Remilia's inspirations seem to be JJBA's vampires and Darkstalker's Dmitri, so I think she's mostly melee oriented.
Flandre is the "495 years old magical girl". I like to think Flandre can dominate Remilia if they're far (Flandre can do more things with her danmaku) but Remilia wins on close combat.
But back to the thread theme, Nue is a bad girl that needs almost constant discipline. Good thing she lives right next a strong, caring and strict woman.