/sci/ - Science & Math

Hope its entertained! I will merge with AI. Im artificially intelligent! Tired of being dehumanized

Not today. Enjoy yourself! Brush your teeth and drink a Pepsi.

>>14857446
I can see why the nootfather would be personally vested in maintaining their business and grabbing a niche which can allow them to stay on top of the market. I don't even think that it's a bad route to take seeing that they're a multimillionaire likely with a family and circle of closely knit employees with some enthusiasm to continue to bring in enough funds to keep the business afloat.
I don't really see why plant based compounds can't find their niche or be better explored. i've been looking at intranasal DHA-curcumin microemulsions for a while. I think that incorporating Borneol, geniposide, berberine, and retinoid acid/vitamin D can be incorporated to make a intranasal solution that would be competitive.
Ibogaine, mushrooms, and other serotoninergic hallucinogens are fairly well regarded from people I've known to be the most well read in the community. Being into drugs you're likely to meet some people that have had years of experience with a large range of compounds and noots have come into focus as a means of maintaining their health and cognition for many more years. Then I know people who're generally younger than me who're exceptionally conscientious and love life that are out to enrich their lives and I think those groups are the lifeblood of what makes me happy to be a part of the community.
I haven't taken any classical psychedelics but from what many have said to me I really go hard on the compounds and concepts Im most enthusiastic about.
I've been enjoying MGF and IGF2 for the past few days. I can say those 2 compounds certainly have played a large part in pulling me out of a slump I've had recently. I've stuck to using about 100mcg each of IGF2 and MGF intranasally per day. I should look into making a small writeup about my thoughts of each soon to put my thoughts together.
My favorite noots always have been the ones that give a powerful sense of clarity and brighten your sense of eyesight and give new crispness to your other senses.

>>14857374
> Wasn't there even some teenager in sir's discord that got autism trying to induce synaesthesia in himself (for whatever reason)?
Yeah there's a large number of people that I've known with noot stacks 10+ compounds long and I think those are some of the harder people to relay info to because they feel what they're doing is great for them and they won't really listen to reason. I've known someone in my server for a time that probably gave one of the first dose reports on intranasal deferoxamine and they were taking that on top of a huge arrangement of other noots and magic mushrooms. Strangely enough they wanted to bring up the idea of me making conjugates every time I see them and my response usually was I'm not interested. It's a bit disheartening to see some people come to me on a repeat basis and ask me my opinion on one of their recent finds. I'm in the same boat relating to you my belief that most who identify as being a scholar in noots are not deeply invested in learning the base essentials. If you really want to optimize cognition and longevity then starting from the point of correction of metabolic disorder and cognitive function are essential before even considering what comes after.
> I seriously hope Bam pays attention to the D21 peptide being safe.
If I have faith that it can be completed I think he has far too much going on to really invest much time into understanding those risks like he used to. He really is dead set in his own biases that correction of metabolic abnormalities is not paramount to cognitive performance it has limited his pursuit past understanding the project where he's placing all of his pride into finishing.
We've had discussions where we have related to each other similar ideas of emotional struggles but having come from different upbringings it has led to different outcomes in how we handle our sense of entitlement.
Do you mind sharing with me what they had said about opiates that got your attention?

>>14850099
No. Phenibut may improve your social anxiety for a bit but it comes with the development of tolerance and dependence. Don't play with strong gabaergics they're basically benzo garbage. If you want to become less socially inept you may have to actually bite the bullet and think of talking to people in person in the real world and not think to yourself that you're really above anyone because you're insecure.
Coming to the noot space it's not incredibly uncommon that everyone is out to pursue drugs just as a social outlet and getting high hides our insecurities. Taking care of yourself and being a strong part of other peoples personal life offline will be good for you.
Otherwise snorting insulin/Rapamycin/Deferoxamine have had great utility for me over the past year and there's few compounds I'd place above those for improving sociability.
>>14851714
>>14853934
I've had great benefits from using intranasal insulin and for me the experience I've had with that over the past year had been magical. While not overwhelmingly powerful compared to classical noots it would reduce tolerance to nicotine and reduce the damage that amphetamines would induce on braincells.
Deferoxamine also has great utility as a stim itself and potentiates other stims while reducing their negative sides.
> Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania
https://www.sciencedirect.com/science/article/abs/pii/S0278584608000730
> Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure
https://pubmed.ncbi.nlm.nih.gov/28884876/
> Intranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation
https://pubmed.ncbi.nlm.nih.gov/28917981/

