/biz/ - Business & Finance

>>17195461
Nooooooo. Muh $k1000k$ .

>>15423309
IM LONELY AND HAVE NO FRIENDS STOP PICKING ON ME REEEEEEE

>>15411145
>Merck makes money because Keytruda is a miracle drug

immunooncology is an important advance in the treatment of cancer, and Keytruda is the face of it, but 5 year overall survival in Keytruda patients is still 23.2% in patients who haven't been treated for cancer before and 15.5% in patients who have had other cancer treatments before (it's lower in this population because many of them are patients who have failed to respond to those other treatments), using NSCLC as an example
merck is doing combination trials with many different companies in an attempt to find drugs that can make keytruda more effective when used in combination therapy, GALT being one of them
galectin-3 is an essential part of the mechanism through which tumors hide themselves from the immune system, and inhibiting it could greatly boost the efficacy of Keytruda by making it easier for the immune system to find and kill tumors

some key evidence of the efficacy of GALT's drug and the mechanism of action itself (galectin-3 inhibition) is the finding that it significantly suppressed MDSCs (another key part of how tumors hide themselves from the immune system) in patients who were treated with it during their Keytruda combo trial

I know you don't know or care about this at all, but it is very much relevant

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828349/
https://investors.merck.com/news/press-release-details/2019/Five-Year-Survival-Data-for-Mercks-KEYTRUDA-pembrolizumab-in-Advanced-Non-Small-Cell-Lung-Cancer-NSCLC-from-First-KEYNOTE-Trial-at-2019-ASCO-Annual-Meeting/default.aspx