/sci/ - Science & Math

>>14518576
no

no one here is qualified to answer

>>14518899
No one here is qualified to make that statement in the first place then.

>>14518576
The joke is exercise. Exercise mitigates all of these things. He posted a laundry list of things exercise prevents or improves.

If he's just high on his own farts, though, researchers have been tossing drug trials at these problems since always. There are whole companies with researchers, computer automated systems for synthesizing new compounds, on and on it goes. As he mentions zero details about this "drug", he's fulla shite. OR it's a joke and the punchline is "exercise fatty".

>>14518901
/pol/ is, /sci/ isn't

>>14518914
LOL, delusional

>>14518914
/pol/ would be hard-pressed to understand how a vaccine even works in the first place

>>14518914
Holy kek

>>14518914
>They hated him because he spoke the truth.
If I could choose the scientists! (not the dimwits) on /pol/ vs those on /sci/, the latter would fuck /sci/ larpers back to the stone age.

Take for example this faggot shill here >>14518941.

>>14520199
That faggot shill is a sub 90IQ big pharma worker or tranny astroturfing the board.

>>14518914
Um yeah, I'm thinking based.

>>14518576
It's me anon.
In that post I aptly described they hypothalmic inflammation model of metabolic disorder.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199695/
In short inflammation in the periphery and within the brain leads to defects in mitochondrial function and cell viability through reducing insulin transport to the brain from the periphery by promoting inflammation in a population of cells within the cerebellum that are responsible for promoting insulin uptake into the brain. saturated fats, and endotoxins reduce neuronal insulin sensitivity making brain cells degrade and this is especially true in the hypothalamus which participates in controlling most endocrine functions in the body. Declines in neuronal insulin sensitivity reduces hypothalmic metabolism of neurosteroids like pregnenolone from cholesterol and this allows cholesterol, and ceramides to accumulate in the lipid rafts of our neurons, endothelial cells and organs.
https://pubmed.ncbi.nlm.nih.gov/35108514/
Metabolic disorder and neurological disorders are both tied to the decline of insulin sensitivity and that reduces the viability of gabaergic cells such as somatostatin interneurons.
https://pubmed.ncbi.nlm.nih.gov/34430981/
Declines of these interneuron populations leads to decline of sensory encoding as well as control of metabolic functions controlled by somatostatin and leads to the disinhibition of insulin release in the periphery sensitization of autoimmunity due to reduced tolerance to inflammation and creating a hyperactive environment for your immune cells to be activated which attack your joints, promote calcification of your arteries and promotion of atherosclerosis. Inflammation in the periphery and in the brain from cortisol or endotoxins increases glutamate release which increases the production of the neurosteroid allopregnanolone which increases gabaergic tone and reduces surface expression of gaba a receptors promoting hpta axis dysfunction through chronic mild stress.

>>14518906
>As he mentions zero details about this "drug", he's fulla shite. OR it's a joke and the punchline is "exercise fatty".

It's no joke anon. I'm financing the development of a drug and there's a reason why I didn't mention details about the drug beyond those 2 posts. I was answering to someone who'd asked about the prospect of immortality and I wanted to grab their attention. It had worked and I had gotten recognized by an anon that has some connections that may work out soon.

The drug that I mention to be a super drug would be making modifications to a somatostatin analog that will allow it to penetrate past the nasal epithelium and go deep into the brain where it can replace the functions of somatostatin and promote the growth and survival of new somatostatin interneurons in order to reverse the progression of transcriptional drift within the brain so we could maintain youthful somatostatin interneuron populations and neuroplasticity for decades longer. This would allow us to have significantly improved insulin sensitivity within our brain which would increase neuroprotection against endotoxins, and glutamate signalling reducing inflammation. Mouse models such as ames dwarf mice are similar to humans with a non functioning growth hormone receptor(Larons syndrome) Ames dwarf mice are reported to have significantly longer lifespans because of reduced inflammation and significantly improved glutamatergic homeostasis.
https://pubmed.ncbi.nlm.nih.gov/25711529/
Ames dwarf mice do not get cancer, they live 70% longer on average, and their muscular and brain function does not decline with age. They're also significantly smarter than wild type mice and have better emotional regulation as well.
People with larons syndrome can't get cancer and are significantly smarter than average. The reason why ames dwarf mice live significantly longer than average is low peripheral IGF1 concentrations and significantly higher brain insulin/igf1 concentrations.

>>14521207
Good now destroy everything you know and abandon your plans, people need to die for growth to occur, or else you'll just sociopathic assholes ruling everything forever, thank god for retard trust fund babies.

>>14521168
if what yo u say is true then recommend me the best supplements for the brain that exist right now

>>14521222
ibuprofen

>>14518576
>anime avatarposter
it's over

>>14521217
If some anon can come up with this, it's likely others are looking at similar pathways. This may be distantly related (Your mention of glutamate pathways), a friend and I stumbled on a neural boosting combo that might interest you:
> N Acetyl Cysteine (NAC) 600 mg to 1200 mg
> Niacin (FLUSH) or Niacinamide - 250 mg to 500 mg
> Piracetam 400 to 800 mg
> Gingko Biloba - 40 mg+
> A diet soda containing Aspartame (100mg ish)

Anecdotal reports are very positive, ranging from long covid sufferers to older people who just need a bit more mental agility. NAC in general seems to help with metabolic issues, as well as being a general mucolytic for upper respiratory disorders.

>>14521222
cyanide is basically the pill from limitless, the trick they don't want you to know is you have to take A LOT of it, not just one little pill

>>14521207
Godspeed anon. Any nootropic recs in the mean time tho?

>>14521207
>better emotional regulation
How can you tell how emotionally stable a mouse is?

