Saturday deadline and launch the campaign next week.

>>9661324
How close is the whitepaper to being done? Percentage-wise.

This is pretty neat. I would even support a tip jar or crypto address if you follow through with efficacy and report back here. Its just a matter of supplies, people who who know what they're doing, and a lab. Crowd supported biomedical research is a cool angle.

>>9661358
same anon

do you have a boinc set up?

>>9661335
What percentage of tokens are held by the developers?

>>9661414
I was talking about the project whitepaper as in a detailed description on what it's all about (scientific principles that make it possible, etc.)

Link to the (unfinished) paper:
https://github.com/EyesOpenCure/EyesOpenProject/blob/master/Whitepaper.md

>>9658785
http://www.fredzone.org/chris-lhomme-qui-veut-soigner-lui-meme-sa-maladie-genetique-665

Just sayin

>>9661694
https://motherboard.vice.com/fr/article/8xk5jp/lhomme-qui-voulait-soigner-sa-maladie-genetique-dans-son-garage

Copypasta

>>9661694
This version is criminally abridged, makes it seem like the op will just make the protein and inject it directly into himself without any prior testing.

>>9660411
What a turn of events. I wish you all the best though. Maybe everything will end up working out in the end, you never know.

It's not a lot, but I can try making a few "laymans" info-graphics to explain this project but don't expect too much. I'm a nurse, so I've had to make stuff like this before. Maybe someone from /gd/ can fix it up.

>>9661414
kek, maybe OP could pull some ICO scam to fund his project

>>9658785
Huh, I was skeptical as soon as I saw this but it seems there is supporting data. I just checked some RNA-data on Ensembl and confirmed that human EYS is expressed highly in the in the fetal stage of eye development, not unlike Agrin in the paper you linked.

Problem is though that you want to use EYS for neural regeneration, not heart or skeletal tissue. Now, I'll have to check the heart tissue regeneration paper tomorrow to see exactly how agrin triggers regeneration, but if it is cell cycle re-entry, then EYS replacement might not work as you intend it to since neuroregeneration is notoriously difficult to trigger post-embryonically. If something does not develop correctly because of a missing morphogen (e. g. mutated EYS), it doesn't mean that injecting said morphogen after the damage has been done will make it any better, at least regarding nervous tissue. From a quick look at all of this, it seems to me you'll bump into the neuron regeneration obstacle before you get this working, which is kind of a dead end without adopting another approach. I'm not an expert at RP-25 though, so I could be wrong, I need to research this stuff more.

>>9658785
Huh, I was skeptical as soon as I saw this but it seems there is supporting data. I just checked some RNA-data on Ensembl and confirmed that human EYS is expressed highly in the in the fetal stage of eye development, not unlike Agrin in the paper you linked.

Problem is though that you want to use EYS for neural regeneration, not heart or skeletal tissue. Now, I'll have to check the heart tissue regeneration paper tomorrow to see exactly how agrin triggers regeneration, but if it is cell cycle re-entry, then EYS replacement might not work as you intend it to since neuroregeneration is notoriously difficult to trigger post-embryonically. If something does not develop correctly because of a missing morphogen (e. g. mutated EYS), it doesn't mean that injecting said morphogen after the damage has been done will make it any better, at least regarding nervous tissue. From a quick look at all of this, it seems to me you'll bump into the neuron regeneration obstacle before you get this working, which is kind of a dead end without adopting another approach. I'm not an expert at RP-25 though, so I could be wrong, I need to research this stuff more.

TL;DR This therapy could work to prevent further damage after the point in which it is administered, but is unlikely to heal back lost neural tissue and restore the original perfect vision without a bunch of neuroregeneration breakthroughs

>>9661335
>>9661606
It's hard to put an exact number on it, but I would say it's at least half way finished.

>>9661358
Thanks anon! We're looking to do a small crowdfunding round in the next couple weeks to pay for supplies.

>>9661366
Not currently, but that might be interesting. Were you thinking about running some protein folding simulations?


>>9661414
>>9663026
I'm not really interested in making money off of this. I only want to fund the bare minimum needed to pay for equipment and reagents.

