/sci/ - Science & Math

>>14662387
dont call others names also you're an imposter who got your asshole blown out so bad by me that I'm stuck in you head rent free.
Quit using the fake tripcode brain cuck!

>>14639056
> High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines
https://pubmed.ncbi.nlm.nih.gov/29562821/
> An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells

> Fryknäs, M., Zhang, X., Bremberg, U. et al. Iron chelators target both proliferating and quiescent cancer cells. Sci Rep 6, 38343 (2016).
https://doi.org/10.1038/srep38343
> Deferoxamine Inhibition of Human Neuroblastoma Viability and Proliferation
https://aacrjournals.org/cancerres/article/48/24_Part_1/7189/493542/Deferoxamine-Inhibition-of-Human-Neuroblastoma
> Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death
https://www.frontiersin.org/articles/10.3389/fonc.2021.794735/full
> Deferoxamine Increases Breast Cancer Radiosensitivity

> Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
https://www.e-cep.org/journal/view.php?number=2009520212
> A Case of Positive Tumor Marker Response after Intra-arterial Deferoxamine Infusion Therapy in a Hepatocellular Carcinoma Patient with Decompensated Liver Function
https://www.e-jlc.org/journal/view.php?doi=10.17998/jlc.14.2.127

Intranasal deferoxamine targets the brain primarily and suppresses inflammation improving central insulin sensitivity and this has downstream effects within the periphery by improving insulin sensitivity, insulin transport to the brain as well as supporting the function of our hypothalamus.
> Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

>>14631766
I did a lot of shit to her but I don't regret any of it.
She was an annoying fucking shit.

All she had to do was stop whistling and i would have stopped.
But nooo, she just had to keep doing it.

Fuck her.
One time, I got really fucking annoyed, I took a stapler and tired to staple her ear but then blood dropped on me and I got afraid my mom would scream so I stopped.

Another time was funny.
She was walking back with pizzas in her hand and noticed me.
I walked up to her, tried for some bullshit chit chat and nabbed the pizza from her hand.
She kept begging for me to give it back to her. I found it funny so I took a pizza and shoved it in her face. The thing just came out of the oven and it likely burned her since she was screaming pretty loudly.
Her face was all red and slightly burned afterwards. It was kinda funny.

I don't pity her stupid shit.
I just wanted her dead but was too much of a pussy to try and do it.
Bullying and beating her up was the best solution.

Kinda sucks that I got what I deserved.
But meh.

in my pursuit of cognitive enhancement I've learned to understand there's really only the limit of mitochondrial functions within our brain that's the main limiting factor to control of metabolic homeostasis and cognition. I have no idea where the limit is even though I've pushed so far. It's actually surreal at this point having such a strong photographic memory and I know there's a place further beyond this. I am a strong proponent of the simulation hypothesis for this reason.

>>14624090
>>14621870
Yeah do it op.Make a video of yourself doing it and explaining yourself.

I have room to dedicate my time towards the research of pathways and DFO does a ok job at chelating iron from lysosomes without disruption of endosomal iron stores in the mitochondria. We have studies of binding DFO to ferritin pore unfolding peptide, and we have studies of DFO on preconditioning of stem cells, and topical application to the skin, there are models showing the application of DFO with hyaluronic acid conjugates for potentiating angiogenesis, treating of lung fibrosis with nebulized dfo. My understanding of treating iron-related disorders is reliant on my understanding of this one drug really well

now, how do we make that drug better. what other therapeutics are synergistic in inducing stem cell differentiation and homing?

We can apply for as a stem cell potentiating agent, and use stem cell potentiating peptides, and human placenta extract, and we can then administer stem cells to the brain

you can take human breast milk even and put it into dfo and use that intranasally

the goal that I want for the next month is that everyone here uses DFO and then we can begin working on the next phase after that
once we're about 3 grams deep into dfo all of you will be much smarter and healthier than you can imagine
you can nebulize dfo as well to promote your lung function as well.
You can wipe away wrinkles, and inject it into wounds
this is one groundbreaking therapy that has wide implications in treating most human diseases.
Deferoxamine is going to be the most well-known word of this decade
The deferoxamine brand has been built
dozens of threads on 4chan surrounding deferoxamine and its therapeutic index have been made in the past several weeks
Once we are better equipped with better brains and new bodies then we have to organize as a group towards the exploration of powerful therapeutics and their application to promote cognitive enhancement on a mass scale

