/sci/ - Science & Math

>>14877550

>>14658559
Faggot, I work in hep theory. There's a reason why you've never made it into academia: because you're a schizophrenic moron. If your paper were worth anything, it would not be rejected by everyone. Now be a good dog and shut the fuck up

>>14657915
>students are immature people who are not yet ready to join the adult world
No, it's just that you are brain-damaged with a shit dopaminergic system. D21 was discovered by researchers studying the relationships of D1 and D2 receptors forming a heterodimer. D1 and 2 receptors have seemingly opposing activity with D1 being excitatory and D2 being inhibitory.
The D1-2 heterodimer is a pseudo-receptor whose expression increases as a consequence of D1 and D2 receptors being targeted and activated at the same time.
This receptor binds a large portion of D1 and 2 receptors together and prevents them from functioning properly so both excitatory and inhibitory dopamine activity is reduced.

When this heterodimer is activated, rewards from activities are greatly reduced and the satisfaction from that reward is reduced (=hedonic appetite).
This is bad in the context of long-term potentiation and in long-term depression where we attempt to learn new concepts because in the concept of dopamine signaling D1 is the reward and D2 is the anti-reward. So If you're anticipating a certain response when learning and you get a wrong answer then D2 exerts this long-term depression or reduced activity in response to an unsatisfactory result and so you don't learn something that is not beneficial.
The heterodimer increases with age, or with mental disorders or drug use and this acts as a brake on further learning, reduces plasticity, and is a contributor to the end of the critical period from adolescence.
It may be an evolutionary adaptation that promotes specialization in individuals and locking in learned memories and survival skills from childhood because it may have been bad for aged humans to compete for resources with younger humans for resources.

>>14568618
>>14566977
>>14566969
>>14566616
>>14565949
>>14565819
>>14565742
>>14570164
https://www.sciencedirect.com/science/article/pii/S2211124716307331
Directly increasing neuronal insulin sensitivity increases metabolic homeostasis and BCAA catabolism. The failure of BCAA catabolism aggravates organ fibrosis, cancer growth, etc
ncbi.nlm.nih.gov/pmc/articles/PMC2728689/
ncbi.nlm.nih.gov/pmc/articles/PMC5813603/
Consuming a plant based diet promotes lower body iron accumulation than heme iron while having similar hemocrit levels.
Consumption of phytonutrient rich plant foods such as cruciferous vegetables and high amounts of fiber from foods like beans increase butyrate production in the gastrointestinal tract that preserves the gastrointestinal barrier. Consuming meals rich in carbohydrates increases tryptophan uptake into the brain which is metabolized into serotonin and then that serotonin activates cells within the cerebellum that increase insulin transport into the brain. This supports why a diet low in bcaa's increase metabolic health is because bcaa's compete with tryptophan for metabolism and this increases cortisol release and cms.
The loss of insulin sensitivity also reduces bcaa catabolism in the body which promotes tumor growth and acceleration of aging
Read the studies
Wont reply to anyone not linking to a study to back their claims up.

>>14542265
>>14541977
>>14541155
still no argument, I see. This place stinks of undergrads

ending was a cherry on the cake

>>6978382
>protip : you don't