/sci/ - Science & Math

>>14503483
>As you can see here, the MCD diet resulted in only the most miniscule increase in liver fat when it was composed of starch (column 4 vs column 2), but when it was combined with sugar (green bar) it produced a massive increase in liver fat. The researchers also found that the MCD-sugar diet led to full-fledged inflammation, while the MCD-starch diet had no such effect (20). They found that on the sucrose diet, the fructose component led to the synthesis of fat in the liver, and because the choline level was deficient, the liver could not export that fat.

>The picture that is clearly emerging from all of these studies is that fat, or anything from which fat is made in the liver, such as fructose and ethanol, are required for the development of fatty liver. But in addition to this some factor — overwhelmingly, it appears to be choline deficiency — must deprive the liver of its ability to export that fat.

>An interesting test tube study using isolated cells found that incubating liver cells with PUFAs would suppress export of fats while incubating the liver cells with saturated fats, vitamin E, or a chelator of free iron would improve the export of fats. The results indicated that lipid peroxidation, that is, the oxidative destruction of PUFAs, causes liver cells to degrade their VLDL particles before they send them forth into what would be the bloodstream if the experiments were conducted in a live animal. They also provided preliminary evidence that this occurs in live animals by directly infusing their bloodstreams with DHA (21).

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