/sci/ - Science & Math

Is the ability to feel pleasure something that can be depleted? Although I've been depressed and suicidal forever I can usually generate a few shots of pleasure from (you)'s and similar things, but there have been occasions in the past where I felt completely mentally empty. Not the oh I feel miserable empty but the it's totally impossible for me to feel anything good at all empty. If I was to do something like jerk of in this state I might feel the physical sensation of orgasm but not the associate pleasure.

Am I draining something physical in my brain to create this state? Some kind of neurotransmitter?