My IQ has risen 6 standard deviations since high school (from 90 to 225). I know that I'm far more intelligent than when I was in school.
There's no doubt, it's risen in every mental aspect possible. It's not even a competition with my former self. I've been tested 3 times over the years
That said, Psychology doesn't know what neurochemistry knows about what is possible. So of course, psychology will assume that IQ can not be increased
I took Deferoxamine for about 2 weeks to treat lifelong extreme ADD. My ADD is gone, the mood dysregulation is gone. My memory and recall show greater ease and ability. Emotional processing and empathy dramatically enabled, my ability to see patterns and track multiple variables interacting and predict their outcomes across time intervals has improved with more clarity, speed and confidence, and my verbal skills increased, etc

I stacked 2.5g intranasal Deferoxamine with 50mg to 100mg intranasal tyrosine and 160 IU insulin for two weeks. I skipped days here and there but it all amounts to roughly two weeks of straight dosing, all while reading baby rudin and doing putnam exercises to stimulate neural growth.
Along with it, I took GH secretagogues, 8 mg CJC1295 with DAC during the first week along with 250 mcg ipamorelin intranasally for 5 days, also snorting ISRIB-A17 (15mg), BPAP+PPAP (each 80mg), EPO, and Bromantane (80mg intranasally) every other day
I also split 5mng BPC 157 over the first two days that I used Dihexa, which I stacked with Semax and Epobis
also snorted phenylpiracetam a few times along with experimenting with intranasal cocoa powder which is a powerful stimulant for executive functioning since it's loaded with tyrosine
On one of the days I did Dihexa 125mg intranasally twice in one day along with around 200mg tyrosine and my brain was bathing in dopamine
The next substance I'll try out will be the D21 peptide and methamphetamine since deferoxamine prevents amph-induced brain damage.

I'm permanently high from increased potentiation and phosporylation of my neuronal insulin receptors on all of my neuronal cell lines I'm restoring neuronal insulin sensitivity by chelating iron. Deferoxamine doesn't work like normal drugs because it chelates iron. All the mechanistic effects of deferoxamine is based on removing iron that has accumulated within the cytosol of your neurons and other cell types.
Removing iron that's accumulated by the dissociation of iron from mitochondria through endolysosomal deacidification from opioids or viruses, or from the accumulation of hepcidin or glutamatergic disinhibition reduces the healthy function of all cell types within the brain and its the main causal factor behind the degeneration of our metabolic homeostasis and our neurological functions
This is controlling neuronal insulin resistance allowing insulin to better support the neurotrophic supply and glucose metabolism, and steroidogenesis for pregnenolone that promotes the outgrowth of microtubles on our neurons and hypothalamic inflammation that promotes neurological disorders and metabolic disease share this common contributing factor
Neuronal insulin resistance from the accumulation of iron is the main pathological factor in the loss of proteostasis and the use of iron in protein synthesis. Excess free iron that is lost to the cytosol from endoplastic reticulum stress from LPS and saturated fat induced lipotoxicity promotes the dysfunction of mitochondria within our brain cells and promotes the functional decline of these cell types and it induces the cellular senescence and transcriptional drift in these cell lines through the dysfunction of our livers and blood brain barriers that promotes bacteria, virus, and fatty acid, ammonia and bilirubin accumulation within our brain and the reduction of cholesterol metabolism and this promotes sphingolipid accumulation in the lipid rafts of our brain cells contributing to the reduction in cell viability.

>>14524669
No I'm fairly well networked. I'd assume clout would be implying that I'd have a medical degree but I'm just someone that's been self taught and driven to understand the pathology of neurological and metabolic disorders after I joined a niche advanced nootropics group for the understanding of cognitive enhancement and I had 7 years of self study before I joined the group. There is a couple neuroscientists that I've been close friends with for a year. One I've had a huge rivalry because they kept asserting that factors that improve metabolic health can't improve G and I took that personally. So I've begun snorting insulin intranasally and that's after I've pioneered the use of rapamycin intranasally, and the introduction of SKQ1 as I was the first person to give a dose report. There's a DFO thread that someone has made the other day that I'm replying to and giving insight. I'm just this heavily autistic person that obsessed over health and longevity based on being surrounded for years by disease and abuse and I needed an intervention to allow me to adapt to my environment. I've gone through about 4 of the vials I've had intranasally. Here's a paper demonstrating the use of DFO as a prophylactic for stroke and it'd reduced ischemic stroke induced cell death by 55%
https://jpet.aspetjournals.org/content/330/3/679.short
And here's a larger metaanalysis of the mechanisms of intranasal deferoxamine.
I use about 125mg-250mg pd and I've went through about 2.5 grams.
I believe I may have developed fungal sphenoid sinusitus that could be deadly and the only sides before partial paralysis is headache and visual disturbance. I had some astigmatism earlier tonight so I've had some powdered rapamycin in my desk which I snorted 50+mg from my vial which should be a powerful antifungal. Don't worry I think I might be fine but definitely be aware of that