/sci/ - Science & Math

Anyone know what the following receptors do:
>NORADRENALIN
Antagonism: α2, α2A, α2B, α2C, β3

>HISTAMINE
Antagonism: H4

>ACETYLCHOLINE
Agonism: asyt T

>NICOTINE
Agonism: α3, α5, β4, δ, ε, α2β2, α3β2 ,α4β4 ,α2β4 ,α6β4 ,α6β2, α6β3β4α5, α3β4
Antagonsim: α6, α7, α4β2, α2β2, α3β2, α4β4, α2β4, α6β4, α6β2, α6β3β4α5

>NMDA
Agonism: NMDA, channel (eg, MK-801)
Antagonism: NR2A

>METABOTROPIC GLUTAMATE RECEPTOR
Agonism: mGluR1, mGluR1a
Antagonism: mGluR4, mGluR7, mGluR8

>IONOTROPIC GLUTAMATE RECEPTOR / KAINATE
Agonism: GluR5, GluR6
Antagonism: mGluR4, mGluR7, mGluR8

>GABA
Agonism: α5, α6, β1, α-ρ1, γ1, γ2, δ, ε, θ
Antagonism: α1, α2, α3, α6, β1, β2, β3, α-ρ1, α-ρ2, α-ρ3, γ1, ε, θ, π

>OPIOID
Agonism: NOR ORL1, NOP
Antagonism: DOR δ1, DOR δ2, NOR, NOR ORL1, ZOR

>TRACE AMINE RECEPTORS
Antagonism: TAAR1

>ADENOSINE
Agonism: A2A
Antagonsim: A3

>cAMP
Antagonism

>PDE
Agonism: 1, 2, 3, 4, 5, 6, 7, 9

>OXYTOCIN
Antagonism

>VASOPRESSIN
Antagonism: 2

>ESTROGEN RECEPTOR
Antagonsim: ERα, GPER

>ESTROGEN-RELATED
Agonism: ERRα, ERRβ
Antagonism: ERRγ

>MEMBRANE ESTROGEN
Antagonism&Agonism: Gq-mER, Erx, ER-X

>ANDROGEN
Antagonism: AR

>PROGESTERONE
Agonism: PR-C
Antagonism&Agonism: mPRγ, mPRδ, mPRα, mPRβ, mPRϵ, AdipoR1, AdipoR2

>CANNABINOID
Antagonism: CB1, CB2, NAGly, GPR119

>NEUROPEPTIDE Y RECEPTOR
Agonism: Y1, Y2, Y4, Y5
Antagonism: Y4

>PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Antagonism: PPAR-γ

>MELANOCORTIN
Agonism: MC3R, MC5R
Antagonism: MC2R

>ZINK RECEPTOR
Antagonism: GRP39

>HISTOMASE DEACETYLASE
Agonism: HDAC1, HDAC2, HDAC3, HDAC8, HDAC9
Antagonism: HDAC1, HDAC8, HDAC9

>COX
Antagonism and Agonism: COX-1
Agonism: COX-2

>NEUROTENSILIN
Agonism: NTS1, NTS2

>ANGLOTENSIN II
Agonism&Antagonism: AT3
Antagonism: AT2, AT4

>>14658357
>SODIUM
Agonism: Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.8, Nav1.9

>POTASSIUM CHANNELS
Agonism: Kv7.1, Kv7.2
Antagonism: K2P2.1

>GPCR KINASE
Agonism: GRK6

>RETINOID
Agonism: RAR-alpha 1, 2, 3

>NUCLEAR RECEPTOR
Antagonism: NCOR2

>NEUROKININ
Agonism: TACR2, TACR3

>ORPHAN
Antagonism: GPR35

PLS LET ME KNOW SO I KNOW WHICH OF THE RECEPTORS I SHOULD TEST MY RATS ON. Couldn't find data on any of these in the literature

>>14658352
Overprescribing antibiotics is NOT the major cause of antibiotic resistance. The most important cause is poverty and corruption in thirdie countries. In first-world countries the most important cause is slamming every neutropenic metastatic cancer cunt 6 inches from death with meropenem/Tazosyn/aztreonam etc.