>>9661694
>>9661707
>>9662220
I'm pretty disappointed with how that guy from Vice turned it into a tabloid-tier human interest story.
>literally INSANE 400 pound HACKER from 4CHAN injects himself with AIDS is his GARAGE and DIES!!!!!1111!!!one1eleven

>>9662405
Thanks, I would really appreciate it!

>>9663049
>>9663070
Retinas are weird, They're actually modified neural stem cell tissue. Part of the reason for this is that they're some of most metabolically active tissue in the body and they need to be able to continuously replace the parts that wear out. In healthy retinas, the outer segment of the photoreceptors gets continuously replaced with fresh membrane discs that contain phototransduction machinery, and the whole outer segment turns over about every 10 days. EYS seems to have a crucial role in regulating this process by stimulating fresh disc formation. For example, if you look at the sun and damage your eyes, you might start pumping out EYS to repair your photoreceptors.

So when will this fall through like every other project 4chan has started in recent years or lost control of like hyperloop?

>>9663112
fall through like every other project 4chan has started in recent years
didn't /lit/ get their 2 books published?

>>9663157
I don't ever go to lit so don't know. Besides, is that paper published or some electronic publishing that's easy to do?

>>9663160
there are paper versions as well as electronic

>>9663091
Thanks for the overview explanation on the retina. But correct me if I'm wrong, the discs can have turnover thanks to repair signalling molecules such as (possibly) EYS, but doesn't RP cause visual degeneration through photoreceptor cell death? If the whole photoreceptor dies during the progression of the disease, then it doesn't matter if you can pump the local environment with cell segment repairing molecules, since there will be less or no cells to repair anyway. Am I missing something?

Also, since EYS seems to be more highly expressed during fetal stages than adult, it's probably also involved in the development and proliferation of retinal cells themselves, a function that may not be possible to replicate in adults. We know that EYS mutations are associated with RP-25, but do we know if the photoreceptor cell death is the result of the loss of EYS' embryonic function or adult function?

>>9663112
>>9663157
>>9663160
>>9663167
I'm going to continue working on this regardless of what happens since I have retinal disease. Whether or not everyone else wants to come along for the ride is up to them.

>>9663244
RP eventually leads to photoreceptor cell death, but nobody really knows what the exact mechanism is. There seems to be correlation with the production of toxic reactive oxygen species, but RP is also caused by over 50 different genes, many of which are structural instead of enzymatic. The usual progression is outer segment atrophy, RPE damage, and then ONL death.

I first mentioned it over here >>9632678, but what I suspect may be happening is that RP-causing mutations may lead to a reduction in the efficiency of disc renewal, and as the discs naturally wear out from use they begin to emit toxic byproducts.

Mutations that cause RP seem to either happen in proteins involved in disc morphogenesis, or in proteins that can cause persistent photoreceptor polarization. The structural proteins obviously harm the formation of fresh discs, but constant polarization also prevents disc renewal because the renewal process is based on the circadian rhythm. This paper [1] goes over it pretty well.

This hypothesis can also help explain why RP has such a delayed age of onset. A modest reduction in disc renewal might eventually lead to a positive feedback loop, where slow disc replacement causes some to wear out, and these worn out discs cause spontaneous hyperpolarization, which in turn further slows down disc renewal.

Though really all of this is speculation until we back it up with some experimental data.

[1] https://www.sciencedirect.com/science/article/pii/S0014483583711322

Day 41:

Continuing to make progress on the whitepaper. Also doing some reading on RP epidemiology and the unit economics of all this.

>>9663091
Well i understand, but when the article popped up on my new's feed i couldn't trust my eyes, no pun intended.

Man i think it's very nice your idea can get some traction, and if i see your kickstarter or whatever i'd like to donate for the first time

in the meantime i wish you luck and to take this fight as far as you can

>>9664086
So you came from the Vice article?

>>9664086
Uh oh, how far is the clickbait spreading? I'm not familiar with the French media.

Also thanks, I appreciate it!

>>9664110
>>9664090
I regularly browse 4chan and more and more /sci/ lately because of the asperger. In the meantime i sow the "clickbait" article and found funny that the guy they talked about was actualy the 4chan cure blindness OP.

I am from the french part of switzerland btw, i wish i would had the willpower to concretize some project as you do

>>9664119
If you're talking about the VICE'S article it's not that bad, especially the edited second version. However, the second tabloid just posted a gutted version of the first article, which portrayed the project very inaccurately to say the least.