>>14518906
What about cartilage.

>>14521227
Ibuprofen will just give you acid reflux because it erodes the stomach lining.
So you would have to take omeprazole constantly which can cause heart problems taking for a long term.

>>14521252
Someone posted a study that NAC long term could cause Alzheimers.

>>14521253
You're a bad entity, go back to hell demon.

>>14521222
metformin
really.

>>14521304
i take
vits a b(all) c d k2
NAC QUERCITIN ASTAXHANTHIN DL-PHENYLANIN ZINC MAGNESIUM COPPER IRON SELENIUM PQQ Q10 L-LYSINE CURCUMIN LIONS MANE ASHWAGANDHA
what do i lack{

>>14521305
You'd have to link the paper, there's a lot of bad studies out there and figuring out the good from bad is a full time job. NAC does have a small chance of increasing micro-bleeds in mice brains, but in mice already susceptible to said micro-bleeds, and if taken in combination with other things it may not matter.
NAC is one of the few things I've shilled openly- I've taken it long term, and it solved or greatly improved many health issues I was having.

If anything I'd think a reduced risk due to increasing cellular anti-oxidant levels

>>14521168
>>14521207
This is "first day researching nootropics" BS.
Just take aspirin.

>>14521207
So, you're saying that you managed to sintethize an NZT-like drug that could potentially make us immortal?

>>14521308
forgot to mention 5-HTP COLLAGEN AND CREATINE HCL

>>14521308
MEDS.

>>14521291
Easy to measure when paired with a keyboard and display hooked up to a PC browsing a congolese pottery throwing forum.
An emotionally unstable mouse will cease movement or flutter aimlessly in the presence of the high faggotry levels found in shitposts - which are swiftly identifiable by the slight alteration of the default name field - whereas an emotionally stable one might ignore them outright or calmly highlight the options field to allow entry of the "sage" keyword when authoring replies to said shitposts, among other maneuvers demonstrating advanced emotional control.

>>14521338
WEW not taking like 20 supplements to be superior because "it would be weird"
the definition of a normie.

>>14521345
If you want to engage "normie mode", take a Delta 10 THC gummie, not even joking.

>>14521349
>being a normie on purpose

>>14521345
WEW Human beings have survived for thousands of years just fine. Maybe try changing your diet and lifestyle, that would be crazy talk haha

>>14520199
browsing the internet and cherry-picking information that fits your narrow and limited world-view isn't science
hence, there are no scientists on /pol/, choose them all you want, you'll just end up circle-jerking on a discord server

>>14521358
infinite humans try that right now
what value does it have me doing the same?
we need to go deeper for the good of the world

>>14521366
No you really don't, you just need to put your mind and energy to the right thing.

>>14521339
High effort

>>14521168
What do you think of Dr Sinclair's works and NMN?

>>14521217
>thank god for retard trust fund babies.
I'm not a trust fund kid anon. I work a full time job and I work with a group of biohackers that i've spent a year+ cementing myself as the most highly esteemed expert.
I've spent close to $12k of my own personal savings financing the research and development of new classes of drugs for the treatment of neurological and metabolic disorders.
This is something I've spent nearly a decade studying medicine iterally reading medical articles while i've lived a tragic life in my 20's
I never set foot into a university. I've also learned from a couple neuroscientists I work closely with that helped mentor me to a degree.

> people need to die for growth to occur
Growth ends when you die anon. The end of your life is the end of the impact you have on it and I don't want to get into the epistemology of stoicism. Adaptation to our environment has created the modern world and it's why medicine exists.

What I aim to use to treat the root causes of aging include promoting increased expression of hemapoeietic stem cells/neuronal stem cell pools,significantly improve neuronal insulin sensitivity with intranasal iron chelation/epo administration,reduce neuroinflammation as much as possible while increasing insulin levels in the brain.
Here's how I aim to accomplish this. I'm currently using intranasal insulin 100 units per day+ 100mcg HA-P6 several times per week.
I've begun using deferoxamine intranasally today which is an iron chelation drug and that will reduce the iron that has accumulated in the cytosol of my neurons, microglial cells, and Oligodendrocytes due to the endolysosomal deacidification due to chronic mild stress, and endotoxins which lead to mitochondrial dysfunction and susceptibility to apoptosis and decline in function. I hope to add epo at some point soon that will shuttle the iron that is chelated by deferoxamine from hepcidin and ferritin into mitochondria to support mitochondrial biogenesis.

>>14521366

no offense but i feel you all you did was essentially circular pathways that are already known to be associated with aging. intracellular calcium and its role in apoptosis is hardly new, excitotoxicity, poor insulin sensitivity, deranged hypothalamic function , these are already known to be bad

ames dwarf mice, fact was cool , but i dont see what this proves. its known for a while that high growth hormone leads to cancer, that's partially why there is an inverse correlation between height and extreme longevity, why people with gigantism die young

https://academic.oup.com/biomedgerontology/article/73/5/588/4086161

>larons syndrome can't get cancer and are significantly smarter than average.

there's like 250 people with laron's syndrome, i tried to find proof they're smarter, couldn't find any, how did you even get this conclusoin? people with laron's syndrome also have micropenises and are mega manlets with facial deformities. If you increase metabolism, you tend to increase ROS and other toxic byproducts, 'live fast die fast' sort of deal, if you make humans manlets, they live longer, just like manlet races like japanese and chinese live longer alraedy than others, but i dont consider that a real solution, its literally just a tradeoff that seeks to conserve energy and health in contrast to the highly consumptive, large, energetic individuals who live shorter lives. you would've arrived to the same conclusion merely observing that women (small biomass, lesser metabolisms, less gh) live longer than men (faster metabolisms, larger, more gh). call me when you can get a 6'5 guy to live to 120. small mammals live longer, so what?

your solution is to take a GH inhibitor? this seems like it will have negative side effects, its used to treat people with gigantism, i.e. EXCESS GH, not normal people.

