/sci/ - Science & Math

>>10529140

>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1288200/
>On this time scale, ages for the Eurasian-distributed Val60Leu, Val92Met, and Arg163Gln variants are 250,000–100,000 years; the ages for African silent variants—Leu106Leu, Cys273Cys, and Phe300Phe—are 110,000–40,000 years. For the European red hair–associated Arg151Cys and Arg160Trp variants, we estimate an age of ∼80,000 years

rs1805005-T = Val60Leu, 250kya-100kya
rs2228479-A = Val92Met, 250kya-100kya
rs885479-T = Arg163Gln, 250kya-100kya
rs1805007-T = Arg151Cys, 80kya
rs1805008-T = Arg160Trp, 80kya

>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917718/
>The AuR sample is a clear mixture of two clusters corresponding to Oceanic ancestry and the majority ancestry component of Western Eurasian populations. Recent admixture with Europeans, who began settling the continent in 1788, is an obvious source for this Western Eurasian component and would be consistent with known genealogical information. However, contact with India earlier in the Holocene has also been proposed on the basis of mtDNA19 and Y chromosome20 data. At K > 5, further population distinction emerges in the Western Eurasian cluster, with gradual separation of European from Central and South Asian populations (Figure S1). Although the distinction is never complete, the non-Oceanic component in the AuR sample is most consistent with European ancestry. Such a conclusion is anecdotally supported by the presence of evolutionarily recent alleles (for example, the blue-eye-associated allele of the rs12913832 SNP, near the OCA2 gene21 [MIM 611409] and the red-hair-associated allele of rs1805007 in the MC1R gene22 [MIM 155555]) that are essentially restricted to (primarily northern) Europeans