/sci/ - Science & Math

Just found out that not only do Asian men suffer from the highest incidence of 'Micropenis' worldwide, literally EVERY SINGLE ONE of them carries the mutated gene that is responsible for it.

This mutation occurs within an gene known as 'SRD5A2', an enzyme that is less active in Asian men and is responsible for processing the hormone testosterone to dihydrotestosterone (DHT), an androgen which is more 5x more potent than regular testosterone.(1)

>Dihydrotestosterone (DHT) is a sex hormone created from testosterone in the body. It plays a major role in the development of characteristics that are typically associated with men (body hair, muscle growth, and a deep voice).

This less active enzyme in Asian men(2) is the reason they have lower DHT levels compared to other races of men,(3) it may also explain why their penises are smaller on average (unconfirmed) as DHT is necessary for the maturation of the penis.

The mutation is known as 'R227Q', and is a non synonymous change in the 'SRD5A2' gene.(4) 'R227Q' been shown to retain approximately 3.2% of normal enzyme activity and appears relatively frequent in Asian populations.(5)

>sources
https://www.news-medical.net/health/What-is-Micropenis.aspx (1)
https://www.ncbi.nlm.nih.gov/pubmed/1827450 (2)
https://www.ncbi.nlm.nih.gov/pubmed/8672990 (3)
https://snpedia.com/index.php/Rs9332964 (4)
https://www.ncbi.nlm.nih.gov/pubmed/12843198 (5)