>>14521468
Eunuchs are known to be long lived as well, should i take anti androgens then? your solution is basically an analogue of the guys who proposed to extend longevity by fasting to slow metabolism, which is technically not an incorrect approach, but its feels regressive and crude, it should be called the Turtle approach because thats what it amounts to 'turn yourself into a turtle / an organism with the metabolism of a turtle and you can live to 120'


GH treatment is also shown to improve many biomarkers in children with GH deficiency. those children

>>14521460
antivaxxers were right accidentally is a persuasion technique dummy, he was always antivax in secret, he didnt even told his fans what he did

>>14521450
this seems more interesting, than what you said previously. i applaud your self experimentation, admirable. how has the intranasal insulin affected you? wb deforxamine?

>>14521252
>a friend and I stumbled on a neural boosting combo that might interest you:
I've probably been responsible for introducing SKQ1, and intranasal rapamycin to the nootropics community.
I've snorted a grams worth of MIF1, swallowed a gram worth of taltirelin, and probably the most life changing of those were up to this point Rapamycin, insulin, skq1, and HAP6
>>14521265
Intranasal insulin.
HA-P6.. You need a lot of it over long periods of time to get the benefits that I see. Both greatly increase glutamate transporters, and nmda, gaba, and ampa surface expression because they improve neuronal insulin receptor activity. Insulin is a potent neurotrophic factor and the most common one in the body. Intranasal insulin bypasses transporters that our bodies rely on to increase insulin transport from the periphery. administering insulin intranasally improves peripheral insulin sensitivity and metabolic homeostasis by improving glucose metabolism in the brain to support mitochondrial energy production.

I'm using deferoxamine intranasally and I've went through about 500mg today and have 9 vials left in my box to go through. It would remove excess iron that accumulated in the brain over your lifetime as a consequence of neuroinflammation or drug use or disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911954/
>>14521308
Go to walmart and buy humulin r over the counter for $25 per box, then snort 30 units of insulin between meals.
>>14521322
I'm working on it. Certainly it'd only be one drug of many that I hope to introduce and make more popular in efforts to target the multiple pathways involved in cognitive decline. Cognitive decline itself is directly tied to metabolic decline and finding a perfect solution to cognitive dysfunction would also be in many ways the cure for most human diseases including autoimmune disorders.

>>14521168
you're full of shit

>>14521468
>no offense but i feel you all you did was essentially circular pathways that are already known to be associated with aging. intracellular calcium and its role in apoptosis is hardly new, excitotoxicity, poor insulin sensitivity, deranged hypothalamic function , these are already known to be bad

Yeah I'm glad that you follow me on this. What I aim to do should not sound like a grand departure from what should be common sense interventions for the mitigation of mitochondrial dysfunction but my aim is to target all of the pathways individually that contribute to cognitive decline and cognitive dysfunction together.

>your solution is to take a GH inhibitor? this seems like it will have negative side effects, its used to treat people with gigantism

Its one therapeutic which would be a somatostatin analog that targets the sst2 and sst5 somatostatin receptors which are ubiquitous within our brain but also in most other cell lines and which somatostatin has many intricate roles in suppression of amylase, TSH, pancreatase, lipase.. it'd suppress multiple hormones throughout the body. Somatostatin's roles within the brain are multiple but it acts dominately on somatostatin interneurons to increase the specificity of the firing of parvalbumin interneurons onto pyramidal cells. so somatostatin serves a role in sensory encoding by reducing the noise of pv activity on pyramidal cells. Disorders such as autism and adhd are marked with increased proportion of parvalbumin to somatostatin interneurons and this leads to improper inhibition and sensory/memory encoding.
I aim to promote somatostatin interneuron overexpression and increase insulin activity/ epo signaling within the brain while also mitigating sphingolipid, and cholesterol deposition in lipid rafts.

There may be many effects I could only hypothesize about because most data we have on somatostatin analogs within the brain have come from intracerebral injections of somatostatin analogs into mouse brains.

>>14520199
You meant prior retard

>>14521481
I do what I can so that people who've had it rough in life can have a leg up on the circumstances that hold them back from reaching their full potential whether it's helping with their mental disorders, insecurities or brain injuries or chronic health conditions. I am surrounded by a community of well meaning people who wish to change their lives so that we can make their future that much brighter. I've been told many times that I've changed peoples lives and saved many lives.

I invite you and any anons present to come to my community where you can meet with me and the incredibly passionate individuals I know.
https://chat.nootropicsrebirth.com/

>>14521479
are iron supplements bad for the brain then?

>>14521479
Any causal links between this and decline in microbial gut health?

>>14521460
did dilbertman get bells palsy?

>>14521479
> Intranasal insulin.
Someone’s going to die because of this post.

>>14518576
Here we go again. Hi, i'm a very junior member of a research group working on ageing and anti ageing technology. These threads come up quite often and i do my best to answer when they do.
The things listed in the image are indeed aspects of ageing, but he did not go very deep beyond mentioning the surface of the hallmarks of ageing. Nothing said there suggests the guy did anything beyond read Lopéz-Otins 2013 review paper "the hallmarks of ageing".
Anyway, there are douzens of people working on ageing, and anyone who is in it seriously understands the complexity of the problem. First, is the poblem that though we do know the key cause of ageing, which is DNA damage, we don't know which of the severa DNA damageing factors is the key contributor. Determineing that will take atleast a few years, if not more. Currently the literature suggests transposons may be the most important, that's what we are working on.
Second is the problem of how to fix the key cause of DNA damage, whatever it may be. Which can be really hard in some cases, and may require new not yet existing technologies.
Third is the problem of unitended consequences. Like how the high longevity daf mutant or FOXO mutant transgenic species tend to be almost sterile.
Fourth is that agein may not be one mechanism, but layers and layers of synergising mechanisms. If this is the case, the solution may be really hard, as eliminating any one cause will have almos no effect.
In reality the opinion of the researchers working on this varies, but it is generally agreed that a cure for ageing or any high longevity treatment will come in 15 years at the earlyest and up to a hundred years at the latest.

