/sci/ - Science & Math

>>14658479
The only person working on the development of D21 within the nootropics space is a huckster that goes by the name cogmetics. They've accepted well over $9k from me in the past year, $6k for oct-ha, and $3k for the development of D21, and to help cover their personal living expenses when they were suffering financially. Cogmetics fails to deliver on their promises, has accepted thousands of dollars from people interested in D21 and is currently taking money from people for the production of nr2b peptide which he intends to use novel peptide chemistry to make it more powerful than was formulated by researchers when the nr2b-cdk5 inhibitory peptide was first discovered. Cogmetics can't complete current projects and he's using whatever means to take money from people that are willing to support his projects when he's incompetent in finishing his current projects. Do not give him financial support. Cogmetics has to follow through on his current obligations before anyone should take his work seriously. I believe that they treat peptide chemistry like their own means to play god and they're not wise enough to mention the possible dangers of what they're trying to create let alone the societal problems it can create or their own superiority complex driven by untreated mental illness. Cogmetics told me he used to beat his head against the wall until he developed a permanent lump and the dude essentially gave himself brain damage. I can say confidently that he has misappropriated what I've given him, he's possibly collecting money from people and telling lies about the circumstances of D21, and their personal financial and educational circumstances while they try to make unregulated drugs that can have great potential to do bodily harm without being mindful of people developing a strong understanding of neuroscience or pharmacology that would reduce potential for self harm.

>>14658394
There are many imitators and impersonators and i've made my tripcode after someone had made posts trying to assert that I use methamphetamine. If you believe the fables told about me and are so incredibly easy to manipulate based on the whims of trolls then you're blinded by the greater lies meant to conceal the truth about Deferoxamine and neuroscience from you. It's very highly possible that the smear campaign against me is meant to drive a greater wedge in the nootropics community as a whole and turn men into beasts. I've known and been associated with a large network of scholars, neuroscientists, narcicists and psychopaths and I will not shy away from telling the truth so that humanity at large can be free to explore their collective destiny freed from the system of greed perpetuated by the most self interested and evil intentions that man could ever fathom. Greed and the seeking of capital is apathetic to the will to improve human quality of life. The system of greed that they perpetuate is powerless to stop the collective ascension of humanity and even if something were to happen to me then still the truth is out there. I will stop at nothing in order to bring a brighter future for humanity to light. The world is rotting.
https://www.youtube.com/watch?v=i_DwUYXifrw
>>14658303
It's been demonstrated in mice that are placed on low iron diets have improvements in metabolic health and slowed cognitive decline but I believe its inconsequential to the inflammatory effects of LPS, Saturated fats, oxidized cholesterol, Covid, other viruses, alcohol, hard drugs, microplastics all promoting defects in cerebral insulin sensitivity promoting transcriptional drift from glutamatergic disinhibition leading to the promotion of endozapine release from neurons increasing gabaergic tone and promoting cognitive decline from hepatic encephalopathy. Insulin resistance leads to the defects in the channeling of iron into protein synthesis and leads to epo resistance.

>>14657946
I've been glued to studying the science of longevity for 8 years and about a year and a half ago I really hit my zenith because I met so many incredible researchers who formed a large community of nootropics scholars and I took it upon myself to double down on the efforts that I spent years studying just for the opportunity. Nowhere did i imagine when I first began that I'd get to where I am now. Being surrounded with incredibly knowledgeable people makes it easy to pick up on the concepts of neuroscience because you're constantly running into debates, networking, organizing projects and sharing research. The wasoru archives are fantastic if you just want to start diving into the archived threads on deferoxamine. I've gotten a tripcode on the 19th of june so everyone else past that point is provably an impersonator. I came to 4chan after people began taking my writeups and posting them on 4chan so I took the opportunity to jump in with the crowd and cleared the air on intranasal deferoxamine while gaining a large group of supporters, many of which have used deferoxamine and had dramatic improvements in their health and cognition.
Post >14547801 is where I can say things really got crazy!

