/sci/ - Science & Math

>>14583989
Intranasal deferoxamine targets the brain in 200 fold higher concentrations than IV use. Here's a study that measures the quantity within differing areas of the brain in a study of deferoxamine for treatment of ischemic stroke in mice.
https://pubmed.ncbi.nlm.nih.gov/19509317/
The ammount used in this study was equivalent to 4500mg of dfo in humans. It reduced stroke volume by 55% in this model and the protection was spared even if dfo was used after the ischemia.
Iron accumulation within our brain promotes tau fibril generation and neuronal insulin resistance and it's accumulation in the brain is aggravated by inflammation, cms, glutametergic neurotransmission, promotes irons accumulation in microglial cells as well. These are the immune cells of the brain and in dementia and diabetes macrophages infiltrate the brain past a leaky blood brain barrier and provokes chronic immune activation in the brain as well as the functions of microglial cells failing with iron accumulation
> Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism
> Aged WT mice showed higher basal expression levels of microglial HO-1 in the brain than adult mice. This increase was even higher when exposed to an inflammatory stimulus (LPS via i.p.) and was accompanied by alterations in different iron-related metabolism proteins, resulting in an increase of iron deposits, oxidative stress, ferroptosis and cognitive decline. Furthermore, microglia exhibited a primed phenotype and increased levels of inflammatory markers such as iNOS, p65, IL-1β, TNF-α, Caspase-1 and NLRP3. Interestingly, all these alterations were prevented in aged HMOX1M-KO and WT mice treated with the HO-1 inhibitor ZnPPIX

>>14548318
could you tell us the dangers there is to doing this and the side effects, so we umderstand more

[math]\textrm{Heard of someone on} \trash\ \textrm{ do it and gain} \textbf{ 100 IQ points}.\textit{ What do you think?}[/math]