>>14521207
Laron's syndrome prevents some types of cancer, not all of them. Growth hormone receptors are often overexpressed in certain types of cancer as a means of outcompeting the surrounding tissue, and if those growth hormone receptors are nonfunctional, that sort of technique isn't going to work.
I'd imagine dysregulation of CDK could still cause cancer in Laron's syndrome patients, but even then that would be rare as the cell-cycle is regulated by growth hormone signalling.
With that being said, I'm pretty sure anti-cancer drugs that specifically target growth hormone receptors already exist. If you happen to be making a similar drug, please look into it.

>>14521207
I have no clue what you're saying because I get bitches, but FOX04-DRI helps maintains senescent cells, watch a guy reduce his biological age by a year using it. It works through targetting p53 and stopping (or helping to prevent) apoptosis. Elizabeth Parrish (I'd fuck) also experimented on herself some form of gene therapy which reduced her biological age. FOX04-DRI is no longer commercially produced but you can order a lab to synthesise if for you for a couple thousand.

Every make a photocopy of a photocopy, and noticed how the quality declines?

Same thing when DNA replicates. That is aging.

>>14521866
I think it’s likely that the problem of aging is something so complicated that only evolutionary pressures, which can address many variables simultaneously, have any hope of addressing it. It seems like animals like to live some multiple of the minimum viable reproductive age. Obviously it wouldn’t be good for an animal that takes 25 years to live only an average of 35. Therefore, it seems reasonable that aging would be addressed by evolution in these cases. It may simply not be possible to address aging as a while by only addressing individual issues - they may be too innumerable and individually insignificant to be solved in that way.

>>14518576
Just eat less carbs. This solves most health problems.

>>14518576
>found on /pol/
opinion discarded
also not reading that

>>14521479
anything for skin and or muscles?

>>14521479
>Rapamycin, insulin
i can confirm this. back when i was an undergrad, i asked a professor that studied aging what the three best anti-aging compounds were and he said rapamycin, resveratrol, and metformin

are you the same wormpill poster?
are you in contact with wormpill poster?

>>14521450
>people need to die for growth to occur
>Growth ends when you die anon.
I think what he meant is that progression and evolution of our species requires new organisms to be made, and obsolete organisms to die/stop consuming resources.
Everything is cyclical. The longer a mind lives, the less it creates/innovates and the more baggage it has weighing it down.
It sounds like you are going for life extension/enhancement instead of transhumanist "immortality" though, so good luck to you. How can we keep up with your progress?

>>14521361
>browsing the internet and cherry-picking information that fits your narrow and limited world-view isn't science
Yes I'd much rather have some jew decide what I read instead of having to think about new information myself

just eat right and exercise
means no chicken tendies from Mcdonalds everyday or every week or every other week.

>>14521366
stupid ppl dont ask questions

hey OP what do you think about cases of anomalously long fasting in humans?

>>14521505
Ah fuck it, English isn't my mother tongue. You're right, but as long as my message reached you, that's what matters.
>>14521361
>browsing the internet and cherry-picking information that fits your narrow and limited world-view isn't science
I agree. But you're mistaken, /pol/ doesn't cherry-pick information, apart from the astroturfing going on, there's wisdom to be found there. As long as you aren't a dogmatic faggot.

Also, take your own advice.

>>14521520
>group of barely finctional junkies
Yep. Thats my /pol/

>>14518576
>/pol/
Disregard immediately

>>14518901
>Hear some dude talk about rocket science
>"Yo man, that stuff is something I don't understand. I can't keep up with talking with you man."
>"acksually, you can't say that. *adjusts glasses*. If you're as much a layman as you say you wouldn't have the ability to judge how little you know. Vis a vis it's the opposite of the dunning kruger effect. Mwhahah'

that's what you sound like.

>>14518576
>I'm a independent researcher in an online syndicate of biohackers
I'm not qualified to address his claims, but based on that line alone, it's probably nothing.

I hope "Pax" doesn't end up like the inventors of water powered cars. If he is successful he would create a massive surge in the world's population.
There are a lot of powerful and rich depopulationists who would be very upset if he were to succeed in creating an anti-ageing solution.

Stay safe, bro.

>>14522400
>>14524258
Join me
https://chat.nootropicsrebirth.com

>>14521207
You're talking about people who have metabolic syndrome.

>you have metabolic disorder because you don't exercise

>you are developing a drug to fix metabolic syndrome to avoid exercising

>>14521450
>Here's how I aim to accomplish this. I'm currently using intranasal insulin 100 units per day+ 100mcg HA-P6 several times per week.

Or... you could just run laps and lift weights. But you won't exercise.

>I've also learned from a couple neuroscientists I work closely with that helped mentor me to a degree.

Ask them about exercise.

>>14524262
HEY LOOK EVERYONE!!
THIS HOMOSEXUAL PEDOPHILE IS LOOK FOR VICTIMS TO COERCE ON 4CHAN
OMG HOW COMPLETELY UNNUSUAL AND CREATIVE
LMAO IMMA GO TELL UBOACHAN ALL ABOUT THIS

>>14524337
>you have metabolic disorder because you don't exercise

>you are developing a drug to fix metabolic syndrome to avoid exercising

If you put it that way that does sound incredibly cool.
>>14524342
I've not made a point anywhere to disparage the efficacy of healthy diet and exercise.
I work closely with a group of people some of which suffer from Chronic Fatigue syndrome.