>>14657777
I have a photographic memory of the medical literature as its known to me. I lead a large group of individuals willing to learn neuroscience from me. I've had phd students, neurologists in training, neuropharmacologists, and former neuroscientists say that I understand more than them. I have been told countless times that I've changed lives with my research.


https://desuarchive.org/fit/thread/67429324/
This thread is all taken from writeups that I've made describing the pathology and mechanisms of neurological and metabolic disorders as well as enterprising therapeutics such as deferoxamine to slow the progression of those disorders and improve health and well being.
> Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease
https://www.sciencedirect.com/science/article/abs/pii/S0022510X17304628
> Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome
https://pubmed.ncbi.nlm.nih.gov/28726200/
It's demonstrated that ames dwarf mice which live 70% longer than wildtype mice also possess significantly better cognitive functions which don't decline with aging. These mice have insulin receptor supersensitivity due to the loss in function of their growth hormone receptor. This promotes increased transport of insulin and IGF1 to the brain. They have significantly improved cognitive and metabolic health through a reduction of inflammation and significantly stronger glutamatergic homeostasis.
> Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging
https://pubmed.ncbi.nlm.nih.gov/25711529/

>>14657268
pic related
>>14656145
Iron accumulation within our braincells promotes cerebral insulin resistance which leads to defects in autophagy and failure of our mitochondria in cognitive decline. Removing the iron that's within the lysosome of our brain cells improves their mitochondrial function and this supports our metabolic functions through improvements in insulin sensitivity reducing hypothalamic inflammation as a consequence of reduced insulin transport to the brain in metabolic disorder. Improving insulin transport and sensitivity within the brain increases neurogenesis, atp generation, protein synthesis and synaptic trafficking of neurotransmitter receptors to the cell surface. Insulin activates Nachar7 receptors on cholinergic gaba interneurons(somatostatin) and this increases synchronicity between the frontal lobe and hippocampus in gabaergic inhibition. Somatostatin interneurons reduce the activity of parvalbumin interneurons disinhibiting pyramidal neurons that are dopamine sensitive to promote reward.
> Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593079/
> Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
Nature Communications volume 6, Article number: 8543 (2015)
> Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766825/
> Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis
Cell Death & Disease volume 8, page e2676 (2017)
> Iron chelation down-regulates dopamine transporter expression by decreasing mRNA stability and increasing endocytosis in N2a cells
https://pubmed.ncbi.nlm.nih.gov/21147099/
> Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina
> https://www.biorxiv.org/content/10.1101/2021.03.30.437706v1.full

>>14654690
> could you still get effects from this without doing it daily?
Yes the effects that we've noticed especially myself is that the effects of deferoxamine are long term and shared similar effects in everyone that's tried it. For people that've done a gram or less all show strong benefits even at less than 500mg. The cost for 500mg is close to $6 if put in context for the whole box. I've dosed about 4 grams so far. I have high levels of mental stamina throughout the day, my emotional resiliency is almost robotic, I don't experience any anxiety for the most part, I'm euphoric almost at all times. I can write reviews of the literature based on a photographic memory of biology and can dedicate large portions of time to describing these ideas without stopping.

>>14652123
> I just wanted to say I highly appreciate your research. You are definitely onto something, and I say that after having skimmed through many of the studies you have posted.

Thanks!
> the well has been poisoned too much already.

We've come far in the past week and I see all of the support, the threads on deferoxamine made by so many different imposters it feels kind of appropriate to say that we've created a reality where there's people that impersonate me and almost blindly go through all efforts to share my research I believe we're past the point of contention. There's about 12 of us and we report amazing improvements in our heath and cognition. My memory is as good as you might possibly imagine and improvements in all cognitive domains including hearing and eyesight.My reaction time is significantly better, I don't experience sadness or anxiety whatsoever. If i can summarize everything in one sentence we just feel life more!

