/sci/ - Science & Math

Rao and Bora 2018 - Timing of Umbilical Cord Clamping and Infant Brain Development
https://www.jpeds.com/article/S0022-3476(18)31079-5/fulltext
"Delaying umbilical cord clamping (DCC) for at least 30-60seconds after birth is recommended in preterm and full-term births.1, 2 Compared with immediate cord clamping (ICC), DCC is associated with better hemodynamic stability, a decreased need for transfusions, and a lower risk of intraventricular hemorrhage and necrotizing enterocolitis in preterm infants.3 In full-term infants, DCC is associated with higher hemoglobin levels after birth, improved iron status at 4-6 months of age,4 and better neurodevelopment, especially in boys, at 4 years of age.5 Mercer et al in this volume of The Journal report an additional benefit of DCC in full-term infants.6"

Mercer et al - Effects of Delayed Cord Clamping on 4-Month Ferritin Levels, Brain Myelin Content, and Neurodevelopment: A Randomized Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259583/
"In the DCC and ICC groups, clamping time was 172±188 seconds vs 28±76 seconds (P<.002), respectively; the 48-hour hematocrit was 57.6% vs 53.1% (P<.01). At 4 months, infants with DCC had significantly greater ferritin levels (96.4 vs 65.3ng/dL, P=.03). There was a positive relationship between ferritin and myelin content. Infants randomized to the DCC group had greater myelin content in the internal capsule and other early maturing brain regions associated with motor, visual, and sensory processing/function."

Mercer et al 2020 - The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial
https://pubmed.ncbi.nlm.nih.gov/32702760/
"At 12 months, infants who had DCC had increased white matter brain growth in regions localized within the right and left internal capsules, the right parietal, occipital, and prefrontal cortex. Gender exerted no difference on any variables."