Bump

Bump

>>9664081
Did you get any response from that French geneticist?

Day 42:

Improvement on methotrexate is starting to get pretty noticeable. Someone brought up that all of this may be due to neurosarcoidosis, but it's going to take two months for them to run the tests to confirm.

>>9666090
I don't think he's going to respond.

>>9666592
Did you ask /gd/ to make the infographics already?

Do you think a guy who had congenital cataract and got his retina severally damaged as consequence of glaucoma, (which developed from a badly performed operation on the cataract) could possibly have any hope for a fix in the future? Dunno about how far your knowledge goes but fuck it here goes nothing.

Since this project is pretty much about "reconstructing" your eyes my idea for the logo would be that represents an eye that is shown to be reconstructed from one side, representing the proteins reconstructing your eyesight, you know what I mean? Posting a rough example of that concept.

>>9663091
i used to do subretinal microinjection back in my days at wilmer.

>>9667534
Not bad for a prototype, a radial rainbow iris would fit a bit better though, since it would mimic the actual structure of a human iris.

>>9667534
that looks like it's breaking apart

>>9667678
Maybe the fracture could be on the other side? People tend to view things from left to right so they would finish on the healthy-looking part.

>>9667678

It's weird, to me it would look breaking apart exactly if it was on the left side.

>>9667685
Rather some pattern that indicates, that the pieces are meant to be put together.
Let's say all those broken off parts had the shape of traditional puzzle-pieces, you would most likely think, that the parts are meant to go together and not meant to be disconnected.

Same would go for another shape.
As long as each little piece has the same shape and size, it would show, that the pieces are meant to be placed together, while differing sizes with varying shapes and hard angles would indicate that it's breaking apart in a chaotic way.

>>9667715
to add and continue

even simple geometric shapes, (square, hexagon) would be a good fit.
Let them come in from slightly above (rainlike), filling in the upper right edge of the eye or something, and it looks like they are "falling into place", completing the eye-shape.

>>9667721
Yeah, that could work.

>>9667721

Can do that too. WHat would you say would be the best shape? Triangles? Squares appear a bit boring to me.

>>9667741
Actual puzzle pieces would be ideal, but triangles could work as well.

>>9667746

That kind of concept looks pretty nice imho.


Fun Fact: The puzzle piece shapes in Photoshop DO NOT FIT TOGETHER with each other! Well done Adobe...

>>9667746

That kind of concept looks pretty nice imho.


Fun Fact: The puzzle piece shapes in Photoshop DO NOT FIT TOGETHER with each other! Well done Adobe...

>>9667534
>>9661010
>>9661015
>>9661018
>>9667643
A logo is not supposed to explain what something is, but act as a visual aid/representation of what that thing is for. In that regard, here is a logo i made just to spite that shitty off-white eye-thing. (reddish-off-white is hideous lets be honest here).

My idea is some white light coming into an eye (as a strand of dna), being fragmented into colours as it enters the eye. Thus representing the dna as the catalyst by which one see's colour/experiences the world visually. I made it in paint.net because i'm a poor-fag, its rather crude but i hope you can all see the aesthetic value in it.

>>9667534
i like your idea.

I hope this becomes a trend where open source cures become a thing because pharmaceuticals don't want to invest in new stuff. When pharmacies can print their own drugs, healthcare will drop like a fat kid in snow.

>>9668823
It might, if it's successful.

>>9667534
>>9668091
maybe less gay colours?

>>9668994
is the focus of this research even on restoring color vision?
I thought it had to do with general vision loss in parts of your field of view.

Having lots of colors and detail makes it hard for the logo to be identifiable on smaller scale.
The simpler, the better imo.

>>9669000
see here kids, this is why actually smart people work in advertising and make bank, while you draw shitty pics in paint on a site for the mentally ill

I may need to take a short term hiatus while I get this other health stuff figured out. I'll let you guys know what happens, especially if there's some kind of settlement that I can use to fund this project.

>>9669032
Take your time.
Hope everything with neuro/ophthalmology goes well.
Bump.

>>9669009
>>9669000
Here's an idea: Half an Eye, on a black background. Other half is a simple piece of a double helix. All in white.