Rapamycin also has great potential for mitigating amphetamine related side effects and neurotoxicity.
https://www.hindawi.com/journals/omcl/2018/6124745/

>>14856991
That's an incredibly apt appraisal of the current environment in the noot space.Plant based noots or at least their current application is a joke and somewhere I feel that is what most people should play with. I've noticed the phenomenon become far too common of people mixing far too many noots in their stack or place strong reliance on a base of compounds like Dihexa and Isrib in their stack.
I wish more understood the risks associated with Isrib and dihexa but so many are just chasing a high.
I've noticed some become incredibly neurotic to the point they're paralyzed with anxiety and intolerant of social situations, similar to Autism.
Worse yet is the quality of discussion has fallen substantially or the ambition to pursue new avenues falls on the narrow subset in the community which have access to labs and think that the newest plant based compound or small molecule to come across their attention is incredibly novel.
I have faith that the community will continue to grow and I hope that it leads to more people becoming more literate about medicine and particularly neuroscience so that change can come to this broken regulatory system.
I've seen some fairly novel peptides and research come out in the past years I'm disgusted in the disparity between application of therapeutics in the lab and the research that is then translated into clinical trials or even go on to become "FDA approved". If some of the best work that I've seen has come from lab research from 10-30 years ago and hasn't reached human trials yet then we are witnessing pure nepotism.

I've paid for the synth of a fragment of soluble amyloid precursor protein alpha(The non amyloidogenic product of app processing which supports memory, neurogenesis, microtubule formation, and protein synthesis).
From an appraisal of the supporting literature it's most effective around the nanomolar range. From what I observed it could possibly be the strongest compound I encountered yet.
I'll update soon.

>>14836519
If Your diet is shit you are compromising your health down the line and in the short term a high salt high fat/high sugar diet will disturb many brain functions which are necessary for support of healthy neurotransmission. You really can't get away with it forever.

Semax has been nice in my experience, I've known a few people who have used nsi and have positive reports. I'm not quite sure if it may benefit you in your case to use intranasal insulin atm as many people who have eaten poor diets are poor responders to intranasal insulin. Deferoxamine I'd say has given me one of the most overwhelmingly positive experiences of all the drugs that I've tried next to insulin. Insulin and DFO are fairly synergistic. Dfo chelates iron that accumulates in the brain as a consequence of aging and inflammation. This iron promotes the failure in autophagy and ultimately insulin sensitivity within our brain cells leading to cognitive decline.

30-50 iu insulin between meals has been one of my favorites for many months. When I was cycling DFO I would mix insulin with dfo 2ml per vial and my typical dose would be 125mg.

All of this advice I believe can't really be of the greatest use to you if you don't take care of your mental health. Being stuck in the belief that your potential is inherently limited due to self doubt or depression really is going to set you back.

>>14836155
Thanks for mentioning Deferoxamine. I wish more anons would try it out. Some time ago I've hit a plateau with people giving dose reports and quite a few people from the 20+ individuals who've given dose reports I've gotten overwhelmingly positive reviews. I have heard from 1 person out of those 20 who had developed mucormycosis and consulted with them in their treatment. They were fortunate enough to have rapamycin and they had incorporated intranasal black seed oil but it's something that everyone should be mindful of. DFO has great potential as one of the most powerful cognitive enhancers especially for the price. Fortunately I've come across a compound that should go well beyond the potency of DFO and chelate labile iron from our braincells by promoting its export.
I believe its synthesis should only take a month and I may have it by late October if not early November.

