/lit/ - Literature

Sloterdijk described Lovecrafts work (or cosmic horror in general) as something that resonated with the prevailing feeling of losing all outer bounds that held the world in place, something people felt at that time and still do today.
God was declared dead and the cosmos opened up more and more without anyone above us to keep the earth safe.

What comes next or after that is up to what kind of fears we collectively develop but one theme that is very popular already and probably will continue to do so in the future is the "Aww sweet, manmade horrors beyond my comprehension" play. All the AI horror like Systemshock, Terminator, Matrix etc resonate well with peoples fears and the OP from cruelty squad also encapsulates that very well.
"looks like mankind was the demons all along" isn't particularly new but it does fit very well and with increasing technology it will just get more horrifying.
My personal choice for a truly horrifying sub-genre of this is medical/body horror.