KISS is the law of good graphic design, also good contrast. None of that gay-ass pink or rainbow-iris bullshit.

>>9669791
That could work.

>>9667534
Maybe less masonic symbol?

>>9670784
>implying conspiracy theorists will fund genetic engineering projects

>>9670314
now we just need someone to make it.
Going to /gd/ now.

bump

Are you a researcher op?
My aunt suffer from this disease so godspeed to you

>>9668241
>reddish-off-white
I believe the technical term is "pink".
Also, I mistook the DNA for a needle.

>>9672843
Yeah, it does kind of look like a needle, but that anon said that this is just a prototype made in MS paint.

I work as a computational biologist and would like to help out. I’m not sure if my skillset would be useful though, my work is primarily in the field of drug discovery where I do things like run simulations to see if a drug binds to a particular target for instance. It seems like you guys want are going to be working in vivo however.

>>9673678
Well, there's a task involving pharmacokinetics on the wiki (https://github.com/EyesOpenCure/EyesOpenProject/wiki/List-of-Open-and-Ongoing-Tasks)), but it doesn't have an article on it yet.

My mom has two cochlear implants. She was completely deaf (it was a progressive thing) but now she can hear as good as anyone else. And now she's a cyborg which is cool.

Just wanted to share that. Medical science always has an answer. Sometimes you just gotta look really hard for it.

>>9672828
He is, but his field is mechanical engineering and applied math, not biology.

>>9658785
>Are you insane?
The correct answer is yes; foolish normalfag.

Bump

free bump

>>9674953
Let's hope this will be the case for OP. Wonder how the other health stuff is going for him.

borp

>>9658785
bump

>>9680445
>>9679720
>>9677939
>>9677541
stop bumping and contribute please.

>>9681056
For now most of us are waiting for op. I mean we already have some ideas for a logo, all that's missing is his confirmation. Also, the
sequence comparison data should be reviewed before anyone can proceed further.

>>9681056
bump

So, when the crowdfunding campaign goes up, what would be your ideas for promotion? I mean we'll obviously mostly target laypeople, but should we make potentiall investors aware of the project early on or later into the campaign?

Also, bump. Wonder how long until OP returns

>>9683878
>should we make potentiall investors aware of the project early on or later into the campaign?
later, that way investors will feel safer knowing the project was successful up to that point.

bump
>>>/sci/thread/9554648

>>9678179
>Wonder how the other health stuff is going for him.
Not well by the looks of it >>>/biz/8995866

>>9685451
I somewhat doubt that's him since the whole essay didn't mention anything about the project or the EYS protein. Though these stories are eerily similar so it could still be him or maybe another sufferer of rp, coincidences do happen.

>>9685451
Definitely not him.

>>9685792
>>9685539
It's OP

Just read the /sci/ thread and then check >>9660411

>>9685871
Ok then, by the looks of it he's pretty mad.

bump

>>9675906
anime is a sin

bump

>>9685871
Yeah you're right, OP probably doesn't have RP25, I guess the project is dead in the water now.

To be fair though, even if everything had worked perfectly and EYS replacement actually protected photoreceptor cells from dying in patients with RP25, it wouldn't be able to replenish lost eyesight or cure already existing blindness because it couldn't regenerate retinal cells, so it's not like OP or many people missed their chance. It was a long shot to begin with.

>>9689931
WTF are you on about?

>>9690185
Specifically? There's nothing confusing about the post I think. OP's motivation to start this project stemmed from him being diagnosed with RP25. But the diagnosis was wrong and he can get better with autoimmune treatments, he no longer has the motivation to keep this going. But even if he did, the project wouldn't cure blindness, it would just prevent it from getting worse for him and other people if everything worked as he wanted it to. What confuses you?

>>9658785
https://en.wikipedia.org/wiki/Coluracetam
This too

>>9690892
Well that's disappointing :^(

>>9690892
Curing RP would still be something even if it wouldn't reverse damages.

OP should just post his official update here to clarify things. Even if he'll end up confirming our fears, we would understand, besides, the whole thing looked and still looks promising so someone could pick it up.

>>9691642
This.