I would like to approach a team of scientists from Israel some time within the next couple years about the possibility of volunteering for a Autologous Pancreatic islet transplant into my spinal cord or in the subarachinoid space in my brain to promote my cognition.
The procedure has been done in mice with a consistent record of success.
> Intracranial Transplantation of Pancreatic Islets Attenuates Cognitive and Peripheral Metabolic Dysfunctions in a Rat Model of Sporadic Alzheimer's Disease
https://pubmed.ncbi.nlm.nih.gov/30175977/

I would also like to approach a team of doctors in Columbia which would be able to transplant fetal/ umbilical cord stem cells into the subarachinoid space in my brain and ask them to inject the stem cells alongside a hydrogel modified YIGSR/IKVAV peptide to support ~30 fold increased survival of the transplanted stem cells. I would be supplying the peptides myself.

How would I ask for this without sounding insane or without any ethics board scrutinizing the ideas.

>>14807632
Yes I dilute it with water or insulin and use intranasally 125mg with 50iu of humulin R insulin by diluting deferoxamine with 2ml of liquid. I use a 1ml luer slip syringe with a removable needle
>>14807645
Deferoxamine has given me great improvements in metabolic health as well as stamina and mental fortitude. Negative side effects besides my interaction with mucormycosis which I had to treat
with intranasal Rapamycin and Cbd.
I had spent a few days in the hospital due to hyponatremia due to nausea. I may have gotten sick and I recently incorporated a peptide called CB3. CB3 is a thioredoxin mimetic peptide that has 10-100k times greater antioxidant potential as n-acetyl cysteine. Cb3 is exceptionally powerful and I'm noticing amazing improvements in my health.
> Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949098/

>>14806689
> Everyone has already told him that you can't convince him even when confronted rationally with conflicting evidence.

I'm very familiar with how single minded and closed off some academics and scholars focused around cognitive enhancement and IQ are. Openness to experience and willingness to explore newly introduced information is sytongly connected to how agreeable someoene may be and for those motivated by their implied superiority or intelligence being tied to their ego then especially when challenged with an idea that conflicts with their preconceived biases then they're going to assert themselves none the less. It's shown that many nobel scientists go on to develop eccentric beliefs or that people with narcicism are going to believe more in fringe beliefs to further enhance their preconceived mental image about themselves. I'm not immune at all to the belief that intelligence is closely tied to my self worth but some people when threatened consider that aggression towards them. I've known people who've worked in academia and state that narcicism and manipulative personalities are very common and predominately are more successful by using whatever means of aggression they can to get ahead. Just being this deep into a community centered directly behind cognitive enhancement is like a perfect breeding ground for narcicistic personality disorder to manifest in the greatest extreme. So I can say yeah its really common for some people who really aren't focused on the truth want something to define themselves.

>>14806617
>>14806653
Anons I have become a large presence within the nootropics and biohacking space for around a year and a half and in my pursuits I've wanted to explore novel drugs to improve human metabolic health and cognition. I'd suffered from Anxiety, depression, brainfog and irritability from from early childhood due to familial abuse. In my time in the nootropics community I've pioneered the use Rapamycin particularly intranasal use to target the brain particularly. I've later found intranasal insulin to be fantastic and intranasal deferoxamine was one of my latest introductions to the community which has attracted a large degree of followers of which 20 used deferoxamine intranasally and most either large positive benefit in cognition on metabolic health. Most have stated that deferoxamine is the best cognitive enhancing drug they've ever used.
Go into the wasoru /sci/ archives, and start looking up deferoxamine. I'd been stalked and impersonators have taken opportunity to plagiarize my work and some are fairly competent and wish to help while some trolls are out to ruin my credibility or motivation to continue. The picrel is about the first post the deferoxamine threads started and that thread was started by an impersonator. There's about 2 whole months of a long string of threads people have made on sci, pol, fit, and other boards about deferoxamine.
This may be one of the better threads in which an impersonator shares a large portion of my body of work which supports the use of intranasal deferoxamine and intranasal insulin for mitigation of cognitive disorders.
https://desuarchive.org/fit/thread/67429324

>>14806602
> its not just the vaccine but also the environment that was created ever since the beginning of the pandemic, overall depression and a feeling of impending doom that has reached majority population
for many normies this was the first time they got to see how much authoritarianism in in liberal western democracies.