>anon comes in with MRSA cellulitis
>give him a lethal dose of morphine

>>14658352

Not a /med/ person but

>Fellas be honest did you ever prescribe antibiotics for the flu because of patient request?

My boss always argued that if you weren't on a prescription, you weren't sick enough to be off work. Ergo every time I had the flu I had to beg for antibiotics. Or come to work and spread it.

Yes it's bullshit.

How does an HT2A&HT2C agonist like 2C-D cause cognitive enhancement? https://erowid.org/chemicals/2cd/2cd_smartpills1.shtml

Is punching through plate glass like this a death sentence?

again: >>14654613

>>14658560
He would've been fine if he hadn't weighted his punch like that. You can see the moment he slams his arm into the bottom of the window where a shard was. It went deep too, right on the brachial artery. If it's not a death sentence it's a possible loss of his arm.

>>14658819
Nice lol. Fuck that drunkie faggot.

>>14658451
>overprescribing antibiotics is not the major cause
>it's actually overprescribing of antibiotics on cancer patients!

>>14658352
Is circumcision good or bad?
Auntie wants to snip my cousin.

>>14660636
Are you kidding me? It's mutilation. Unless this cousin of yours has some serious phimosis or another diagnosis dont let her snip him

>>14660636
jewish tradition
people nowadays are staying away from it

>>14660636
Why do so many Americans mutilate their children?

>>14660636
nevermind the fact that it's mutilation, makes you need lube, reduces sensitivity, procedure is so painful it rewires your brain, etc
The rate of complications is not insignificant, pretty often the penis can gain a curvature due to scar tissue formation, but some boys lose their dicks entirely after the procedure as it can lead to a serious infection. Botched circumcisions are a thing.

>>14660962
>makes you need lube
Uhhhh, that's just you troon fag with a smelly hole between your skinny soii legs.

>>14660966
projecting much, huh? The keratinization that occurs in the penis after circumcision makes it dry out like a an old piece of gum. Sex (or mastubartion) is never the same afterwards. Lube somewhat alleviates some of this.

>>14658485
thanks doc

>>14660978
>his dock and balls aren't sweaty enough to be lubed that way
Shame

does braindeath mean that the entire brain is irreversibly dead or does it mean that only the neocortex is dead?
a person can maintain life if their brain stem, thalamus and midbrain are still alive while their neocrotex is dead but they would have the same cognitive function as a potato

>>14661427
according to ((google)) you need to qualify certain criteria for being ""brain dead"" which includes
- unresponsiveness
- reflex absence
- inability to breath without a ventilator

if your brain stem is alive then you would 100% respond to mee peeing on your eyeball which would be a reflex performed by your brain stem even if you are in a coma hence you are not brain dead

>>14658352
You doctors are criminal scum and should be rounded up and shot in the future.

A new study published by researchers at the Seattle Children’s Hospital found that heart abnormalities were detected in some adolescents, months after receiving the COVID-19 vaccine.

Specifically, these researchers were reviewing the cases of children who came into their hospital within a week of getting their second dose of the Pfizer vaccine.

https://www.jpeds.com/article/S0022-3476(22)00282-7/fulltext#%20

https://www.theepochtimes.com/post-vaccination-heart-issues-detected-months-after-covid-19-vaccination-study_4364565.html

https://www.youtube.com/watch?v=D32vE0-cmoc

Safe and effective®

>>14661903
Man I love waking up every day and seeing the daily big pharma cash bag next to my bed. Living the dream

The schizos are back at it i guess

Anyone have a good neat and tidy explanation for the physiological purpose behind the presence of mu-opioid receptors in the chemotrigger zone and in the GI tract? I can understand the role for endogenous opioids as a negative regulator synthesized at the same time as sympathetic activation (hence activity of CRH enhances synthesis of enkephalins/beta-endorphin) and hence why there is pain modulation, respiratory depression and sedation. But I don't understand how this physiological function explains why there are mu-opioid receptors in the medullary chemotrigger zone that would cause nausea/vomiting and why they cause decrease in GI motility (if anything, since sympathetic activity by itself decreases GI motility, it is a wonder why opioids contribute), similarly opioids cause urinary retention, which is also synergistic with sympathetic activation.