Covid, epstein barre virus, chronic chemical exposure, metal toxicity all promoting a not well understood disorder that is known to have the worst quality of life index of all chronic ilnesses.

Diet and exercise are great for promoting health and longevity for those who possess grit, and self control to be health conscious. There's still ways in which we can improve people's quality of life with chronic health conditions or mental disorders such as ASD,intellectual disabilities, Schizophrenia, and neurodegenerative diseases, Traumatic brain injury, stroke, Multiple sclerosis, Huntingtons disease. Diet and Exercise is not a silver bullet that's going to cut through the progression of these chronic health conditions the way that targeted therapies can treat the disorder

>>14524345
Excuse me? I find it hard to understand how you'd jump to such a conclusion and make such an egregious accusation about me or have the thought to compare me to someone that would do such a disgusting act. I'm a scientist doing what I can to improve the lives of people from all backgrounds that wish to become better versions of themselves.
I don't know how you'd make such a baseless accusation but you have. I'm Trying to do what I can to make people smarter and healthier so they can be more empowered to brighten the lives of everyone they know. I wish you well anon

>>14518576
So...brain insulin resistance? That's not a novel idea.

>>14524381
why not reply to >>14521866 >>14521873 or >>14522066 ? Of course I know why, because you're a schizo on a manic episode ignoring all the evidence that goes againt you

>>14521168

Please anon, don't get your self kill, I believe in you

>>14521479
as long as you don't deceive people into being your lab rats it's all fine. Keep on posting the experimentation you did with your body here, don't encourage others to do so.

>>14521168
have you heard of ray peat? what do you think of his ideas?

>>14521207
>low igf good
so I shouldn't drink milk?

>>14524381
>Diet and Exercise is not a silver bullet that's going to cut through the progression of these chronic health conditions the way that targeted therapies can treat the disorder

No. Its the stainless steel bullet. The one that works.

The one that doesn't work is the mythical silver bullet. The one sold to the gullible, the lazy, and the stupid, that has been shilled since time immemorial.

By the way, neuroscientists aren't your friends.

Don't mistake their enthusiasm for someone willing to undergo uncontrolled experiments with novel chemicals for friendship.

>>14525073
off yourself, brainlet. You know nothing about neuroscience. That anon is right about deferoxamine and insulin doing what it does. Exercise doesn't heal CFS and other disorders.

>>14524381
The fact that you're going to make a drug hurts your credibility. Sure, it might be more effective if you can get it to market, but if it actually is effective it'll get buried one way or another. The best thing you could do is find existing chemicals that can't really be owned, but have the same function.

>>14521168
>>14521207
My reply from the thread you spammed on /pol/:
I understood 100% of what he is saying. Most of it is intentionally complex to confuse the reader and pump up OP's ego.

Obviously, oxidative stress causes tissue inflammation which induces cell death more rapidly. In turn, this ensures that DNA is continually damaged with each replication and the telomeres are shortened. This is what causes aging, not only aging, but to anyone who understands biology, most chronic, degenerative diseases.

OP does not even attempt to address how he intends to prevent telomeres from shortening. It seems he desires to prevent cell death which would quickly induce cancer as cells would not die and instead replicate uncontrollably. To administer such a "drug" would be to commit mass murder.

Or perhaps he also intends to modulate cell replication, which would also be a nearly impossible feat, unless you could manage to hijack the body with nanomachines but that also brings up dire issues.

>TLDR;
OP's idea is fake and gay. It's not revolutionary either.

>>14518576
>anime pircel
>you still question the legitimacy of the information

OP is a faggot exhibit A

>>14527187
so all that stuff about people with Laron's disease don't get cancer and the shit with the rats is all fake?

>>14518576
>found on /pol/
lolno

>>14518576
where are the jannies when you need them
obvious troll thread

>>14518576
>anime nigger tranny keeps spamming the same unreadable retarded /x/ tier thread
>/pol/tards will still reply to it

>>14522104
I disagree with this in some parts, though your idea on longevity, evolution and reproductive age is interesting and a good observation.
However... We understand the overview of ageing enough that we know it can be fixed. It just may be really hard. Transposons can be silenced via targeted methyl transferase enzymes, telomers can be regrown through extopic expression of telomerase enzyme, epigenetic cellular rejuvination can be done through application of yamanaka factor, stem cell attrition may be solvable by forced expression of the PIWI-piRNA pathway, a unique marker of scenescence was recently identifyed which woul alow us to increase clearance, declining proteostasis is a hard one, but increased expression of proteosomes helps, sterile inflamatin can be reduiced via targeting cDNA...
We know the problems and have some solutions, all we need are more effective solutions, and a clearer ide as to what to focuse on most.
Evolution actually has cured ageing in some cases, like hydra vulgaris, some sponges, some acoels, planarians and all germlines. Also to understand ageing and evolution it is worth looking at the vast age difference between tha major wokers and reproductives of macrotermes bellicosus.
>>14522066
Yes, and no. It's actually really interesting. Copying errors are a factor of ageing, but if it were the only one, ageing would be linear. But ageing doesn't show linear growth. We can show this quantifiably but just think about it. How much do you age from 0-40 (keep in mind development is a totally different process from ageing). How much more do you age from 40-80, and how much more form 80-120. It's exponential.
There are two factors in this: one) the antagonistic haulmarks of ageing pass their tippingpoint, two) transposon expression is exponential and so it's DNA damageing effects are too.
Basically ageing is a series of hierarchical DNA damageing factors, each of which causes and is caused by the other.