> a pandemic with a less than 1% death rate for people that are healthy and dont have any comorbidities served as a convenient excuse to fuck you out of your freedom and basic rights

Have you considered the fact that 70% of U.S adults over the age of 18 are overweight or obese and that Long covid effects a large proportion of the young US population with estimates as high as one in 5 people who'd developed covid have long covid which has increased the prevalence of chronic fatigue syndrome especially adults of around age 30. I've known large numbers of people that I've worked closely with that either had suffered from chronic fatigue syndrome which I was formerly a well respected member of a online community centered on the treatment of cfs.
In many cased large numbers of people who'd developed covid or some who have taken the vaccines had a reactivation or developed Epstein-Barr virus after receiving the vaccine or developing covid. CFS is surprisingly common and its prevalence is increasing dramatically. So yes covid vaccinations are promoting cases of individuals who may've had a history of past EBV infection or newly developed EBV or had CFS from other sources.

> they have to keep up the act that covid is serious and these measures were totally necessary after scaremongering for basically nothing

1million americans have died and a dramatically larger proportion of people have went on to have life altering health or financial consequences from developing covid, long covid. or CFS of undefined cause.
Governments at large had failed to adequately address the covid pandemic and gave pharma companies a blank check. Stay healthy anon.

>>14793333
A predominately plant based diet rich in cruciferous vegetables such as kale, collard greens, broccoli, allium vegetables, beans, whole grains, nuts, berries, flax and chia ground for omega 3's preferrably low in processed oils, sugars, or refined grains with heavy emphasis on bean consumption.
It's demonstrated in feeding experiments, metabolic ward studies, and animal trials that its demonstrated through support of mechanistic data even through a observation of intracellular interactions proinflammatory factors pose on health, measurement of diet quality supports a diet lower in branch chain amino acids support an improvement in metabolic and mental health
> Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health
https://www.sciencedirect.com/science/article/pii/S2211124716307331
Its shown that branch chain amino acids compete with tryptophan for transport to the brain and interfere with serotonin metabolism. and this increases overeating and anxiety in mice.
> Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988204/
In this study population included 6,381 adults ages 50 and over from NHANES III, a nationally representative, cross-sectional study it;s shown that high protein respondents have a 75% increased risk of all cause mortality in the 50-65 age group and among subjects with no diabetes at baseline those in the high protein group had a 73-fold increase in risk of diabetes. "These associations were either abolished or attenuated if the source of proteins was plant-based".
> The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
https://www.sciencedirect.com/science/article/pii/S1550413121001662

I've been predominately whole food plant based for about 8 years until I'd become more active in the biohacking/nootropics community and cooked less.

>>14802735
Following general health and wellness guidelines such as maintenance of a diet rich in cruciferous vegetables (such as kale, collard greens, broccoli), Berries, Beans. Beans are the one food group most closely tied to longevity. It's been found that in what researchers in nutrition have called blue zones of longevity or locations of large demographics of octogenarians such as sardinia, and formerly okinowa or amongst 7th day adventists find that diets predominately focused on whole plant foods improves lifespan by average of 14 years.
A predominately plant based diet rich in fiber, antioxidants, and low in inflammatory endotoxins. advanced glycation endproducts, oxidized cholesterol. Animal proteins are found to significantly tied to increased all cause mortality through increased methionine, and bcaa's that increase serum igf1 levels. It's found that igf1 levels are tied closely to longevity with average vegans having 14% less igf1 levels than omnivores
>>14804911
Hey I'm aware of your struggles and I want to say coming from someone that has become the target for slander I think that discourse has become bloodsports especially in the Biohacking community which I believe has become a space ripe for bad business practices, gatekeeping, antisocial behavior in which I believe may come from attracting many individuals who have superiority complexes, and are concerned with gaining power. I can say I have had many qualities that have made it more likely for me to be arrogant.
Science is and will always be a concrete and easily understandable concept to practice through the scientific method but its rarely treated like that and in modern times replication of studies further expands on research that has been done in the past. You don't deserve that kind of treatment from people even if you're wrong that angular momentum is not concerved then people need to replicate your experiments to demonstate that and not through slander.

