/sci/ - Science & Math

>>11293726
>>11293776
>>11294061
So, /sci/. Diving deeper into the "boosting" LSA concept. I recently watched a psychedelic science lecture by David E. Nichols on the pharmacology and brain chemistry of multiple psychedelic drugs. Amazing info, but LSD vs LSA in particular was interestingly relevant. I don't fully comprehend the material, but he talks about when LSD enters the 5-HT2A receptor, the diethyl moiety forms a non-polar linkage "lid" with other extracellular amino acid receptors [?] trapping the molecule. This "lid" that forms is the difference as to why ergotamine and LSA doesn't have similar potency to the 5-HT2A receptors: ergotamine is to large and LSA lacks the diethyl moiety for non-polar linkage so it can escape. Looking at LSH, which is half the diethyl moiety, we see half potency to LSD. So the question is, what additional drug(s) could be taken in conjunction with LSA/LSH that could form the "lid" to increase potency?

I made an experimental extract of LSA once which contained:

>Mtn Dew Ice (fresh carbonated)
>Anise Extract
>Peppermint Extract
>Ketel One Botanically infused cucumber and mint vodka (if they use fresh herbs like they advertise, could be great source of acetaldehyde and cucumber aldehyde)
>Great Value Dragon Fruit Energy Mix (phenylalanine)
>Keto BHB Mango Flavor (beta-hydroxybutyrate, BHB)
>Morning glory extract that has no nausea

Morning glory extract:
>Ground seed material
>Put in glass jar with Acetone
>Did x3 pulls for ~2 hours each, filtered through coffee filters and metal sink mesh drain into glass container
>evap Acetone
>Add cold distilled water (do it yourself, don't trust stores could have added Cl) with a pinch of tartaric acid to flat pyrex pan with Acetone dehydrate
>Swish for ~20 minutes by hand, use a blacklight to see the alkaloids entering solution.
>filter, done.

When I tried this it was the most potent of all extracts ever tried. Like 3/4 a hit of LSD. Could anything listed create that "lid"?