Just wondering if there is a neat teleological explanation that would fit why opioids act endogenously the way they do.

Anesthesia really makes me just resent fat people. I'm thinking of switching to internal medicine, at least I can be like, you are fucking fat, here, take some pills so your piece of shit body can function.

Did you get your 4th booster yet?

>>14662994
t. angry white trash poltard loser who likes to look down on people with different lifestyles and habits

>>14661992
>Man I love waking up every day and seeing the daily big pharma cash bag next to my bed. Living the dream

Growing up mom and dad had a friend of the family, a "drug dealer" they called him.

Every few months we got a post card from some exotic tropical location where he was conducting "seminars" on behalf of a pharmaceutical company, for doctors.

They cant give you a bag of money, but they CAN hold an all expenses paid trip to a tropical lolcation to teach you about a new wonderdrug!

Also, it's not even illegal for physicians to hold stock in het companies they prescribe, it's total lulz, 100% corruption.

Physicians should have to invest through a blind trust.

MY LASTEST MESSAGE TO THE /MED/ GENERAL
>MY LASTEST MESSAGE TO THE /MED/ GENERAL
MY LASTEST MESSAGE TO THE /MED/ GENERAL
>MY LASTEST MESSAGE TO THE /MED/ GENERAL

https://vocaroo.com/1L9wgY6kb0Ms
https://vocaroo.com/1L9wgY6kb0Ms
https://vocaroo.com/1L9wgY6kb0Ms
https://vocaroo.com/1L9wgY6kb0Ms
https://vocaroo.com/1L9wgY6kb0Ms

>>14663133
haha lardass

>>14663150
you have a literal speech impediment.

>>14663150
>the schizo impregnated his sister three times and developed early-on-set Alzheimers from meth abuse
makes sense. Stop posting, Pax.

>>14663229
>>14663234
The vaccine will impair your speech, soientists scrubs.
Repent before it's too late. I know you have a big arrogant ego but it's never too late.
Pray to God and Jesus for help.

>>14663150
you should definitely visit a psychiatrist. You keep on losing words.
>>14663330
you aren't even better. Go on and try to define "arymanique". Steiner just makes up words, that's not indicative of a high verbal iq.

>>14663370

>get sunburn on back two weeks ago
>it's completely healed now
>just noticed I had small colorless pimples that appeared on my back, kind of similar to molluscum pendulum (I can't pop them, I have to tear them off) but smaller
>they weren't there before but I can't find anything on the internet about UV exposure causing something like this
Does someone know what this could be and if it's permanent?
Yeah I know don't ask for advice and all but there's a six month long waiting list to see a dermatologist in this shithole so I'll ask here in the meantime

>>14664124
mollusca contagiosa. you have aids

>YOU WILL TAKE THE ANTIPSYCHOTIC
>YOU WILL STOP HEARING VOICES
>YOU WILL BE DISCHARGED FROM THE PSYCH WARD

>>14662970
>teleological explanations
ngmi

>>14664172
typical good doc bad doc routine. this guy got owned

>>14664191
They can be good memory and teaching aids, e.g. fight or flight for sympathetic activity, mast cells/histamine/IgE and presence in the GI tract/skin/bronchi as an anti-parasitic mechanism, hypoxic pulmonary vasoconstriction to resolve V/Q mismatching etc. etc. and biological explanation is incomplete without teleological explanation. It just seems kind of random why opioids act the way they do.

>>14658352
https://www.youtube.com/watch?v=tMsvnzwtBqI
why is this guy the best youtube med guy. been watching him for a while since i am BALDING. but his videos are pretty good