>>14521222
Dr. Pepper

>>14527021
>Exercise doesn't heal CFS and other disorders.

Lifelong dietary derangement and sedentary lifestyle can be overcome with painful and consistent exercise.

Good luck with your single miracle molecule vaporware/placebo, you degenerate moron.

>>/x/ is that way

>intranasal insulin
Don't do the shit you read in this thread, you could die. OP is trolling.

>>14518576
the only think you need to focus on is "biohacker".
That right there tells you all you need to know about this shill.

>>14518576
medfags will do what they do best and say

it MAY be true
but UNLIKELY

>>14518576
morons can't even create a single cell from scratch or cure balding yet they trust the science we have now to be the end-all-be-all true model of exact reality instead of fanfictions we pretend to represent the actual thing

>>14521505
former is the word (and I'm not even a native speaker)

>>14518576
I wish him luck, but he talks too much.

>>14530302
Because we don't want to create cells from scratch an we don't care about our haircuts.

>>14530311
>Because we don't want to create cells from scratch
It's not that you don't want to, you simply cannot
https://www.youtube.com/watch?v=zU7Lww-sBPg

>>14518576
poster is fake and gay

>>14530343
Define "from scratch".
They recently made up a synthetic molecule by placing a preprogrammed dna assembled by nucleotide into an existing cell.
If you think they cannot create the membrane and the organelles, you have to tell me why you think so.
Printing whole cells is the next step, but it will be only a show-off to demonstrate the power of their 3d atomary printers.
But then you will say "why don't you come up with your own atoms first" and when they finally find ways to weave particles out of the thin air, you will scream "why don't you come up with your own ether" and so on.
But boldness is cool, because it's a safe aging indicator, and if your immortality serine makes your hair grow, you will not have to wait for twenty years to tell if you succeeded or not, two will be enough.
I'm not watching that evangelist shit, if I'm missing something, feel free to inform me on it.

>>14530393
>synthetic molecule
synthetic cell (synthetic molecules were made looong time ago)

>>14524381
a close family member works at the top of Flagship Pioneering. should I show stuff to him? hundreds of millions in funding is their daily business

>>14530393
>Define "from scratch".
Create a cell wall using only its components.

>>14530393
>you have to tell me why you think so.
You just said it, they had to use a preexisting cell to build it for them

C'mon, create a DNA using only the aminoacids that compose it

>>14530455
that has happened
whell it was a plasma membrane but still
the hard thing is puting them together
or creating dna code from scratch

>>14530462
>whell it was a plasma membrane but still
>the hard thing is puting them together
Yeah that's what I'm saying, a synthetic organic chemist said this has never been done, putting the lipids and the machinery together like Lego blocks

>>14518576
Anime has really created a generation of sociopathic and delusional narcisists.

>>14530462
Is this what you're talking about?
https://dodamp.com/how-to-make-your-plasma-membrane-from-scratch/

I meant an actual cell membrane with its proteins and phospholipides

One of the points James Tour makes is that even scientists can't build a cell given all the components, yet they claim random collisions can do it
https://www.youtube.com/watch?v=r4sP1E1Jd_Y

>>14530456
>create a DNA using only the aminoacids that compose it
You're a clueless faggot. It's proteins consist of aminoacids. Forchong educative.

>>14530466
the phospolipids did create a double layer
so a cell part being created from their base componets did happen
>>14530476
no it was an expiramnet in the 60s it had phospholipds but no proteins on the surface or spaning the with of the membrane

>>14530473
Do not bring Anime into this. All Americans are what you described

>>14521207
so where are we on Space Marines

>>14521866
While studying COVID-19, I couldn't help but notice many similarities between the effects of the virus and the effects of aging.
>amyloid deposition
>DNA damage
>lipid peroxidation
>iron dysmetabolism
>glucose dysmetabolism
>chronic inflammation
In fact, studying COVID-19 opened up new and interesting vistas for me in terms of analyzing the causes and effects of aging processes and pathways. It's not just one thing, like copying errors. Cosmic radiation, oxidative stress, and various other factors contribute to genomic damage in somatic cells. Once the blueprints are damaged, protein synthesis starts failing, and the failing protein synthesis, in turn, promotes further aging by inducing various stress pathways that recursively cause more oxidation, more DNA damage, and so on. So, in a sense, Linus Pauling was right, but he was also wrong. This cannot be fixed by chugging antioxidants. Normally, the body itself and numerous enzymatic pathways regulate ROS very tightly, provided that one has balanced nutrition, particularly nutrition rich in the "master" antioxidant substrates that improve glutathione and selenoprotein production (i.e. foods high in cysteine and selenium). Japanese diets provide some interesting clues as to how aging may be forestalled. One might say that the pescatarian, vegetable-rich diet in Asia is a huge boon to endothelial health and longevity.

