/sci/ - Science & Math

>>14584125
Blood donation does not remove iron that accumulates within the brain from inflammatory insult. Iron accumulates in our brain cells with chronic inflammation in our bodies
> Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
https://pubmed.ncbi.nlm.nih.gov/23506423/
The iron is locked up within the brain inside of your braincells trapped in ferritin and dissociated from our mitochondria as free iron that fails to be incorporated in mitochondrial biogenesis. this induces a failure in autophagy within our braincells and turnover of ferritin and this promotes cellular senescence. Blood donation does not chelate the iron that accumulates in your brain cells. Inflammation removes iron from the iron proteome and reduces proper protein synthesis within braincells and this same thing occurs in our livers, kidneys, eyes, hearts, lungs.
I can't donate braincells to remove iron from my brain. Deferoxamine intranasally penetrates deep into the brain and sequesters this iron that accumulates directly within the lysosomes of our brain cells as well as free iron in the extracellular space. It's not comparable whatsoever to blood donation. Blood donation may be a good strategy for mitigating the development of cancers, and cardiovascular disease, possibly brain aging as well, except Deferoxamine can begin to remove iron accumulation within your brain that occurs over a lifetime within minutes of administration. Within days you can have a superhuman brain and metabolic health to go along with it.