>>14801489
DMT and serotoninergic hallucinogens promote neuroplasticity through increasing mtor and bdnf activity within the brain to support neurogenesis. Its shown that somatostatin shares coexpression with serotonin 2a receptors within the brain and certain populations of serotonin expressing cells within the brain are responsible for transporting insulin from the periphery into the brain to support cell metabolism and neurogenesis. This may also support the function of somatostatin interneurons through suppressing pv interneurons to increase social reward through disinhibition of dopaminergic neurotransmission.
> Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission
https://www.pnas.org/doi/10.1073/pnas.2020705118
> Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons
https://www.pnas.org/doi/10.1073/pnas.2019295118
> Serotonin suppresses slow oscillations by activating somatostatin interneurons via the 5-HT2A receptor
https://www.biorxiv.org/content/10.1101/2020.05.26.113373v1.full
> Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline
https://pubmed.ncbi.nlm.nih.gov/35301424/
>Modulation of Serum Brain-Derived Neurotrophic Factor by a Single Dose of Ayahuasca: Observation From a Randomized Controlled Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558429/
> Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
https://pubmed.ncbi.nlm.nih.gov/24058344/
The underlined section
"POTENTIAL MECHANISMS OF SELECTIVE VULNERABILITY OF SOMATOSTATIN-EXPRESSING INTERNEURONS" is identifying different factors that contribute to the functional decline of somatostatin interneurons which are
>OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTIONS
> HIGH DEPENDENCE ON NEUROTROPHIC ENVIRONMENT
> INFLAMMATION AND CELLULAR AGING

>>14801111
CHECKED!

Scientists have implanted pancreatic stem cells within the brains of mice through injection through the subarachinoid space to create a new pseudo-pancreas within the brain to release insulin when stimulated with glucose and this supports greatly improved cognition and anti-diabetic effects within the brain.
> Intracranial Transplantation of Pancreatic Islets Attenuates Cognitive and Peripheral Metabolic Dysfunctions in a Rat Model of Sporadic Alzheimer's Disease
https://pubmed.ncbi.nlm.nih.gov/30175977/
> Anti-diabetic and neuroprotective effects of pancreatic islet transplantation into the central nervous system
https://pubmed.ncbi.nlm.nih.gov/25708430/
It's possible to take stemcells that we can extract from our skin cells, adipocytes, bone marrow or umbilical cord/fetal stem cells and differentiate them into islet like cells that release insulin and we can potentiate those stem cells with deferoxamine, gene therapy, and laminin derived peptides to support the migration, pluripotency and survival of stem cells and these can be implanted in the subarachinoid space by injecting them through our spinal cord and this could be used alongside a few other novel peptides and therapeutics that I'm investigating to promote direct brain tissue engineering on a cellular level through a multifaceted approach to provoke neuronal epo signalling, insulin signaling and sensitivity as well as directly targeting microtubule assembly within our neurons, reduction of oxidative stress through inhibition of oxidative stress through use of the thioredoxin mimetic peptide cb3 which delivers cysteine to mitochondria to support glutathione production 10k times more effectively than N acetyl cysteine, inhibition of metastatic vegf1 signaling through use of a flt1 inhibiting peptide. flt1 also is shown to be strongly tied to cognitive decline, atherosclerosis, organ dysfunction, macular degeneration and diabetic retinopathy.
Soon it will all be according to plan.

Autistic individuals have a reduced proportion of a certain population of gabaergic internuerons called somatostatin inhibitory interneurons and this reduces the accurate processing of faces or some other forms of sensory stimuli as sst interneurons gate and control the activity of parvalbumin interneurons and glutamatergic pyramidal cells within the brain. Somatostatin interneurons serve many roles in controlling metabolism, mood, emotional regulation and even learning and memory. A functional deficit in somatostatin inhibitory interneurons may predispose autistic individuals to have other mental disorders but particularly deficits through reduced neuronal synchronicity between the prefrontal cortex, the visual cortex, the auditory cortex and olfactory bulb.
Some gene mutation models are even tested in mice to change the morphology of somatostatin interneurons to express parvalbumin and become more like PV internuerons.
> Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
https://pubmed.ncbi.nlm.nih.gov/31844317/
> "Optogenetic manipulations revealed a double dissociation between the role of interneurons in social cognition. Specifically, inhibition of mPFC somatostatin (SOM+), but not of parvalbumin (PV+) interneurons, abolishes affective state discrimination. Accordingly, synchronized activation of mPFC SOM+ interneurons selectively induces social discrimination. As visualized by in vivo single-cell microendoscopic Ca2+ imaging, an increased synchronous activity of mPFC SOM+ interneurons, guiding inhibition of pyramidal neurons, is associated with affective state discrimination."