>>9691642
Indeed it would be great, my point was that it wasn't what OP wanted in the first place, because he already had significant vision loss IIRC, so the cure wouldn't help him that much assuming it all worked as he wanted it to and in time to be of use to him. I think he misunderstood what he was shooting for with this project.

Other than that I agree with what you said.

>>9685451
Shit. Some of the symptoms OP is describing sound like what I have.
Unfortunately, if OPs issue is neurology related, it's gonna be a more complicated affair. You don't want to mess with the brain.

page 10 bump
just in case

Bump, good luck OP

I'd help but all I can do atm is basic bioinformatics and and biochem lab techniques

Sorry for disappearing. Still trying to get stuff figured out and waiting on an EMG study.

>>9696018
Godspeed anon

>>9696018
is it true that you gave up on the project?

>>9696849
No, but I also need to get my health stabilized and secure a more reliable source of income. I should have a much clearer picture by early next week.

bump

Bump.
Finals are over at my uni, so maybe I can start working on helping out a bit. Good to hear the project isn't being abandoned.

>>9697510
So I presume that a review of the results we already have has been postponed?>>9699933

>>9658785
Bump.

bump

Important Update:

I fast tracked the testing and used a salve to place the EYS over my cornea to allow passive diffusion through to the retina. I assumed this would have little effect but be safe due to immune complexes being able to neutralize it if needed. However i definitely experienced an improvement on vision over the next few hours, i could see Jamarcis' nubian form better than ever before. I was able to grip his shaft with no fumbling and guide it towards my mouth without accidently jabbing my face for the first time, which normally enrages him and can result in a beating. Anyway suffice to say i pleasured him to completion (didn't need eyesight for that part!) and swallowed thereby confirming no glossopharyngeal damage from the treatment. I'll be repeating the experiment several times to be sure but this time I'll start a thread on /gif/ with my experimental video diaries.

>>9703494
fake news

>>9675906
fag
>>>/pol/

>>9658785
How in the fuck is 4chan actually getting engaged in scientific research
Interesting

>>9704732
anything is possible when you have literally nothing else to do.

Also historically 4chan has always been free-market advocacy, if you care about something then you contribute, otherwise just sage.

bump

>>9705735
When ML comes into play, I'd probably be interested
or just backend dev

>>9708343
Why don't you have a look at the open problems and see if you can solve it with ML? fucking script kiddie

bump

bump

>>9685451
>>/biz/thread/8995866
>I know it sounds like I'm exaggerating all of this, because there's no way that medical care could be so terrible, but I'm not. I still don't understand how this could have gone so badly.
I had lymphoma some years ago, and spent a lot of time between hospitals and shit. you wouldn't believe the stuff I saw...
also, props to your mom. mine did a LOT of things for me, suffered a lot and helped me all the time. without her, I'd probably have killed myself or simply had let cancer kill me. and yeah, some doctors, nurses, secretaries, etc. don't give a shit unless you push them to do their fucking job.
though, in the end, I'm really grateful for them. the 1st doctors that saw me spotted my illness immediately, and the hemato/oncologist was great.

also
>that whole thread
fucking hell, no matter how serious the topic is, /biz/ is always manages to make it funny

wish you the best luck, OP. I hope they manage to find what causes your health issues and you recover well. I know how horrible medical-related things are (plus I've always hated hospitals, they make me paranoid), and I've seen people live worse stuff than me. it sucks.

>>9669009
>smart people work in advertising and make bank
do you have some data on this? marketing people are usually not the smartest ones, or the ones that make bank... their employers are

>Cure blindness

Just wear glasses

>>9703494
It would be better to start a thread on work safe gif instead of gif.

>>9712891
I'm sure the other wageslaves of /wsg would be thrilled to learn new tricks, yes.

>>9697510
Get well!

bump

bump

bump

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>>9658785
Pretty interesting thread. Thanks for a great read. Really hope this goes somewhere

keeping this bumped

>>9659577
Why? Did you even get the context?

>>9720423
Designing the logo is an old /g/ meme.

What blindness are you trying to cure, a problem with the eyes or a problem with the brain? If eyes, what part is not working? If brain, same question. There's A LOT that could go wrong with eyesight, are you trying to cure them all?

>>9721750
read the thread

>>9658785
How would you go about fixing a lazy eye.

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