>>14530960
You know the old saying "you are only as old as your endothelium", right? Well, COVID-19, being a viral vascular endotheliitis, directly attacks the endothelium, promoting endothelial glycocalyx degradation, endothelial dysfunction, edema of the small capillaries in the lungs, et cetera (this ultimately leads to viremia, sepsis, and death in the severe cases). The vascular endothelium is a major site of redox activity in the body. Lots of different reactive oxygen and nitrogen species are constantly being produced. Endothelial nitric oxide synthase is constantly releasing tons of NO to regulate vascular tone. When you dig into the redox pathways of the blood vessels, the whole affair is surprisingly violent, but normally well-regulated by enzymatic activity. Megadosing Vitamin C is kind of superfluous. Normally, glutathione peroxidase, glutaredoxin, thioredoxin, and other key oxidation-reduction pathways deal with excess oxidative stress automatically, but they can only do so if one has balanced nutrition. A diet high in processed food promotes more rapid aging for the simple fact that it is carbohydrate-rich but micronutrient-poor, so many of these enzymes run short on these substrates, and that's what you see in people who have elevated rates of COVID-19 mortality; surprisingly low glutathione levels despite their young age. Diabetes, obesity, and hypertension all have the aged vascular phenotype in common. African-Americans suffer from higher COVID-19 mortality because of rampant endothelial dysfunction due to genetic differences in eNOS efficiency and higher rates of Vitamin D deficiency, leading to calcification and stress of vascular endothelial cells. These conditions make COVID-19 substantially worse, for numerous reasons (lack of proper regulation of ROS, lack of proper regulation of inflammatory transcription factors). In fact, low endothelial NO makes the virus replicate much faster because NO is antiviral against SARS-CoV-2 Spike.

>>14530975
There are papers that explicitly describe the effects of COVID-19 as, and I quote, "a challenge to the physiology of aging":

https://www.frontiersin.org/articles/10.3389/fphys.2020.584248/full

Martin L. Pall has described, in his papers, something called NO/ONOO- disease, which is a feedback loop in the vascular endothelium whereby excess superoxide production leads to NOS uncoupling.
>NO reacts with superoxide to make peroxynitrite
>peroxynitrite, as a damaging nitrogen radical, nitrates tyrosine to make nitrotyrosine
>peroxynitrite also destroys BH4 cofactors needed by eNOS to make NO
>eNOS enzymes enter "uncoupled" state
>the product of uncoupled eNOS is now more superoxide
>NO reacts with superoxide to make even more peroxynitrite
>rinse, repeat
COVID-19 induces this directly. SARS-CoV-2's viroporins act as calcium ion channels and draw calcium into cells. The action of Spike on ACE2 also leads to a bradykinin storm, which further enhances intracellular calcium pathway activity, leading to metabolic overdrive, mitochondrial stress, and extreme ROS release in the vascular endothelium, which, in turn, promotes NO/ONOO- disease. This leads to runaway kindling radical formation, liberation of iron stores, hydroxyl radical formation, and, inevitably, lipid peroxidation, ferroptosis, and parthanatos of the tissues.

>>14530987
SARS-CoV-2's Spike has been said to inhibit nuclear DNA repair, and both Spike and Nucleocapsid are amyloidogenic and promote amyloid fibril formation.

This is 100% relevant to the processes of aging. The very definition of an Alzheimer's-afflicted brain is:
>DNA damage
>amyloid deposition
>iron dysmetabolism
>lipid peroxidation
>ferroptosis and parthanatos of brain tissues

From this basic analysis, we have something of a perfect portrait of a cell undergoing aging processes. Its DNA is damaged by oxidative stress, cosmic radiation, copy errors, et cetera. The cell cannot synthesize various proteins that it needs for optimal function as efficiently as before. There are insoluble protein plaques accumulating in the tissues. Iron is being mishandled. Insulin resistance develops. Proper and regulated glucose metabolism and lipid metabolism are breaking down. Reactive oxygen species are not being detoxified as efficiently.

In fact, a recent article puts all of this into perspective. All species die after accumulating the same number of somatic cell mutations:

https://www.biorxiv.org/content/10.1101/2021.08.19.456982v2

(the final version of this was published in Nature, but 4chan's anti-spam filter blocks links to Nature articles)

This kind of puts the anti-aging crowd in a bit of a bind. It looks like the most important thing, for reversing aging, is to undo mutations in somatic cells. This is an immense bioengineering/nanodrug challenge, because our bodies contain countless somatic cells that each have their own copies of our genetic material, and to reverse mutations, you'd need to have the ability to go in and edit basically all of them with precision gene snipping, without giving yourself cancer or destroying your chromosomes.

I actually mean it when I say good luck. This would be basically the pinnacle of achievement in medicine. So many illnesses are linked to aging processes, it's not even funny.

>>14527367
Yes

>>14531020
BTW, this can't be fixed by lengthening telomeres. Those are just nature's little CRC check on the chromosomes. They indicate the likelihood of genetic damage, just like the expiration date on a pack of meat indicates the likelihood of spoilage. You can't reverse chromosomal damage by lengthening telomeres, just as you can't put off the spoilage of meat by slapping a later date sticker on the package. However, after restoring the condition of the nuclear DNA in a cell, one might want to give it a "clean bill of health" by lengthening them, of course. In order to restore nuclear DNA to a youthful condition, one must know what it looked like before accumulating damage. Lots of gene sequencing is necessary. The younger the subject, the better. That way, you can establish a baseline of what the cells are supposed to look like before aging sets in. Of course, not all cells in the body age uniformly. It's kind of like a swarm. Some populations of cells degrade faster than others, such that the aged body is a mixture of middle-aged and senescent cells. Also, if someone is already aged, then their body is made up of a large proportion of, essentially, malfunctioning cells, and these would have to be turned over and disposed of over time.
This poses a problem for the human brain, for which there is actually very little turnover. It also poses a problem for the heart, where scar tissue is basically permanent. Some populations of cells act kind of like roadblocks to regeneration.

>>14531035
Actually no. You can take the consensus sequence data of people in perfect health so to speak. Then you can simply substitute that set of sequences in the genome as a completely new chromosome. Restoring the original is not necessary if you're gonna be substituting anyway.

>>14531035
Yeah but the stuff that causes telomere lengthening, usually causes apoptosis in the clearly damaged cells. See Epitalon.
On that note, look into Amalaki fruit. (amla/amrita, indian gooseberry.)
It's name is linguistically connected to Ambrosia.