>>14664145
No, I don't

is the phenomenon of "brain zaps" with respect to antidepressant discontinuation understood meaningfully?
i quit taking lexapro about four days ago, and i can reliably induce a shocking sensation with lateral eye movement. it feels as if the sensation is centered in a region just in front of my ears, and roughly forms a triangle region between the crown of my head and my temples. it exists behind my eyes, so it's a pretty narrow range of space.
it only happens when i move my eyes laterally, further than about 45 degrees from the center of my FOV. that is, outside of the central 90 degrees of my vision. it doesn't happen with any up and down movement, and it happens with saccades, smooth pursuit, and with vestibulo-ocular movements (eyes closed).
it's not painful. it's somewhat similar to the feeling of a brain freeze in level of discomfort. it lasts a fraction of a second, maybe 200 ms or so. there's an audible "hiss" during the sensation, not too dissimilar to the sound of muscles tensing. i wouldn't call it painful, but it's distinctly unlike any other sort of feeling i've had before. i struggle to compare it to anything.

one would assume that it's related to depleted serotonin in the brain. but, why is it linked to vision? specifically, eye movement?

>>14663370

>>14658512
Should've gotten Tamiflu homie or ask the doc to write you a bs prescription for something that's otc

>>14659165
I never see ID/pharmacy say anything about those cancer patients, besides when people say overprescribing they use it to shit on GPs prescribing Amoxil for a coof

>>14663133
>t. fat cope
You should and you are ashamed at yourself.

why does every clinic fag wear these shoes?

Newest NRMP is out for medschoolfags
https://www.nrmp.org/wp-content/uploads/2022/07/Charting-Outcomes-MD-Seniors-2022_Final.pdf

I feel somthing ar the end of my recutm
It feels like somthing coming out
Is it cancer ?
>inb4 see a doctor
I'm too shy and poor, I can't afford treatment anyway
I just want the cold truth
How likely is it to be somthing serious?
I'm in my early 20s, 60kg, 180cm
Is there any practices i should do or stop doing or certain foods?

>>14668082
Forgot to add, male. If that matters.
I don't take any drugs(medicine or crack) too.
I don't smoke or drink
I drink very little water due to being poor, sometimes I go days without drinking anything.

>>14658352
Imagine being a doctor nowadays lol. You fucks should all kill yourselves.

>>14668082
>>14668090
The feeling disappeared
Thank God
I have to say this wasn't the first time, but it was more intense than the past
What could the condition be?

>>14661865
google didn't give me a conclusive answer
>if your brain stem is alive then you would 100% respond to mee peeing on your eyeball which would be a reflex performed by your brain stem even if you are in a coma hence you are not brain dead
so in theory a person can stay under care in a hospital for decades just because their stem still works? i guess scenarios where only the neocortex is irreversibly dead are rare

>>14658352
How does it feel to be hated by most people for your crimes?

>>14668318
use quantum rife, binural beats, bioresonance, qi rife, ascension codes, anti archon, dr7 virtual, et. al

rob a store invoke the name of Jesus Christ Emmanuel and all Ascended True Gods

fuck the feds, screw archons and demiurge

>>14668689
>fuck the feds, screw archons and demiurge
Fucking based. We're gonna make it

>>14660636
Bad anon. Stop your cousin from bring mutilated forever.

>>14660636
Get that whore under control before it is too late, genital mutilation is not funny. Show her social media posts from men who want their foreskin back and are bitter about it.

It is often said that drinking a lot of water is healthy, but to me drinking it is uncomfortable and when I drink more than a little my head hurts.

>>14660952
so they're less likely to fall into fap/porn addiction

Why do doctors prescribe drugs rather than looking for environmental or lifestyle causes?

>>14669336
because patients usually arent looking for livestyle advice
you always say to the dm2 patient that they need to excercise more and eat healthier but theyre just not gonna do it, otherwise they wouldnt end up with dm2

>>14663150
the state of /med/ anons

>>14663150
>let me just schizobabble about myself for 50 minutes (!) and post it to /med/
meds

>>14663150
As a dentist, you should definitely consider going to one

>>14664858
see >>14663150
this is literally you

https://www.medrxiv.org/content/10.1101/2021.05.03.21256520v1
The mRNA-based BNT162b2 vaccine from Pfizer/BioNTech was the first registered COVID-19 vaccine and has been shown to be up to 95% effective in preventing SARS-CoV-2 infections. Little is known about the broad effects of the new class of mRNA vaccines especially whether they have combined effects on innate and adaptive immune responses
Here we confirmed that BNT162b2 vaccination of healthy individuals induced effective humoral and cellular immunity against several SARS-CoV-2 variants. Interestingly however the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal &bacterial) stimuli. The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination while fungi-induced cytokine responses were stronger. In conclusion the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses which should be considered in the development and use of this new class of vaccines.

