/sci/ - Science & Math

don't make the mistake I did and go on a keto-diet as a student. It's a /fit/ meme and it will make you euphoric as fuck but also really, really fucking stupid. My IQ dropped 20 points.

Consuming meat promotes inflammation by adding endotoxins to our diet and by saturated fats disrupting the gastrointestinal barrier allowing endotoxins to spill into the bloodstream. Tumor necrosis factor which is increased by endotoxins that activate TLR4 and TLR2 within the body directly contributes to neuronal cell death by inducing microglial inflammation through activation of kv1.3channels. This also promotes neuronal insulin resistance and contributes to hypothalamic neuroinflammation which is the root cause of all metabolic and neurodegenerative disorders.
There's metabolic ward experiments and feeding trials showing the direct consequences of consumption of a high fat, high protein meal on markers of endothelial function: increases in markers of peripheral inflammation, reduction in serotonin metabolism in the brain, and these can be extrapolated to disease pathology because we can observe the direct consequences of lipotoxicity and endotoxicity within the brain and reduction in cognitive function and metabolic homeostasis through understanding of the hypothalamic model of metabolic disorder
pubmed.ncbi.nlm.nih.gov/28677618
pubmed.ncbi.nlm.nih.gov/9036757
ncbi.nlm.nih.gov/pmc/articles/PMC2858203
pubmed.ncbi.nlm.nih.gov/28045396
pubmed.ncbi.nlm.nih.gov/19116375
ncbi.nlm.nih.gov/pmc/articles/PMC2853195
ncbi.nlm.nih.gov/pmc/articles/PMC4424797
pubmed.ncbi.nlm.nih.gov/28323986
ncbi.nlm.nih.gov/pmc/articles/PMC6506390
ncbi.nlm.nih.gov/pmc/articles/PMC6814438
sciencedirect.com/science/article/pii/S2211124716307331
Directly increasing neuronal insulin sensitivity increases metabolic homeostasis and BCAA catabolism. The failure of BCAA catabolism aggravates organ fibrosis, cancer growth, etc
ncbi.nlm.nih.gov/pmc/articles/PMC2728689
ncbi.nlm.nih.gov/pmc/articles/PMC5813603