/sci/ - Science & Math

/Fuck Death/ edition

Because that's what it's all about.

Rentry is
/CR_General

Excerpt (source in rentry)
"Functional analysis of SMs and their targets revealed that they are distributed between three major categories: epigenetics, intra- and inter-cellular signaling, and metabolic “switchers”. All these categories appear to be mandatorily presented in each SM cocktail to induce cell reprogramming. Specifically, it seems that sufficient components for a “minimal reprogramming” cocktail have to include an inhibitor of HDAC (e.g. VPA or NaB), an inhibitor of TGFβ signaling (e.g. RepSox), and GSK3-inhibiting SMs (e.g. CHIR99021 or LiCl). This assumption was further confirmed by the KEGG pathways enrichment analysis. The unusually significant enrichment of epigenetic and signaling pathways highlights their importance in chemical iP. Remarkably, many enriched pathways were related to aging, longevity and age-related diseases, thus presumably connecting them with the processes of cell reprogramming. "
So that's the inhibition of three things
TGFβ
GSK3
HDAC

And incidentally, Apigenin does all three. The HDAC inhibition is done by conditioning the gut over time to increase levels of Butyrate. Which is listed in the compiled analysis as a inducer of re-programming. Apigenin is labeled as a enhancer. However when in concert with several other compounds I think the breakthrough is in the acknowledgement of Apigenin as a master director of cellular activity in relation to human health. My protocol would also add Curcumin for additional GSK3 inhibition and it's synergistic boost in Butyrate levels too. Apigenin activates the yamanaka Factors via NFATc1, which is calcium hungry. Make sure you have some extra B12 or you will encode logorithmic scale errors.

My DNAge results should be here mid-Feburary.