I can say its everything I've gotten from researching for 8 years its insane how its possible for me to learn as much as i now know like the back of my hand.

I hope its been entertaining. The imposters have little credibility and people see through that.

>>14648737
There's a lot of data here to suggest that iron chelation will improve chemotherapy and help reverse oncogenic transformation. Through the mitigation of hypothalamic inflammation within the brain with intranasal deferoxamine and insulin would help maintain peripheral insulin sensitivity and may improve survival in cancer, and improve diabetes, liver disease, many different facets of cognitive and metabolic disorders that are all treatable by reducing inflammation within the hypothalamus and promoting cerebral insulin supersensitivity. I would not say that this would cure cancer I'm sure that I can make the statement that it wouldn't cause cancer and will improve the therapeutic index of chemotherapy and I'd be happy enough with people developing an understanding to which they can apply that towards helping others or perhaps even changing the direction of scientific research. Happy to see you excited. This should be evaluated based on the evidence presented and people can form their own insights based on it.

>>14645168
I get it. I've been a researcher in the nootropics community for over a year and prior to that I've been studying for many years. It was not something I intended when I began researching deferoxamine and sharing the information I learned with my community that it would be plagiarized from my former community and it would get here. When things really began to take off it was many people that had decided to run off with it and impersonate me while using the name "Pax". My identity within my own community is tied to my research. I take pride in my work that has been years within the making. When anons began making posts telling lies that I was abusing meth or worse began appearing I need this tripcode to identify myself because my anonymity was taken from me. I was happy in the community that I had, probably much less so than I am now after everything that has developed from this. It was not my choice that forced me to come here. I want you to remember that anon. I was happy keeping it to my small community of nootropics enthusiasts. Now that deferoxamine has attracted so much attention I have an interest in making sure that the pharmacology of deferoxamine is understood as well as the treatment of neurological and metabolic disorders. There's about 12 of us that have used deferoxamine intranasally and we're for the most part healthier, happier and smarter for it. I think its appropriate that I take time away from /sci/, let my research run its course, possibly fill people in more in possibly a month how far things have gone. All of the deferoxamine threads on 4chan were started by other anons. This tripcode is the real me and you can look at where i've posted in the recent days the frequency of my activity is responding to anons that are doing what they can to destroy my reputation, probably its gone to the point where there is no doubt this is aggravated stalking. I don't encourage others to post in my name. It's time i probably go, if anons let me be.

>>14644171
you're a lying piece of shit. show pictures of your meth and deferoxamine vials.
I use a tripcode. I don't care anymore about you or any of the lies told about me and deferoxamine. You represent the greatest evil to exist and are suppressing the ascension of humanity.Everyone can know you're a fake because in all of your posts you never once mentioned Deathnote in any fashion or shared any scientific literature or even provided evidence for your claims. This doesn't bother me in the slightest
https://www.youtube.com/watch?v=9QLT1Aw_45s
https://www.youtube.com/watch?v=9QLT1Aw_45s

>>14639129
Share this information that possibly him and others are willingly using whatever means possible to destroy me including lying about use of deferoxamine to suppress the truth about its therapeutic index from coming out. I've heard from others that sirsadalot outright denies deferoxamine has any therapeutic index on their own server and is encouraging this behavior.

>>14639056
> High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines
https://pubmed.ncbi.nlm.nih.gov/29562821/
> An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells

> Fryknäs, M., Zhang, X., Bremberg, U. et al. Iron chelators target both proliferating and quiescent cancer cells. Sci Rep 6, 38343 (2016).
https://doi.org/10.1038/srep38343
> Deferoxamine Inhibition of Human Neuroblastoma Viability and Proliferation
https://aacrjournals.org/cancerres/article/48/24_Part_1/7189/493542/Deferoxamine-Inhibition-of-Human-Neuroblastoma
> Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death
https://www.frontiersin.org/articles/10.3389/fonc.2021.794735/full
> Deferoxamine Increases Breast Cancer Radiosensitivity

> Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
https://www.e-cep.org/journal/view.php?number=2009520212
> A Case of Positive Tumor Marker Response after Intra-arterial Deferoxamine Infusion Therapy in a Hepatocellular Carcinoma Patient with Decompensated Liver Function
https://www.e-jlc.org/journal/view.php?doi=10.17998/jlc.14.2.127

Intranasal deferoxamine targets the brain primarily and suppresses inflammation improving central insulin sensitivity and this has downstream effects within the periphery by improving insulin sensitivity, insulin transport to the brain as well as supporting the function of our hypothalamus.
> Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

>>14636737
Op is an impersonator. Don't believe anything that fake pax's say. There's also floating around fake allegations that I've worked for the RCMP, abused women, and children including fake screenshots trying to implicate me as a pedophile.
[>>14633667]
^This post confirms my innocence and there's others in the same thread which confirmed that the screenshots have been fabricated and stories about deferoxamine causing liver fibrosis and sterility are fabrications which i've demonstrated to be not possible mechanistically based on the research available. The op in that thread when pressured for proof that they had indeed bought deferoxamine redirected people to kekma.net which is a screamer type shock site.

>>14631587
This has been confirmed fake by me and others in the other thread. [>>14633667]

>>14633895
High dose deferoxamine has been shown to slow the progression of cancers and reduce resistance to chemotherapy. The risks of fungal infection are not due to hif-1 but a sidephore mediated reaction with deferoxamine's iron chelate.
> High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines
https://pubmed.ncbi.nlm.nih.gov/29562821/

>>14633902
Sirsadalot has been running a concentrated campaign against me and has banned dozens of people for less and would go through the effort to destroy my reputation at a whim.

>>14633812
fake. get fucked
Gnomes are real is not a member of the server.
Netizen does not go by internet stranger.

>>14633708
yeah and its not formatted properly. Here's an example of what a post should look like on desuarchive. Notice how none of the formatting matches that of what is seen in this image. More posts of the same thing of people out to make me look delusional.
> My tripcode was made on 06/19/22(Sun)12:47:05. Not only is that a fake but So is op's story that deferoxamine intranasally would cause sterility or liver fibrosis.

If the post did come from an archive then post the link to the board that shows the thread. It's fake and noone can back it up thats why they didn't post a link.

>>14633499
it's not even formatted right. When we see a 4chan post the name date, time, and post number are posted above the image. Then the text wraps around the image. We see here that this is a doctored screenshot of a post supposedly dated Fri 13 Jun 2014. The date format isn't even correct. The date format for 4chan is MM/DD/YY(Day of the week)Time.
My tripcode was made on 06/19/22(Sun)12:47:05. Not only is that a fake but So is op's story that deferoxamine intranasally would cause sterility or liver fibrosis. In the study.
> Intranasal administration of deferoxamine to iron overloaded patients
https://www.sciencedirect.com/science/article/abs/pii/S0002962915363114
deferoxamine was given up to 3.5 grams in a 12 hour period to iron overloaded patients and the only side effects noticed were "mild nasal irritation and a bad taste in the mouth".
Liver disease mechanistically is a disorder of iron overload due to hepatic insulin resistance and that promotes the failure of proteostasis inducing iron accumulation.
> Iron and liver fibrosis: Mechanistic and clinical aspects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371002/
> Deferoxamine but not Dexrazoxane Alleviates Liver Injury Induced by Endotoxemia in Rats
https://journals.lww.com/shockjournal/Fulltext/2014/10000/Deferoxamine_but_not_Dexrazoxane_Alleviates_Liver.13.aspx
>>14633602
Good looking out! I've made many enemies in the past year+. There are people that would rather see me dead and all of you suffer from inadequacy forever just so that I do not succeed. I've turned an entire industry on its head and have 8+ people that I talk to on a frequent basis who've all used dfo intranasally and we have all had amazing transformations in our health and cognition.

