IMMORTALITY IS BECOMING REALITY

[Anonymous No.19668739]

There is decent progress being made on this front. There are several avenues, several points of attack when it comes to the ageing process, and there is slow but steady progress being made on all front.
PIWI piRNA pathway:
Its what the genetics department at my uni is researching, and how it can help make high longevity transgenic animals. This is the research i have just joined. Quite promising, as there are active immortal cells in humans with this pathway active, namely the germline progenitor cells. There are also hydra which are immortal, and they also have this pathway active in all their cells.
Cell turnover:
Ageing is esentually accumulation of somatic mutations. These often happen at mitosis, and any cell which proliferates focuses less on DNA repair and more on synthesizing the necesseary proteins. There are different methods being tryed to combat this here, Mutations that decrease the effectiveness of insulin receptors puts cells in maintenace mode insted of proliferation mode. In rats this has doubled, an in nematodes has quadroupled lifespan. Others are working on better gene repair, lower protein turnover, cellular longevity...
Telomers and telomerase:
I actually don't have much to say on this front, other than the fact that recent therapy methods have increased telomer length by 30% so thats good too. Not my area of research though, so i don't no more than the basics.
Apoptosis research:
The role of apoptosis in ageing and development is not fully understood, but it has been shown that mutations can have significant effect on longevity in both positive and negative way. Reserach in this are is also very active, though it has died down a bit lately, as it seems not to be as important as initially thought.
Epigenetics:
A very recent discovery is that cromatin structure changes as we age, and cromatin problems can cause progeria. Histone and DNA methylation also plays a part, but we don't really know how.

[Anonymous No.19668764]

Death is the true end to suffering

[Anonymous No.19668770]

>immortality

truly no worse fate than this.

[Anonymous No.19668820]

There is no reason why immortality would be fundamentally impossible - it has simply long since been selected against. Though the mortal individual is trivially weaker, the group is made immeasurably stronger through being forced to become resilient to churn.

[Anonymous No.19668841]

Ok, but is this books or literature.

[Anonymous No.19668856]

>>19668841
here is some literature
Chen, Ingfei. Wake-Up Call, Sciencemag.org, 19 February 2003.
Cox, Hugo. Aubrey de Grey: scientist who says humans can live for 1,000 years, Financial Times, 8 February 2017.
Bushko, Renata G., ed. (2005). Future of Intelligent and Extelligent Health Environment, volume 118. IOS Press. p. 328. ISBN 978-1-58603-571-6.
de Grey, A.; Jacobsen, S.D. (8 June 2014). "Dr. Aubrey de Grey: SENS Research Foundation, Co-founder; Rejuvenation Research, Editor-in-Chief". In-Sight (5.A): 29–33.
"Fall 2014 Biology Distinguished Lecturer – Aubrey de Grey, Ph.D. of the Sens Research Foundation". Northeastern University. Retrieved 23 April 2015.
"Live to 120 Plus—Utopia or Dystopia? – The UCLA Institute for Society and Genetics". ucla.edu. Archived from the original on 22 December 2015. Retrieved 23 April 2015. de Grey, Aubrey D.N.J (8 April 2018), The chromatic number of the plane is at least 5, arXiv:1804.02385, Bibcode:2018arXiv180402385D
Lamb, Evelyn (17 April 2018). "Decades-Old Graph Problem Yields to Amateur Mathematician".
Dockrill, Peter (19 April 2018). "An Amateur Solved a 60-Year-Old Maths Problem About Colours That Can Never Touch". ScienceAlert. Archived from the original on 5 February 2021.
Mixon, Dustin G. (8 July 2019). "Polymath16, thirteenth thread: Bumping the deadline?".
"Agex to develop powerful regenerative and anti-aging treatments". Next Big Future. 16 December 2017.
"Biotime unit Agex Therapeutics appoints Aubrey De Grey as VP of new technology discovery" Reuters. 13 July 2017 Archived from the original on 5 February 2021
"AgeX Therapeutics lands $10 mln". PE HUB. 17 August 2017
Pontin, Jason (11 July 2006). "Is Defeating Aging Only a Dream?" MIT Technology Review. Technology Review. Archived from the original on 16 February 2013. Retrieved 23 August 2012
"Life Extension Pseudoscience and the SENS Plan" (PDF)
Warner, Huber; Anderson, Julie; Austad, Steven; Bergamini, Ettore; Bredesen, Dale; Butler, Robert; Carnes, Bruce A.; Clark, Brian F. C.; Cristofalo, Vincent; Faulkner, John; Guarente, Leonard; Harrison, David E.; Kirkwood, Tom; Lithgow, Gordon; Martin, George; Masoro, Ed; Melov, Simon; Miller, Richard A.; Olshansky, S. Jay; Partridge, Linda; Pereira-Smith, Olivia; Perls, Tom; Richardson, Arlan; Smith, James; Von Zglinicki, Thomas; Wang, Eugenia; Wei, Jeanne Y.; Williams, T. Franklin (November 2005). "Science fact and the SENS agenda. What can we reasonably expect from ageing research?". EMBO Reports. 6 (11): 1006–1008. doi:10.1038/sj.embor.7400555. ISSN 1469-221X. PMC 1371037. PMID 16264422.
"SENS Research Foundation FAQ". SENS Research Foundation. Archived from the original on 14 July 2011. Retrieved 26 June 2011.
De Grey, Aubrey (2005). "Like it or not, life-extension research extends beyond biogerontology". EMBO Reports. 6 (11): 1000. doi:10.1038/sj.embor.7400565. PMC 1371043. PMID 16264420.
"Research Advisory Board". sens.org. Archived from the original on 14 June 2021. Retrieved 15 July 2021.

[Sage No.19668861]

Off topic.
Sage in all fields.

[Anonymous No.19668973]

I am afraid of /sci/ transhumanist wizards