In other words, the immune system becomes depressed against viruses and bacteria and intensifies against fungi. Plus, once you create an adaptive immune response, the body tends to rely on it over innate immunity. So, for example, when a person who is vaccinated encounters a current variant, their immune system will respond with antibodies generated from the original Wuhan strain. Unfortunately these are not a good match. So the immune system will pump out a bunch of antibodies that fail to bind properly to the virus while suppressing IgM and killer T cells. This will allow the virus to continue replicating

Take deferoxamine instead to combat COVID
COVID through endolysosomal deacidification causes iron disbiosys within the brain via release of hepcidin through downregulation of FPN1 and upregulation of DMT1. Iron-induced ROS is responsible for COVID brain damage

>>14669445
Surely giving them drugs is the worse thing you can do for something that could trivially be solved with lifestyle changes? I'm not ignorant to how hard things can be to change, but its always better long term and drugs can only make it worse.

>>14669559
doing lifestyle is better than drugs
doing drugs is better than doing nothing
and as I've said before, patients dont want to or are able to change their lifestyles (often)

>>14663150
>>14663330
vaxcattle will never get it

>>14669336
>*ahem*
>stop being unhealthy
>thank you

how about that. just solved most diseases.

>>14669336
you have never talked to a patient

>>14669579
this

>>14658352
I'm in my last year of med school and I still feel that I don't know shit, so many things I studied I forgot. My question is:

Do you think I can study/restudy Anatomy, Physiology, Biochemistry, Pharmacology, Pathology, Microbiology, Obstetrics and Gynecology, Paediatrics, Surgery, in just 5 months, if I study a minimum of 6-7 hours a day? I'll use nearly every resource at my disposal, textbooks, online questiom banks, video lectures, etc.

I had surgery on the 11th for a left leg osteochondroma removal. Doc said I would be walking same day and back to squatting in 3~ weeks. It’s been almost a week and I still can’t walk normal (I’m just swinging my leg around) and walking hurts a lot. Like I can’t walk for more than 5 minutes without the pin becoming unbearable. I have a follow up on the 28th. Is there any point in me trying to see a doctor before then ? Or is this just normal

>>14666549
a lot of personnel I've seen wear sketchers. I'm guessing the main reason is comfort

>>14658451
>In first-world countries the most important cause is slamming every neutropenic metastatic cancer cunt 6 inches from death with meropenem/Tazosyn/aztreonam etc.
i lol'd aint finna lie frfr
but what's the alternative no cap

>>14670183
i dont think the studying ever ends

>>14669579
>be me
>stand in a job for 7 hours straight
>no sitting down
>I maybe sit down in break for 2 hours
>Stand for another 4 hours
>Every day for 5 and a half years
I never would have thought I'd get a varicose vein before 30 but I can tell you that'll do it. Is their any hope now I'm off that nightmare my valve will repair? I don't want to feel like a mug anymore...
After

>>14658352
In your medical opinion, which is a better suicide method
>Helium exit bag
>Lots of ketamine from a vet + lots of alcohol

>>14671651
>has a ketamine connect
>conemplates suicide
how about you get high a few times

>>14669719
This world would be better off without scientists and doctors like you.

>>14658352

Hey anons, if you want some useful insight into Hospital politics, I recommend this episode of Star Trek: Voyager. Season 7 ep 5 'Critical Care'.

Amazing episode that I'm sure will help you better understand how to navigate the social environment in a hospital.

>>14669336

Because you cannot charge patients for lifestyle changes.

>>14671948
your parents will never be proud of you and you are not the stoic genius freethinker you think of yourself

>>14671954
>tv show for homosexual mouth-breathing redditors
no thanks

So lads, given the probability of population collapse, are we going to initiate operation boomer remover?

>>14672152
Not an argument child murderer.
Once you end up in Hell, repent, pray to God and Jesus and you will be saved.

