/sci/ - Science & Math

>>10745545
You would probably shit yourself after a couple hours.

>>10745551
Why?

>>10745563
symbiotes in the gi tract are necessary to digest many foods and ward off invasion by pathogenic microbes, you would not necessarily shit yourself but you'd become very ill

>>10745545
We can't live without bacteria.

Fuck parasites, bacteria are bros though.

What would happen if you CRISPRd a notmal intestinal bacteria to produce massive amounts of estrogen and somehow got some one to eat it? Would they die or just grow massive boobs?

>>10745697
He would grow big nipples and he would become sterile.

>>10745569
>We can't live without bacteria.
No, you definitely can. Animals made that way are useful as test subjects because it limits the number of factors to consider in how they respond to whatever you're exposing them to.
https://en.wikipedia.org/wiki/Gnotobiosis
You might have health problems, but your life doesn't depend on bacteria to continue in any direct sense.

>>10745799
>You might have health problems
>You might have health problems
>but life will go on haha
Enjoy your shortened lifespan, tard.

>>10745545
cute :3

>>10745799
Just because you can keep a rat alive this way under laboratory conditions for a week doesn't mean you'd survive being stripped of 2 kilos of microorganisms whilst fapping to loli porn in your sister's bedroom.

Because you wouldn't.

>>10745697
>>10745785
what about other drugs?

I'm worried I know for a fact one day someone is going to engineer a bacteria that can be easily manipulated to produce any illicit drug they want. They could have a beer can sized microbrewery that pumps out LSD, or heroin, or pure HTC. What would happen if that bacteria began to colonize a peoples GI tract? Would it be contained to a single person, or would it spread from person to person till everyone on the planet's permanently tripping on acid?

>>10745881
>Enjoy your shortened lifespan, tard.
What the fuck are you talking about? How can you possibly get "I'm personally going to sterilize all microbes from my body" out of what I wrote? I just pointed out it's something that's already been done and it doesn't directly kill an animal not to have bacteria.
>>10745898
What specifically do you think would kill someone without bacteria? Do you have any idea how much of that bacteria is in the large intestine? People have their entire large intestine taken out in what isn't even an exceptionally rare procedure (proctocoloectomy i.e. colon and rectum excised). And the procedure isn't associated with a shortened lifespan.

>>10745921
The most obvious are vitamin K and B12 deficiencies, but you bet gut microbes are involved in a hundred other metabolic functions we know about and a thousand we have no idea about. People without a large intestine still have gut microbes.

Additionally, you'll be fucked up by pathogens such as c. difficile and s.pneumonia who are competitively controlled by your microbiome. I severely doubt you'll last long if they're removed.

>>10745563
Because you're only ever a few hours away from your next shit?

>>10745957
People also take broad-spectrum antibiotics which pretty indiscriminately and thoroughly genocide your gut bacteria (has been raised a lot as an issue of concern with recommendations about probiotic therapy to try to replace all the eliminated species).
>People without a large intestine still have gut microbes.
Some, but the vast majority of bacteria lives in the large intestine. If you have your large intestine removed and replaced with some length of small intestine (ileoanal anastomosis) then some bacteria will start to grow in that replacement intestinal tissue in a way that begins to resemble just the rectum at least. But if you just have an ostomy bag then you aren't having anywhere near that bacteria count because your insides are just emptying from a piece of intestine pulled through your abdomen instead of collecting and sitting in an internal area for long periods of time like in a normal person's colon.
>vitamin K and B12 deficiencies
Definitely true. Doesn't kill you, but someone without a colon could have problems not clotting as much during other medical procedures with the impaired vitamin K absorption.
Kind of surprising though how *little* you need your large intestine. Like a lot of people don't realize it has almost nothing to do with how much food energy you take in. People with problems in the small intestine as children experience stunted growth, but if a comparable illness is contained to the large intestine you don't see the same growth stunting. It's mostly just for salt and water absorption.

>>10745545
Why is this nigga so long

>>10745961
Hahaha. Jokes on you I shit every 3 days

>>10746053
Did you know that drastically increases your chances of getting alzheimer's?

>>10746025
You didn't reply to the part where you get infected by staph and die. People on antibiotics still have a microbiome, and so do people without a colon. Just because most of it is in the gut (because that's where the food is) doesn't mean that's where it's necessarily most essential. It's in your skin, lungs and blood as well, and there are probably countless interactions with our immune systems a hundred years away from being understood as well. If it's been in a successful symbiosis with our bodies for millions of years, I'd be hesitant about grtting rid of it.

>>10745545
Immune system wouldn't go apeshit, but your immune system would definitely be shit. Bacteria in general "primes" the immune system and kicks it into gear. Without bacteria, mortality rates would in the very least be considerably higher, and the average lifespan would certainly be shortened. Economically, it would probably destroy government budgets for healthcare spending too. So all and all the I'd guess the world would slowly turn to shit as more people get sick and governments don't have the means to do much about it.

>But what the fuck do I know, I'm just some dude on the internet.

>>10746053
Anon...

>>10745697
>>10745785
>>10745915
Would not work. You would have to wipe out the existing bacteria in that person first. Likely through a coctail of high-dose antibiotics that make it to the colon. This is very dangerous in of itself. The GI tract microbiome is already very stable. Or you would have to make your bacterium immune to an antibiotic that it produces, which would be difficult as well.

>>10746962
what about horizontal gene transfer?
Introduce a bacteria with a specific gene, and it shares that gene with the entire gut biome.

>>10746979
That's not how bacteria reproduce.

>>10746067
>I shit every day you shit every 3 days. I won. hahaha

>>10747768
It is not a joke, you should work on improving your gut flora. Healthy people shit everyday. All great mathematicians constipation free people.

>>10748646
Anon, his IQ is already been stunted. its too late for him
He clearly give no shits

>>10745697
>editing the gene of a bacteria wanting it to produce an eukaryotic lipoprotein
Fucking brainlets, man

>>10746067
Sources? I shit every 7-10 days since I was born. Nobody knows why. It does not happen to my parents

>>10745545
I had a friend who got some bacterial disease while serving peace corp in Uguanda. She had to have all her stomach biota nuked with a bunch of antibiotics, then restored it all by taking some prescription probiotics.
It wasn't a pleasant experience. A lot of shitting.

>>10748710
>>10746053
Jesus, seek help

>>10745697
Reminds me of this guy on youtube who cloned beta-galactosidase in an AAV vector, infected himself with the virus and cured his lactose intolerance. Somehow I doubt it but its what he claims.

>>10748710
It only means you are full of shit all week

>>10746044
He ate his veggies when he was a lad

>>10746067
>>10748710

Don't worry, the studies just suffer from reverse causality bias.


You already have Alzheimer's and that's why you only remember shitting ever 7 to 10 days