/sci/ - Science & Math

>>12203885

They literally created the CRISPR-Cas9 system. Biology is the best science.

>>12203885
actually deserved though. although i can see diversity pushing the timeline up since usually Nobel prizes are for old shit

>>12203922
The guy who discovered CRISPR itself got nothing. If that's too irrelevant for a nobel prize then this should be as well.

>>12203949
>The guy who discovered CRISPR
Who?

>>12203949

The discovery of something deserves an award. Creating something deserves a Nobel Prize.

Yoshizumi Ishino who first identified the existence of CRISPR sequences in the late 1980s .. but after stating that the significance was unknown didn't do further research on it (for whatever reason).
Francisco Mojica who identified that the CRISPR sequences were apparently captured from bacterial viruses somehow. In my opinion he should definitely get a Nobel because he pursued the most curiosity driven and thoughtful work without much apparent reward. That's the sort of thing the Nobel prize should encourage.
Eugene Koonin -- who suggested it might be related to bacterial immunity
Horvath -- who proved it was related to bacterial immunity
John van der Oost - figured out the guide RNA system (CRISPR's targeting mechanism)
Luciano Marraffini and Erik Sontheimer - who showed it does something to DNA not necessarily RNA
Sylvain Moineau -- found out it can cut DNA, discovered cas9
Emmanuelle Charpentier - discovered how exactly cas9 works
Siksnys, Gasiunas, and Karvelis -- filed the first provisional patent on gene editing with cas9 on Apr. 17, 2012 but it's not very detailed.
Siksnys submits paper to a journal prior to Jennifer Doudna showing details on how cas9 mediated gene editing would work but it doesnt get published till September 2012
Jennifer Doudna applies for a patent on cas9 gene editing in May 2012
Jennifer Doudna first to publication on a paper detailing how cas9 gene editing can work (June 2012) but doesn't show how to make it work in animal cells
Feng Zhang applies for a patent on cas9 gene editing in mammalian cells December 2012.

Dozens of men do hard science and have brilliant insights for decades them two wammen come in an file a patent.

imagine caring about the nobel lmao

>>12203885
>>12203887

>>12204349
This is why academia will die.
All the people that do the heavy lifting get ignored and a couple patent trolls get all the credit.
This will incentivize people to not share their research.

>>12204387

>>12204387
yup, join the club anons. Our government and universities hate us because of our skin color. I'm just gonna do math by myself innawoods.

>>12204387
It's just sad that even something as "pure" as science is falling against {them}.

>>12204349
>Dr. Charpentier and Dr. Doudna both stumbled across Crispr by accident. Dr. Charpentier, a microbiologist, spent a number of years studying Streptococcus pyogenes, a species of bacteria that causes scarlet fever and other diseases. Inspecting the microbe’s DNA in 2006, she and her colleagues discovered a puzzling series of repeating segments.

straight out of the new york times, one of you is lying and I think it's them.

>>12204890
>the new york times

>>12204002
Yoshizumi IshinoYoshizumi IshinoYoshizumi IshinoYoshizumi IshinoYoshizumi IshinoYoshizumi IshinoYoshizumi IshinoYoshizumi IshinoYoshizumi IshinoYoshizumi Ishino

>>12204890
Holy shit that quote should be criminal. Either the NYT or D&C. They didn't "stumble across it by accident". Doudna was working in RNA genetic editing and obviously this was interesting to her when >>12204349
Koonin/der Oost began publishing.

>>12204771
Also Doudna had the big brain idea of getting the criminal mafia called UC berkeley behind her with muh cut of the patent-pie promise. She literally moved to Berkeley out of nowhere right before she filed the patent to get their lawyers on her side. Kinda sleazy.

>Publication of CRISPR-Cas
>Since 2007 V. Šikšnys focused on mechanistic studies of CRISPR-Cas, the newly discovered bacterial antiviral systems, and was among the first to demonstrate programmable DNA cleavage by the Cas9 protein.[4][5][6][7] According to V.Šikšnys, his article was not even considered as serious by the editor board of the academic journal and was not sent to the reviewers, therefore the time needed to be recognized as first was lost.[8]
>Martin Schlak reported that Šikšnys submitted his article describing DNA cleavage by Cas9 to Cell Reports on April 18, 2012. After its rejection without peer review, he sent it to PNAS one month later, and it took several months for review and publication. In the meantime, Jennifer Doudna and Emmanuelle Charpentier had published their findings in Science where their findings were reviewed and accepted within two weeks.[9]

>The genome editing technology based on Cas9 was licensed to DuPont.[10][11]

Doudna is going to become a billionaire btw. She has like 10 companies out of her lab, including ticker:CRISP...

>>12205093
who fuckin cares lol

>>12205095
Heads up. Its not just a middle school science competition. Hundreds of billions are at stake.She's going to be known like Archimedes. CRISPR is a serious technology that will only become more important.

>>12205102
eh im an anti-social bi-polar psychotic schizophrenic, this shit means nothing to me. i edit my own fucking genes from the inside.

>>12205109
Based?

>>12205093
Good, she will fund many "girls in science" scholarships that are desperately needed right now

>>12203922
No they didn't. Some Chink did.

>>12205109
how does one reach this level of enlightenment

>>12205159
lots of pain (physical and emotional) and recovery

>>12205165
Just mAXX out your science stats bro and get some credentials and you're good.

>>12204890
What fucking retards. Why are women allowed in academia again? Bitches are out here literally getting national recognition for rediscovering shit people knew for 4 decades.

The amount of bitter coping in this thread is hilarious. Only here would the years of hard work of an elite biochemist be totally dismissed because of genitalia.

>>12205260
People are just pointing out that the swedish academy of sciences did exactly that.

>>12205268
No,they're acting like the women didn't do ANYTHING. I think Virginijus Šikšnys should have been included in the award too,but to pretend these women didn't play a leading role in the development in this technology is insanity.

>>12205260
Nah, they dismissed the years of hard work of a japanese chemist because he had a penis.

>>12205272
They literally didn't though. They discovered something that already existed accidentally.

>>12203885
They made valuable contributions, but I'm wondering why Feng Zhang didn't get it as well

>>12205278
Bullshit. They figured out how something worked. It's the difference between finding out about uranium existing and finding out how to use it to do fission. It took years of experimentation and hypothesizing. Or do you think they just looked in a book, said "oh let's patent this" and did nothing else?

>>12203885
Eh, not sure I'd have sex with either of them...but I probably would.

>>12205272
It is suspect how Sinksnys filed for patent and submitted a paper for peer review, got pretty much rejected, resubmitted, and had to wait months, meanwhile sometime later suddenly these two women submitted a paper, got accepted, reviewed, and they applied for a patent which got approved, while Sinksnys was still waiting for his paper to be accepted.

>>12205285
Have you even read their paper? Zhang Feng figured out how to use it almost a decade before they did.

>>12205312
There's nothing "sudden" about it. They did similar work at around the same time. Are you claiming they ripped him off? I've seen zero evidence of that.

>>12205341
Literally read the paper, it's the exact same conclusion.

>>12205341
>Berkeley online defense force has arrived
Are they paying you in Credits or Meal points?

>>12205341
It just too much of a coincidence, timing is just too perfect. I don't know if they did, his approach isn't exactly the same however is not totally unrelated.

>>12205356
Moreover Doudna used to work at Harvard Broad institute before moving to Berkeley.

>>12205360
no she didn't.

>>12205375
It’s public record. Look it up. Do you want me to screenshot it for you?