/sci/ - Science & Math

>>14639129
Share this information that possibly him and others are willingly using whatever means possible to destroy me including lying about use of deferoxamine to suppress the truth about its therapeutic index from coming out. I've heard from others that sirsadalot outright denies deferoxamine has any therapeutic index on their own server and is encouraging this behavior.

We are on the job ascertaining the pharmacokinetics of this compound and considering it alongside other options such as (DHA-)curcumin and mimosine-capped gold nanoparticles for the chelation of iron in neural tissue and their lysosomes from ferritin, hepcidin, and the labile iron pool and usage alongside intranasal erythropoietin.
As you may know there is a risk of mucormycosis with deferoxamine which can be attenuated with safe antifungals like intranasal rapamycin (I took 150mg over the course of a day) or NAC. This risk is due to the siderophore structure of deferoxamine and the resultant iron chelate, ferrioxamine B, giving life to this strain of fungus, while healthy people are normally immune to it.
However, the large molecular structure gives deferoxamine a low membrane permeability whereby it can only enter the cell via endocytosis instead of passive diffusion. This favors chelation of ferritin via endolysosomal degradation upon entering the lysosomal lumen. Whereas more permeable, small molecules like desferasirox and deferiprone induce ferritin degradation via the proteasome.
>Specific iron chelators determine the route of ferritin degradation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777130/
We leave it as an exercise to the reader to find out which side of the coin of autophagy is more important for ferritin: lysosomal, or ubiquitin-proteasomal.
https://www.youtube.com/watch?v=adrDDB3foDo

>>14571939
My man, I wish I knew what CFS server you were on. I've read basically every study you've sent at this point so I'd love to see the more organized writeups you're working on.