Can someone point out the flaws with this paper? I looked at the pictures and skimmed through the words, looks like Masamitsu Oshima and co made something funny. All just cope & hope?
QRD,
1 get a pregnant mouse,
2 kill her,
3 steal her unborn baby,
4 cut it's head off,
5 steal it's not-yet-formed molars,
6 extract mesenchymal what-it cells from the molar and separate them from eachother,
7 grow the cells a bit in the lab so they form a clump again (undo what 6 just did)
8 acquire another mouse
9 cut him open, pull his kidney out (gently)
10 open the thin membrane surroudning the kidney forming a little pocket
11 package the clump of tooth-forming cells in a plastic tube
12 put the cump of cells and plastic tube into the mouse kidney
13 sew him and his kideny back up
14 let everything heal
15 wait about 60 days
16 get the now grow mouse tooth from the kidney
17 remove plastic tube from tooth
18 remove mouse's fully functional molar (owie)
19 let it heal over
20 cut the gum open again
21 stick that newly grown mouse tooth in the hole
22 ???
23 profit, mouse now has tooth again!!!! :)
If I had to guess the big problem with this paper is that the original source of tooth forming cells was from a mouse embryo, sadly adult humans probably don't have any of those stem cells in their jaws that we could extract and grow as shown above.
Either that or big-dentist would assassinate anyone who tried.
oh btw, source:
https://pubmed.ncbi.nlm.nih.gov/28361313/
lolpaywall:
https://sci-hub.se/10.1007/978-1-4939-6949-4_8