/sci/ - Science & Math

http://www.pnas.org/content/early/2016/06/27/1602413113.full

>Functional MRI (fMRI) is 25 years old, yet surprisingly its most common statistical methods have not been validated using real data

>In theory, we should find 5% false positives (for a significance threshold of 5%), but instead we found that the most common software packages for fMRI analysis (SPM, FSL, AFNI) can result in false-positive rates of up to 70%

>a 15-year-old bug was found in 3dClustSim while testing the three software packages (the bug was fixed by the AFNI group as of May 2015, during preparation of this manuscript)

>It is not feasible to redo 40,000 fMRI studies, and lamentable archiving and data-sharing practices mean most could not be reanalyzed either

>>8418203
Actual 3dClustSim code and comments.