/sci/ - Science & Math

>>15049971
the fact that 90% of the people here are coddling him instead of calling him a faggot tells you all you need to know about this shit site. it's been infested with attention whores and faggots posting dick pics on /soc/ ever since /r9k/ was allowed to stay up. Have you ever accidentally clicked /soc/ instead of /sci/? It's literally all dick pics.

Anyways, let's rescience this thread by spamming random abstracts from our favorite journals. Here's one about NPCs which suits OP perfectly:

https://www.cell.com/cell/fulltext/S0092-8674(22)01423-4

Summary
Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins and RNAs. However, it remains unclear whether composition, structure, and permeability of NPCs dynamically change during the cleavage period of vertebrate embryos and affect embryonic development. Here, we report that the comprehensive NPC maturity (CNM) controls the onset of zygotic genome activation (ZGA) during zebrafish early embryogenesis. We show that more nucleoporin proteins are recruited to and assembled into NPCs with development, resulting in progressive increase of NPCs in size and complexity. Maternal transcription factors (TFs) transport into nuclei more efficiently with increasing CNM. Deficiency or dysfunction of Nup133 or Ahctf1/Elys impairs NPC assembly, maternal TFs nuclear transport, and ZGA onset, while nup133 overexpression promotes these processes. Therefore, CNM may act as a molecular timer for ZGA by controlling nuclear transport of maternal TFs that reach nuclear concentration thresholds at a given time to initiate ZGA.