>>14626508
in my pursuit of cognitive enhancement I've learned to understand there's really only the limit of mitochondrial functions within our brain that's the main limiting factor to control of metabolic homeostasis and cognition. I have no idea where the limit is even though I've pushed so far. It's actually surreal at this point having such a strong photographic memory and I know there's a place further beyond this. I am a strong proponent of the simulation hypothesis for this reason.

>>14625241
> I've went to university so I have a sense of entitlement.
Honestly when are you going to get it that your competency as a businessperson depends on factors such as conscientiousness and openness to experience which are commonly held traits in self made millionaire entrepreneurs which should be common sense.
From the journal nature:
> The personality traits of self-made and inherited millionaires

I've received messages from someone yesterday saying that they ordered the last of the HA-P6 on the 19th and you still haven't sent it and you think I wouldn't find out about that. Follow through with your obligations god damn!
You are using other peoples money to fund your pleasure projects to design a peptide that you're making more powerful with niche chemistry thats overly convoluted and rife with potential setbacks which you've had countless setbacks in the past year that you've failed to hold yourself accountable for including help from me. You are incapable of using copper click chemistry and cell penetrating peptides to make nr2b when you're dependent on the financial contributions of others to make it possible and you have little to no understanding of the risks that could come from nr2b that don't even include interpersonal relationships. You've been thinking only about yourself for the past year + and you're even missing the point of having accountability for your actions. There will be significant issues with nr2b and risks of increased excitotoxicity and you say its not your obligation to spoon feed your future customer base about potential risks. THAT IS YOUR FUCKING JOB! You need to get your goddamn head out of your ass and think for a moment that this world doesn't fucking revolve around our personal views on cognitive enhancement and you have to be a diligent teacher as much as a researcher because describing scientific concepts to other people requires social aptitude that you need to develop.

>>14624430
> Looks like pharma is interested in trialing it: https://clinicaltrials.gov/ct2/show/NCT04510233

A intention of a clinical trial is not evidence reported in a clinical trial of its evidence. that was dated august 2020. You aren't capable of providing more mechanistic data supporting its use or applications in mice or humans? Like this study?
> Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19
https://pubmed.ncbi.nlm.nih.gov/34163159/

Theres evidence here that it can be safe and effective but you have to have a strong understanding of pharmacology to go about this safely without injuring yourself. Snorting ivermectin tablets sound like it could be dangerous without considerations that it could kill you. Go ahead and do the whole bottle I don't care. OP wants to impersonate me to sound smart by namefagging and there's many others. This thread has been made before and they modified a screenshot of me to support its use by using Inspect element to change the html to state all of this. The message in the pic was initially in support of intranasal deferoxamine and it was modified to state that I developed cysts from injecting young cows blood XD .

>>14624894
its not relevant because we cant use fossil records to look at iron contents within the brain and we're current examining on a intracellular level how inflammation can influence iron disposition within our braincells and how that contributes to cognitive decline through induction of cerebral insulin resistance, hypothalamic inflammation, and glutamatergic excitotoxicity. Anthropology can't contribute significantly to understanding of mechanistic data supporting iron dysbiosis and the development of cognitive decline or even cognitive functions.

>>14624170
I have photographic memory of the mechanisms behind the pathology of cognitive decline and metabolic disorder and recall speed is instant. I can spend hours typing non stop, no decline in cognitive function throughout the day.I don't have any anxiety or fears. I am incredibly emotionally resilient to the point that I don't experience negative feelings. All of the other people that have joined me have noticed substantial gains including a man who claimed a gram of deferoxamine increased his IQ 1 standard deviation by having a cognitive function test.
I have more ambitious goals in teaching as many people neuroscience as possible and proposing deferoxamine for the mitigation of all disorders of cognitive decline and metabolic disorders. There's a lot to be done.