>>14669559
>Surely giving them drugs is the worse thing you can do
dumb faggot patientoid wants his fellow patientoids to go blind and die 20 years early because he doesn't like pills

>>14670183
Yes I have about 3 months to finals as well and have been diligently revising my anatomy, physiology and pathology. It's a lot easier going through it now, you underestimate how much you actually know and how much you've learnt in the past few years that when you revisit it, it comes back very quickly and you can even gain new insights and modes of understanding.

It's also a lot nicer to now have tonnes of understanding and examples regarding the actual clinical utility of all the knowledge. For example just last night I was revising pelvic floor anatomy and things just were so much easier now that I've already done O&G and surgery rotations, you can think of a lot more clinical applicability to topics. Same for respiratory physiology after a crit care/anesthetics rotation and many other topics.

In my opinion anatomy/physiology and pathology are the most important topics to revise in terms of preclinical sciences as they are the foundation of and will strength your clinical knowledge.

>>14660636
a good figure to point out to her is the percentage of men who get circumcised after they're 18, when they can choose for themselves, and are presumably the most concerned with their dicks: less than 1% of uncut boys choose to get circumcised when they are men. I'm glad I still have all of my dick.

>>14660966
you are retarded
circumcision can vary in tightness, if you got unlucky and got circumcised really tight, masturbation without lube is basically impossible

>>14672303
Oy vey

>>14669559
>>14669567
Pretty much, the people that cared about their health, don't end up with shit that's easily treatable through lifestyle choices, and the people that didn't more often than not aren't going to turn their life around now that they have an acute condition on top of their shitty habbits. Elevating the dregs of humanity isn't a task that the medical system can accomplish, best we can do is barely provide a safety net so they don't kick the bucket immediatly.

>>14658352
My semen has been green tinted for a few weeks now and it very faintly hurts near my dick. Went to the doc and he told me to just take some pain killers if need be then sent me home in the next minute.

Should I be worried or what and should I change my doctors? I'm in Sweden and this guy was a foreigner from Turkey.

>>14672934
see a proper andrologist please

>>14672934
beast boy is that you?

is it normal having to cut cysts out of your nutsack several times every year?

>>14673926
obviously

I have a recurring problem where for periods that last around 1 week, and occur around once a month, I get really horny at night and it affects my sleep. beating off doesn't help and by the time i've done it it's already later and then my boner is back and I still can't sleep. i dont want to talk to my real doc about it

>>14673926
Those are your testicles, but yes it is normal, they grow back quickly. It's the people who are too afraid to that end up with old testicles that develop cancer

Started sertraline (Zoloft) today for persistent depression I've had for 15 years. Never been on SSRIs before, what am I in for lads? Is it true I'll want to kill myself for a couple of weeks then get better?
Also can't find trustworthy numbers for sexual dysfunction or weight gain. What are the actual numbers docs?

>>14658352
Maybe you fucks can answer this.

How do you take arterial blood samples from newborns in the first try? I never hit the artery and have trouble looking for it even when i'm feeling it. Once the needle is inside i feel everything is 3D space and there's no way i can pinpoint the shit, how deep should I go? If i miss it how do I angle the shit to find it? I have no point of reference other than my imprecise fingers which move in the gelatinous texture of the kids's moving arm.

>doing radiology rotation
>all these stupid-named "signs" for fractures and shit
>scottie dog
>winking owl
>inverted napoleon hat
>thumbprint
I had enough with McBurney, murphy, and the others. When will it stop?

So I often start sobbing uncontrollably when I laugh very hard
Googling why this happens has given me two hypotheses
The first is that the act of laughing causes the tear ducts to be stimulated which leads to tears being produced, presumably then the production of tears leads to the sobbing
The second is that an intense experience of emotion brings up suppressed emotions which boils over causing me to experience sobbing without conscious sadness
Now the 1st explanation seems the most likely but the second part of it is making me a bit sceptical
Do we have any cases of bodily phenomena which are usually caused by a certain mental/bodily state which the stimulation of that bodily phenomena can cause the mental/bodily state to occur?

Can pretty high prolactin levels disregulate apetite?

>>14671672
But anon, anesthesiologists are some of the most suicidal specs