I'm planning my sells on the idea that crypto will bubble and crash again and the economic devastation will be on the level of the dotcom crash in the early 2000s. There will be a few Amazons and Apples that will survive and thrive, but 99% of the coins out there will go to zero. Cue another round of bailouts, and so it goes.
The dotcom crash destroyed about 20 trillion dollars of "value", so accounting for 20 years of inflation since then, I'm not planning on making any big sales until the collective crypto market cap hits 40 trillion or so. I do have some small sales planned at various multiples to take profit. Example: I got a 20x on VGX, so I sold 5%. Everything else in that bag is house money now. But you do you, boo.