/sci/ - Science & Math

>>14824287
>300mg Fluvoxamine
Fluvoxamine increases acetylcholine in the hippocampus and PFC and boosts neurogenesis and function of the PFC via sigma-1 receptor activation
>4mg Brexpiprazole
Brexpiprazole boosts working/episodic memory via a2c adrenergic antagonism and it's alpha 1b/2c adrenergic antagonism increases catecholamine in the PFC, 5ht1a agonism increases neurogenesis and boosts dopamine in the PFC and striatum]
>nicotine
Nicotine strengthens synapses and boosts memory long term
>fortified wine and cannabis
these reduce akathisia from the above drugs and provide euphoria

>>14593686
Brexpiprazole is the best antipsychotic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558054/
https://pubmed.ncbi.nlm.nih.gov/23063647/
atomoxetine is the best ADHD drug.

>>14487252
brexpiprazole is a partial agonist and a1, a2c adrenergic antagonist like clozapine but lacks the anticholinergic and antihistamine activity.
Brexpiprazole
>5ht1a agonist (increases hippocampal neurogenesis)
>a2c adrenergic antagonism improves cognition
>low intrinic activity at DA receptors alleviates psychosis without elevating prolactin or inducing compulsive disorders
>potent 5ht2a and a1b adrenergic antagonism contributes to the antipsychotic effect.
brexpiprazole > clozapine