/sci/ - Science & Math

>>10033485
I take a daily dose of 10mg meth for about 3 months. No tolerance has developed, I've been able to get off of it with no cravings or withdrawals. It helps me remain goal orientated and focused and awake which helps me in my final year at university. My sleep is improved if anything.


Meta analysis extract in figure. And before anyone comments, yes it does mention uncertainty regarding IV dosing. But IV dosing wont change much and is more bio available. Meth has a long half life so it will remain in the body for long either way. I guess oral would make it more XR and hence more therapeutic but you'd lose ~30% of the drug.
>https://www.ncbi.nlm.nih.gov/pubmed/17694436

Other studies discuss how tolerance doesn't develop meaning dependence doesn't either at such doses.
>study showing reverse tolerance at low intermittent doses of meth(?) really cba reading it now so I can't tell for sure but look into it.
>https://www.jstage.jst.go.jp/article/jphs1951/49/2/49_2_197/_pdf
>I've had previously researched this and I believe it's serotonin dependent and serotonin depletion due to meth only occurs at high euphoric doses.(?)

An old study included children
>imgur.com/a/OLaEtuW

Difference between high and low dose in rats
>i.imgur.com/FN2PJqi.jpg

More on dose dependent effect
>https://www.ncbi.nlm.nih.gov/pubmed/25724762

And believe me I've tried really hard to find a study that shows a negative effect of low dose meth

I'll reply tomorrow with better literature and responses to anything questions or criticism

>>10033655
As I was researching through the meth studies. I found this study which looks are protective compounds to be taken in combination with amphetamines.
https://www.ncbi.nlm.nih.gov/pubmed/8531070

I will address all this again tomorrow properly. Really tired rn