> The Parvalbumin/Somatostatin Ratio Is Increased in Pten Mutant Mice and by Human PTEN ASD Alleles
https://www.sciencedirect.com/science/article/pii/S2211124715004064
> What is the mechanism of loudness hyperacusis in autism?
https://www.sciencedirect.com/science/article/abs/pii/S0306987721002784

>>14801337
opioids induce endolysosomal deacidification within mitochondria leading to dissociation of iron from proteostatic processing of iron to support protein synthesis and this triggers the leakage of iron from mitochondrial membranes. Iron accumulates in ferritin in the cytosol of our neurons and promotes oxidative stress in the lysosome reducing mitochondrial function resulting in synaptic deficits through slowed transport of mitochondria to synaptic vesicles and exocytosis of glutamate receptors to the cell surface.
> Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons
https://www.eneuro.org/content/6/4/ENEURO.0237-19.2019
In this study it's demonstrated that opioids like morphine reduces synaptic outgrowth and viability through the accumulation of iron within our neurons and this promotes neuronal erythropoeitin resistance as well as insulin resistance. Opioids also promote the disinhibition of glutamate signalling to provoke reward based on somatostatin evoked inhibition of parvalbumin interneurons to disinhibit pyramidal cells. opioid induced glutamatergic disinhibition also provokes the endocytosis of iron into neurons through gtpase, and dexras1
> Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1
Chelation of iron from the cytosol of our neurons with chelation agents such as deferoxamine completely mitigates opioid induced synaptic deficits as well as mitigates glutamate evoked iron uptake into neurons. iron within the cytosol of our neurons reduces cell excitability as well.
> Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066355/
> Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911954/

>>14801161
>how would you even go about getting that stuff though.. go to the wasoru sci archives. My work has been shared by many impersonators on sci, fit, pol, tv and possibly other boards so checking those archives are possibly worth it if you want to dive through them. My unique tripcode was made on june 19th and anything I've posted is under this tripcode. There's been many impersonators and people that've went to great lengths to attempt to undermine the work I've put into the community.
Being able to get insulin shouldnt be hard.
Getting access to
Pharma grade dfo shouldn't be hard if you look into the sci archives.
https://desuarchive.org/fit/thread/67429324
This is one of the better imitators sharing my work and they were actually fairly competent as I've seen they've been able to write some well worded unique replies when answering questions. There's been many who've gotten their own secured trip codes and some with unsecured tripcodes.
>>14801308
I think that in my experience I've enjoyed higher dose nalrexone but it's really not the best to use higher dose naltrexone its fairly dysphoric at high doses. 4.5mg/pd is what I've used when i used LDN. I think that naltrexone may be great for off days or low dose naltrexone may be interesting as well to incorporate but I think there's better antiinflammatories than LDN for the price. Intranasal use of Deferoxamine is something that really propelled me into being discovered by an audience adjacent to 4chan and that's something that Ive encouraged about 20 people to use and all say its life changing
>Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630208/
Naltrexone facilitates improved ampa receptor phosphorylation by improving neuronal insulin signalling by suppressing the actions of endorphins which may suppress neurogenesis and neuroplasticity through opioid receptor mediated actions.cont

>>14801031
cont.
> Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia
https://pubmed.ncbi.nlm.nih.gov/27090509/
A heavily processed diet and endotoxicity from leakage of gram negative bacteria from the gastrointestinal tract which can be promoted by Sugar, ssri's, high salt diets, saturated fats (particularly palmitic acid), and endotoxins from animal product consumption as bacteria such as e.coli have lipid cell linings that are inflammatory(lipopolysaccharides). A heavily processed diet further compounds chronic mild stress in invoking a dysbiosis in our microbiome by promoting the growth of inflammatory bacteria within the gastrointestinal tract, or highly glycemic foods promoting serotonin levels within the gastrointestinal tract increasing mtor tone within the gastrointestinal tract and the metabolism of kyurenic and quinolinic acid within the gastrointestinal tract which can then enter past a damaged blood brain barrier and exert neurotoxic effects. There's many different contributing factors in which diet and social stressors interact together to deteriorate cognitive functions.
Exercise, environmental enrichment, meditation are all great approaches for mitigation of cognitive decline and there's strong evidence to support all of these interventions alongside diet for improving mental health and ultimately cognition.