>>14518914
Lmfao

>>14520199 Chek'd
Praise Kek!
Heil Hitler!
Sieg Heil! Sieg Heil! Sieg Heil!

>>14521207
>larons syndrome
symptoms
>Affected individuals classically present with short stature between −4 to −10 standard deviations below median height, obesity, craniofacial abnormalities, micropenis, low blood sugar, and low serum IGF-1 despite elevated basal serum GH
>micropenis
NEXT!

>>14521252
Replace Piracetam with Phenylpiracetam. Remove (((aspartame)))

>>14522411
you don't think about new information yourself
you have it picked up by a mob of disenfranchised and uneducated people, along with their grifters and enablers
being a contrarian doesn't make you special or enlightened
>>14523551
>/pol/ doesn't cherry-pick information
I've yet to see /pol/ agree with a mainstream source like WHO, even if their information is completely correct and well-researched, out of sheer resentment

>>14530960
>>14530975
>>14530987
>>14531020
>>14531035
>tripfaggoting this hard
interesting read nonetheless

Thank your parents for "adapted" genes. "Omega Incel" it's fate. Weak inter low reactive psychics and autism - you've been a loser since birth.

>>14530960
>One might say that the pescatarian, vegetable-rich diet in Asia is a huge boon to endothelial health and longevity
Bullshit
https://www.carnivoreisvegan.com/hong-kong-long-life-eat-meat/

>>14531020
Yeah you'd hit the nail on the head describing aging pathologies and it's all directly tied to iron dysbiosis within the brain.
The spike protein for covid promotes iron dysbiosis by the same mechanisms and amyloid beta, bacterial endotoxins, and through promoting iron dysbiosis within the cytosol of our neurons, microglial cells, astrocytes, and oligodendrocytes they all promote reactive oxygen species formation within the cell including catalysing the production of peroxynitrates. Through a variety of factors which increase intracellular iron within our brain cells this promotes cellular senescence and in the case of microglial cells, and astrocytes inflammatory reprogramming. This produces brainfog, cerebral insulin resistance, reduces insulin transport into the brain and aggravates the aging of our braincells and cognitive decline. The failure of cerebral insulin sensitivity promotes endolysosomal deacidification that dissociates iron from our mitochondrial machinery and forms free iron within the endosome as well as promotes leakage of iron into the cytosol directly contributing to oxidative stress and aggravation of glutamatergic excitotoxicity. increasing iron accumulation in microglial cells promote senescence of microglia and the same is observed for astrocytes.
Chelating iron from the brain with intranasal deferoxamine would mitigate and reverse the iron accumulation in the brain that leads to cognitive decline and likely decline of metabolic homeostasis through restoration of proteostasis and mitochondrial function to a youthful state.
https://elifesciences.org/articles/73456
https://www.frontiersin.org/articles/10.3389/fpubh.2022.881412/full
https://pubmed.ncbi.nlm.nih.gov/14975450/
https://pubmed.ncbi.nlm.nih.gov/33057378/
https://www.sciencedirect.com/science/article/pii/S2213231720309940

>>14521168
>saturated fats reduce neuronal insulin sensitivity
Way to out yourself as a moron
https://www.usagainstalzheimers.org/content/march-2015-can-coconut-oil-really-help-alzheimers

Are there any communities or good resources to keep up with developments towards this? Some of you have very interesting responses and I'm curious where you go to or participate in regularly.

>>14531313
chat.nootropicsrebirth.com

>>14521168
You do you anon

A promise to any who can deliver me immortality:
Grant me immortality and you shall have my loyalty without question.

>>14531313

>>14531388
Join me.

>>14531422
Бaceд

>>14531388
Go study Judaism then, if you don't want to taste death you will have to reach Enoch's level
https://www.youtube.com/watch?v=6SEhJ_7TyZc

>>14531422
I shall lurk around for now, as I currently lack the knowledge to actively participate.
But know that I will be around, waiting and learning patiently for the moment to re-announce my pledge.

Imagine wanting to linger in this hellhole forever

>>14521168
can i just eat 2-3 pcs of boiled egg everyday?

>>14530975
Thoughts on glutathione/NAC supplementation? OP image also talks about glutamate, which is supposedly reduced by NAC, a precursor to glutathione.

>>14521232
anime board, spic faggot go shoot some baboons.

>>14521168
Please anon don't let me down. Achieve it. I want to be in my twenties forever.

>>14521168
Biz here, what's your company name and how can we invest in it.

>>14527187
>Obviously, oxidative stress causes tissue inflammation which induces cell death more rapidly. In turn, this ensures that DNA is continually damaged with each replication and the telomeres are shortened
Unironically how does exercise help with this? Doesn't exercise actually cause more oxidative stress?

>>14531967
my associate will get back to you soon

>>14521358
they all die tf are you talking about?

>>14531967
I'm his friend and associate, reach out for Pax here https://chat.nootropicsrebirth.com/channel/a-casual-chat (that's him not me)

>>14518576
Someone transcript this into simple english for brainlets like me.

>>14532233
Yeah I don't understand any posts I swear these terms are not even english I can't even understand how you can string together a paragraph where not even a single sentence is accessible

>>14518906
>still doesnt have an answer for scarring and general skin degredation,
Will look like shit and be forced onto an iron lung real fountain of youtth that one.

>>14522544
Well yeah, stupid people think they have all the answers.

>>14521168
We have an ambitious one here, I am also making a breakthrough in a different field. It's nice to see those that strive for more, but I don't know how you'll turn once you achieve it, I will keep watch over you now. Don't disappoint me.

>>14521168
too much jargon

>>14531429
Why would ((s)He(m)) make you guys so homosexual?
https://www.youtube.com/watch?v=5ibb12IXeDM