I've been an active member of the nootropics community for over the past year and have made many contributions to advance the development and advocacy of novel drugs for the promotion of longevity and cognitive enhancement. Prior to that i've have been rooted in the study of nutrition and biochemistry for many years.
in my experience the best interventions for improving quality of life and cognition are intranasal insulin, intranasal rapamycin and intranasal deferoxamine.

>>14796999
There's demonstrated proof that engaging in cognitive work increases the long term potentiation or the "connections between neurons" through a variety of mechanisms and models that test this are called "environmental enrichment" within the literature. Increasing the load or demand that we place on our neurons when we learn strengthens the connections between neurons as well as neuronal morphology through induction of functional hypoxia.
As we place high degrees of stress on neurons in a cognitively demanding task this promotes erythropoeitin signalling within neurons by transiently inducing a small degree of oxygen glucose deprivation that preconditions neurons to become more resistant to inflammatory stressors.
> Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance
https://pubmed.ncbi.nlm.nih.gov/35414656/
> CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge
https://pubmed.ncbi.nlm.nih.gov/33804598/
>>14800526
Depression has a large connection to the reduction in motivation and learning through invoking neuroinflammation which may be connected to cortisol promoting glutamate release, increasing the production of allopregnanolone( an endogenous benzodiazepine), and endogenous cannabinoids which all have negative effects on neuronal insulin sensitivity which our brains are largely dependent on for glucose metabolism, neurogenesis, production of neurosteroids from cholesterol etc. These are investigated in a lab setting and are often called chronic mild stress models.
Reduced insulin transport and sensitivity within the brain as a direct result of iron dysbiosis within the brain promotes amyloidogenic processing of Amyloid precursor protein and the phosphorylation of tau.

>>14786310
Ive known a couple schizophrenic noot users. Both of them developed their schizophrenia from stimulant psychosis. One induced it through abusing pea and the second one had 72 hour sleep wake cycles and had a nootropic list with close to 20+ compounds on it. There's probably a point where use of highly experimental compounds enhance the human experiwnce beyond the point where most people can be defined as neurotypical. Im probably one of the biggest examples of someone by any measure could be defined as having a high conflict personality disorder. It really requires a large degree of grandiosity to have the ambition to use highly experimental drugs in a way that is synergistic and with risks that can be easily defined and mitigated.

>>14783933
Your brain is reliant on glucose metabolism to support all of our cognitive functions and its seen that is particularly important in the context of adhd. When I became most ambitious exploring novel nootropics and became a part of the cognitive enhancement community at large I had huge breakthroughs with skq1 at 200mcg subq for a few months. Intranasal Rapamycin when i first began using it was one of the more awe inspiring experiences of my life. Both of those compounds did incredibly well mitigating brainfog and negative mood states. Intranasal insulin i had found early this year and it had been the most amazing addition to my stack upto that point. Nothing gave me more ambition or better cognitive function upto that point. Then a few months ago i began using deferoxamine intranasally. All of these compounds strongly support mitochondrial functions through mitigation of oxidative stress and supporting autophagy. By improving mitochondrial atp generation we promote higher function of our braincell lines which supports attention, memory and sensory processing. Insulin is otc in the united states. I just go to the pharmacy counter and ask for humulin r. I use about 100iu of insulin intranasally daily. I incorporate deferoxamine a few times a week and I havent noticed a sticking point yet where i would notice negative sides from dfo and ive been consistent about using it intranasally. Im about 7 grams deep. Im eager to try mechano growth factor and ara290 intranasally. If i had the opportunity i would try epo intranasally. I am most eager about the projects that i will greenlight in the next couple months. I have plans on financing multiple projects in the short term all of compiunds that haven't been tested in humans before. I'm very excited about the possibilities as these compounds are likely to be the most powerful cognitive enhancers and longevity promoting agents to ever be discovered.